Science 2 April 1993: Vol. 260. no. 5104, pp. 85 - 88 DOI: 10.1126/science.8465203

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Articles

Oncogenic KRAS and BRAF Differentially Regulate Hypoxia-Inducible Factor-1{alpha} and -2{alpha} in Colon Cancer.

H. Kikuchi, M. S. Pino, M. Zeng, S. Shirasawa, and D. C. Chung (2009)
Cancer Res. 69, 8499-8506
 |  Abstract »  |  Full Text »  |  PDF »

RAS Mutations Affect Tumor Necrosis Factor-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects.

P. K. Kreeger, R. Mandhana, S. K. Alford, K. M. Haigis, and D. A. Lauffenburger (2009)
Cancer Res. 69, 8191-8199
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of the Tumor Suppressor Protein {alpha}-Catenin by Ischemic Microenvironment.

C. L. Plumb, U. Adamcic, S. Shahrzad, K. Minhas, S. A.I. Adham, and B. L. Coomber (2009)
Am. J. Pathol. 175, 1662-1674
 |  Abstract »  |  Full Text »  |  PDF »

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells.

J. Yun, C. Rago, I. Cheong, R. Pagliarini, P. Angenendt, H. Rajagopalan, K. Schmidt, J. K. V. Willson, S. Markowitz, S. Zhou, et al. (2009)
Science 325, 1555-1559
 |  Abstract »  |  Full Text »  |  PDF »

PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers.

S. Wee, Z. Jagani, K. X. Xiang, A. Loo, M. Dorsch, Y.-M. Yao, W. R. Sellers, C. Lengauer, and F. Stegmeier (2009)
Cancer Res. 69, 4286-4293
 |  Abstract »  |  Full Text »  |  PDF »

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription.

M. Paramasivam, A. Membrino, S. Cogoi, H. Fukuda, H. Nakagama, and L. E. Xodo (2009)
Nucleic Acids Res. 37, 2841-2853
 |  Abstract »  |  Full Text »  |  PDF »

How molecular pathology is changing and will change the therapeutics of patients with follicular cell-derived thyroid cancer.

J P. Couto, H Prazeres, P Castro, J Lima, V Maximo, P Soares, and M Sobrinho-Simoes (2009)
J. Clin. Pathol. 62, 414-421
 |  Abstract »  |  Full Text »  |  PDF »

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.

J. J. Yeh, E. D. Routh, T. Rubinas, J. Peacock, T. D. Martin, X. J. Shen, R. S. Sandler, H. J. Kim, T. O. Keku, and C. J. Der (2009)
Mol. Cancer Ther. 8, 834-843
 |  Abstract »  |  Full Text »  |  PDF »

Down-regulation of Death-associated Protein Kinase-2 Is Required for {beta}-Catenin-induced Anoikis Resistance of Malignant Epithelial Cells.

H. Li, G. Ray, B. H. Yoo, M. Erdogan, and K. V. Rosen (2009)
J. Biol. Chem. 284, 2012-2022
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance.

N. T. Ihle, R. Lemos Jr., P. Wipf, A. Yacoub, C. Mitchell, D. Siwak, G. B. Mills, P. Dent, D. L. Kirkpatrick, and G. Powis (2009)
Cancer Res. 69, 143-150
 |  Abstract »  |  Full Text »  |  PDF »

The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells.

B. L. Ruis, K. R. Fattah, and E. A. Hendrickson (2008)
Mol. Cell. Biol. 28, 6182-6195
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of a Diamine Exporter in Colon Epithelial Cells.

T. Uemura, H. F. Yerushalmi, G. Tsaprailis, D. E. Stringer, K. E. Pastorian, L. Hawel III, C. V. Byus, and E. W. Gerner (2008)
J. Biol. Chem. 283, 26428-26435
 |  Abstract »  |  Full Text »  |  PDF »

Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation.

A. P. Martin, A. Miller, L. Emad, M. Rahmani, T. Walker, C. Mitchell, M. P. Hagan, M. A. Park, A. Yacoub, P. B. Fisher, et al. (2008)
Mol. Pharmacol. 74, 807-822
 |  Abstract »  |  Full Text »  |  PDF »

Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells.

F. J. Fattah, N. F. Lichter, K. R. Fattah, S. Oh, and E. A. Hendrickson (2008)
PNAS 105, 8703-8708
 |  Abstract »  |  Full Text »  |  PDF »

TATA Box-Binding Protein-Associated Factor 12 Is Important for RAS-Induced Transformation Properties of Colorectal Cancer Cells.

A. Voulgari, S. Voskou, L. Tora, I. Davidson, T. Sasazuki, S. Shirasawa, and A. Pintzas (2008)
Mol. Cancer Res. 6, 1071-1083
 |  Abstract »  |  Full Text »  |  PDF »

Defining the blueprint of the cancer genome.

V. E. Velculescu (2008)
Carcinogenesis 29, 1087-1091
 |  Abstract »  |  Full Text »  |  PDF »

PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab.

M. Jhawer, S. Goel, A. J. Wilson, C. Montagna, Y.-H. Ling, D.-S. Byun, S. Nasser, D. Arango, J. Shin, L. Klampfer, et al. (2008)
Cancer Res. 68, 1953-1961
 |  Abstract »  |  Full Text »  |  PDF »

Knock-in of Mutant K-ras in Nontumorigenic Human Epithelial Cells as a New Model for Studying K-ras Mediated Transformation.

H. Konishi, B. Karakas, A. M. Abukhdeir, J. Lauring, J. P. Gustin, J. P. Garay, Y. Konishi, E. Gallmeier, K. E. Bachman, and B. H. Park (2007)
Cancer Res. 67, 8460-8467
 |  Abstract »  |  Full Text »  |  PDF »

Histone Deacetylase Inhibitors Induce Cell Death Selectively in Cells That Harbor Activated kRasV12: The Role of Signal Transducers and Activators of Transcription 1 and p21.

L. Klampfer, J. Huang, S. Shirasawa, T. Sasazuki, and L. Augenlicht (2007)
Cancer Res. 67, 8477-8485
 |  Abstract »  |  Full Text »  |  PDF »

Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.

H. Hao, V. M. Muniz-Medina, H. Mehta, N. E. Thomas, V. Khazak, C. J. Der, and J. M. Shields (2007)
Mol. Cancer Ther. 6, 2220-2229
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role for Fas-Associated Death Domain-Like Interleukin-1-Converting Enzyme-Like Inhibitory Protein in Anoikis Resistance and Distant Tumor Formation.

I. A. Mawji, C. D. Simpson, R. Hurren, M. Gronda, M. A. Williams, J. Filmus, J. Jonkman, R. S. Da Costa, B. C. Wilson, M. P. Thomas, et al. (2007)
J Natl Cancer Inst 99, 811-822
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Control of the Human High Mobility Group A1 Gene: Basal and Oncogenic Ras-Regulated Expression.

I. Cleynen, C. Huysmans, T. Sasazuki, S. Shirasawa, W. Van de Ven, and K. Peeters (2007)
Cancer Res. 67, 4620-4629
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Ras-Related Nuclear Protein, Targeting Protein for Xenopus Kinesin-like Protein 2, and Stearoyl-CoA Desaturase 1 as Promising Cancer Targets from an RNAi-Based Screen.

S. E. Morgan-Lappe, L. A. Tucker, X. Huang, Q. Zhang, A. V. Sarthy, D. Zakula, L. Vernetti, M. Schurdak, J. Wang, and S. W. Fesik (2007)
Cancer Res. 67, 4390-4398
 |  Abstract »  |  Full Text »  |  PDF »

Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells.

F. H. Psahoulia, S. Moumtzi, M. L. Roberts, T. Sasazuki, S. Shirasawa, and A. Pintzas (2007)
Carcinogenesis 28, 1021-1031
 |  Abstract »  |  Full Text »  |  PDF »

Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA.

J.-S. Kim, C. Lee, C. L. Bonifant, H. Ressom, and T. Waldman (2007)
Mol. Cell. Biol. 27, 662-677
 |  Abstract »  |  Full Text »  |  PDF »

Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.

A. V. Sarthy, S. E. Morgan-Lappe, D. Zakula, L. Vernetti, M. Schurdak, J. C.L. Packer, M. G. Anderson, S. Shirasawa, T. Sasazuki, and S. W. Fesik (2007)
Mol. Cancer Ther. 6, 269-276
 |  Abstract »  |  Full Text »  |  PDF »

Radiotherapy-induced signal transduction.

A. Yacoub, A. Miller, R. W Caron, L. Qiao, D. A Curiel, P. B Fisher, M. P Hagan, S. Grant, and P. Dent (2006)
Endocr. Relat. Cancer 13, S99-S114
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Sterile20-Like Kinase 1 in Proteasome Inhibitor Bortezomib-Induced Apoptosis in Oncogenic K-ras-Transformed Cells..

F. Teraishi, W. Guo, L. Zhang, F. Dong, J. J. Davis, T. Sasazuki, S. Shirasawa, J. Liu, and B. Fang (2006)
Cancer Res. 66, 6072-6079
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic Ras Inhibits Anoikis of Intestinal Epithelial Cells by Preventing the Release of a Mitochondrial Pro-apoptotic Protein Omi/HtrA2 into the Cytoplasm.

Z. Liu, H. Li, M. Derouet, A. Berezkin, T. Sasazuki, S. Shirasawa, and K. Rosen (2006)
J. Biol. Chem. 281, 14738-14747
 |  Abstract »  |  Full Text »  |  PDF »

KRASD13 Promotes Apoptosis of Human Colorectal Tumor Cells by ReovirusT3D and Oxaliplatin but not by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand..

N. Smakman, D. J.M. van den Wollenberg, S. G. Elias, T. Sasazuki, S. Shirasawa, R. C. Hoeben, I. H.M. Borel Rinkes, and O. Kranenburg (2006)
Cancer Res. 66, 5403-5408
 |  Abstract »  |  Full Text »  |  PDF »

Thematic review series: Lipid Posttranslational Modifications. Farnesyl transferase inhibitors.

A. D. Basso, P. Kirschmeier, and W. R. Bishop (2006)
J. Lipid Res. 47, 15-31
 |  Abstract »  |  Full Text »  |  PDF »

ras Oncogene Triggers Up-regulation of cIAP2 and XIAP in Intestinal Epithelial Cells: EPIDERMAL GROWTH FACTOR RECEPTOR-DEPENDENT AND -INDEPENDENT MECHANISMS OF ras-INDUCED TRANSFORMATION.

Z. Liu, H. Li, M. Derouet, J. Filmus, E. C. LaCasse, R. G. Korneluk, R. S. Kerbel, and K. V. Rosen (2005)
J. Biol. Chem. 280, 37383-37392
 |  Abstract »  |  Full Text »  |  PDF »

Glutathione S-Transferase {pi}1 Promotes Tumorigenicity in HCT116 Human Colon Cancer Cells.

D. T. Dang, F. Chen, M. Kohli, C. Rago, J. M. Cummins, and L. H. Dang (2005)
Cancer Res. 65, 9485-9494
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenes and Angiogenesis: Down-regulation of Thrombospondin-1 in Normal Fibroblasts Exposed to Factors from Cancer Cells Harboring Mutant Ras.

W. Kalas, J. L. Yu, C. Milsom, J. Rosenfeld, R. Benezra, P. Bornstein, and J. Rak (2005)
Cancer Res. 65, 8878-8886
 |  Abstract »  |  Full Text »  |  PDF »

Ischemia-Induced K-ras Mutations in Human Colorectal Cancer Cells: Role of Microenvironmental Regulation of MSH2 Expression.

S. Shahrzad, L. Quayle, C. Stone, C. Plumb, S. Shirasawa, J. W. Rak, and B. L. Coomber (2005)
Cancer Res. 65, 8134-8141
 |  Abstract »  |  Full Text »  |  PDF »

Manganese Superoxide Dismutase Induces p53-Dependent Senescence in Colorectal Cancer Cells.

L. Behrend, A. Mohr, T. Dick, and R. M. Zwacka (2005)
Mol. Cell. Biol. 25, 7758-7769
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role of p38{gamma} in K-Ras Transformation Independent of Phosphorylation.

J. Tang, X. Qi, D. Mercola, J. Han, and G. Chen (2005)
J. Biol. Chem. 280, 23910-23917
 |  Abstract »  |  Full Text »  |  PDF »

Transformation by Oncogenic RAS Sensitizes Human Colon Cells to TRAIL-induced Apoptosis by Up-regulating Death Receptor 4 and Death Receptor 5 through a MEK-dependent Pathway.

K. G. Drosopoulos, M. L. Roberts, L. Cermak, T. Sasazuki, S. Shirasawa, L. Andera, and A. Pintzas (2005)
J. Biol. Chem. 280, 22856-22867
 |  Abstract »  |  Full Text »  |  PDF »

Ras-mediated Loss of the Pro-apoptotic Response Protein Par-4 Is Mediated by DNA Hypermethylation through Raf-independent and Raf-dependent Signaling Cascades in Epithelial Cells.

K. Pruitt, A. S. Ulku, K. Frantz, R. J. Rojas, V. M. Muniz-Medina, V. M. Rangnekar, C. J. Der, and J. M. Shields (2005)
J. Biol. Chem. 280, 23363-23370
 |  Abstract »  |  Full Text »  |  PDF »

Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells.

D. Cavallo-Medved, J. Mai, J. Dosescu, M. Sameni, and B. F. Sloane (2005)
J. Cell Sci. 118, 1493-1503
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic K-RAS Is Required to Maintain Changes in Cytoskeletal Organization, Adhesion, and Motility in Colon Cancer Cells.

C. B. Pollock, S. Shirasawa, T. Sasazuki, W. Kolch, and A. S. Dhillon (2005)
Cancer Res. 65, 1244-1250
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.

J. L. Yu, L. May, V. Lhotak, S. Shahrzad, S. Shirasawa, J. I. Weitz, B. L. Coomber, N. Mackman, and J. W. Rak (2005)
Blood 105, 1734-1741
 |  Abstract »  |  Full Text »  |  PDF »

H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.

R. W. Caron, A. Yacoub, X. Zhu, C. Mitchell, S. I. Han, T. Sasazuki, S. Shirasawa, M. P. Hagan, S. Grant, and P. Dent (2005)
Mol. Cancer Ther. 4, 243-255
 |  Abstract »  |  Full Text »  |  PDF »

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

R. W. Caron, A. Yacoub, M. Li, X. Zhu, C. Mitchell, Y. Hong, W. Hawkins, T. Sasazuki, S. Shirasawa, A. P. Kozikowski, et al. (2005)
Mol. Cancer Ther. 4, 257-270
 |  Abstract »  |  Full Text »  |  PDF »

Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells.

G. P. Collett and F. C. Campbell (2004)
Carcinogenesis 25, 2183-2189
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic Ras Promotes Butyrate-induced Apoptosis through Inhibition of Gelsolin Expression.

L. Klampfer, J. Huang, T. Sasazuki, S. Shirasawa, and L. Augenlicht (2004)
J. Biol. Chem. 279, 36680-36688
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Tumor Growth by Galectin-7 Gene Transfer.

S. Ueda, I. Kuwabara, and F.-T. Liu (2004)
Cancer Res. 64, 5672-5676
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of Histone Deacetylase Activity for Signaling by STAT1.

L. Klampfer, J. Huang, L.-A. Swaby, and L. Augenlicht (2004)
J. Biol. Chem. 279, 30358-30368
 |  Abstract »  |  Full Text »  |  PDF »

p38 MAPK Activation Selectively Induces Cell Death in K-ras-mutated Human Colon Cancer Cells through Regulation of Vitamin D Receptor.

X. Qi, J. Tang, R. Pramanik, R. M. Schultz, S. Shirasawa, T. Sasazuki, J. Han, and G. Chen (2004)
J. Biol. Chem. 279, 22138-22144
 |  Abstract »  |  Full Text »  |  PDF »

B-Raf Is Dispensable for K-Ras-Mediated Oncogenesis in Human Cancer Cells1.

J.-S. Kim, C. Lee, A. Foxworth, and T. Waldman (2004)
Cancer Res. 64, 1932-1937
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic Ki-Ras Inhibits the Expression of Interferon-responsive Genes through Inhibition of STAT1 and STAT2 Expression.

L. Klampfer, J. Huang, G. Corner, J. Mariadason, D. Arango, T. Sasazuki, S. Shirasawa, and L. Augenlicht (2003)
J. Biol. Chem. 278, 46278-46287
 |  Abstract »  |  Full Text »  |  PDF »

Eradication of pathogenic {beta}-catenin by Skp1/Cullin/F box ubiquitination machinery.

Y. Su, S. Ishikawa, M. Kojima, and B. Liu (2003)
PNAS 100, 12729-12734
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Interferon {gamma} Signaling by the Short Chain Fatty Acid Butyrate.

L. Klampfer, J. Huang, T. Sasazuki, S. Shirasawa, and L. Augenlicht (2003)
Mol. Cancer Res. 1, 855-862
 |  Abstract »  |  Full Text »  |  PDF »

Application of Gene Expression Profiling to Colon Cell Maturation, Transformation and Chemoprevention.

L. H. Augenlicht, A. Velcich, L. Klampfer, J. Huang, G. Corner, M. Aranes, C. Laboisse, B. Rigas, M. Lipkin, K. Yang, et al. (2003)
J. Nutr. 133, 2410S-2416
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate.

A. M. Winter-Vann, B. A. Kamen, M. O. Bergo, S. G. Young, S. Melnyk, S. J. James, and P. J. Casey (2003)
PNAS 100, 6529-6534
 |  Abstract »  |  Full Text »  |  PDF »

Met Receptor Overexpression and Oncogenic Ki-ras Mutation Cooperate to Enhance Tumorigenicity of Colon Cancer Cells in Vivo.

I. S. Long, K. Han, M. Li, S. Shirasawa, T. Sasazuki, M. Johnston, and M.-S. Tsao (2003)
Mol. Cancer Res. 1, 393-401
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Validation of Genes Involved in the Pathogenesis of Colorectal Cancer Using cDNA Microarrays and RNA Interference.

N. S. Williams, R. B. Gaynor, S. Scoggin, U. Verma, T. Gokaslan, C. Simmang, J. Fleming, D. Tavana, E. Frenkel, and C. Becerra (2003)
Clin. Cancer Res. 9, 931-946
 |  Abstract »  |  Full Text »  |  PDF »

The Ras/Raf/MEK/Extracellular Signal-Regulated Kinase Pathway Induces Autocrine-Paracrine Growth Inhibition via the Leukemia Inhibitory Factor/JAK/STAT Pathway.

J.-I. Park, C. J. Strock, D. W. Ball, and B. D. Nelkin (2003)
Mol. Cell. Biol. 23, 543-554
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Catenin mutation is selected during malignant transformation in colon carcinogenesis.

Y. Yamada, T. Oyama, Y. Hirose, A. Hara, S. Sugie, K. Yoshida, N. Yoshimi, and H. Mori (2003)
Carcinogenesis 24, 91-97
 |  Abstract »  |  Full Text »  |  PDF »

Cell Detachment Triggers p38 Mitogen-activated Protein Kinase-dependent Overexpression of Fas Ligand. A NOVEL MECHANISM OF ANOIKIS OF INTESTINAL EPITHELIAL CELLS.

K. Rosen, W. Shi, B. Calabretta, and J. Filmus (2002)
J. Biol. Chem. 277, 46123-46130
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Mechanism of Nuclear Factor {kappa}B Activation through the Binding between Inhibitor of Nuclear Factor-{kappa}B{alpha} and the Processed NH2-terminal Region of Mig-6.

T. Tsunoda, J. Inokuchi, I. Baba, K. Okumura, S. Naito, T. Sasazuki, and S. Shirasawa (2002)
Cancer Res. 62, 5668-5671
 |  Abstract »  |  Full Text »  |  PDF »

Raf-independent Deregulation of p38 and JNK Mitogen-activated Protein Kinases Are Critical for Ras Transformation.

K. Pruitt, W. M. Pruitt, G. K. Bilter, J. K. Westwick, and C. J. Der (2002)
J. Biol. Chem. 277, 31808-31817
 |  Abstract »  |  Full Text »  |  PDF »

Targeted inactivation of CTNNB1 reveals unexpected effects of beta -catenin mutation.

T. A. Chan, Z. Wang, L. H. Dang, B. Vogelstein, and K. W. Kinzler (2002)
PNAS 99, 8265-8270
 |  Abstract »  |  Full Text »  |  PDF »

p53 Is Necessary for the Apoptotic Response Mediated by a Transient Increase of Ras Activity.

P. Ma, M. Magut, X. Chen, and C.-Y. Chen (2002)
Mol. Cell. Biol. 22, 2928-2938
 |  Abstract »  |  Full Text »  |  PDF »

Opposing Roles of the Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Cascades in Ras-Mediated Downregulation of Tropomyosin.

J. M. Shields, H. Mehta, K. Pruitt, and C. J. Der (2002)
Mol. Cell. Biol. 22, 2304-2317
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Transgelin in Breast and Colon Tumors and in RIE-1 Cells by Ras Deregulation of Gene Expression through Raf-independent Pathways.

J. M. Shields, K. Rogers-Graham, and C. J. Der (2002)
J. Biol. Chem. 277, 9790-9799
 |  Abstract »  |  Full Text »  |  PDF »

Oncolytic Reovirus against Ovarian and Colon Cancer.

K. Hirasawa, S. G. Nishikawa, K. L. Norman, T. Alain, A. Kossakowska, and P. W. K. Lee (2002)
Cancer Res. 62, 1696-1701
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines.

M. G. Callow, F. Clairvoyant, S. Zhu, B. Schryver, D. B. Whyte, J. R. Bischoff, B. Jallal, and T. Smeal (2002)
J. Biol. Chem. 277, 550-558
 |  Abstract »  |  Full Text »

Inhibition of Kirsten-ras Expression in Human Colorectal Cancer Using Rationally Selected Kirsten-ras Antisense Oligonucleotides.

P. J. Ross, M. George, D. Cunningham, F. DiStefano, H. J. N. Andreyev, P. Workman, and P. A. Clarke (2001)
Mol. Cancer Ther. 1, 29-41
 |  Abstract »  |  Full Text »  |  PDF »

Blocking Oncogenic Ras Signaling for Cancer Therapy.

A. A. Adjei (2001)
J Natl Cancer Inst 93, 1062-1074
 |  Abstract »  |  Full Text »  |  PDF »

Induction of {beta}3-Integrin Gene Expression by Sustained Activation of the Ras-Regulated Raf-MEK-Extracellular Signal-Regulated Kinase Signaling Pathway.

D. Woods, H. Cherwinski, E. Venetsanakos, A. Bhat, S. Gysin, M. Humbert, P. F. Bray, V. L. Saylor, and M. McMahon (2001)
Mol. Cell. Biol. 21, 3192-3205
 |  Abstract »  |  Full Text »  |  PDF »

Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells.

B. H. Park, B. Vogelstein, and K. W. Kinzler (2001)
PNAS 98, 2598-2603
 |  Abstract »  |  Full Text »  |  PDF »

Direct Evidence for the Contribution of Activated N-ras and K-ras Oncogenes to Increased Intrinsic Radiation Resistance in Human Tumor Cell Lines.

E. J. Bernhard, E. J. Stanbridge, S. Gupta, A. K. Gupta, D. Soto, V. J. Bakanauskas, G. J. Cerniglia, R. J. Muschel, and W. G. McKenna (2000)
Cancer Res. 60, 6597-6600
 |  Abstract »  |  Full Text »

Involvement of Deregulated Epiregulin Expression in Tumorigenesis in Vivo through Activated Ki-Ras Signaling Pathway in Human Colon Cancer Cells.

I. Baba, S. Shirasawa, R. Iwamoto, K. Okumura, T. Tsunoda, M. Nishioka, K. Fukuyama, K. Yamamoto, E. Mekada, and T. Sasazuki (2000)
Cancer Res. 60, 6886-6889
 |  Abstract »  |  Full Text »

Influence of K-ras Activation on the Survival Responses of Caco-2 Cells to the Chemopreventive Agents Sulindac and Difluoromethylornithine.

K. R. Lawson, N. A. Ignatenko, G. A. Piazza, H. Cui, and E. W. Gerner (2000)
Cancer Epidemiol. Biomarkers Prev. 9, 1155-1162
 |  Abstract »  |  Full Text »

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?.

C. W. M. Reuter, M. A. Morgan, and L. Bergmann (2000)
Blood 96, 1655-1669
 |  Abstract »  |  Full Text »  |  PDF »

Regrowth of 5-Fluorouracil-treated Human Colon Cancer Cells Is Prevented by the Combination of Interferon {{gamma}}, Indomethacin, and Phenylbutyrate.

Y. Huang, C. M. Horvath, and S. Waxman (2000)
Cancer Res. 60, 3200-3206
 |  Abstract »  |  Full Text »

Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure.

M. Mutoh, M. Takahashi, K. Fukuda, Y. Matsushima-Hibiya, H. Mutoh, T. Sugimura, and K. Wakabayashi (2000)
Carcinogenesis 21, 959-963
 |  Abstract »  |  Full Text »  |  PDF »

Mouse Mammary Tumor Virus-Ki-rasB Transgenic Mice Develop Mammary Carcinomas That Can Be Growth-inhibited by a Farnesyl:Protein Transferase Inhibitor.

C. A. Omer, Z. Chen, R. E. Diehl, M. W. Conner, H. Y. Chen, M. E. Trumbauer, S. Gopal-Truter, G. Seeburger, H. Bhimnathwala, M. T. Abrams, et al. (2000)
Cancer Res. 60, 2680-2688
 |  Abstract »  |  Full Text »

Activated ras Prevents Downregulation of Bcl-XL Triggered by Detachment from the Extracellular Matrix: A Mechanism of ras-Induced Resistance to Anoikis in Intestinal Epithelial Cells.

K. Rosen, J. Rak, T. Leung, N. M. Dean, R. S. Kerbel, and J. Filmus (2000)
J. Cell Biol. 149, 447-456
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenes and Tumor Angiogenesis: Differential Modes of Vascular Endothelial Growth Factor Up-Regulation in ras-transformed Epithelial Cells and Fibroblasts.

J. Rak, Y. Mitsuhashi, C. Sheehan, A. Tamir, A. Viloria-Petit, J. Filmus, S. J. Mansour, N. G. Ahn, and R. S. Kerbel (2000)
Cancer Res. 60, 490-498
 |  Abstract »  |  Full Text »

Combination Therapy with the Farnesyl Protein Transferase Inhibitor SCH66336 and SCH58500 (p53 Adenovirus) in Preclinical Cancer Models.

L. L. Nielsen, B. Shi, G. Hajian, B. Yaremko, P. Lipari, E. Ferrari, M. Gurnani, M. Malkowski, J. Chen, W. R. Bishop, et al. (1999)
Cancer Res. 59, 5896-5901
 |  Abstract »  |  Full Text »  |  PDF »

Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development.

E. K. Rowinsky, J. J. Windle, and D. D. Von Hoff (1999)
J. Clin. Oncol. 17, 3631-3652
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of the MAP kinase cascade for cell cycle progression and differentiation of human intestinal cells.

J. C. Aliaga, C. Deschenes, J.-F. Beaulieu, E. L. Calvo, and N. Rivard (1999)
Am J Physiol Gastrointest Liver Physiol 277, G631-G641
 |  Abstract »  |  Full Text »  |  PDF »

Phase I Clinical/Pharmacokinetic and Pharmacodynamic Trial of the c-raf-1 Antisense Oligonucleotide ISIS 5132 (CGP 69846A).

J. P. Stevenson, K.-S. Yao, M. Gallagher, D. Friedland, E. P. Mitchell, A. Cassella, B. Monia, T. J. Kwoh, R. Yu, J. Holmlund, et al. (1999)
J. Clin. Oncol. 17, 2227
 |  Abstract »  |  Full Text »  |  PDF »

Activated Ki-Ras Suppresses 12-O-Tetradecanoylphorbol-13-acetate-induced Activation of the c-Jun NH2-Terminal Kinase Pathway in Human Colon Cancer Cells.

K. Okumura, S. Shirasawa, M. Nishioka, and T. Sasazuki (1999)
Cancer Res. 59, 2445-2450
 |  Abstract »  |  Full Text »  |  PDF »

T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta -catenin.

A. I. M. Barth, D. B. Stewart, and W. J. Nelson (1999)
PNAS 96, 4947-4952
 |  Abstract »  |  Full Text »  |  PDF »

Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src.

N. Aziz, H. Cherwinski, and M. McMahon (1999)
Mol. Cell. Biol. 19, 1101-1115
 |  Abstract »  |  Full Text »  |  PDF »

p21WAF1/CIP1 Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor beta - and Sp1-Responsive Element: Involvement of the Small GTPase RhoA.

J. Adnane, F. A. Bizouarn, Y. Qian, A. D. Hamilton, and S. M. Sebti (1998)
Mol. Cell. Biol. 18, 6962-6970
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Cell Death Protease Caspase-9 by Phosphorylation.

M. H. Cardone, N. Roy, H. R. Stennicke, G. S. Salvesen, T. F. Franke, E. Stanbridge, S. Frisch, and J. C. Reed (1998)
Science 282, 1318-1321
 |  Abstract »  |  Full Text »

Elevated Expression of Ets2 or Distinct Portions of Ets2 Can Reverse Ras-mediated Cellular Transformation.

G. Foos, J. J. Garcia-Ramirez, C. K. Galang, and C. A. Hauser (1998)
J. Biol. Chem. 273, 18871-18880
 |  Abstract »  |  Full Text »  |  PDF »

Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells.

F. Okada, J. W. Rak, B. St. Croix, B. Lieubeau, M. Kaya, L. Roncari, S. Shirasawa, T. Sasazuki, and R. S. Kerbel (1998)
PNAS 95, 3609-3614
 |  Abstract »  |  Full Text »  |  PDF »

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors.

D. B. Whyte, P. Kirschmeier, T. N. Hockenberry, I. Nunez-Oliva, L. James, J. J. Catino, W. R. Bishop, and J.-K. Pai (1997)
J. Biol. Chem. 272, 14459-14464
 |  Abstract »  |  Full Text »  |  PDF »

Antisense Oligonucleotides Demonstrate a Dominant Role of c-Ki-RAS Proteins in Regulating the Proliferation of Diploid Human Fibroblasts.

G. Chen, S. Oh, B. P. Monia, and D. W. Stacey (1996)
J. Biol. Chem. 271, 28259-28265
 |  Abstract »  |  Full Text »  |  PDF »

K-ras Status Does Not Predict Successful Hepatic Resection of Colorectal Cancer Metastasis.

W. V. Kastrinakis, N. Ramchurren, M. Maggard, G. Steele Jr, and I. C. Summerhayes (1995)
Arch Surg 130, 9-14
 |  Abstract »  |  PDF »

Ras Uses the Novel Tumor Suppressor RASSF1 as an Effector to Mediate Apoptosis.

M. D. Vos, C. A. Ellis, A. Bell, M. J. Birrer, and G. J. Clark (2000)
J. Biol. Chem. 275, 35669-35672
 |  Abstract »  |  Full Text »  |  PDF »

Dual Growth Arrest Pathways in Astrocytes and Astrocytic Tumors in Response to Raf-1 Activation.

C. P. Fanton, M. McMahon, and R. O. Pieper (2001)
J. Biol. Chem. 276, 18871-18877
 |  Abstract »  |  Full Text »  |  PDF »

Bile Acid-induced Activation of Activator Protein-1 Requires Both Extracellular Signal-regulated Kinase and Protein Kinase C Signaling.

D. Qiao, W. Chen, E. D. Stratagoules, and J. D. Martinez (2000)
J. Biol. Chem. 275, 15090-15098
 |  Abstract »  |  Full Text »  |  PDF »

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