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Science 2 April 1993:
Vol. 260. no. 5104, pp. 58 - 63
DOI: 10.1126/science.8465201
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Articles

Science, Vol 260, Issue 5104, 58-63
Copyright © 1993 by American Association for the Advancement of Science

articles

DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor

L Schaeffer, R Roy, S Humbert, V Moncollin, W Vermeulen, JH Hoeijmakers, P Chambon, and JM Egly

UPR 6520 (CNRS), Unite 184 (INSERM), Faculte de Medecine, Strasbourg, France.

The human BTF2 basic transcription factor (also called TFIIH), which is similar to the delta factor in rat and factor b in yeast, is required for class II gene transcription. A strand displacement assay was used to show that highly purified preparation of BTF2 had an adenosine triphosphate-dependent DNA helicase activity, in addition to the previously characterized carboxyl-terminal domain kinase activity. Amino acid sequence analysis of the tryptic digest generated from the 89-kilodalton subunit of BTF2 indicated that this polypeptide corresponded to the ERCC-3 gene product, a presumed helicase implicated in the human DNA excision repair disorders xeroderma pigmentosum and Cockayne's syndrome. These findings suggest that transcription and nucleotide excision repair may share common factors and hence may be considered to be functionally related.


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Molecular mechanism of nucleotide excision repair.
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Cancer Res. 59, 843-848
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Activation of Transcription in Vitro by the BRCA1 Carboxyl-terminal Domain.
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J. Biol. Chem. 274, 2113-2117
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The Hematopoietic Transcription Factor SCL Binds the p44 Subunit of TFIIH.
X.-F. Zhao and P. D. Aplan (1999)
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RNA Polymerase II Elongation Complexes Containing the Cockayne Syndrome Group B Protein Interact with a Molecular Complex Containing the Transcription Factor IIH Components Xeroderma Pigmentosum B and p62.
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A Novel Function of the DNA Repair Gene rhp6 in Mating-Type Silencing by Chromatin Remodeling in Fission Yeast.
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Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery.
M. Hampsey (1998)
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J. Virol. 72, 4183-4191
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Immunoaffinity Purification of the Human Multisubunit Transcription Factor IIH.
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Repression of TFIIH Transcriptional Activity and TFIIH-Associated cdk7 Kinase Activity at Mitosis.
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Mol. Cell. Biol. 18, 1467-1476
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Affinity Purification of Human DNA Repair/Transcription Factor TFIIH Using Epitope-tagged Xeroderma Pigmentosum B Protein.
G. S. Winkler, W. Vermeulen, F. Coin, J.-M. Egly, J. H. J. Hoeijmakers, and G. Weeda (1998)
J. Biol. Chem. 273, 1092-1098
   Abstract »    Full Text »    PDF »
Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination.
D. Melton, A. Ketchen, F Nunez, S Bonatti-Abbondandolo, A Abbondandolo, S Squires, and R. Johnson (1998)
J. Cell Sci. 111, 395-404
   Abstract »    PDF »
The RNA Polymerase II General Transcription Factors: Past, Present, and Future.
D. REINBERG, G. ORPHANIDES, R. EBRIGHT, S. AKOULITCHEV, J. CARCAMO, H. CHO, P. CORTES, R. DRAPKIN, O. FLORES, I. HA, et al. (1998)
Cold Spring Harb Symp Quant Biol 63, 83-105
   Abstract »    PDF »
DDB, a Putative DNA Repair Protein, Can Function as a Transcriptional Partner of E2F1.
S. Hayes, P. Shiyanov, X. Chen, and P. Raychaudhuri (1998)
Mol. Cell. Biol. 18, 240-249
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Ten Years of TFIIH.
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Cold Spring Harb Symp Quant Biol 63, 105-110
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Mechanism of Promoter Escape by RNA Polymerase II.
J.W. CONAWAY, A. DVIR, R.J. MORELAND, Q. YAN, B.J. ELMENDORF, S. TAN, and R.C. CONAWAY (1998)
Cold Spring Harb Symp Quant Biol 63, 357-364
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Characterization of Reaction Intermediates of Human Excision Repair Nuclease.
D. Mu, M. Wakasugi, D. S. Hsu, and A. Sancar (1997)
J. Biol. Chem. 272, 28971-28979
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Enhancement of DNA repair in human skin cells by thymidine dinucleotides: Evidence for a p53-mediated mammalian SOS response.
M. S. Eller, T. Maeda, C. Magnoni, D. Atwal, and B. A. Gilchrest (1997)
PNAS 94, 12627-12632
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Interaction of Elongation Factors TFIIS and Elongin A with a Human RNA Polymerase II Holoenzyme Capable of Promoter-specific Initiation and Responsive to Transcriptional Activators.
G. Pan, T. Aso, and J. Greenblatt (1997)
J. Biol. Chem. 272, 24563-24571
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DNA Damage Recognition by XPA Protein Promotes Efficient Recruitment of Transcription Factor II H.
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J. Biol. Chem. 272, 22991-22994
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J. Biol. Chem. 272, 18910-18919
   Abstract »    Full Text »    PDF »
Transitions in the coupling of transcription and nucleotide excision repair within RNA polymerase II-transcribed genes of Saccharomyces cerevisiae.
M. Tijsterman, R. A. Verhage, P. van de Putte, J. G. T.-d. Jong, and J. Brouwer (1997)
PNAS 94, 8027-8032
   Abstract »    Full Text »    PDF »
Bipartite substrate discrimination by human nucleotide excision repair.
M. T. Hess, U. Schwitter, M. Petretta, B. Giese, and H. Naegeli (1997)
PNAS 94, 6664-6669
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The Non-catalytic Function of XPG Protein during Dual Incision in Human Nucleotide Excision Repair.
M. Wakasugi, J. T. Reardon, and A. Sancar (1997)
J. Biol. Chem. 272, 16030-16034
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Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells.
A. S. Balajee, A. May, G. L. Dianov, E. C. Friedberg, and V. A. Bohr (1997)
PNAS 94, 4306-4311
   Abstract »    Full Text »    PDF »
A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: Implications for a second XPG function.
T. Nouspikel, P. Lalle, S. A. Leadon, P. K. Cooper, and S. G. Clarkson (1997)
PNAS 94, 3116-3121
   Abstract »    Full Text »    PDF »
SUG1, a Putative Transcriptional Mediator and Subunit of the PA700 Proteasome Regulatory Complex, Is a DNA Helicase.
R. A. Fraser, M. Rossignol, D. J. Heard, J.-M. Egly, and P. Chambon (1997)
J. Biol. Chem. 272, 7122-7126
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Characterization of Putative Human Homologues of the Yeast Chromosome Transmission Fidelity Gene, CHL1.
J. Amann, V. J. Kidd, and J. M. Lahti (1997)
J. Biol. Chem. 272, 3823-3832
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Assessing the Requirements for Nucleotide Excision Repair Proteins of Saccharomyces cerevisiae in an in Vitro System.
Z. He, J. M. S. Wong, H. S. Maniar, S. J. Brill, and C. J. Ingles (1996)
J. Biol. Chem. 271, 28243-28249
   Abstract »    Full Text »    PDF »
The general transcription factors of RNA polymerase II..
G Orphanides, T Lagrange, and D Reinberg (1996)
Genes & Dev. 10, 2657-2683
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RNA Polymerase Signals UvrAB Landing Sites.
B. Ahn and L. Grossman (1996)
J. Biol. Chem. 271, 21453-21461
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DNA End Joining by the Klenow Fragment of DNA Polymerase I.
J. S. King, C. F. Fairley, and W. F. Morgan (1996)
J. Biol. Chem. 271, 20450-20457
   Abstract »    Full Text »    PDF »
Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II.
M. E. Dahmus and M. E. Dahmus (1996)
J. Biol. Chem. 271, 19009-19012
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A 3' right-arrow 5' XPB Helicase Defect in Repair/Transcription Factor TFIIH of Xeroderma Pigmentosum Group B Affects Both DNA Repair and Transcription.
J. R. Hwang, V. Moncollin, W. Vermeulen, T. Seroz, H. van Vuuren, J. H.J. Hoeijmakers, and J. M. Egly (1996)
J. Biol. Chem. 271, 15898-15904
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The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway..
X W Wang, W Vermeulen, J D Coursen, M Gibson, S E Lupold, K Forrester, G Xu, L Elmore, H Yeh, J H Hoeijmakers, et al. (1996)
Genes & Dev. 10, 1219-1232
   Abstract »    PDF »
Reaction Mechanism of Human DNA Repair Excision Nuclease.
D. Mu, D. S. Hsu, and A. Sancar (1996)
J. Biol. Chem. 271, 8285-8294
   Abstract »    Full Text »    PDF »


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