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Science 2 April 1993:
Vol. 260. no. 5104, pp. 58 - 63
DOI: 10.1126/science.8465201
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Articles

Science, Vol 260, Issue 5104, 58-63
Copyright © 1993 by American Association for the Advancement of Science

articles

DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor

L Schaeffer, R Roy, S Humbert, V Moncollin, W Vermeulen, JH Hoeijmakers, P Chambon, and JM Egly

UPR 6520 (CNRS), Unite 184 (INSERM), Faculte de Medecine, Strasbourg, France.

The human BTF2 basic transcription factor (also called TFIIH), which is similar to the delta factor in rat and factor b in yeast, is required for class II gene transcription. A strand displacement assay was used to show that highly purified preparation of BTF2 had an adenosine triphosphate-dependent DNA helicase activity, in addition to the previously characterized carboxyl-terminal domain kinase activity. Amino acid sequence analysis of the tryptic digest generated from the 89-kilodalton subunit of BTF2 indicated that this polypeptide corresponded to the ERCC-3 gene product, a presumed helicase implicated in the human DNA excision repair disorders xeroderma pigmentosum and Cockayne's syndrome. These findings suggest that transcription and nucleotide excision repair may share common factors and hence may be considered to be functionally related.


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Role and Regulation of p53 during an Ultraviolet Radiation-induced G1 Cell Cycle Arrest.
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G. S. Winkler, S. J. Araujo, U. Fiedler, W. Vermeulen, F. Coin, J.-M. Egly, J. H. J. Hoeijmakers, R. D. Wood, H. Th. M. Timmers, and G. Weeda (2000)
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J. Bradsher, F. Coin, and J.-M. Egly (2000)
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M. Yan and J. D. Gralla (1999)
J. Biol. Chem. 274, 34819-34824
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   Abstract »    Full Text »
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Cancer Res. 59, 3489-3494
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Inhibition of Transcription by the Trimeric Cyclin-dependent Kinase 7 Complex.
D. A. Bochar, Z.-Q. Pan, R. Knights, R. P. Fisher, A. Shilatifard, and R. Shiekhattar (1999)
J. Biol. Chem. 274, 13162-13166
   Abstract »    Full Text »    PDF »
Molecular Characterization of Mutant Alleles of the DNA Repair/Basal Transcription Factor haywire/ERCC3 in Drosophila.
L. C. Mounkes and M. T. Fuller (1999)
Genetics 152, 291-297
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Inhibition of Nuclear Receptor Signalling by Poly(ADP-Ribose) Polymerase.
T. Miyamoto, T. Kakizawa, and K. Hashizume (1999)
Mol. Cell. Biol. 19, 2644-2649
   Abstract »    Full Text »    PDF »
Molecular mechanism of nucleotide excision repair.
W. L. de Laat, N. G.J. Jaspers, and J. H.J. Hoeijmakers (1999)
Genes & Dev. 13, 768-785
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The Drosophila melanogaster Homologue of the Xeroderma Pigmentosum D Gene Product Is Located in Euchromatic Regions and Has a Dynamic Response to UV Light-induced Lesions in Polytene Chromosomes.
E. Reynaud, H. Lomelí, M. Vázquez, and M. Zurita (1999)
Mol. Biol. Cell 10, 1191-1203
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Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin.
F. Carrier, P. T. Georgel, P. Pourquier, M. Blake, H. U. Kontny, M. J. Antinore, M. Gariboldi, T. G. Myers, J. N. Weinstein, Y. Pommier, et al. (1999)
Mol. Cell. Biol. 19, 1673-1685
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The General Transcription Factors IIA, IIB, IIF, and IIE Are Required for RNA Polymerase II Transcription from the Human U1 Small Nuclear RNA Promoter.
T. C. Kuhlman, H. Cho, D. Reinberg, and N. Hernandez (1999)
Mol. Cell. Biol. 19, 2130-2141
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Postnatal Growth Failure, Short Life Span, and Early Onset of Cellular Senescence and Subsequent Immortalization in Mice Lacking the Xeroderma Pigmentosum Group G Gene.
Y.-N. Harada, N. Shiomi, M. Koike, M. Ikawa, M. Okabe, S. Hirota, Y. Kitamura, M. Kitagawa, T. Matsunaga, O. Nikaido, et al. (1999)
Mol. Cell. Biol. 19, 2366-2372
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COOH-Terminal Domain of p53 Modulates p53-mediated Transcriptional Transactivation, Cell Growth, and Apoptosis.
X. Zhou, X. W. Wang, L. Xu, K. Hagiwara, M. Nagashima, R. Wolkowicz, I. Zurer, V. Rotter, and C. C. Harris (1999)
Cancer Res. 59, 843-848
   Abstract »    Full Text »    PDF »
Activation of Transcription in Vitro by the BRCA1 Carboxyl-terminal Domain.
D. T. Haile and J. D. Parvin (1999)
J. Biol. Chem. 274, 2113-2117
   Abstract »    Full Text »    PDF »
The Hematopoietic Transcription Factor SCL Binds the p44 Subunit of TFIIH.
X.-F. Zhao and P. D. Aplan (1999)
J. Biol. Chem. 274, 1388-1393
   Abstract »    Full Text »    PDF »
UV-enhanced reactivation of a UV-damaged reporter gene suggests transcription-coupled repair is UV-inducible in human cells.
M. A. Francis and A. J. Rainbow (1999)
Carcinogenesis 20, 19-26
   Abstract »    Full Text »    PDF »
Mutation in P0, a Dual Function Ribosomal Protein/Apurinic/Apyrimidinic Endonuclease, Modifies Gene Expression and Position Effect Variegation in Drosophila.
M. V. Frolov and J. A. Birchler (1998)
Genetics 150, 1487-1495
   Abstract »    Full Text »
The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.
S. Akoulitchev and D. Reinberg (1998)
Genes & Dev. 12, 3541-3550
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Use of DNA Repair-Deficient XPA Transgenic Mice in Short-Term Carcinogenicity Testing.
H. Van Steeg, H. Klein, R. B. Beems, and C. F. Van Kreijl (1998)
Toxicol Pathol 26, 742-749
   Abstract »    PDF »
RNA Polymerase II Elongation Complexes Containing the Cockayne Syndrome Group B Protein Interact with a Molecular Complex Containing the Transcription Factor IIH Components Xeroderma Pigmentosum B and p62.
D. Tantin (1998)
J. Biol. Chem. 273, 27794-27799
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A Novel Function of the DNA Repair Gene rhp6 in Mating-Type Silencing by Chromatin Remodeling in Fission Yeast.
J. Singh, V. Goel, and A. J. S. Klar (1998)
Mol. Cell. Biol. 18, 5511-5522
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Promoter escape limits the rate of RNA polymerase II transcription and is enhanced by TFIIE, TFIIH, and ATP on negatively supercoiled DNA.
J. F. Kugel and J. A. Goodrich (1998)
PNAS 95, 9232-9237
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Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery.
M. Hampsey (1998)
Microbiol. Mol. Biol. Rev. 62, 465-503
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Biochemical and Biological Characterization of Wild-type and ATPase-deficient Cockayne Syndrome B Repair Protein.
E. Citterio, S. Rademakers, G. T. J. van der Horst, A. J. van Gool, J. H.J. Hoeijmakers, and W. Vermeulen (1998)
J. Biol. Chem. 273, 11844-11851
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Adenovirus Type 12-Induced Fragility of the Human RNU2 Locus Requires p53 Function.
Z. Li, A. Yu, and A. M. Weiner (1998)
J. Virol. 72, 4183-4191
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Immunoaffinity Purification of the Human Multisubunit Transcription Factor IIH.
G. LeRoy, R. Drapkin, L. Weis, and D. Reinberg (1998)
J. Biol. Chem. 273, 7134-7140
   Abstract »    Full Text »    PDF »
Repression of TFIIH Transcriptional Activity and TFIIH-Associated cdk7 Kinase Activity at Mitosis.
J. J. Long, A. Leresche, R. W. Kriwacki, and J. M. Gottesfeld (1998)
Mol. Cell. Biol. 18, 1467-1476
   Abstract »    Full Text »
Affinity Purification of Human DNA Repair/Transcription Factor TFIIH Using Epitope-tagged Xeroderma Pigmentosum B Protein.
G. S. Winkler, W. Vermeulen, F. Coin, J.-M. Egly, J. H. J. Hoeijmakers, and G. Weeda (1998)
J. Biol. Chem. 273, 1092-1098
   Abstract »    Full Text »    PDF »
Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination.
D. Melton, A. Ketchen, F Nunez, S Bonatti-Abbondandolo, A Abbondandolo, S Squires, and R. Johnson (1998)
J. Cell Sci. 111, 395-404
   Abstract »    PDF »
The RNA Polymerase II General Transcription Factors: Past, Present, and Future.
D. REINBERG, G. ORPHANIDES, R. EBRIGHT, S. AKOULITCHEV, J. CARCAMO, H. CHO, P. CORTES, R. DRAPKIN, O. FLORES, I. HA, et al. (1998)
Cold Spring Harb Symp Quant Biol 63, 83-105
   Abstract »    PDF »
DDB, a Putative DNA Repair Protein, Can Function as a Transcriptional Partner of E2F1.
S. Hayes, P. Shiyanov, X. Chen, and P. Raychaudhuri (1998)
Mol. Cell. Biol. 18, 240-249
   Abstract »    Full Text »
Ten Years of TFIIH.
F. COIN and J.-M. EGLY (1998)
Cold Spring Harb Symp Quant Biol 63, 105-110
   Abstract »    PDF »
Mechanism of Promoter Escape by RNA Polymerase II.
J.W. CONAWAY, A. DVIR, R.J. MORELAND, Q. YAN, B.J. ELMENDORF, S. TAN, and R.C. CONAWAY (1998)
Cold Spring Harb Symp Quant Biol 63, 357-364
   Abstract »    PDF »
Characterization of Reaction Intermediates of Human Excision Repair Nuclease.
D. Mu, M. Wakasugi, D. S. Hsu, and A. Sancar (1997)
J. Biol. Chem. 272, 28971-28979
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Enhancement of DNA repair in human skin cells by thymidine dinucleotides: Evidence for a p53-mediated mammalian SOS response.
M. S. Eller, T. Maeda, C. Magnoni, D. Atwal, and B. A. Gilchrest (1997)
PNAS 94, 12627-12632
   Abstract »    Full Text »    PDF »
Interaction of Elongation Factors TFIIS and Elongin A with a Human RNA Polymerase II Holoenzyme Capable of Promoter-specific Initiation and Responsive to Transcriptional Activators.
G. Pan, T. Aso, and J. Greenblatt (1997)
J. Biol. Chem. 272, 24563-24571
   Abstract »    Full Text »    PDF »
DNA Damage Recognition by XPA Protein Promotes Efficient Recruitment of Transcription Factor II H.
S. Nocentini, F. Coin, M. Saijo, K. Tanaka, and J.-M. Egly (1997)
J. Biol. Chem. 272, 22991-22994
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Sequence-specific and Domain-specific DNA Repair in Xeroderma Pigmentosum and Cockayne Syndrome Cells.
Y. Tu, S. Bates, and G. P. Pfeifer (1997)
J. Biol. Chem. 272, 20747-20755
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Genes For Tfb2, Tfb3, and Tfb4 Subunits of Yeast Transcription/Repair Factor IIH. HOMOLOGY TO HUMAN CYCLIN-DEPENDENT KINASE ACTIVATING KINASE AND IIH SUBUNITS.
W. J. Feaver, N. L. Henry, Z. Wang, X. Wu, J. Q. Svejstrup, D. A. Bushnell, E. C. Friedberg, and R. D. Kornberg (1997)
J. Biol. Chem. 272, 19319-19327
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Repression of p53-mediated transcription by MDM2: a dual mechanism.
C. J. Thut, J. A. Goodrich, and R. Tjian (1997)
Genes & Dev. 11, 1974-1986
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A DNA Helicase from Schizosaccharomyces pombe Stimulated by Single-stranded DNA-binding Protein at Low ATP Concentration.
J. S. Park, E. Choi, S.-H. Lee, C. Lee, and Y.-S. Seo (1997)
J. Biol. Chem. 272, 18910-18919
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Transitions in the coupling of transcription and nucleotide excision repair within RNA polymerase II-transcribed genes of Saccharomyces cerevisiae.
M. Tijsterman, R. A. Verhage, P. van de Putte, J. G. T.-d. Jong, and J. Brouwer (1997)
PNAS 94, 8027-8032
   Abstract »    Full Text »    PDF »
Bipartite substrate discrimination by human nucleotide excision repair.
M. T. Hess, U. Schwitter, M. Petretta, B. Giese, and H. Naegeli (1997)
PNAS 94, 6664-6669
   Abstract »    Full Text »    PDF »
The Non-catalytic Function of XPG Protein during Dual Incision in Human Nucleotide Excision Repair.
M. Wakasugi, J. T. Reardon, and A. Sancar (1997)
J. Biol. Chem. 272, 16030-16034
   Abstract »    Full Text »    PDF »
Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells.
A. S. Balajee, A. May, G. L. Dianov, E. C. Friedberg, and V. A. Bohr (1997)
PNAS 94, 4306-4311
   Abstract »    Full Text »    PDF »
A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: Implications for a second XPG function.
T. Nouspikel, P. Lalle, S. A. Leadon, P. K. Cooper, and S. G. Clarkson (1997)
PNAS 94, 3116-3121
   Abstract »    Full Text »    PDF »
SUG1, a Putative Transcriptional Mediator and Subunit of the PA700 Proteasome Regulatory Complex, Is a DNA Helicase.
R. A. Fraser, M. Rossignol, D. J. Heard, J.-M. Egly, and P. Chambon (1997)
J. Biol. Chem. 272, 7122-7126
   Abstract »    Full Text »    PDF »
Characterization of Putative Human Homologues of the Yeast Chromosome Transmission Fidelity Gene, CHL1.
J. Amann, V. J. Kidd, and J. M. Lahti (1997)
J. Biol. Chem. 272, 3823-3832
   Abstract »    Full Text »    PDF »
Assessing the Requirements for Nucleotide Excision Repair Proteins of Saccharomyces cerevisiae in an in Vitro System.
Z. He, J. M. S. Wong, H. S. Maniar, S. J. Brill, and C. J. Ingles (1996)
J. Biol. Chem. 271, 28243-28249
   Abstract »    Full Text »    PDF »
The general transcription factors of RNA polymerase II..
G Orphanides, T Lagrange, and D Reinberg (1996)
Genes & Dev. 10, 2657-2683
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RNA Polymerase Signals UvrAB Landing Sites.
B. Ahn and L. Grossman (1996)
J. Biol. Chem. 271, 21453-21461
   Abstract »    Full Text »    PDF »
DNA End Joining by the Klenow Fragment of DNA Polymerase I.
J. S. King, C. F. Fairley, and W. F. Morgan (1996)
J. Biol. Chem. 271, 20450-20457
   Abstract »    Full Text »    PDF »
Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II.
M. E. Dahmus and M. E. Dahmus (1996)
J. Biol. Chem. 271, 19009-19012
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A 3' right-arrow 5' XPB Helicase Defect in Repair/Transcription Factor TFIIH of Xeroderma Pigmentosum Group B Affects Both DNA Repair and Transcription.
J. R. Hwang, V. Moncollin, W. Vermeulen, T. Seroz, H. van Vuuren, J. H.J. Hoeijmakers, and J. M. Egly (1996)
J. Biol. Chem. 271, 15898-15904
   Abstract »    Full Text »    PDF »
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway..
X W Wang, W Vermeulen, J D Coursen, M Gibson, S E Lupold, K Forrester, G Xu, L Elmore, H Yeh, J H Hoeijmakers, et al. (1996)
Genes & Dev. 10, 1219-1232
   Abstract »    PDF »
Reaction Mechanism of Human DNA Repair Excision Nuclease.
D. Mu, D. S. Hsu, and A. Sancar (1996)
J. Biol. Chem. 271, 8285-8294
   Abstract »    Full Text »    PDF »
A Role for ATP and TFIIH in Activation of the RNA Polymerase II Preinitiation Complex Prior to Transcription Initiation.
A. Dvir, K. P. Garrett, C. Chalut, J.-M. Egly, J. W. Conaway, and R. C. Conaway (1996)
J. Biol. Chem. 271, 7245-7248
   Abstract »    Full Text »    PDF »


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