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Science 2 April 1993:
Vol. 260. no. 5104, pp. 103 - 106
DOI: 10.1126/science.7682010
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Articles

Science, Vol 260, Issue 5104, 103-106
Copyright © 1993 by American Association for the Advancement of Science

articles

Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan

V Nurcombe, MD Ford, JA Wildschut, and PF Bartlett

Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia.

Murine neural precursor cells and cell lines derived from them are stimulated by members of the heparin-binding fibroblast growth factor (FGF) family. The activity of FGF is regulated by heparan sulfate proteoglycans (HSPGs), and this interaction is an essential prerequisite for the binding of growth factor to the signal transducing receptors. Messenger RNA for FGF-2 was detectable in the neuroepithelium at embryonic day 9, and the HSPGs produced by these cells at this time preferentially bound FGF-2. However, at embryonic day 11, when messenger RNA for FGF-1 was first detectable, there was a switch in the binding specificity of the HSPG to FGF-1. Thus, a single species of HSPG undergoes a rapid, tightly controlled change in growth factor-binding specificity concomitant with the temporal expression of the FGFs.


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Development 124, 4867-4878
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Essential role of heparan sulfates in axon navigation and targeting in the developing visual system.
A Walz, S McFarlane, Y. Brickman, V Nurcombe, P. Bartlett, and C. Holt (1997)
Development 124, 2421-2430
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Purification and Characterization of Heparan Sulfate 2-Sulfotransferase from Cultured Chinese Hamster Ovary Cells.
M. Kobayashi, H. Habuchi, O. Habuchi, M. Saito, and K. Kimata (1996)
J. Biol. Chem. 271, 7645-7653
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S. Joseph, M. Ford, C Barth, S Portbury, P. Bartlett, V Nurcombe, and U Greferath (1996)
Development 122, 3443-3452
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Heparan Sulfates Mediate the Binding of Basic Fibroblast Growth Factor to a Specific Receptor on Neural Precursor Cells.
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J. Biol. Chem. 270, 24941-24948
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H. Habuchi, O. Habuchi, and K. Kimata (1995)
J. Biol. Chem. 270, 4172-4179
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Regulation of regional differences in the differentiation of cerebral cortical neurons by EGF family-matrix interactions.
R. Ferri and P Levitt (1995)
Development 121, 1151-1160
   Abstract »    PDF »
Increased axon regeneration in astrocytes grown in the presence of proteoglycan synthesis inhibitors.
L. Smith-Thomas, J Stevens, J Fok-Seang, A Faissner, J. Rogers, and J. Fawcett (1995)
J. Cell Sci. 108, 1307-1315
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Heparan sulfate proteoglycans are required for mesoderm formation in Xenopus embryos.
K. Itoh and S. Y. Sokol (1994)
Development 120, 2703-2711
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FGF2 regulates proliferation of neural crest cells, with subsequent neuronal differentiation regulated by LIF or related factors.
M Murphy, K Reid, M Ford, J. Furness, and P. Bartlett (1994)
Development 120, 3519-3528
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Function of the syndecans--a family of cell surface proteoglycans.
K Elenius and M Jalkanen (1994)
J. Cell Sci. 107, 2975-2982
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Immunocytochemical and in situ hybridization studies of the heparan sulfate proteoglycan, glypican, in nervous tissue.
L Karthikeyan, M Flad, M Engel, B Meyer-Puttlitz, R. Margolis, and R. Margolis (1994)
J. Cell Sci. 107, 3213-3222
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The Proliferative and Migratory Activities of Breast Cancer Cells Can Be Differentially Regulated by Heparan Sulfates.
V. Nurcombe, C. E. Smart, H. Chipperfield, S. M. Cool, B. Boilly, and H. Hondermarck (2000)
J. Biol. Chem. 275, 30009-30018
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Binding of Heparin/Heparan Sulfate to Fibroblast Growth Factor Receptor 4.
B.-M. Loo, J. Kreuger, M. Jalkanen, U. Lindahl, and M. Salmivirta (2001)
J. Biol. Chem. 276, 16868-16876
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J. Kreuger, M. Salmivirta, L. Sturiale, G. Gimenez-Gallego, and U. Lindahl (2001)
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S. Paine-Saunders, B. L. Viviano, A. N. Economides, and S. Saunders (2002)
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   Abstract »    Full Text »    PDF »


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