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Science 26 March 1993:
Vol. 259. no. 5103, pp. 1915 - 1917
DOI: 10.1126/science.8456317
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Articles

Science, Vol 259, Issue 5103, 1915-1917
Copyright © 1993 by American Association for the Advancement of Science

articles

Activity-dependent regulation of conductances in model neurons

G LeMasson, E Marder, and LF Abbott

Department of Biology, Brandeis University, Waltham, MA 02254.

Neurons maintain their electrical activity patterns despite channel turnover, cell growth, and variable extracellular conditions. A model is presented in which maximal conductances of ionic currents depend on the intracellular concentration of calcium ions and so, indirectly, on activity. Model neurons with activity-dependent maximal conductances modify their conductances to maintain a given behavior when perturbed. Moreover, neurons that are described by identical sets of equations can develop different properties in response to different patterns of presynaptic activity.


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