Science 19 March 1993: Vol. 259. no. 5102, pp. 1769 - 1771 DOI: 10.1126/science.8456305

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Articles

Short-term magnesium deficiency results in decreased levels of serum sphingomyelin, lipid peroxidation, and apoptosis in cardiovascular tissues.

B. M. Altura, N. C. Shah, X.-C. Jiang, Z. Li, J. L. Perez-Albela, A. C. Sica, and B. T. Altura (2009)
Am J Physiol Heart Circ Physiol 297, H86-H92
 |  Abstract »  |  Full Text »  |  PDF »

Bioactive sphingolipids: metabolism and function.

N. Bartke and Y. A. Hannun (2009)
J. Lipid Res. 50, S91-S96
 |  Abstract »  |  Full Text »  |  PDF »

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1{beta}.

S. Balosso, M. Maroso, M. Sanchez-Alavez, T. Ravizza, A. Frasca, T. Bartfai, and A. Vezzani (2008)
Brain 131, 3256-3265
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Mg2+-dependent Neutral Sphingomyelinase 1 as a Mediator of Heat Stress-induced Ceramide Generation and Apoptosis.

T. Yabu, S. Imamura, M. Yamashita, and T. Okazaki (2008)
J. Biol. Chem. 283, 29971-29982
 |  Abstract »  |  Full Text »  |  PDF »

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets.

K. Takabe, S. W. Paugh, S. Milstien, and S. Spiegel (2008)
Pharmacol. Rev. 60, 181-195
 |  Abstract »  |  Full Text »  |  PDF »

Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies.

C. A. Corcoran, Q. He, S. Ponnusamy, B. Ogretmen, Y. Huang, and M. S. Sheikh (2008)
Mol. Cancer Res. 6, 795-807
 |  Abstract »  |  Full Text »  |  PDF »

Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels.

L. J. Siskind, L. Feinstein, T. Yu, J. S. Davis, D. Jones, J. Choi, J. E. Zuckerman, W. Tan, R. B. Hill, J. M. Hardwick, et al. (2008)
J. Biol. Chem. 283, 6622-6630
 |  Abstract »  |  Full Text »  |  PDF »

Pivotal Role of the Cyclin-dependent Kinase Inhibitor p21WAF1/CIP1 in Apoptosis and Autophagy.

K. Fujiwara, S. Daido, A. Yamamoto, R. Kobayashi, T. Yokoyama, H. Aoki, E. Iwado, N. Shinojima, Y. Kondo, and S. Kondo (2008)
J. Biol. Chem. 283, 388-397
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Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes.

M. S. Han, S. Y. Park, K. Shinzawa, S. Kim, K. W. Chung, J.-H. Lee, C. H. Kwon, K.-W. Lee, J.-H. Lee, C. K. Park, et al. (2008)
J. Lipid Res. 49, 84-97
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Staphylococcal Enterotoxin B Domains Involved in Binding to Cultured Human Kidney Proximal Tubular Cells: Imparting Proliferation and Death.

S. Chatterjee, R. Neill, J. W. Shupp, R. Hammamieh, B. Ionin, and M. Jett (2007)
Experimental Biology and Medicine 232, 1142-1151
 |  Abstract »  |  Full Text »  |  PDF »

Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells.

W.-K. Lee, B. Torchalski, and F. Thevenod (2007)
Am J Physiol Cell Physiol 293, C839-C847
 |  Abstract »  |  Full Text »  |  PDF »

JNK3 Signaling Pathway Activates Ceramide Synthase Leading to Mitochondrial Dysfunction.

J. Yu, S. A. Novgorodov, D. Chudakova, H. Zhu, A. Bielawska, J. Bielawski, L. M. Obeid, M. S. Kindy, and T. I. Gudz (2007)
J. Biol. Chem. 282, 25940-25949
 |  Abstract »  |  Full Text »  |  PDF »

Porphyromonas gingivalis Dihydroceramides Induce Apoptosis in Endothelial Cells.

J. Zahlten, B. Riep, F.C. Nichols, C. Walter, B. Schmeck, J.-P. Bernimoulin, and S. Hippenstiel (2007)
Journal of Dental Research 86, 635-640
 |  Abstract »  |  Full Text »  |  PDF »

Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity.

G. S. Dbaibo, Y. Kfoury, N. Darwiche, S. Panjarian, L. Kozhaya, R. Nasr, M. Abdallah, O. Hermine, M. El-Sabban, H. de The, et al. (2007)
Haematologica 92, 753-762
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I.

A. B. Ghering and W. S. Davidson (2006)
J. Lipid Res. 47, 2781-2788
 |  Abstract »  |  Full Text »  |  PDF »

Penta-Acetyl Geniposide Induce Apoptosis in C6 Glioma Cells by Modulating the Activation of Neutral Sphingomyelinase-Induced p75 Nerve Growth Factor Receptor and Protein Kinase C{delta} Pathway.

C.-H. Peng, C.-N. Huang, S.-P. Hsu, and C.-J. Wang (2006)
Mol. Pharmacol. 70, 997-1004
 |  Abstract »  |  Full Text »  |  PDF »

SAP155 Binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA.

A. Massiello, J. R. Roesser, and C. E. Chalfant (2006)
FASEB J 20, 1680-1682
 |  Abstract »  |  Full Text »  |  PDF »

Protein Phosphatase 2A Enhances the Proapoptotic Function of Bax through Dephosphorylation.

M. Xin and X. Deng (2006)
J. Biol. Chem. 281, 18859-18867
 |  Abstract »  |  Full Text »  |  PDF »

Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts.

R. Valaperta, V. Chigorno, L. Basso, A. Prinetti, R. Bresciani, A. Preti, T. Miyagi, and S. Sonnino (2006)
FASEB J 20, 1227-1229
 |  Abstract »  |  Full Text »  |  PDF »

Fas Signaling Induces Raft Coalescence That Is Blocked by Cholesterol Depletion in Human RPE Cells Undergoing Apoptosis.

J. E. Lincoln, M. Boling, A. N. Parikh, Y. Yeh, D. G. Gilchrist, and L. S. Morse (2006)
Invest. Ophthalmol. Vis. Sci. 47, 2172-2178
 |  Abstract »  |  Full Text »  |  PDF »

SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsiveness.

A. Massiello and C. E. Chalfant (2006)
J. Lipid Res. 47, 892-897
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide is a Mediator of Apoptosis in Retina Photoreceptors..

O. L. German, G. E. Miranda, C. E. Abrahan, and N. P. Rotstein (2006)
Invest. Ophthalmol. Vis. Sci. 47, 1658-1668
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The BAR Domain Proteins: Molding Membranes in Fission, Fusion, and Phagy.

G. Ren, P. Vajjhala, J. S. Lee, B. Winsor, and A. L. Munn (2006)
Microbiol. Mol. Biol. Rev. 70, 37-120
 |  Abstract »  |  Full Text »  |  PDF »

Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death..

K.-J. Yin, C. Y. Hsu, X.-Y. Hu, H. Chen, S.-W. Chen, J. Xu, and J.-M. Lee (2006)
J. Neurosci. 26, 2290-2299
 |  Abstract »  |  Full Text »  |  PDF »

Role of Sphingolipids in Microbial Pathogenesis.

L. J. Heung, C. Luberto, and M. Del Poeta (2006)
Infect. Immun. 74, 28-39
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Tumor necrosis factor-{alpha} inhibits hTERT gene expression in human myeloid normal and leukemic cells.

O. Beyne-Rauzy, N. Prade-Houdellier, C. Demur, C. Recher, J. Ayel, G. Laurent, and V. Mansat-De Mas (2005)
Blood 106, 3200-3205
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.

E. Le Scolan, D. Pchejetski, Y. Banno, N. Denis, P. Mayeux, W. Vainchenker, T. Levade, and F. Moreau-Gachelin (2005)
Blood 106, 1808-1816
 |  Abstract »  |  Full Text »  |  PDF »

Complete Genome Sequence and Lytic Phase Transcription Profile of a Coccolithovirus.

W. H. Wilson, D. C. Schroeder, M. J. Allen, M. T. G. Holden, J. Parkhill, B. G. Barrell, C. Churcher, N. Hamlin, K. Mungall, H. Norbertczak, et al. (2005)
Science 309, 1090-1092
 |  Abstract »  |  Full Text »  |  PDF »

Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-{alpha}.

Y. Osawa, H. Uchinami, J. Bielawski, R. F. Schwabe, Y. A. Hannun, and D. A. Brenner (2005)
J. Biol. Chem. 280, 27879-27887
 |  Abstract »  |  Full Text »  |  PDF »

Laser Induces Apoptosis and Ceramide Production in Human Retinal Pigment Epithelial Cells.

A. Barak, T. Goldkorn, and L. S. Morse (2005)
Invest. Ophthalmol. Vis. Sci. 46, 2587-2591
 |  Abstract »  |  Full Text »  |  PDF »

Transcription Factor NF-{kappa}B Differentially Regulates Death Receptor 5 Expression Involving Histone Deacetylase 1.

S. Shetty, B. A. Graham, J. G. Brown, X. Hu, N. Vegh-Yarema, G. Harding, J. T. Paul, and S. B. Gibson (2005)
Mol. Cell. Biol. 25, 5404-5416
 |  Abstract »  |  Full Text »  |  PDF »

Down-regulation of ATM Protein Sensitizes Human Prostate Cancer Cells to Radiation-induced Apoptosis.

J.-P. Truman, N. Gueven, M. Lavin, S. Leibel, R. Kolesnick, Z. Fuks, and A. Haimovitz-Friedman (2005)
J. Biol. Chem. 280, 23262-23272
 |  Abstract »  |  Full Text »  |  PDF »

LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia.

Z. Xu, J. Zhou, D. M. McCoy, and R. K. Mallampalli (2005)
J. Lipid Res. 46, 1229-1238
 |  Abstract »  |  Full Text »  |  PDF »

Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse.

J. Matsuda, M. Kido, K. Tadano-Aritomi, I. Ishizuka, K. Tominaga, K. Toida, E. Takeda, K. Suzuki, and Y. Kuroda (2004)
Hum. Mol. Genet. 13, 2709-2723
 |  Abstract »  |  Full Text »  |  PDF »

Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert.

E. Suzuki, K. Handa, M. S. Toledo, and S. Hakomori (2004)
PNAS 101, 14788-14793
 |  Abstract »  |  Full Text »  |  PDF »

Sphingosine Contributes to Glucocorticoid-Induced Apoptosis of Thymocytes Independently of the Mitochondrial Pathway.

S. Lepine, B. Lakatos, M.-P. Courageot, H. Le Stunff, J.-C. Sulpice, and F. Giraud (2004)
J. Immunol. 173, 3783-3790
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide Reduction and Transcriptional Up-Regulation of Glucosylceramide Synthase through Doxorubicin-Activated Sp1 in Drug-Resistant HL-60/ADR Cells.

Y. Uchida, M. Itoh, Y. Taguchi, S. Yamaoka, H. Umehara, S.-i. Ichikawa, Y. Hirabayashi, W. M. Holleran, and T. Okazaki (2004)
Cancer Res. 64, 6271-6279
 |  Abstract »  |  Full Text »  |  PDF »

Drosophila Glucosylceramide Synthase: A NEGATIVE REGULATOR OF CELL DEATH MEDIATED BY PROAPOPTOTIC FACTORS.

A. Kohyama-Koganeya, T. Sasamura, E. Oshima, E. Suzuki, S. Nishihara, R. Ueda, and Y. Hirabayashi (2004)
J. Biol. Chem. 279, 35995-36002
 |  Abstract »  |  Full Text »  |  PDF »

The xipotl Mutant of Arabidopsis Reveals a Critical Role for Phospholipid Metabolism in Root System Development and Epidermal Cell Integrity.

A. Cruz-Ramirez, J. Lopez-Bucio, G. Ramirez-Pimentel, A. Zurita-Silva, L. Sanchez-Calderon, E. Ramirez-Chavez, E. Gonzalez-Ortega, and L. Herrera-Estrella (2004)
PLANT CELL 16, 2020-2034
 |  Abstract »  |  Full Text »  |  PDF »

Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma Cells.

S. Daido, T. Kanzawa, A. Yamamoto, H. Takeuchi, Y. Kondo, and S. Kondo (2004)
Cancer Res. 64, 4286-4293
 |  Abstract »  |  Full Text »  |  PDF »

Novel Ceramide Analogs as Potential Chemotherapeutic Agents in Breast Cancer.

A. P. Struckhoff, R. Bittman, M. E. Burow, S. Clejan, S. Elliott, T. Hammond, Y. Tang, and B. S. Beckman (2004)
J. Pharmacol. Exp. Ther. 309, 523-532
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.

V. Gouaze, J. Y. Yu, R. J. Bleicher, T.-Y. Han, Y.-Y. Liu, H. Wang, M. M. Gottesman, A. Bitterman, A. E. Giuliano, and M. C. Cabot (2004)
Mol. Cancer Ther. 3, 633-640
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Soy Sphingolipids Suppress Tumorigenesis and Gene Expression in 1,2-Dimethylhydrazine-Treated CF1 Mice and ApcMin/+ Mice.

H. Symolon, E. M. Schmelz, D. L. Dillehay, and A. H. Merrill Jr. (2004)
J. Nutr. 134, 1157-1161
 |  Abstract »  |  Full Text »  |  PDF »

Role of FAN in Tumor Necrosis Factor-{alpha} and Lipopolysaccharide-induced Interleukin-6 Secretion and Lethality in D-Galactosamine-sensitized Mice.

S. Malagarie-Cazenave, B. Segui, S. Leveque, V. Garcia, S. Carpentier, M.-F. Altie, A. Brouchet, V. Gouaze, N. Andrieu-Abadie, Y. Barreira, et al. (2004)
J. Biol. Chem. 279, 18648-18655
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Two RNA cis-Elements That Function to Regulate the 5' Splice Site Selection of Bcl-x Pre-mRNA in Response to Ceramide.

A. Massiello, A. Salas, R. L. Pinkerman, P. Roddy, J. R. Roesser, and C. E. Chalfant (2004)
J. Biol. Chem. 279, 15799-15804
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide-induced Apoptosis by Translocation, Phosphorylation, and Activation of Protein Kinase C{delta} in the Golgi Complex.

T. Kajimoto, Y. Shirai, N. Sakai, T. Yamamoto, H. Matsuzaki, U. Kikkawa, and N. Saito (2004)
J. Biol. Chem. 279, 12668-12676
 |  Abstract »  |  Full Text »  |  PDF »

The structural requirements for ceramide activation of serine-threonine protein phosphatases.

C. E. Chalfant, Z. Szulc, P. Roddy, A. Bielawska, and Y. A. Hannun (2004)
J. Lipid Res. 45, 496-506
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide in the antiapoptotic effect of ischemic preconditioning.

L. Argaud, A.-F. Prigent, L. Chalabreysse, J. Loufouat, M. Lagarde, and M. Ovize (2004)
Am J Physiol Heart Circ Physiol 286, H246-H251
 |  Abstract »  |  Full Text »  |  PDF »

Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells.

C.M. Perks, P.V. Newcomb, M. Grohmann, R.J. Wright, H.D. Mason, and J.M.P. Holly (2003)
Hum. Reprod. 18, 2672-2677
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial Cytochrome c Release Mediates Ceramide-induced Activator Protein 2 Activation and Gene Expression in Keratinocytes.

S. Grether-Beck, I. Felsner, H. Brenden, and J. Krutmann (2003)
J. Biol. Chem. 278, 47498-47507
 |  Abstract »  |  Full Text »  |  PDF »

Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors.

C. Riebeling, J. C. Allegood, E. Wang, A. H. Merrill Jr., and A. H. Futerman (2003)
J. Biol. Chem. 278, 43452-43459
 |  Abstract »  |  Full Text »  |  PDF »

Reovirus-Induced Alteration in Expression of Apoptosis and DNA Repair Genes with Potential Roles in Viral Pathogenesis.

R. L. DeBiasi, P. Clarke, S. Meintzer, R. Jotte, B. K. Kleinschmidt-Demasters, G. L. Johnson, and K. L. Tyler (2003)
J. Virol. 77, 8934-8947
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis in Keratocytes Caused by Mitomycin C.

T.-i. Kim, H. Tchah, S.-a. Lee, K. Sung, B. J. Cho, and M. S. Kook (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1912-1917
 |  Abstract »  |  Full Text »  |  PDF »

BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis.

L. Scorrano, S. A. Oakes, J. T. Opferman, E. H. Cheng, M. D. Sorcinelli, T. Pozzan, and S. J. Korsmeyer (2003)
Science 300, 135-139
 |  Abstract »  |  Full Text »  |  PDF »

Significant Role of Ceramide Pathway in Experimental Gastric Ulcer Formation in Rats.

K. Uehara, S. Miura, T. Takeuchi, T. Taki, M. Nakashita, M. Adachi, T. Inamura, T. Ogawa, Y. Akiba, H. Suzuki, et al. (2003)
J. Pharmacol. Exp. Ther. 305, 232-239
 |  Abstract »  |  Full Text »

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

F. Darios, O. Corti, C. B. Lucking, C. Hampe, M.-P. Muriel, N. Abbas, W.-J. Gu, E. C. Hirsch, T. Rooney, M. Ruberg, et al. (2003)
Hum. Mol. Genet. 12, 517-526
 |  Abstract »  |  Full Text »  |  PDF »

Altered Sphingolipid Metabolism in N-(4-Hydroxyphenyl)- retinamide-resistant A2780 Human Ovarian Carcinoma Cells.

A. Prinetti, L. Basso, V. Appierto, M. G. Villani, M. Valsecchi, N. Loberto, S. Prioni, V. Chigorno, E. Cavadini, F. Formelli, et al. (2003)
J. Biol. Chem. 278, 5574-5583
 |  Abstract »  |  Full Text »  |  PDF »

Impact of mitochondrial {beta}-oxidation in fatty acid-mediated inhibition of glioma cell proliferation.

K. Berge, K. J. Tronstad, P. Bohov, L. Madsen, and R. K. Berge (2003)
J. Lipid Res. 44, 118-127
 |  Abstract »  |  Full Text »  |  PDF »

Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity.

A. J. Ryan, D. M. McCoy, S. E. McGowan, R. G. Salome, and R. K. Mallampalli (2003)
J Appl Physiol 94, 253-258
 |  Abstract »  |  Full Text »  |  PDF »

Possible Role of Ceramide as an Indicator of Chemoresistance: Decrease of the Ceramide Content via Activation of Glucosylceramide Synthase and Sphingomyelin Synthase in Chemoresistant Leukemia.

M. Itoh, T. Kitano, M. Watanabe, T. Kondo, T. Yabu, Y. Taguchi, K. Iwai, M. Tashima, T. Uchiyama, and T. Okazaki (2003)
Clin. Cancer Res. 9, 415-423
 |  Abstract »  |  Full Text »  |  PDF »

Cytosolic Retention of Phosphorylated Extracellular Signal-Regulated Kinase and a Rho-Associated Kinase-Mediated Signal Impair Expression of p21Cip1/Waf1 in Phorbol 12-Myristate-13- Acetate-Induced Apoptotic Cells.

J.-M. Lai, S. Wu, D.-Y. Huang, and Z.-F. Chang (2002)
Mol. Cell. Biol. 22, 7581-7592
 |  Abstract »  |  Full Text »  |  PDF »

Soluble Fas Ligand Activates the Sphingomyelin Pathway and Induces Apoptosis in Luteal Steroidogenic Cells Independently of Stress-Activated p38MAPK.

J. K. Pru, I. R. Hendry, J. S. Davis, and B. R. Rueda (2002)
Endocrinology 143, 4350-4357
 |  Abstract »  |  Full Text »  |  PDF »

Acute Activation of de Novo Sphingolipid Biosynthesis upon Heat Shock Causes an Accumulation of Ceramide and Subsequent Dephosphorylation of SR Proteins.

G. M. Jenkins, L. A. Cowart, P. Signorelli, B. J. Pettus, C. E. Chalfant, and Y. A. Hannun (2002)
J. Biol. Chem. 277, 42572-42578
 |  Abstract »  |  Full Text »  |  PDF »

Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells?.

I. GOUNI-BERTHOLD and A. SACHINIDIS (2002)
FASEB J 16, 1477-1487
 |  Abstract »  |  Full Text »  |  PDF »

c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide.

F.-Q. Wen, A. A. Jabbar, Y.-X. Chen, T. Kazarian, D. A. Patel, and L. A. Valentino (2002)
Blood 100, 912-916
 |  Abstract »  |  Full Text »  |  PDF »

Importance of C1B Domain for Lipid Messenger-induced Targeting of Protein Kinase C.

K. Kashiwagi, Y. Shirai, M. Kuriyama, N. Sakai, and N. Saito (2002)
J. Biol. Chem. 277, 18037-18045
 |  Abstract »  |  Full Text »  |  PDF »

Sphingoid Bases and Ceramide Induce Apoptosis in HT-29 and HCT-116 Human Colon Cancer Cells.

E. H. Ahn and J. J. Schroeder (2002)
Experimental Biology and Medicine 227, 345-353
 |  Abstract »  |  Full Text »  |  PDF »

De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells. DEPENDENCE ON PROTEIN PHOSPHATASE-1.

C. E. Chalfant, K. Rathman, R. L. Pinkerman, R. E. Wood, L. M. Obeid, B. Ogretmen, and Y. A. Hannun (2002)
J. Biol. Chem. 277, 12587-12595
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line. ROLE FOR ENDOGENOUS CERAMIDE IN MEDIATING THE ACTION OF EXOGENOUS CERAMIDE.

B. Ogretmen, B. J. Pettus, M. J. Rossi, R. Wood, J. Usta, Z. Szulc, A. Bielawska, L. M. Obeid, and Y. A. Hannun (2002)
J. Biol. Chem. 277, 12960-12969
 |  Abstract »  |  Full Text »  |  PDF »

Coupled assay of sphingomyelin and ceramide molecular species by gas liquid chromatography.

C. Vieu, F. Terce, F. Chevy, C. Rolland, R. Barbaras, H. Chap, C. Wolf, B. Perret, and X. Collet (2002)
J. Lipid Res. 43, 510-522
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor {alpha} Enhances Oocyte/Follicle Apoptosis in the Neonatal Rat Ovary.

L. J. Morrison and J. L. Marcinkiewicz (2002)
Biol Reprod 66, 450-457
 |  Abstract »  |  Full Text »  |  PDF »

E5 Protein of Human Papillomavirus Type 16 Protects Human Foreskin Keratinocytes from UV B-Irradiation-Induced Apoptosis.

B. Zhang, D. F. Spandau, and A. Roman (2002)
J. Virol. 76, 220-231
 |  Abstract »  |  Full Text »  |  PDF »

Human Group IIA Secretory Phospholipase A2 Induces Neuronal Cell Death via Apoptosis.

T. Yagami, K. Ueda, K. Asakura, S. Hata, T. Kuroda, T. Sakaeda, N. Takasu, K. Tanaka, T. Gemba, and Y. Hori (2002)
Mol. Pharmacol. 61, 114-126
 |  Abstract »  |  Full Text »  |  PDF »

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis.

H. BIRBES, S. EL BAWAB, Y. A. HANNUN, and L. M. OBEID (2001)
FASEB J 15, 2669-2679
 |  Abstract »  |  Full Text »  |  PDF »

The IL-15R{alpha} Chain Signals Through Association with Syk in Human B Cells.

E. Bulanova, V. Budagian, T. Pohl, H. Krause, H. Durkop, R. Paus, and S. Bulfone-Paus (2001)
J. Immunol. 167, 6292-6302
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide inhibition of NF-{kappa}B activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response.

P. SIGNORELLI, C. LUBERTO, and Y. A. HANNUN (2001)
FASEB J 15, 2401-2414
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Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria.

O. Cuvillier and T. Levade (2001)
Blood 98, 2828-2836
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Tumor Necrosis Factor-alpha Induces Stress Fiber Formation through Ceramide Production: Role of Sphingosine Kinase.

A. N. Hanna, L. G. Berthiaume, Y. Kikuchi, D. Begg, S. Bourgoin, and D. N. Brindley (2001)
Mol. Biol. Cell 12, 3618-3630
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Modulation of Intracellular {beta}-Catenin Localization and Intestinal Tumorigenesis in Vivo and in Vitro by Sphingolipids.

E. M. Schmelz, P. C. Roberts, E. M. Kustin, L. A. Lemonnier, M. C. Sullards, D. L. Dillehay, and A. H. Merrill Jr. (2001)
Cancer Res. 61, 6723-6729
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Signaling pathways activated by daunorubicin.

G. Laurent and J.-P. Jaffrezou (2001)
Blood 98, 913-924
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A Monoclonal Antibody That Induces Neuronal Apoptosis Binds a Metastasis Marker.

L.-t. Zhong, A. Manzi, E. Skowronski, L. Notterpek, A. L. Fluharty, K. F. Faull, I. Masada, S. Rabizadeh, M. Varsanyi-Nagy, Y. Ruan, et al. (2001)
Cancer Res. 61, 5741-5748
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TNF-{{alpha}}-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes.

Y. Osawa, Y. Banno, M. Nagaki, D. A. Brenner, T. Naiki, Y. Nozawa, S. Nakashima, and H. Moriwaki (2001)
J. Immunol. 167, 173-180
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Synthetic Phytoceramides Induce Apoptosis with Higher Potency than Ceramides.

O. Hwang, G. Kim, Y. J. Jang, S. W. Kim, G. Choi, H. J. Choi, S. Y. Jeon, D. G. Lee, and J. D. Lee (2001)
Mol. Pharmacol. 59, 1249-1255
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Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells.

I. Spyridopoulos, P. Mayer, K. S. Shook, D. I. Axel, R. Viebahn, and K. R. Karsch (2001)
Cardiovasc Res 50, 97-107
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Subtype-Specific Translocation of the {delta} Subtype of Protein Kinase C and Its Activation by Tyrosine Phosphorylation Induced by Ceramide in HeLa Cells.

T. Kajimoto, S. Ohmori, Y. Shirai, N. Sakai, and N. Saito (2001)
Mol. Cell. Biol. 21, 1769-1783
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Cystemustine Induces Redifferentiation of Primary Tumors and Confers Protection against Secondary Tumor Growth in a Melanoma Murine Model.

A. Demidem, D. Morvan, J. Papon, M. De Latour, and J. C. Madelmont (2001)
Cancer Res. 61, 2294-2300
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Diseases of liporegulation: new perspective on obesity and related disorders.

R. H. UNGER and L. ORCI (2001)
FASEB J 15, 312-321
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Ceramide: A Potential Mediator of Apoptosis in Human Retinal Pigment Epithelial Cells.

A. Barak, L. S. Morse, and T. Goldkorn (2001)
Invest. Ophthalmol. Vis. Sci. 42, 247-254
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Human Diploid Fibroblasts That Undergo a Senescent-like Differentiation Have Elevated Ceramide and Diacylglycerol.

C. J. Miller and G. H. Stein (2001)
J. Gerontol. A Biol. Sci. Med. Sci. 56, 8B-20
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Regulation of Bcl2 Phosphorylation and Potential Significance for Leukemic Cell Chemoresistance.

X. Deng, S. M. Kornblau, P. P. Ruvolo, and W. S. May Jr. (2000)
J Natl Cancer Inst Monographs 2000, 30-37
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Apoptosis Induced by Rac GTPase Correlates with Induction of FasL and Ceramides Production.

N. Embade, P. F. Valerón, S. Aznar, E. López-Collazo, and J. C. Lacal (2000)
Mol. Biol. Cell 11, 4347-4358
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Elevated ceramide is downstream of altered calcium homeostasis in low serum-induced apoptosis.

S. Jayadev, J. C. Barrett, and E. Murphy (2000)
Am J Physiol Cell Physiol 279, C1640-C1647
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Physiology of apoptosis.

E. Gulbins, A. Jekle, K. Ferlinz, H. Grassme, and F. Lang (2000)
Am J Physiol Renal Physiol 279, F605-F615
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Ligation of the WC1 Receptor Induces {gamma}{delta} T Cell Growth Arrest Through Fumonisin B1-Sensitive Increases in Cellular Ceramide.

P. A. Kirkham, H.-H. Takamatsu, E. W.-F. Lam, and R. M. E. Parkhouse (2000)
J. Immunol. 165, 3564-3570
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The Bioflavonoid Galangin Blocks Aryl Hydrocarbon Receptor Activation and Polycyclic Aromatic Hydrocarbon-Induced Pre-B Cell Apoptosis.

S. A. Quadri, A. N. Qadri, M. E. Hahn, K. K. Mann, and D. H. Sherr (2000)
Mol. Pharmacol. 58, 515-525
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Activation of Nuclear Factor {kappa}B and Induction of Apoptosis by Tumor Necrosis Factor-{alpha} in the Mouse Uterine Epithelial WEG-1 Cell Line.

S. Pampfer, S. Cordi, S. Cikos, B. Picry, I. Vanderheyden, and R. D. Hertogh (2000)
Biol Reprod 63, 879-886
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Sindbis Virus Entry into Cells Triggers Apoptosis by Activating Sphingomyelinase, Leading to the Release of Ceramide.

J.-T. Jan, S. Chatterjee, and D. E. Griffin (2000)
J. Virol. 74, 6425-6432
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Induction of apoptosis using sphingolipids activates a chloride current in Xenopus laevis oocytes.

R. Souktani, A. Berdeaux, B. Ghaleh, J. F. Giudicelli, L. Guize, J. Y. Le Heuzey, and P. Henry (2000)
Am J Physiol Cell Physiol 279, C158-C165
 |  Abstract »  |  Full Text »  |  PDF »

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