Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Signaling - Call For Papers

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 March 1993:
Vol. 259. no. 5102, pp. 1769 - 1771
DOI: 10.1126/science.8456305
Prev | Table of Contents | Next

Articles

Science, Vol 259, Issue 5102, 1769-1771
Copyright © 1993 by American Association for the Advancement of Science

articles

Programmed cell death induced by ceramide

LM Obeid, CM Linardic, LA Karolak, and YA Hannun

Department of Medicine, Duke University Medical Center, Durham, NC 27710.

Sphingomyelin hydrolysis and ceramide generation have been implicated in a signal transduction pathway that mediates the effects of tumor necrosis factor-alpha (TNF-alpha) and other agents on cell growth and differentiation. In many leukemic cells, TNF-alpha causes DNA fragmentation, which leads to programmed cell death (apoptosis). C2-ceramide (0.6 to 5 microM), a synthetic cell-permeable ceramide analog, induced internucleosomal DNA fragmentation, which was inhibited by zinc ion. Other amphiphilic lipids failed to induce apoptosis. The closely related C2-dihydroceramide was also ineffective, which suggests a critical role for the sphingolipid double bond. The effects of C2-ceramide on DNA fragmentation were prevented by the protein kinase C activator phorbol 12-myristate 13-acetate, which suggests the existence of two opposing intracellular pathways in the regulation of apoptosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets.
K. Takabe, S. W. Paugh, S. Milstien, and S. Spiegel (2008)
Pharmacol. Rev. 60, 181-195
   Abstract »    Full Text »    PDF »
Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies.
C. A. Corcoran, Q. He, S. Ponnusamy, B. Ogretmen, Y. Huang, and M. S. Sheikh (2008)
Mol. Cancer Res. 6, 795-807
   Abstract »    Full Text »    PDF »
Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels.
L. J. Siskind, L. Feinstein, T. Yu, J. S. Davis, D. Jones, J. Choi, J. E. Zuckerman, W. Tan, R. B. Hill, J. M. Hardwick, et al. (2008)
J. Biol. Chem. 283, 6622-6630
   Abstract »    Full Text »    PDF »
Pivotal Role of the Cyclin-dependent Kinase Inhibitor p21WAF1/CIP1 in Apoptosis and Autophagy.
K. Fujiwara, S. Daido, A. Yamamoto, R. Kobayashi, T. Yokoyama, H. Aoki, E. Iwado, N. Shinojima, Y. Kondo, and S. Kondo (2008)
J. Biol. Chem. 283, 388-397
   Abstract »    Full Text »    PDF »
Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes.
M. S. Han, S. Y. Park, K. Shinzawa, S. Kim, K. W. Chung, J.-H. Lee, C. H. Kwon, K.-W. Lee, J.-H. Lee, C. K. Park, et al. (2008)
J. Lipid Res. 49, 84-97
   Abstract »    Full Text »    PDF »
Identification of Staphylococcal Enterotoxin B Domains Involved in Binding to Cultured Human Kidney Proximal Tubular Cells: Imparting Proliferation and Death.
S. Chatterjee, R. Neill, J. W. Shupp, R. Hammamieh, B. Ionin, and M. Jett (2007)
Experimental Biology and Medicine 232, 1142-1151
   Abstract »    Full Text »    PDF »
Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells.
W.-K. Lee, B. Torchalski, and F. Thevenod (2007)
Am J Physiol Cell Physiol 293, C839-C847
   Abstract »    Full Text »    PDF »
JNK3 Signaling Pathway Activates Ceramide Synthase Leading to Mitochondrial Dysfunction.
J. Yu, S. A. Novgorodov, D. Chudakova, H. Zhu, A. Bielawska, J. Bielawski, L. M. Obeid, M. S. Kindy, and T. I. Gudz (2007)
J. Biol. Chem. 282, 25940-25949
   Abstract »    Full Text »    PDF »
Porphyromonas gingivalis Dihydroceramides Induce Apoptosis in Endothelial Cells.
J. Zahlten, B. Riep, F.C. Nichols, C. Walter, B. Schmeck, J.-P. Bernimoulin, and S. Hippenstiel (2007)
J. Dent. Res. 86, 635-640
   Abstract »    Full Text »    PDF »
Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity.
G. S. Dbaibo, Y. Kfoury, N. Darwiche, S. Panjarian, L. Kozhaya, R. Nasr, M. Abdallah, O. Hermine, M. El-Sabban, H. de The, et al. (2007)
Haematologica 92, 753-762
   Abstract »    Full Text »    PDF »
Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I.
A. B. Ghering and W. S. Davidson (2006)
J. Lipid Res. 47, 2781-2788
   Abstract »    Full Text »    PDF »
Penta-Acetyl Geniposide Induce Apoptosis in C6 Glioma Cells by Modulating the Activation of Neutral Sphingomyelinase-Induced p75 Nerve Growth Factor Receptor and Protein Kinase C{delta} Pathway.
C.-H. Peng, C.-N. Huang, S.-P. Hsu, and C.-J. Wang (2006)
Mol. Pharmacol. 70, 997-1004
   Abstract »    Full Text »    PDF »
Sphingosine, a Product of Ceramide Hydrolysis, Influences the Formation of Ceramide Channels.
M. J. Elrick, S. Fluss, and M. Colombini (2006)
Biophys. J. 91, 1749-1756
   Abstract »    Full Text »    PDF »
SAP155 Binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA.
A. Massiello, J. R. Roesser, and C. E. Chalfant (2006)
FASEB J 20, 1680-1682
   Abstract »    Full Text »    PDF »
Protein Phosphatase 2A Enhances the Proapoptotic Function of Bax through Dephosphorylation.
M. Xin and X. Deng (2006)
J. Biol. Chem. 281, 18859-18867
   Abstract »    Full Text »    PDF »
Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts.
R. Valaperta, V. Chigorno, L. Basso, A. Prinetti, R. Bresciani, A. Preti, T. Miyagi, and S. Sonnino (2006)
FASEB J 20, 1227-1229
   Abstract »    Full Text »    PDF »
Fas Signaling Induces Raft Coalescence That Is Blocked by Cholesterol Depletion in Human RPE Cells Undergoing Apoptosis.
J. E. Lincoln, M. Boling, A. N. Parikh, Y. Yeh, D. G. Gilchrist, and L. S. Morse (2006)
Invest. Ophthalmol. Vis. Sci. 47, 2172-2178
   Abstract »    Full Text »    PDF »
SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsiveness.
A. Massiello and C. E. Chalfant (2006)
J. Lipid Res. 47, 892-897
   Abstract »    Full Text »    PDF »
Ceramide is a Mediator of Apoptosis in Retina Photoreceptors..
O. L. German, G. E. Miranda, C. E. Abrahan, and N. P. Rotstein (2006)
Invest. Ophthalmol. Vis. Sci. 47, 1658-1668
   Abstract »    Full Text »    PDF »
The BAR Domain Proteins: Molding Membranes in Fission, Fusion, and Phagy.
G. Ren, P. Vajjhala, J. S. Lee, B. Winsor, and A. L. Munn (2006)
Microbiol. Mol. Biol. Rev. 70, 37-120
   Abstract »    Full Text »    PDF »
Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death..
K.-J. Yin, C. Y. Hsu, X.-Y. Hu, H. Chen, S.-W. Chen, J. Xu, and J.-M. Lee (2006)
J. Neurosci. 26, 2290-2299
   Abstract »    Full Text »    PDF »
Role of Sphingolipids in Microbial Pathogenesis.
L. J. Heung, C. Luberto, and M. Del Poeta (2006)
Infect. Immun. 74, 28-39
   Full Text »    PDF »
Tumor necrosis factor-{alpha} inhibits hTERT gene expression in human myeloid normal and leukemic cells.
O. Beyne-Rauzy, N. Prade-Houdellier, C. Demur, C. Recher, J. Ayel, G. Laurent, and V. Mansat-De Mas (2005)
Blood 106, 3200-3205
   Abstract »    Full Text »    PDF »
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.
E. Le Scolan, D. Pchejetski, Y. Banno, N. Denis, P. Mayeux, W. Vainchenker, T. Levade, and F. Moreau-Gachelin (2005)
Blood 106, 1808-1816
   Abstract »    Full Text »    PDF »
Complete Genome Sequence and Lytic Phase Transcription Profile of a Coccolithovirus.
W. H. Wilson, D. C. Schroeder, M. J. Allen, M. T. G. Holden, J. Parkhill, B. G. Barrell, C. Churcher, N. Hamlin, K. Mungall, H. Norbertczak, et al. (2005)
Science 309, 1090-1092
   Abstract »    Full Text »    PDF »
Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-{alpha}.
Y. Osawa, H. Uchinami, J. Bielawski, R. F. Schwabe, Y. A. Hannun, and D. A. Brenner (2005)
J. Biol. Chem. 280, 27879-27887
   Abstract »    Full Text »    PDF »
Laser Induces Apoptosis and Ceramide Production in Human Retinal Pigment Epithelial Cells.
A. Barak, T. Goldkorn, and L. S. Morse (2005)
Invest. Ophthalmol. Vis. Sci. 46, 2587-2591
   Abstract »    Full Text »    PDF »
Transcription Factor NF-{kappa}B Differentially Regulates Death Receptor 5 Expression Involving Histone Deacetylase 1.
S. Shetty, B. A. Graham, J. G. Brown, X. Hu, N. Vegh-Yarema, G. Harding, J. T. Paul, and S. B. Gibson (2005)
Mol. Cell. Biol. 25, 5404-5416
   Abstract »    Full Text »    PDF »
Down-regulation of ATM Protein Sensitizes Human Prostate Cancer Cells to Radiation-induced Apoptosis.
J.-P. Truman, N. Gueven, M. Lavin, S. Leibel, R. Kolesnick, Z. Fuks, and A. Haimovitz-Friedman (2005)
J. Biol. Chem. 280, 23262-23272
   Abstract »    Full Text »    PDF »
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia.
Z. Xu, J. Zhou, D. M. McCoy, and R. K. Mallampalli (2005)
J. Lipid Res. 46, 1229-1238
   Abstract »    Full Text »    PDF »
Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse.
J. Matsuda, M. Kido, K. Tadano-Aritomi, I. Ishizuka, K. Tominaga, K. Toida, E. Takeda, K. Suzuki, and Y. Kuroda (2004)
Hum. Mol. Genet. 13, 2709-2723
   Abstract »    Full Text »    PDF »
Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert.
E. Suzuki, K. Handa, M. S. Toledo, and S. Hakomori (2004)
PNAS 101, 14788-14793
   Abstract »    Full Text »    PDF »
Sphingosine Contributes to Glucocorticoid-Induced Apoptosis of Thymocytes Independently of the Mitochondrial Pathway.
S. Lepine, B. Lakatos, M.-P. Courageot, H. Le Stunff, J.-C. Sulpice, and F. Giraud (2004)
J. Immunol. 173, 3783-3790
   Abstract »    Full Text »    PDF »
Ceramide Reduction and Transcriptional Up-Regulation of Glucosylceramide Synthase through Doxorubicin-Activated Sp1 in Drug-Resistant HL-60/ADR Cells.
Y. Uchida, M. Itoh, Y. Taguchi, S. Yamaoka, H. Umehara, S.-i. Ichikawa, Y. Hirabayashi, W. M. Holleran, and T. Okazaki (2004)
Cancer Res. 64, 6271-6279
   Abstract »    Full Text »    PDF »
Drosophila Glucosylceramide Synthase: A NEGATIVE REGULATOR OF CELL DEATH MEDIATED BY PROAPOPTOTIC FACTORS.
A. Kohyama-Koganeya, T. Sasamura, E. Oshima, E. Suzuki, S. Nishihara, R. Ueda, and Y. Hirabayashi (2004)
J. Biol. Chem. 279, 35995-36002
   Abstract »    Full Text »    PDF »
The xipotl Mutant of Arabidopsis Reveals a Critical Role for Phospholipid Metabolism in Root System Development and Epidermal Cell Integrity.
A. Cruz-Ramirez, J. Lopez-Bucio, G. Ramirez-Pimentel, A. Zurita-Silva, L. Sanchez-Calderon, E. Ramirez-Chavez, E. Gonzalez-Ortega, and L. Herrera-Estrella (2004)
PLANT CELL 16, 2020-2034
   Abstract »    Full Text »    PDF »
Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma Cells.
S. Daido, T. Kanzawa, A. Yamamoto, H. Takeuchi, Y. Kondo, and S. Kondo (2004)
Cancer Res. 64, 4286-4293
   Abstract »    Full Text »    PDF »
Novel Ceramide Analogs as Potential Chemotherapeutic Agents in Breast Cancer.
A. P. Struckhoff, R. Bittman, M. E. Burow, S. Clejan, S. Elliott, T. Hammond, Y. Tang, and B. S. Beckman (2004)
J. Pharmacol. Exp. Ther. 309, 523-532
   Abstract »    Full Text »    PDF »
Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.
V. Gouaze, J. Y. Yu, R. J. Bleicher, T.-Y. Han, Y.-Y. Liu, H. Wang, M. M. Gottesman, A. Bitterman, A. E. Giuliano, and M. C. Cabot (2004)
Mol. Cancer Ther. 3, 633-640
   Abstract »    Full Text »    PDF »
Dietary Soy Sphingolipids Suppress Tumorigenesis and Gene Expression in 1,2-Dimethylhydrazine-Treated CF1 Mice and ApcMin/+ Mice.
H. Symolon, E. M. Schmelz, D. L. Dillehay, and A. H. Merrill Jr. (2004)
J. Nutr. 134, 1157-1161
   Abstract »    Full Text »    PDF »
Role of FAN in Tumor Necrosis Factor-{alpha} and Lipopolysaccharide-induced Interleukin-6 Secretion and Lethality in D-Galactosamine-sensitized Mice.
S. Malagarie-Cazenave, B. Segui, S. Leveque, V. Garcia, S. Carpentier, M.-F. Altie, A. Brouchet, V. Gouaze, N. Andrieu-Abadie, Y. Barreira, et al. (2004)
J. Biol. Chem. 279, 18648-18655
   Abstract »    Full Text »    PDF »
Identification of Two RNA cis-Elements That Function to Regulate the 5' Splice Site Selection of Bcl-x Pre-mRNA in Response to Ceramide.
A. Massiello, A. Salas, R. L. Pinkerman, P. Roddy, J. R. Roesser, and C. E. Chalfant (2004)
J. Biol. Chem. 279, 15799-15804
   Abstract »    Full Text »    PDF »
Ceramide-induced Apoptosis by Translocation, Phosphorylation, and Activation of Protein Kinase C{delta} in the Golgi Complex.
T. Kajimoto, Y. Shirai, N. Sakai, T. Yamamoto, H. Matsuzaki, U. Kikkawa, and N. Saito (2004)
J. Biol. Chem. 279, 12668-12676
   Abstract »    Full Text »    PDF »
The structural requirements for ceramide activation of serine-threonine protein phosphatases.
C. E. Chalfant, Z. Szulc, P. Roddy, A. Bielawska, and Y. A. Hannun (2004)
J. Lipid Res. 45, 496-506
   Abstract »    Full Text »    PDF »
Ceramide in the antiapoptotic effect of ischemic preconditioning.
L. Argaud, A.-F. Prigent, L. Chalabreysse, J. Loufouat, M. Lagarde, and M. Ovize (2004)
Am J Physiol Heart Circ Physiol 286, H246-H251
   Abstract »    Full Text »    PDF »
Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells.
C.M. Perks, P.V. Newcomb, M. Grohmann, R.J. Wright, H.D. Mason, and J.M.P. Holly (2003)
Hum. Reprod. 18, 2672-2677
   Abstract »    Full Text »    PDF »
Mitochondrial Cytochrome c Release Mediates Ceramide-induced Activator Protein 2 Activation and Gene Expression in Keratinocytes.
S. Grether-Beck, I. Felsner, H. Brenden, and J. Krutmann (2003)
J. Biol. Chem. 278, 47498-47507
   Abstract »    Full Text »    PDF »
Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors.
C. Riebeling, J. C. Allegood, E. Wang, A. H. Merrill Jr., and A. H. Futerman (2003)
J. Biol. Chem. 278, 43452-43459
   Abstract »    Full Text »    PDF »
Reovirus-Induced Alteration in Expression of Apoptosis and DNA Repair Genes with Potential Roles in Viral Pathogenesis.
R. L. DeBiasi, P. Clarke, S. Meintzer, R. Jotte, B. K. Kleinschmidt-Demasters, G. L. Johnson, and K. L. Tyler (2003)
J. Virol. 77, 8934-8947
   Abstract »    Full Text »    PDF »
Apoptosis in Keratocytes Caused by Mitomycin C.
T.-i. Kim, H. Tchah, S.-a. Lee, K. Sung, B. J. Cho, and M. S. Kook (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1912-1917
   Abstract »    Full Text »    PDF »
BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis.
L. Scorrano, S. A. Oakes, J. T. Opferman, E. H. Cheng, M. D. Sorcinelli, T. Pozzan, and S. J. Korsmeyer (2003)
Science 300, 135-139
   Abstract »    Full Text »    PDF »
Significant Role of Ceramide Pathway in Experimental Gastric Ulcer Formation in Rats.
K. Uehara, S. Miura, T. Takeuchi, T. Taki, M. Nakashita, M. Adachi, T. Inamura, T. Ogawa, Y. Akiba, H. Suzuki, et al. (2003)
J. Pharmacol. Exp. Ther. 305, 232-239
   Abstract »    Full Text »
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.
F. Darios, O. Corti, C. B. Lucking, C. Hampe, M.-P. Muriel, N. Abbas, W.-J. Gu, E. C. Hirsch, T. Rooney, M. Ruberg, et al. (2003)
Hum. Mol. Genet. 12, 517-526
   Abstract »    Full Text »    PDF »
Altered Sphingolipid Metabolism in N-(4-Hydroxyphenyl)- retinamide-resistant A2780 Human Ovarian Carcinoma Cells.
A. Prinetti, L. Basso, V. Appierto, M. G. Villani, M. Valsecchi, N. Loberto, S. Prioni, V. Chigorno, E. Cavadini, F. Formelli, et al. (2003)
J. Biol. Chem. 278, 5574-5583
   Abstract »    Full Text »    PDF »
Impact of mitochondrial {beta}-oxidation in fatty acid-mediated inhibition of glioma cell proliferation.
K. Berge, K. J. Tronstad, P. Bohov, L. Madsen, and R. K. Berge (2003)
J. Lipid Res. 44, 118-127
   Abstract »    Full Text »    PDF »
Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity.
A. J. Ryan, D. M. McCoy, S. E. McGowan, R. G. Salome, and R. K. Mallampalli (2003)
J Appl Physiol 94, 253-258
   Abstract »    Full Text »    PDF »
Possible Role of Ceramide as an Indicator of Chemoresistance: Decrease of the Ceramide Content via Activation of Glucosylceramide Synthase and Sphingomyelin Synthase in Chemoresistant Leukemia.
M. Itoh, T. Kitano, M. Watanabe, T. Kondo, T. Yabu, Y. Taguchi, K. Iwai, M. Tashima, T. Uchiyama, and T. Okazaki (2003)
Clin. Cancer Res. 9, 415-423
   Abstract »    Full Text »    PDF »
Cytosolic Retention of Phosphorylated Extracellular Signal-Regulated Kinase and a Rho-Associated Kinase-Mediated Signal Impair Expression of p21Cip1/Waf1 in Phorbol 12-Myristate-13- Acetate-Induced Apoptotic Cells.
J.-M. Lai, S. Wu, D.-Y. Huang, and Z.-F. Chang (2002)
Mol. Cell. Biol. 22, 7581-7592
   Abstract »    Full Text »    PDF »
Soluble Fas Ligand Activates the Sphingomyelin Pathway and Induces Apoptosis in Luteal Steroidogenic Cells Independently of Stress-Activated p38MAPK.
J. K. Pru, I. R. Hendry, J. S. Davis, and B. R. Rueda (2002)
Endocrinology 143, 4350-4357
   Abstract »    Full Text »    PDF »
Acute Activation of de Novo Sphingolipid Biosynthesis upon Heat Shock Causes an Accumulation of Ceramide and Subsequent Dephosphorylation of SR Proteins.
G. M. Jenkins, L. A. Cowart, P. Signorelli, B. J. Pettus, C. E. Chalfant, and Y. A. Hannun (2002)
J. Biol. Chem. 277, 42572-42578
   Abstract »    Full Text »    PDF »
Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells?.
I. GOUNI-BERTHOLD and A. SACHINIDIS (2002)
FASEB J 16, 1477-1487
   Abstract »    Full Text »    PDF »
c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide.
F.-Q. Wen, A. A. Jabbar, Y.-X. Chen, T. Kazarian, D. A. Patel, and L. A. Valentino (2002)
Blood 100, 912-916
   Abstract »    Full Text »    PDF »
Importance of C1B Domain for Lipid Messenger-induced Targeting of Protein Kinase C.
K. Kashiwagi, Y. Shirai, M. Kuriyama, N. Sakai, and N. Saito (2002)
J. Biol. Chem. 277, 18037-18045
   Abstract »    Full Text »    PDF »
Sphingoid Bases and Ceramide Induce Apoptosis in HT-29 and HCT-116 Human Colon Cancer Cells.
E. H. Ahn and J. J. Schroeder (2002)
Experimental Biology and Medicine 227, 345-353
   Abstract »    Full Text »    PDF »
De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells. DEPENDENCE ON PROTEIN PHOSPHATASE-1.
C. E. Chalfant, K. Rathman, R. L. Pinkerman, R. E. Wood, L. M. Obeid, B. Ogretmen, and Y. A. Hannun (2002)
J. Biol. Chem. 277, 12587-12595
   Abstract »    Full Text »    PDF »
Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line. ROLE FOR ENDOGENOUS CERAMIDE IN MEDIATING THE ACTION OF EXOGENOUS CERAMIDE.
B. Ogretmen, B. J. Pettus, M. J. Rossi, R. Wood, J. Usta, Z. Szulc, A. Bielawska, L. M. Obeid, and Y. A. Hannun (2002)
J. Biol. Chem. 277, 12960-12969
   Abstract »    Full Text »    PDF »
Coupled assay of sphingomyelin and ceramide molecular species by gas liquid chromatography.
C. Vieu, F. Terce, F. Chevy, C. Rolland, R. Barbaras, H. Chap, C. Wolf, B. Perret, and X. Collet (2002)
J. Lipid Res. 43, 510-522
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor {alpha} Enhances Oocyte/Follicle Apoptosis in the Neonatal Rat Ovary.
L. J. Morrison and J. L. Marcinkiewicz (2002)
Biol Reprod 66, 450-457
   Abstract »    Full Text »    PDF »
E5 Protein of Human Papillomavirus Type 16 Protects Human Foreskin Keratinocytes from UV B-Irradiation-Induced Apoptosis.
B. Zhang, D. F. Spandau, and A. Roman (2002)
J. Virol. 76, 220-231
   Abstract »    Full Text »    PDF »
Human Group IIA Secretory Phospholipase A2 Induces Neuronal Cell Death via Apoptosis.
T. Yagami, K. Ueda, K. Asakura, S. Hata, T. Kuroda, T. Sakaeda, N. Takasu, K. Tanaka, T. Gemba, and Y. Hori (2002)
Mol. Pharmacol. 61, 114-126
   Abstract »    Full Text »    PDF »
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis.
H. BIRBES, S. EL BAWAB, Y. A. HANNUN, and L. M. OBEID (2001)
FASEB J 15, 2669-2679
   Abstract »    Full Text »    PDF »
The IL-15R{alpha} Chain Signals Through Association with Syk in Human B Cells.
E. Bulanova, V. Budagian, T. Pohl, H. Krause, H. Durkop, R. Paus, and S. Bulfone-Paus (2001)
J. Immunol. 167, 6292-6302
   Abstract »    Full Text »    PDF »
Ceramide inhibition of NF-{kappa}B activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response.
P. SIGNORELLI, C. LUBERTO, and Y. A. HANNUN (2001)
FASEB J 15, 2401-2414
   Abstract »    Full Text »    PDF »
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria.
O. Cuvillier and T. Levade (2001)
Blood 98, 2828-2836
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor-alpha Induces Stress Fiber Formation through Ceramide Production: Role of Sphingosine Kinase.
A. N. Hanna, L. G. Berthiaume, Y. Kikuchi, D. Begg, S. Bourgoin, and D. N. Brindley (2001)
Mol. Biol. Cell 12, 3618-3630
   Abstract »    Full Text »    PDF »
Modulation of Intracellular {beta}-Catenin Localization and Intestinal Tumorigenesis in Vivo and in Vitro by Sphingolipids.
E. M. Schmelz, P. C. Roberts, E. M. Kustin, L. A. Lemonnier, M. C. Sullards, D. L. Dillehay, and A. H. Merrill Jr. (2001)
Cancer Res. 61, 6723-6729
   Abstract »    Full Text »    PDF »
Signaling pathways activated by daunorubicin.
G. Laurent and J.-P. Jaffrezou (2001)
Blood 98, 913-924
   Abstract »    Full Text »    PDF »
A Monoclonal Antibody That Induces Neuronal Apoptosis Binds a Metastasis Marker.
L.-t. Zhong, A. Manzi, E. Skowronski, L. Notterpek, A. L. Fluharty, K. F. Faull, I. Masada, S. Rabizadeh, M. Varsanyi-Nagy, Y. Ruan, et al. (2001)
Cancer Res. 61, 5741-5748
   Abstract »    Full Text »    PDF »
TNF-{{alpha}}-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes.
Y. Osawa, Y. Banno, M. Nagaki, D. A. Brenner, T. Naiki, Y. Nozawa, S. Nakashima, and H. Moriwaki (2001)
J. Immunol. 167, 173-180
   Abstract »    Full Text »    PDF »
Synthetic Phytoceramides Induce Apoptosis with Higher Potency than Ceramides.
O. Hwang, G. Kim, Y. J. Jang, S. W. Kim, G. Choi, H. J. Choi, S. Y. Jeon, D. G. Lee, and J. D. Lee (2001)
Mol. Pharmacol. 59, 1249-1255
   Abstract »    Full Text »
Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells.
I. Spyridopoulos, P. Mayer, K. S. Shook, D. I. Axel, R. Viebahn, and K. R. Karsch (2001)
Cardiovasc Res 50, 97-107
   Abstract »    Full Text »    PDF »
Subtype-Specific Translocation of the {delta} Subtype of Protein Kinase C and Its Activation by Tyrosine Phosphorylation Induced by Ceramide in HeLa Cells.
T. Kajimoto, S. Ohmori, Y. Shirai, N. Sakai, and N. Saito (2001)
Mol. Cell. Biol. 21, 1769-1783
   Abstract »    Full Text »
Cystemustine Induces Redifferentiation of Primary Tumors and Confers Protection against Secondary Tumor Growth in a Melanoma Murine Model.
A. Demidem, D. Morvan, J. Papon, M. De Latour, and J. C. Madelmont (2001)
Cancer Res. 61, 2294-2300
   Abstract »    Full Text »
Diseases of liporegulation: new perspective on obesity and related disorders.
R. H. UNGER and L. ORCI (2001)
FASEB J 15, 312-321
   Abstract »    Full Text »    PDF »
Ceramide: A Potential Mediator of Apoptosis in Human Retinal Pigment Epithelial Cells.
A. Barak, L. S. Morse, and T. Goldkorn (2001)
Invest. Ophthalmol. Vis. Sci. 42, 247-254
   Abstract »    Full Text »
Human Diploid Fibroblasts That Undergo a Senescent-like Differentiation Have Elevated Ceramide and Diacylglycerol.
C. J. Miller and G. H. Stein (2001)
J. Gerontol. A Biol. Sci. Med. Sci. 56, 8B-20
   Abstract »    Full Text »
Regulation of Bcl2 Phosphorylation and Potential Significance for Leukemic Cell Chemoresistance.
X. Deng, S. M. Kornblau, P. P. Ruvolo, and W. S. May Jr. (2000)
J Natl Cancer Inst Monographs 2000, 30-37
   Abstract »    Full Text »    PDF »