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Science 19 March 1993: Vol. 259. no. 5102, pp. 1760 - 1763 DOI: 10.1126/science.7681220
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Articles
Science, Vol 259, Issue 5102, 1760-1763
Copyright © 1993 by American Association for the Advancement of Science
An osmosensing signal transduction pathway in yeast
JL Brewster,
T de Valoir,
ND Dwyer,
E Winter,
and
MC Gustin
Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251.
Yeast genes were isolated that are required for restoring the osmotic gradient across the cell membrane in response to increased external osmolarity. Two of these genes, HOG1 and PBS2, encode members of the mitogen-activated protein kinase (MAP kinase) and MAP kinase kinase gene families, respectively. MAP kinases are activated by extracellular ligands such as growth factors and function as intermediate kinases in protein phosphorylation cascades. A rapid, PBS2-dependent tyrosine phosphorylation of HOG1 protein occurred in response to increases in extracellular osmolarity. These data define a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.
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- Cytoplasmic Localization of Wis1 MAPKK by Nuclear Export Signal Is Important for Nuclear Targeting of Spc1/Sty1 MAPK in Fission Yeast.
- A. N. Nguyen, A. D. Ikner, M. Shiozaki, S. M. Warren, and K. Shiozaki (2002)
Mol. Biol. Cell
13, 2651-2663
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- The MEK Kinase Ssk2p Promotes Actin Cytoskeleton Recovery After Osmotic Stress.
- T. Yuzyuk, M. Foehr, and D. C. Amberg (2002)
Mol. Biol. Cell
13, 2869-2880
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- Pheromone induction promotes Ste11 degradation through a MAPK feedback and ubiquitin-dependent mechanism.
- R. K. Esch and B. Errede (2002)
PNAS
99, 9160-9165
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- Regulation of MTK1/MEKK4 Kinase Activity by Its N-Terminal Autoinhibitory Domain and GADD45 Binding.
- H. Mita, J. Tsutsui, M. Takekawa, E. A. Witten, and H. Saito (2002)
Mol. Cell. Biol.
22, 4544-4555
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- A Third Osmosensing Branch in Saccharomyces cerevisiae Requires the Msb2 Protein and Functions in Parallel with the Sho1 Branch.
- S. M. O'Rourke and I. Herskowitz (2002)
Mol. Cell. Biol.
22, 4739-4749
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- Regulation of Stress Response Signaling by the N-terminal Dishevelled/EGL-10/Pleckstrin Domain of Sst2, a Regulator of G Protein Signaling in Saccharomyces cerevisiae.
- S. A. Burchett, P. Flanary, C. Aston, L. Jiang, K. H. Young, P. Uetz, S. Fields, and H. G. Dohlman (2002)
J. Biol. Chem.
277, 22156-22167
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- Osmotic Stress Signaling and Osmoadaptation in Yeasts.
- S. Hohmann (2002)
Microbiol. Mol. Biol. Rev.
66, 300-372
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- The Serine/Threonine Kinase Cmk2 Is Required for Oxidative Stress Response in Fission Yeast.
- M. Sanchez-Piris, F. Posas, V. Alemany, I. Winge, E. Hidalgo, O. Bachs, and R. Aligue (2002)
J. Biol. Chem.
277, 17722-17727
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- Transient Inhibition of Translation Initiation by Osmotic Stress.
- Y. Uesono and A. Toh-e (2002)
J. Biol. Chem.
277, 13848-13855
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- Altered Phosphotransfer in an Activated Mutant of the Saccharomyces cerevisiae Two-Component Osmosensor Sln1p.
- A. D. Ault, J. S. Fassler, and R. J. Deschenes (2002)
Eukaryot. Cell
1, 174-180
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- The Drosophila inebriated-Encoded Neurotransmitter/Osmolyte Transporter: Dual Roles in the Control of Neuronal Excitability and the Osmotic Stress Response.
- X. Huang, Y. Huang, R. Chinnappan, C. Bocchini, M. C. Gustin, and M. Stern (2002)
Genetics
160, 561-569
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- Osmotic Shock Induces G1 Arrest through p53 Phosphorylation at Ser33 by Activated p38MAPK without Phosphorylation at Ser15 and Ser20.
- H. Kishi, K. Nakagawa, M. Matsumoto, M. Suga, M. Ando, Y. Taya, and M. Yamaizumi (2001)
J. Biol. Chem.
276, 39115-39122
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- Perturbation of the Nucleus: A Novel Hog1p-independent, Pkc1p-dependent Consequence of Hypertonic Shock in Yeast.
- J. Nanduri and A. M. Tartakoff (2001)
Mol. Biol. Cell
12, 1835-1841
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- Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast.
- M. Teige, E. Scheikl, V. Reiser, H. Ruis, and G. Ammerer (2001)
PNAS
98, 5625-5630
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- Hyperosmotic Stress Induces the Rapid Phosphorylation of a Soybean Phosphatidylinositol Transfer Protein Homolog through Activation of the Protein Kinases SPK1 and SPK2.
- D. E. Monks, K. Aghoram, P. D. Courtney, D. B. DeWald, and R. E. Dewey (2001)
PLANT CELL
13, 1205-1219
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- Activation of Phosphatidylinositol 3-Kinase and Akt by tert-Butylhydroquinone Is Responsible for Antioxidant Response Element-Mediated rGSTA2 Induction in H4IIE Cells.
- K. W. Kang, M. K. Cho, C. H. Lee, and S. G. Kim (2001)
Mol. Pharmacol.
59, 1147-1156
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- Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions.
- G. Pearson, F. Robinson, T. Beers Gibson, B.-e Xu, M. Karandikar, K. Berman, and M. H. Cobb (2001)
Endocr. Rev.
22, 153-183
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- Hypertonicity-induced phosphorylation and nuclear localization of the transcription factor TonEBP.
- S. C. Dahl, J. S. Handler, and H. M. Kwon (2001)
Am J Physiol Cell Physiol
280, C248-C253
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- Peroxide Sensors for the Fission Yeast Stress-activated Mitogen-activated Protein Kinase Pathway.
- V. Buck, J. Quinn, T. S. Pino, H. Martin, J. Saldanha, K. Makino, B. A. Morgan, and J. B.A. Millar (2001)
Mol. Biol. Cell
12, 407-419
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