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Science 19 March 1993: Vol. 259. no. 5102, pp. 1742 - 1745 DOI: 10.1126/science.8456301
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Articles
Science, Vol 259, Issue 5102, 1742-1745
Copyright © 1993 by American Association for the Advancement of Science
Immune response in mice that lack the interferon-gamma receptor
S Huang,
W Hendriks,
A Althage,
S Hemmi,
H Bluethmann,
R Kamijo,
J Vilcek,
RM Zinkernagel,
and
M Aguet
Institute of Molecular Biology I, University of Zurich, Switzerland.
Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance, they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
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- Role for Innate IFNs in Determining Respiratory Syncytial Virus Immunopathology.
- T. R. Johnson, S. E. Mertz, N. Gitiban, S. Hammond, R. LeGallo, R. K. Durbin, and J. E. Durbin (2005)
J. Immunol.
174, 7234-7241
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- Interference by interferons: Janus faces in vascular proliferative diseases.
- R. Wessely (2005)
Cardiovasc Res
66, 433-443
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- Cutting Edge: Re-evaluating the In Vivo Cytokine Responses of CD8+ T Cells during Primary and Secondary Viral Infections.
- F. Liu and J. L. Whitton (2005)
J. Immunol.
174, 5936-5940
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- Interferon-{gamma} acts directly on CD8+ T cells to increase their abundance during virus infection.
- J. K. Whitmire, J. T. Tan, and J. L. Whitton (2005)
J. Exp. Med.
201, 1053-1059
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- Natural Killer Dendritic Cells Have Both Antigen Presenting and Lytic Function and in Response to CpG Produce IFN-{gamma} via Autocrine IL-12.
- V. G. Pillarisetty, S. C. Katz, J. I. Bleier, A. B. Shah, and R. P. DeMatteo (2005)
J. Immunol.
174, 2612-2618
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- Reduced Local Growth and Spread but Preserved Pathogenicity of a {Delta}purC Mycobacterium tuberculosis Auxotrophic Mutant in Gamma Interferon Receptor-Deficient Mice after Aerosol Infection.
- N. Brown, M. Jacobs, S. K. Parida, T. Botha, A. Santos, L. Fick, B. Gicquel, M. Jackson, V. Quesniaux, and B. Ryffel (2005)
Infect. Immun.
73, 666-670
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- Impairment of Host Resistance to Listeria monocytogenes Infection in Liver of db/db and ob/ob Mice.
- S. Ikejima, S. Sasaki, H. Sashinami, F. Mori, Y. Ogawa, T. Nakamura, Y. Abe, K. Wakabayashi, T. Suda, and A. Nakane (2005)
Diabetes
54, 182-189
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- Gamma Interferon Does Not Enhance Clearance of Pseudomonas aeruginosa but Does Amplify a Proinflammatory Response in a Murine Model of Postseptic Immunosuppression.
- E. D. Murphey, D. N. Herndon, and E. R. Sherwood (2004)
Infect. Immun.
72, 6892-6901
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- From The Cover: Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments.
- A. Sato and A. Iwasaki (2004)
PNAS
101, 16274-16279
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- Cutting Edge: Immunity and IFN-{gamma} Production during Listeria monocytogenes Infection in the Absence of T-bet.
- S. S. Way and C. B. Wilson (2004)
J. Immunol.
173, 5918-5922
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- Prolonged Toll-Like Receptor Signaling by Mycobacterium tuberculosis and Its 19-Kilodalton Lipoprotein Inhibits Gamma Interferon-Induced Regulation of Selected Genes in Macrophages.
- R. K. Pai, M. E. Pennini, A. A. R. Tobian, D. H. Canaday, W. H. Boom, and C. V. Harding (2004)
Infect. Immun.
72, 6603-6614
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- The Host Resistance Locus sst1 Controls Innate Immunity to Listeria monocytogenes Infection in Immunodeficient Mice.
- V. Boyartchuk, M. Rojas, B.-S. Yan, O. Jobe, N. Hurt, D. M. Dorfman, D. E. Higgins, W. F. Dietrich, and I. Kramnik (2004)
J. Immunol.
173, 5112-5120
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- Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.
- P. Geserick, F. Kaiser, U. Klemm, S. H. E. Kaufmann, and J. Zerrahn (2004)
Int. Immunol.
16, 1535-1548
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- Presence of Permanently Activated Signal Transducers and Activators of Transcription in Nuclear Interchromatin Granules of Unstimulated Mouse Oocytes and Preimplantation Embryos.
- S. Truchet, M. Chebrout, C. Djediat, J. Wietzerbin, and P. Debey (2004)
Biol Reprod
71, 1330-1339
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- Exacerbation of autoantibody-mediated thrombocytopenic purpura by infection with mouse viruses.
- A. Musaji, F. Cormont, G. Thirion, C. L. Cambiaso, and J.-P. Coutelier (2004)
Blood
104, 2102-2106
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- Impaired IgG Production in Mice Deficient for Heat Shock Transcription Factor 1.
- S. Inouye, H. Izu, E. Takaki, H. Suzuki, M. Shirai, Y. Yokota, H. Ichikawa, M. Fujimoto, and A. Nakai (2004)
J. Biol. Chem.
279, 38701-38709
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- Vaccine-Induced Immunity against Helicobacter pylori Infection Is Impaired in IL-18-Deficient Mice.
- A. A. Akhiani, K. Schon, and N. Lycke (2004)
J. Immunol.
173, 3348-3356
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- Type I Interferon Sensitizes Lymphocytes to Apoptosis and Reduces Resistance to Listeria Infection.
- J. A. Carrero, B. Calderon, and E. R. Unanue (2004)
J. Exp. Med.
200, 535-540
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