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Science 19 March 1993: Vol. 259. no. 5102, pp. 1739 - 1742 DOI: 10.1126/science.8456300
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Articles
Science, Vol 259, Issue 5102, 1739-1742
Copyright © 1993 by American Association for the Advancement of Science
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
DK Dalton,
S Pitts-Meek,
S Keshav,
IS Figari,
A Bradley,
and
TA Stewart
Genentech Inc., South San Francisco, CA 94080.
Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma had impaired production of macrophage antimicrobial products and reduced expression of macrophage major histocompatibility complex class II antigens. IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen. After a mixed lymphocyte reaction, T cell cytolytic activity was enhanced against allogeneic target cells. Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system.
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| Abstract »
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| Abstract »
| Full Text »
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| Abstract »
| Full Text »
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| Abstract »
| Full Text »
| PDF »
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177, 3554-3563
| Abstract »
| Full Text »
| PDF »
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| Full Text »
| PDF »
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177, 1416-1420
| Abstract »
| Full Text »
| PDF »
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177, 1786-1795
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- M. Pesu, L. Muul, Y. Kanno, and J. J. O'Shea (2006)
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| PDF »
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- X. Wu, W. Hou, S. Sun, E. Bi, Y. Wang, M. Shi, J. Zang, C. Dong, and B. Sun (2006)
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177, 934-943
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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J. Virol.
80, 6339-6344
| Abstract »
| Full Text »
| PDF »
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- R. Sporri, N. Joller, U. Albers, H. Hilbi, and A. Oxenius (2006)
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176, 6162-6171
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- S. J. Yang, S. Ahn, C. S. Park, K. L Holmes, J. Westrup, C. H. Chang, and M. G Kim (2006)
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| Abstract »
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66, 4468-4477
| Abstract »
| Full Text »
| PDF »
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Infect. Immun.
74, 2031-2042
| Abstract »
| Full Text »
| PDF »
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- E. N. Kersh, D. R. Fitzpatrick, K. Murali-Krishna, J. Shires, S. H. Speck, J. M. Boss, and R. Ahmed (2006)
J. Immunol.
176, 4083-4093
| Abstract »
| Full Text »
| PDF »
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Infect. Immun.
74, 1516-1527
| Abstract »
| Full Text »
| PDF »
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J. Immunol.
176, 2758-2764
| Abstract »
| Full Text »
| PDF »
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J. Immunol.
176, 2857-2863
| Abstract »
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| PDF »
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Infect. Immun.
74, 1043-1049
| Abstract »
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- D. Gao, J. Kasten-Jolly, and D. A. Lawrence (2006)
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| Abstract »
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| Abstract »
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| PDF »
- Lung infection with {gamma}-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice.
- A. L. Mora, C. R. Woods, A. Garcia, J. Xu, M. Rojas, S. H. Speck, J. Roman, K. L. Brigham, and A. A. Stecenko (2005)
Am J Physiol Lung Cell Mol Physiol
289, L711-L721
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- Th1 Cytokines Are Essential for Placental Immunity to Listeria monocytogenes.
- E. M. Barber, M. Fazzari, and J. W. Pollard (2005)
Infect. Immun.
73, 6322-6331
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- NK Cells in Gamma-Interferon-Deficient Mice Suppress Lung Innate Immunity against Mycoplasma spp..
- M. D. Woolard, D. Hudig, L. Tabor, J. A. Ivey, and J. W. Simecka (2005)
Infect. Immun.
73, 6742-6751
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- Increased Susceptibility of Mice Lacking T-bet to Infection with Mycobacterium tuberculosis Correlates with Increased IL-10 and Decreased IFN-{gamma} Production.
- B. M. Sullivan, O. Jobe, V. Lazarevic, K. Vasquez, R. Bronson, L. H. Glimcher, and I. Kramnik (2005)
J. Immunol.
175, 4593-4602
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- Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development.
- Y. Morimoto, Y. Bian, P. Gao, Y. Yashiro-Ohtani, X.-Y. Zhou, S. Ono, H. Nakahara, M. Kogo, T. Hamaoka, and H. Fujiwara (2005)
J. Leukoc. Biol.
78, 753-761
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- Impaired Virus Control and Severe CD8+ T-Cell-Mediated Immunopathology in Chimeric Mice Deficient in Gamma Interferon Receptor Expression on both Parenchymal and Hematopoietic Cells.
- P. Henrichsen, C. Bartholdy, J. P. Christensen, and A. R. Thomsen (2005)
J. Virol.
79, 10073-10076
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- {alpha}-Galactosylceramide, a Ligand of Natural Killer T Cells, Inhibits Allergic Airway Inflammation.
- H. Matsuda, T. Suda, J. Sato, T. Nagata, Y. Koide, K. Chida, and H. Nakamura (2005)
Am. J. Respir. Cell Mol. Biol.
33, 22-31
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- The Functional Heterogeneity of Type 1 Effector T Cells in Response to Infection Is Related to the Potential for IFN-{gamma} Production.
- K. D. Mayer, K. Mohrs, S. R. Crowe, L. L. Johnson, P. Rhyne, D. L. Woodland, and M. Mohrs (2005)
J. Immunol.
174, 7732-7739
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- Regulation of IFN-{gamma} Production by B Effector 1 Cells: Essential Roles for T-bet and the IFN-{gamma} Receptor.
- D. P. Harris, S. Goodrich, A. J. Gerth, S. L. Peng, and F. E. Lund (2005)
J. Immunol.
174, 6781-6790
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- Dynamic Regulation of IFN-{gamma} Signaling in Antigen-Specific CD8+ T Cells Responding to Infection.
- J. S. Haring, G. A. Corbin, and J. T. Harty (2005)
J. Immunol.
174, 6791-6802
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- Neutrophils That Infiltrate the Central Nervous System Regulate T Cell Responses.
- S. P. Zehntner, C. Brickman, L. Bourbonniere, L. Remington, M. Caruso, and T. Owens (2005)
J. Immunol.
174, 5124-5131
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- Receptors and Counterreceptors Involved in NK-B Cell Interactions.
- N. Gao, T. Dang, W. A. Dunnick, J. T. Collins, B. R. Blazar, and D. Yuan (2005)
J. Immunol.
174, 4113-4119
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- The IL-27 Receptor Chain WSX-1 Differentially Regulates Antibacterial Immunity and Survival during Experimental Tuberculosis.
- C. Holscher, A. Holscher, D. Ruckerl, T. Yoshimoto, H. Yoshida, T. Mak, C. Saris, and S. Ehlers (2005)
J. Immunol.
174, 3534-3544
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- Natural Killer Dendritic Cells Have Both Antigen Presenting and Lytic Function and in Response to CpG Produce IFN-{gamma} via Autocrine IL-12.
- V. G. Pillarisetty, S. C. Katz, J. I. Bleier, A. B. Shah, and R. P. DeMatteo (2005)
J. Immunol.
174, 2612-2618
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- IFN-{gamma} Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis.
- A. K. Wensky, G. C. Furtado, M. C. Garibaldi Marcondes, S. Chen, D. Manfra, S. A. Lira, D. Zagzag, and J. J. Lafaille (2005)
J. Immunol.
174, 1416-1423
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- Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs.
- S. L. Uprichard, B. Boyd, A. Althage, and F. V. Chisari (2005)
PNAS
102, 773-778
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- Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1{beta} System by IL-13.
- C. J. Scotton, F. O. Martinez, M. J. Smelt, M. Sironi, M. Locati, A. Mantovani, and S. Sozzani (2005)
J. Immunol.
174, 834-845
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- Thioredoxin Peroxidase Secreted by Fasciola hepatica Induces the Alternative Activation of Macrophages.
- S. Donnelly, S. M. O'Neill, M. Sekiya, G. Mulcahy, and J. P. Dalton (2005)
Infect. Immun.
73, 166-173
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