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Science 19 March 1993:
Vol. 259. no. 5102, pp. 1739 - 1742
DOI: 10.1126/science.8456300

Articles

Science, Vol 259, Issue 5102, 1739-1742
Copyright © 1993 by American Association for the Advancement of Science


articles

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

DK Dalton, S Pitts-Meek, S Keshav, IS Figari, A Bradley, and TA Stewart

Genentech Inc., South San Francisco, CA 94080.

Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma had impaired production of macrophage antimicrobial products and reduced expression of macrophage major histocompatibility complex class II antigens. IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen. After a mixed lymphocyte reaction, T cell cytolytic activity was enhanced against allogeneic target cells. Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system.


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Impaired Virus Control and Severe CD8+ T-Cell-Mediated Immunopathology in Chimeric Mice Deficient in Gamma Interferon Receptor Expression on both Parenchymal and Hematopoietic Cells.
P. Henrichsen, C. Bartholdy, J. P. Christensen, and A. R. Thomsen (2005)
J. Virol. 79, 10073-10076
   Abstract »    Full Text »    PDF »
{alpha}-Galactosylceramide, a Ligand of Natural Killer T Cells, Inhibits Allergic Airway Inflammation.
H. Matsuda, T. Suda, J. Sato, T. Nagata, Y. Koide, K. Chida, and H. Nakamura (2005)
Am. J. Respir. Cell Mol. Biol. 33, 22-31
   Abstract »    Full Text »    PDF »
The Functional Heterogeneity of Type 1 Effector T Cells in Response to Infection Is Related to the Potential for IFN-{gamma} Production.
K. D. Mayer, K. Mohrs, S. R. Crowe, L. L. Johnson, P. Rhyne, D. L. Woodland, and M. Mohrs (2005)
J. Immunol. 174, 7732-7739
   Abstract »    Full Text »    PDF »
Regulation of IFN-{gamma} Production by B Effector 1 Cells: Essential Roles for T-bet and the IFN-{gamma} Receptor.
D. P. Harris, S. Goodrich, A. J. Gerth, S. L. Peng, and F. E. Lund (2005)
J. Immunol. 174, 6781-6790
   Abstract »    Full Text »    PDF »
Dynamic Regulation of IFN-{gamma} Signaling in Antigen-Specific CD8+ T Cells Responding to Infection.
J. S. Haring, G. A. Corbin, and J. T. Harty (2005)
J. Immunol. 174, 6791-6802
   Abstract »    Full Text »    PDF »
Neutrophils That Infiltrate the Central Nervous System Regulate T Cell Responses.
S. P. Zehntner, C. Brickman, L. Bourbonniere, L. Remington, M. Caruso, and T. Owens (2005)
J. Immunol. 174, 5124-5131
   Abstract »    Full Text »    PDF »
Receptors and Counterreceptors Involved in NK-B Cell Interactions.
N. Gao, T. Dang, W. A. Dunnick, J. T. Collins, B. R. Blazar, and D. Yuan (2005)
J. Immunol. 174, 4113-4119
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The IL-27 Receptor Chain WSX-1 Differentially Regulates Antibacterial Immunity and Survival during Experimental Tuberculosis.
C. Holscher, A. Holscher, D. Ruckerl, T. Yoshimoto, H. Yoshida, T. Mak, C. Saris, and S. Ehlers (2005)
J. Immunol. 174, 3534-3544
   Abstract »    Full Text »    PDF »
Natural Killer Dendritic Cells Have Both Antigen Presenting and Lytic Function and in Response to CpG Produce IFN-{gamma} via Autocrine IL-12.
V. G. Pillarisetty, S. C. Katz, J. I. Bleier, A. B. Shah, and R. P. DeMatteo (2005)
J. Immunol. 174, 2612-2618
   Abstract »    Full Text »    PDF »
IFN-{gamma} Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis.
A. K. Wensky, G. C. Furtado, M. C. Garibaldi Marcondes, S. Chen, D. Manfra, S. A. Lira, D. Zagzag, and J. J. Lafaille (2005)
J. Immunol. 174, 1416-1423
   Abstract »    Full Text »    PDF »
Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs.
S. L. Uprichard, B. Boyd, A. Althage, and F. V. Chisari (2005)
PNAS 102, 773-778
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Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1{beta} System by IL-13.
C. J. Scotton, F. O. Martinez, M. J. Smelt, M. Sironi, M. Locati, A. Mantovani, and S. Sozzani (2005)
J. Immunol. 174, 834-845
   Abstract »    Full Text »    PDF »
Thioredoxin Peroxidase Secreted by Fasciola hepatica Induces the Alternative Activation of Macrophages.
S. Donnelly, S. M. O'Neill, M. Sekiya, G. Mulcahy, and J. P. Dalton (2005)
Infect. Immun. 73, 166-173
   Abstract »    Full Text »    PDF »



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