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Science 12 March 1993:
Vol. 259. no. 5101, pp. 1619 - 1622
DOI: 10.1126/science.8456285
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Articles

Science, Vol 259, Issue 5101, 1619-1622
Copyright © 1993 by American Association for the Advancement of Science

articles

Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans

ME Warchol, PR Lambert, BJ Goldstein, A Forge, and JT Corwin

Department of Otolaryngology-Head and Neck Surgery, University of Virginia School of Medicine, Charlottesville 22908.

Supporting cells in the vestibular sensory epithelia from the ears of mature guinea pigs and adult humans proliferate in vitro after treatments with aminoglycoside antibiotics that cause sensory hair cells to die. After 4 weeks in culture, the epithelia contained new cells with some characteristics of immature hair cells. These findings are in contrast to expectations based on previous studies, which had suggested that hair cell loss is irreversible in mammals. The loss of hair cells is responsible for hearing and balance deficits that affect millions of people.


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Induction of Cell Proliferation by Fibroblast and Insulin-Like Growth Factors in Pure Rat Inner Ear Epithelial Cell Cultures.
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Regenerative Proliferation in Organ Cultures of the Avian Cochlea: Identification of the Initial Progenitors and Determination of the Latency of the Proliferative Response.
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Response.
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Response.
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Ultrastructural evidence for hair cell regeneration in the mammalian inner ear.
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Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function.
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