Science 12 March 1993: Vol. 259. no. 5101, pp. 1604 - 1607 DOI: 10.1126/science.8456283

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Articles

Betacellulin Overexpression in the Mouse Ovary Leads to MAPK3/MAPK1 Hyperactivation and Reduces Litter Size by Impairing Fertilization.

A. A Gratao, M. Dahlhoff, F. Sinowatz, E. Wolf, and M. R Schneider (2008)
Biol Reprod 78, 43-52
 |  Abstract »  |  Full Text »  |  PDF »

The binding of human betacellulin to heparin, heparan sulfate and related polysaccharides.

R. S Mummery, B. Mulloy, and C. C Rider (2007)
Glycobiology 17, 1094-1103
 |  Abstract »  |  Full Text »  |  PDF »

Activation of a Nuclear Factor {kappa}B/Interleukin-1 Positive Feedback Loop by Amphiregulin in Human Breast Cancer Cells.

K. L. Streicher, N. E. Willmarth, J. Garcia, J. L. Boerner, T. G. Dewey, and S. P. Ethier (2007)
Mol. Cancer Res. 5, 847-861
 |  Abstract »  |  Full Text »  |  PDF »

Mitogenic Activity and Signaling Mechanism of 2-(14,15- Epoxyeicosatrienoyl)Glycerol, a Novel Cytochrome P450 Arachidonate Metabolite.

J. Chen, J.-K. Chen, J. R. Falck, S. Anjaiah, J. H. Capdevila, and R. C. Harris (2007)
Mol. Cell. Biol. 27, 3023-3034
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Autocrine and Juxtacrine Effects of Amphiregulin on the Proliferative, Invasive, and Migratory Properties of Normal and Neoplastic Human Mammary Epithelial Cells.

N. E. Willmarth and S. P. Ethier (2006)
J. Biol. Chem. 281, 37728-37737
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Epidermal Growth Factor Network in Ovarian Follicles.

M. Conti, M. Hsieh, J.-Y. Park, and Y.-Q. Su (2006)
Mol. Endocrinol. 20, 715-723
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A Functional Variant in the Human Betacellulin Gene Promoter Is Associated With Type 2 Diabetes.

Y. Nakano, H. Furuta, A. Doi, S. Matsuno, T. Nakagawa, H. Shimomura, S. Sakagashira, Y. Horikawa, M. Nishi, H. Sasaki, et al. (2005)
Diabetes 54, 3560-3566
 |  Abstract »  |  Full Text »  |  PDF »

Betacellulin Overexpression in Transgenic Mice Causes Disproportionate Growth, Pulmonary Hemorrhage Syndrome, and Complex Eye Pathology.

M. R. Schneider, M. Dahlhoff, N. Herbach, I. Renner-Mueller, C. Dalke, O. Puk, J. Graw, R. Wanke, and E. Wolf (2005)
Endocrinology 146, 5237-5246
 |  Abstract »  |  Full Text »  |  PDF »

Betacellulin-{delta}4, a Novel Differentiation Factor for Pancreatic {beta}-Cells, Ameliorates Glucose Intolerance in Streptozotocin-Treated Rats.

T. Ogata, A. J. Dunbar, Y. Yamamoto, Y. Tanaka, M. Seno, and I. Kojima (2005)
Endocrinology 146, 4673-4681
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-Binding Epidermal Growth Factor-Like Growth Factor, Collateral Vessel Development, and Angiogenesis in Skeletal Muscle Ischemia.

D. Chalothorn, S. M. Moore, H. Zhang, S. W. Sunnarborg, D. C. Lee, and J. E. Faber (2005)
Arterioscler Thromb Vasc Biol 25, 1884-1890
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G Protein Coupling and Second Messenger Generation Are Indispensable for Metalloprotease-dependent, Heparin-binding Epidermal Growth Factor Shedding through Angiotensin II Type-1 Receptor.

M. Mifune, H. Ohtsu, H. Suzuki, H. Nakashima, E. Brailoiu, N. J. Dun, G. D. Frank, T. Inagami, S. Higashiyama, W. G. Thomas, et al. (2005)
J. Biol. Chem. 280, 26592-26599
 |  Abstract »  |  Full Text »  |  PDF »

The Membrane-anchoring Domain of Epidermal Growth Factor Receptor Ligands Dictates Their Ability to Operate in Juxtacrine Mode.

J. Dong, L. K. Opresko, W. Chrisler, G. Orr, R. D. Quesenberry, D. A. Lauffenburger, and H. S. Wiley (2005)
Mol. Biol. Cell 16, 2984-2998
 |  Abstract »  |  Full Text »  |  PDF »

The Exon 1 Cys7Gly Polymorphism Within the Betacellulin Gene Is Associated With Type 2 Diabetes in African Americans.

K. Silver, M. Tolea, J. Wang, T. I. Pollin, F. Yao, and B. D. Mitchell (2005)
Diabetes 54, 1179-1184
 |  Abstract »  |  Full Text »  |  PDF »

ADAM10 Mediates Ectodomain Shedding of the Betacellulin Precursor Activated by p-Aminophenylmercuric Acetate and Extracellular Calcium Influx.

M. P. Sanderson, S. N. Erickson, P. J. Gough, K. J. Garton, P. T. Wille, E. W. Raines, A. J. Dunbar, and P. J. Dempsey (2005)
J. Biol. Chem. 280, 1826-1837
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of Epidermal Growth Factor (EGF) Receptor Downstream Signaling Pathways by Betacellulin and EGF.

T. Saito, S. Okada, K. Ohshima, E. Yamada, M. Sato, Y. Uehara, H. Shimizu, J. E. Pessin, and M. Mori (2004)
Endocrinology 145, 4232-4243
 |  Abstract »  |  Full Text »  |  PDF »

Signal transduction of betacellulin in growth and migration of vascular smooth muscle cells.

M. Mifune, H. Ohtsu, H. Suzuki, G. D. Frank, T. Inagami, H. Utsunomiya, P. J. Dempsey, and S. Eguchi (2004)
Am J Physiol Cell Physiol 287, C807-C813
 |  Abstract »  |  Full Text »  |  PDF »

Phenotypic Variation Resulting From a Deficiency of Epidermal Growth Factor Receptor in Mice Is Caused by Extensive Genetic Heterogeneity That Can Be Genetically and Molecularly Partitioned.

K. E. Strunk, V. Amann, and D. W. Threadgill (2004)
Genetics 167, 1821-1832
 |  Abstract »  |  Full Text »  |  PDF »

Selective Roles for Tumor Necrosis Factor {alpha}-converting Enzyme/ADAM17 in the Shedding of the Epidermal Growth Factor Receptor Ligand Family: THE JUXTAMEMBRANE STALK DETERMINES CLEAVAGE EFFICIENCY.

C. L. Hinkle, S. W. Sunnarborg, D. Loiselle, C. E. Parker, M. Stevenson, W. E. Russell, and D. C. Lee (2004)
J. Biol. Chem. 279, 24179-24188
 |  Abstract »  |  Full Text »  |  PDF »

Wound-Induced HB-EGF Ectodomain Shedding and EGFR Activation in Corneal Epithelial Cells.

K.-P. Xu, Y. Ding, J. Ling, Z. Dong, and F.-S. X. Yu (2004)
Invest. Ophthalmol. Vis. Sci. 45, 813-820
 |  Abstract »  |  Full Text »  |  PDF »

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.

U. Sahin, G. Weskamp, K. Kelly, H.-M. Zhou, S. Higashiyama, J. Peschon, D. Hartmann, P. Saftig, and C. P. Blobel (2004)
J. Cell Biol. 164, 769-779
 |  Abstract »  |  Full Text »  |  PDF »

Activin A and Betacellulin: Effect on Regeneration of Pancreatic {beta}-Cells in Neonatal Streptozotocin-Treated Rats.

L. Li, Z. Yi, M. Seno, and I. Kojima (2004)
Diabetes 53, 608-615
 |  Abstract »  |  Full Text »  |  PDF »

Differential Expression of Ezrin/Radixin/Moesin (ERM) and ERM-Associated Adhesion Molecules in the Blastocyst and Uterus Suggests Their Functions During Implantation.

H. Matsumoto, T. Daikoku, H. Wang, E. Sato, and S.K. Dey (2004)
Biol Reprod 70, 729-736
 |  Abstract »  |  Full Text »  |  PDF »

Regulated Cell Surface Pro-EGF Ectodomain Shedding Is a Zinc Metalloprotease-dependent Process.

S. M. Le Gall, R. Auger, C. Dreux, and P. Mauduit (2003)
J. Biol. Chem. 278, 45255-45268
 |  Abstract »  |  Full Text »  |  PDF »

Betacellulin improves glucose metabolism by promoting conversion of intraislet precursor cells to {beta}-cells in streptozotocin-treated mice.

L. Li, M. Seno, H. Yamada, and I. Kojima (2003)
Am J Physiol Endocrinol Metab 285, E577-E583
 |  Abstract »  |  Full Text »  |  PDF »

Betacellulin and Amphiregulin Induce Upregulation of Cyclin D1 and DNA Synthesis Activity Through Differential Signaling Pathways in Vascular Smooth Muscle Cells.

H. S. Shin, H. J. Lee, M. Nishida, M.-S. Lee, R. Tamura, S. Yamashita, Y. Matsuzawa, I.-K. Lee, and G. Y. Koh (2003)
Circ. Res. 93, 302-310
 |  Abstract »  |  Full Text »  |  PDF »

Glucagon-Like Peptide 1 Induces Pancreatic {beta}-Cell Proliferation Via Transactivation of the Epidermal Growth Factor Receptor.

J. Buteau, S. Foisy, E. Joly, and M. Prentki (2003)
Diabetes 52, 124-132
 |  Abstract »  |  Full Text »  |  PDF »

ErbB Signaling Regulates Lineage Determination of Developing Pancreatic Islet Cells in Embryonic Organ Culture.

M.-A. Huotari, P. J. Miettinen, J. Palgi, T. Koivisto, J. Ustinov, D. Harari, Y. Yarden, and T. Otonkoski (2002)
Endocrinology 143, 4437-4446
 |  Abstract »  |  Full Text »  |  PDF »

PDX-1 Induces Differentiation of Intestinal Epithelioid IEC-6 Into Insulin-Producing Cells.

S. Yoshida, Y. Kajimoto, T. Yasuda, H. Watada, Y. Fujitani, H. Kosaka, T. Gotow, T. Miyatsuka, Y. Umayahara, Y. Yamasaki, et al. (2002)
Diabetes 51, 2505-2513
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-independent Dimer Formation of Epidermal Growth Factor Receptor (EGFR) Is a Step Separable from Ligand-induced EGFR Signaling.

X. Yu, K. D. Sharma, T. Takahashi, R. Iwamoto, and E. Mekada (2002)
Mol. Biol. Cell 13, 2547-2557
 |  Abstract »  |  Full Text »  |  PDF »

Receptor-Based Antidote for Diphtheria.

J.-H. Cha, J. S. Brooke, M. Y. Chang, and L. Eidels (2002)
Infect. Immun. 70, 2344-2350
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture.

A. E. DeWitt, J. Y. Dong, H. S. Wiley, and D. A. Lauffenburger (2002)
J. Cell Sci. 114, 2301-2313
 |  Abstract »  |  Full Text »  |  PDF »

Promotion of {beta}-Cell Regeneration by Betacellulin in Ninety Percent-Pancreatectomized Rats.

L. Li, M. Seno, H. Yamada, and I. Kojima (2001)
Endocrinology 142, 5379-5385
 |  Abstract »  |  Full Text »  |  PDF »

A Subclass of HER1 Ligands Are Prognostic Markers for Survival in Bladder Cancer Patients.

V. B. Thogersen, B. S. Sorensen, S. S. Poulsen, T. F. Orntoft, H. Wolf, and E. Nexo (2001)
Cancer Res. 61, 6227-6233
 |  Abstract »  |  Full Text »  |  PDF »

Teratogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Mice Lacking the Expression of EGF and/or TGF-{{alpha}}.

P. L. Bryant, J. E. Schmid, S. E. Fenton, A. R. Buckalew, and B. D. Abbott (2001)
Toxicol. Sci. 62, 103-114
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian Sprouty-1 and -2 Are Membrane-Anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells.

M.-A. Impagnatiello, S. Weitzer, G. Gannon, A. Compagni, M. Cotten, and G. Christofori (2001)
J. Cell Biol. 152, 1087-1098
 |  Abstract »  |  Full Text »  |  PDF »

Fibroblast Growth Factors Are Required for Efficient Tumor Angiogenesis.

A. Compagni, P. Wilgenbus, M.-A. Impagnatiello, M. Cotten, and G. Christofori (2000)
Cancer Res. 60, 7163-7169
 |  Abstract »  |  Full Text »

Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression.

A. E. Marjou, A. Delouvee, J. P. Thiery, and F. Radvanyi (2000)
Carcinogenesis 21, 2211-2218
 |  Abstract »  |  Full Text »  |  PDF »

Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing.

S. Tokumaru, S. Higashiyama, T. Endo, T. Nakagawa, J.-i. Miyagawa, K. Yamamori, Y. Hanakawa, H. Ohmoto, K. Yoshino, Y. Shirakata, et al. (2000)
J. Cell Biol. 151, 209-220
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Activin A and Betacellulin in Human Fetal Pancreatic Cell Differentiation and Growth.

C. Demeterco, G. M. Beattie, S. A. Dib, A. D. Lopez, and A. Hayek (2000)
J. Clin. Endocrinol. Metab. 85, 3892-3897
 |  Abstract »  |  Full Text »

Dysregulation of EGF Family of Growth Factors and COX-2 in the Uterus during the Preattachment and Attachment Reactions of the Blastocyst with the Luminal Epithelium Correlates with Implantation Failure in LIF- Deficient Mice.

H. Song, H. Lim, S. K. Das, B. C. Paria, and S. K. Dey (2000)
Mol. Endocrinol. 14, 1147-1161
 |  Abstract »  |  Full Text »

Antisense Inhibition of Epidermal Growth Factor Receptor Decreases Expression of Human Surfactant Protein A.

J. M. Klein, T. A. McCarthy, J. M. Dagle, and J. M. Snyder (2000)
Am. J. Respir. Cell Mol. Biol. 22, 676-684
 |  Abstract »  |  Full Text »

Lessons From Genetically Engineered Animal Models: X. Trefoil peptide and EGF receptor/ligand transgenic mice.

A. S. Giraud (2000)
Am J Physiol Gastrointest Liver Physiol 278, G501-G506
 |  Abstract »  |  Full Text »  |  PDF »

Epiregulin, a Novel Member of the Epidermal Growth Factor Family, Is an Autocrine Growth Factor in Normal Human Keratinocytes.

Y. Shirakata, T. Komurasaki, H. Toyoda, Y. Hanakawa, K. Yamasaki, S. Tokumaru, K. Sayama, and K. Hashimoto (2000)
J. Biol. Chem. 275, 5748-5753
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor-like Ligands Differentially Up-Regulate Matrix Metalloproteinase 9 in Head and Neck Squamous Carcinoma Cells.

P. O-charoenrat, H. Modjtahedi, P. Rhys-Evans, W. J. Court, G. M. Box, and S. A. Eccles (2000)
Cancer Res. 60, 1121-1128
 |  Abstract »  |  Full Text »

Trafficking and Proteolytic Release of Epidermal Growth Factor Receptor Ligands Are Modulated by Their Membrane-anchoring Domains.

J. Dong and H. S. Wiley (2000)
J. Biol. Chem. 275, 557-564
 |  Abstract »  |  Full Text »  |  PDF »

Ribozyme-mediated Down-Regulation of ErbB-4 in Estrogen Receptor-positive Breast Cancer Cells Inhibits Proliferation Both in Vitro and in Vivo.

C. K. Tang, X.-Z. W. Concepcion, M. Milan, X. Gong, E. Montgomery, and M. E. Lippman (1999)
Cancer Res. 59, 5315-5322
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 Growth Factor Receptors and Their Ligands, Neuregulin-1 {{alpha}}, Neuregulin-1 {{beta}}, and Betacellulin, in Normal Endometrium and Endometrial Cancer.

R. Srinivasan, E. Benton, F. McCormick, H. Thomas, and W. J. Gullick (1999)
Clin. Cancer Res. 5, 2877-2883
 |  Abstract »  |  Full Text »  |  PDF »

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor.

J. Dong, L. K. Opresko, P. J. Dempsey, D. A. Lauffenburger, R. J. Coffey, and H. S. Wiley (1999)
PNAS 96, 6235-6240
 |  Abstract »  |  Full Text »  |  PDF »

Expression of c-erbB Receptors and Ligands in Human Bronchial Mucosa.

R. Polosa, G. Prosperini, S.-H. Leir, S. T. Holgate, P. M. Lackie, and D. E. Davies (1999)
Am. J. Respir. Cell Mol. Biol. 20, 914-923
 |  Abstract »  |  Full Text »

A Differential Requirement for the COOH-terminal Region of the Epidermal Growth Factor (EGF) Receptor in Amphiregulin and EGF Mitogenic Signaling.

L. Wong, T. B. Deb, S. A. Thompson, A. Wells, and G. R. Johnson (1999)
J. Biol. Chem. 274, 8900-8909
 |  Abstract »  |  Full Text »  |  PDF »

Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin.

D. S. Taylor, X. Cheng, J. E. Pawlowski, A. R. Wallace, P. Ferrer, and C. J. Molloy (1999)
PNAS 96, 1633-1638
 |  Abstract »  |  Full Text »  |  PDF »

EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells.

V. P. Krymskaya, R. Hoffman, A. Eszterhas, S. Kane, V. Ciocca, and R. A. Panettieri Jr. (1999)
Am J Physiol Lung Cell Mol Physiol 276, L246-L255
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation.

B. Paria, K Elenius, M Klagsbrun, and S. Dey (1999)
Development 126, 1997-2005
 |  Abstract »  |  PDF »

Biological Response to ErbB Ligands in Nontransformed Cell Lines Correlates with a Specific Pattern of Receptor Expression.

S. Sundaresan, P. E. Roberts, K. L. King, M. X. Sliwkowski, and J. P. Mather (1998)
Endocrinology 139, 4756-4764
 |  Abstract »  |  Full Text »  |  PDF »

Removal of the Membrane-anchoring Domain of Epidermal Growth Factor Leads to Intracrine Signaling and Disruption of Mammary Epithelial Cell Organization.

H. S. Wiley, M. F. Woolf, L. K. Opresko, P. M. Burke, B. Will, J. R. Morgan, and D. A. Lauffenburger (1998)
J. Cell Biol. 143, 1317-1328
 |  Abstract »  |  Full Text »  |  PDF »

Cell Surface Ectodomain Cleavage of Human Amphiregulin Precursor Is Sensitive to a Metalloprotease Inhibitor. RELEASE OF A PREDOMINANT N-GLYCOSYLATED 43-kDa SOLUBLE FORM.

C. L. Brown, K. S. Meise, G. D. Plowman, R. J. Coffey, and P. J. Dempsey (1998)
J. Biol. Chem. 273, 17258-17268
 |  Abstract »  |  Full Text »  |  PDF »

TGF{alpha} is Dispensable for Skin Tumorigenesis in Tg.AC Mice.

M. C. Humble, C. J. Szczesniak, N. C. Luetteke, J. W. Spalding, R. E. Cannon, L. A. Hansen, D. C. Lee, and R. W. Tennant (1998)
Toxicol Pathol 26, 562-569
 |  Abstract »  |  PDF »

ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4.

L.-M. Wang, A. Kuo, M. Alimandi, M. C. Veri, C.-C. Lee, V. Kapoor, N. Ellmore, X.-H. Chen, and J. H. Pierce (1998)
PNAS 95, 6809-6814
 |  Abstract »  |  Full Text »  |  PDF »

Growth Factor-Mediated Proliferation and Differentiation of Insulin-Producing INS-1 and RINm5F Cells: Identification of Betacellulin as a Novel {beta}-Cell Mitogen.

M.-A. Huotari, J. Palgi, and T. Otonkoski (1998)
Endocrinology 139, 1494-1499
 |  Abstract »  |  Full Text »  |  PDF »

Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site.

M. Suzuki, G. Raab, M. A. Moses, C. A. Fernandez, and M. Klagsbrun (1997)
J. Biol. Chem. 272, 31730-31737
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Heparin-binding Epidermal Growth Factor-like Growth Factor during Pancreas Development. A POTENTIAL ROLE OF PDX-1 IN TRANSCRIPTIONAL ACTIVATION.

H. Kaneto, J.-i. Miyagawa, Y. Kajimoto, K. Yamamoto, H. Watada, Y. Umayahara, T. Hanafusa, Y. Matsuzawa, Y. Yamasaki, S. Higashiyama, et al. (1997)
J. Biol. Chem. 272, 29137-29143
 |  Abstract »  |  Full Text »  |  PDF »

Intermediate endocrine-acinar pancreatic cells in duct ligation conditions.

E. Bertelli and M. Bendayan (1997)
Am J Physiol Cell Physiol 273, C1641-C1649
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Juxtamembrane Domain Isoform of HER4/ErbB4. ISOFORM-SPECIFIC TISSUE DISTRIBUTION AND DIFFERENTIAL PROCESSING IN RESPONSE TO PHORBOL ESTER.

K. Elenius, G. Corfas, S. Paul, C. J. Choi, C. Rio, G. D. Plowman, and M. Klagsbrun (1997)
J. Biol. Chem. 272, 26761-26768
 |  Abstract »  |  Full Text »  |  PDF »

Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4.

D. Zhang, M. X. Sliwkowski, M. Mark, G. Frantz, R. Akita, Y. Sun, K. Hillan, C. Crowley, J. Brush, and P. J. Godowski (1997)
PNAS 94, 9562-9567
 |  Abstract »  |  Full Text »  |  PDF »

Differential Expression of the erbB2 Gene in the Periimplantation Mouse Uterus: Potential Mediator of Signaling by Epidermal Growth Factor-Like Growth Factors.

H. Lim, S. K. Dey, and S. K. Das (1997)
Endocrinology 138, 1328-1337
 |  Abstract »  |  Full Text »  |  PDF »

A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation.

M. Shen, H Wang, and P Leder (1997)
Development 124, 429-442
 |  Abstract »  |  PDF »

Amino-terminal Processing of Cell Surface Heparin-binding Epidermal Growth Factor-like Growth Factor Up-regulates Its Juxtacrine but Not Its Paracrine Growth Factor Activity.

T. Nakagawa, S. Higashiyama, T. Mitamura, E. Mekada, and N. Taniguchi (1996)
J. Biol. Chem. 271, 30858-30863
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Mouse Epidermal Growth Factor Promoter and 5'-Flanking Region. ROLE FOR AN ATYPICAL TATA SEQUENCE.

S. E. Fenton, N. S. Groce, and D. C. Lee (1996)
J. Biol. Chem. 271, 30870-30878
 |  Abstract »  |  Full Text »  |  PDF »

Cysteines 153 and 154 of Transmembrane Transforming Growth Factor-alpha Are Palmitoylated and Mediate Cytoplasmic Protein Association.

L. Shum, C. W. Turck, and R. Derynck (1996)
J. Biol. Chem. 271, 28502-28508
 |  Abstract »  |  Full Text »  |  PDF »

COOH-terminal Extended Recombinant Amphiregulin with Bioactivity Comparable with Naturally Derived Growth Factor.

S. A. Thompson, A. Harris, D. Hoang, M. Ferrer, and G. R. Johnson (1996)
J. Biol. Chem. 271, 17927-17931
 |  Abstract »  |  Full Text »  |  PDF »

The Significance of Valine 33as a Ligand-specific Epitope of Transforming Growth Factor alpha.

S. M. Puddicombe, S. G. Chamberlin, J. MacGarvie, A. Richter, D. R. Drummond, J. Collins, L. Wood, and D. E. Davies (1996)
J. Biol. Chem. 271, 15367-15372
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities.

R. R. Beerli and N. E. Hynes (1996)
J. Biol. Chem. 271, 6071-6076
 |  Abstract »  |  Full Text »  |  PDF »

The Human Urinary Epidermal Growth Factor (EGF) Precursor.

G. Parries, K. Chen, K. S. Misono, and S. Cohen (1995)
J. Biol. Chem. 270, 27954-27960
 |  Abstract »  |  Full Text »  |  PDF »

HER4 Receptor Activation and Phosphorylation of Shc Proteins by Recombinant Heregulin-Fc Fusion Proteins.

J.-M. Culouscou, G. W. Carlton, and A. Aruffo (1995)
J. Biol. Chem. 270, 12857-12863
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability..

L A Donehower, L A Godley, C M Aldaz, R Pyle, Y P Shi, D Pinkel, J Gray, A Bradley, D Medina, and H E Varmus (1995)
Genes & Dev. 9, 882-895
 |  Abstract »  |  PDF »

Epiregulin.

H. Toyoda, T. Komurasaki, D. Uchida, Y. Takayama, T. Isobe, T. Okuyama, and K. Hanada (1995)
J. Biol. Chem. 270, 7495-7500
 |  Abstract »  |  Full Text »  |  PDF »

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase..

N C Luetteke, H K Phillips, T H Qiu, N G Copeland, H S Earp, N A Jenkins, and D C Lee (1994)
Genes & Dev. 8, 399-413
 |  Abstract »  |  PDF »

Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth.

M.S. O'Reilly, L. Holmgren, Y. Shing, C. Chen, R.A. Rosenthal, Y. Cao, M. Moses, W.S. Lane, E.H. Sage, and J. Folkman (1994)
Cold Spring Harb Symp Quant Biol 59, 471-482
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Cloning and Biological Activity of Epigen, a Novel Member of the Epidermal Growth Factor Superfamily.

L. Strachan, J. G. Murison, R. L. Prestidge, M. A. Sleeman, J. D. Watson, and K. D. Kumble (2001)
J. Biol. Chem. 276, 18265-18271
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Novel Betacellulin Derivatives. SEPARATION OF THE DIFFERENTIATION ACTIVITY FROM THE MITOGENIC ACTIVITY.

T. Itoh, M. Kondo, Y. Tanaka, M. Kobayashi, R. Sasada, K. Igarashi, M. Suenaga, N. Koyama, O. Nishimura, and M. Fujino (2001)
J. Biol. Chem. 276, 40698-40703
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