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Science 5 March 1993:
Vol. 259. no. 5100, pp. 1463 - 1466
DOI: 10.1126/science.8451643
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Articles

Science, Vol 259, Issue 5100, 1463-1466
Copyright © 1993 by American Association for the Advancement of Science

articles

Optical time-of-flight and absorbance imaging of biologic media

DA Benaron and DK Stevenson

Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305.

Imaging the interior of living bodies with light may assist in the diagnosis and treatment of a number of clinical problems, which include the early detection of tumors and hypoxic cerebral injury. An existing picosecond time-of-flight and absorbance (TOFA) optical system has been used to image a model biologic system and a rat. Model measurements confirmed TOFA principles in systems with a high degree of photon scattering; rat images, which were constructed from the variable time delays experienced by a fixed fraction of early-arriving transmitted photons, revealed identifiable internal structure. A combination of light-based quantitative measurement and TOFA localization may have applications in continuous, noninvasive monitoring for structural imaging and spatial chemometric analysis in humans.


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