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Science 5 March 1993:
Vol. 259. no. 5100, pp. 1460 - 1463
DOI: 10.1126/science.8451642
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Articles

Science, Vol 259, Issue 5100, 1460-1463
Copyright © 1993 by American Association for the Advancement of Science

articles

Inhibition of human colon cancer growth by antibody-directed human LAK cells in SCID mice

H Takahashi, T Nakada, and I Puisieux

Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Charlestown 02129.

Advanced human colon cancer does not respond to lymphokine-activated killer (LAK) cells. In order to direct cytotoxic cells to the tumor, human LAK cells linked with antibodies to a tumor cell surface antigen were tested with established hepatic metastases in severe combined immunodeficient (SCID) mice. These cells had increased uptake into the tumor and suppression of tumor growth as compared with LAK cells alone, thereby improving the survival of tumor-bearing mice. Thus, tumor growth can be inhibited by targeted LAK cells, and SCID mice can be used to test the antitumor properties of human effector cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effect Of Human Natural Killer and {gamma}{delta} T Cells on the Growth of Human Autologous Melanoma Xenografts in SCID Mice.
F. Lozupone, D. Pende, V. L. Burgio, C. Castelli, M. Spada, M. Venditti, F. Luciani, L. Lugini, C. Federici, C. Ramoni, et al. (2004)
Cancer Res. 64, 378-385
   Abstract »    Full Text »    PDF »
Visualizing the kinetics of tumor-cell clearance in living animals.
T. J. Sweeney, V. Mailander, A. A. Tucker, A. B. Olomu, W. Zhang, Y.-a. Cao, R. S. Negrin, and C. H. Contag (1999)
PNAS 96, 12044-12049
   Abstract »    Full Text »    PDF »
Cure of xenografted human tumors by bispecific monoclonal antibodies and human T cells.
C Renner, W Jung, U Sahin, R Denfeld, C Pohl, L Trumper, F Hartmann, V Diehl, R van Lier, and M Pfreundschuh (1994)
Science 264, 833-835
   Abstract »    PDF »


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