Science 12 February 1993: Vol. 259. no. 5097, pp. 984 - 987 DOI: 10.1126/science.8438159

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Articles

G Clustering Is Important for the Initiation of Transcription-Induced R-Loops In Vitro, whereas High G Density without Clustering Is Sufficient Thereafter.

D. Roy and M. R. Lieber (2009)
Mol. Cell. Biol. 29, 3124-3133
 |  Abstract »  |  Full Text »  |  PDF »

Ikaros controls isotype selection during immunoglobulin class switch recombination.

M. Sellars, B. Reina-San-Martin, P. Kastner, and S. Chan (2009)
J. Exp. Med. 206, 1073-1087
 |  Abstract »  |  Full Text »  |  PDF »

Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination.

P. Gottipati and T. Helleday (2009)
Mutagenesis 24, 203-210
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.

T. Perlot, G. Li, and F. W. Alt (2008)
PNAS 105, 3843-3848
 |  Abstract »  |  Full Text »  |  PDF »

Does antisense make sense of AID targeting?.

S. Roa, F. L. Kuang, and M. D. Scharff (2008)
PNAS 105, 3661-3662
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Transcription-Associated Recombination Is Dependent on Replication in Mammalian Cells.

P. Gottipati, T. N. Cassel, L. Savolainen, and T. Helleday (2008)
Mol. Cell. Biol. 28, 154-164
 |  Abstract »  |  Full Text »  |  PDF »

Replacement of I{gamma}3 germ-line promoter by I{gamma}1 inhibits class-switch recombination to IgG3.

Z. Oruc, A. Boumediene, M. Le Bert, and A. A. Khamlichi (2007)
PNAS 104, 20484-20489
 |  Abstract »  |  Full Text »  |  PDF »

Sequence and Characterization of the Ig Heavy Chain Constant and Partial Variable Region of the Mouse Strain 129S1.

I. Retter, C. Chevillard, M. Scharfe, A. Conrad, M. Hafner, T.-H. Im, M. Ludewig, G. Nordsiek, S. Severitt, S. Thies, et al. (2007)
J. Immunol. 179, 2419-2427
 |  Abstract »  |  Full Text »  |  PDF »

Cotranscriptional processes and their influence on genome stability.

X. Li and J. L. Manley (2006)
Genes & Dev. 20, 1838-1847
 |  Abstract »  |  Full Text »  |  PDF »

Germ line transcription in mice bearing neor gene downstream of I{gamma}3 exon in the Ig heavy chain locus.

M. Samara, Z. Oruc, H.-L. Dougier, T. Essawi, M. Cogne, and A. A. Khamlichi (2006)
Int. Immunol. 18, 581-589
 |  Abstract »  |  Full Text »  |  PDF »

Negative regulation of activation-induced cytidine deaminase in B cells.

T. Muto, I.-m. Okazaki, S. Yamada, Y. Tanaka, K. Kinoshita, M. Muramatsu, H. Nagaoka, and T. Honjo (2006)
PNAS 103, 2752-2757
 |  Abstract »  |  Full Text »  |  PDF »

AID-dependent histone acetylation is detected in immunoglobulin S regions.

L. Wang, N. Whang, R. Wuerffel, and A. L. Kenter (2006)
J. Exp. Med. 203, 215-226
 |  Abstract »  |  Full Text »  |  PDF »

Inducible DNA breaks in Ig S regions are dependent on AID and UNG.

C. E. Schrader, E. K. Linehan, S. N. Mochegova, R. T. Woodland, and J. Stavnezer (2005)
J. Exp. Med. 202, 561-568
 |  Abstract »  |  Full Text »  |  PDF »

Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity.

C. L. Bennett, E. van Rijn, S. Jung, K. Inaba, R. M. Steinman, M. L. Kapsenberg, and B. E. Clausen (2005)
J. Cell Biol. 169, 569-576
 |  Abstract »  |  Full Text »  |  PDF »

Interallelic Class Switch Recombination Contributes Significantly to Class Switching in Mouse B Cells.

S. Reynaud, L. Delpy, L. Fleury, H.-L. Dougier, C. Sirac, and M. Cogne (2005)
J. Immunol. 174, 6176-6183
 |  Abstract »  |  Full Text »  |  PDF »

Nibrin functions in Ig class-switch recombination.

S. Kracker, Y. Bergmann, I. Demuth, P.-O. Frappart, G. Hildebrand, R. Christine, Z.-Q. Wang, K. Sperling, M. Digweed, and A. Radbruch (2005)
PNAS 102, 1584-1589
 |  Abstract »  |  Full Text »  |  PDF »

ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions.

B. Reina-San-Martin, H. T. Chen, A. Nussenzweig, and M. C. Nussenzweig (2004)
J. Exp. Med. 200, 1103-1110
 |  Abstract »  |  Full Text »  |  PDF »

Germline Transcription and Switch Recombination of a Transgene Containing the Entire H Chain Constant Region Locus: Effect of a Mutation in a STAT6 Binding Site in the {gamma}1 Promoter.

W. A. Dunnick, J. Shi, K. A. Graves, and J. T. Collins (2004)
J. Immunol. 173, 5531-5539
 |  Abstract »  |  Full Text »  |  PDF »

DNA Acrobats of the Ig Class Switch.

C. L. Wang and M. Wabl (2004)
J. Immunol. 172, 5815-5821
 |  Abstract »  |  Full Text »  |  PDF »

Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase.

K. M. McBride, V. Barreto, A. R. Ramiro, P. Stavropoulos, and M. C. Nussenzweig (2004)
J. Exp. Med. 199, 1235-1244
 |  Abstract »  |  Full Text »  |  PDF »

S{epsilon}S{micro} and S{epsilon}S{gamma} Switch Circles in Human Nasal Mucosa Following Ex Vivo Allergen Challenge: Evidence for Direct as Well as Sequential Class Switch Recombination.

L. Cameron, A. S. Gounni, S. Frenkiel, F. Lavigne, D. Vercelli, and Q. Hamid (2003)
J. Immunol. 171, 3816-3822
 |  Abstract »  |  Full Text »  |  PDF »

Visualization of the Genesis and Fate of Isotype-switched B Cells during a Primary Immune Response.

K. A. Pape, V. Kouskoff, D. Nemazee, H. L. Tang, J. G. Cyster, L. E. Tze, K. L. Hippen, T. W. Behrens, and M. K. Jenkins (2003)
J. Exp. Med. 197, 1677-1687
 |  Abstract »  |  Full Text »  |  PDF »

H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation.

B. Reina-San-Martin, S. Difilippantonio, L. Hanitsch, R. F. Masilamani, A. Nussenzweig, and M. C. Nussenzweig (2003)
J. Exp. Med. 197, 1767-1778
 |  Abstract »  |  Full Text »  |  PDF »

Accessibility control and machinery of immunoglobulin class switch recombination.

K. Zhang (2003)
J. Leukoc. Biol. 73, 323-332
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line Cepsilon transcription of IL-4-stimulated B cells.

A. Suto, H. Nakajima, K. Hirose, K. Suzuki, S.-i. Kagami, Y. Seto, A. Hoshimoto, Y. Saito, D. C. Foster, and I. Iwamoto (2002)
Blood 100, 4565-4573
 |  Abstract »  |  Full Text »  |  PDF »

T-bet regulates IgG class switching and pathogenic autoantibody production.

S. L. Peng, S. J. Szabo, and L. H. Glimcher (2002)
PNAS 99, 5545-5550
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitously Expressed DNA-Binding Protein Late SV40 Factor Binds Ig Switch Regions and Represses Class Switching to IgA.

E. E. Drouin, C. E. Schrader, J. Stavnezer, and U. Hansen (2002)
J. Immunol. 168, 2847-2856
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1.

C. M. Litterst and E. Pfitzner (2001)
J. Biol. Chem. 276, 45713-45721
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role of Stat5 for IL-5-Dependent IgH Switch Recombination in Mouse B Cells.

K. Horikawa, H. Kaku, H. Nakajima, H. W. Davey, L. Henninghausen, I. Iwamoto, T. Yasue, A. Kariyone, and K. Takatsu (2001)
J. Immunol. 167, 5018-5026
 |  Abstract »  |  Full Text »  |  PDF »

HS1,2 Enhancer Regulation of Germline {epsilon} and {gamma}2b Promoters in Murine B Lymphocytes: Evidence for Specific Promoter-Enhancer Interactions.

J. Laurencikiene, V. Deveikaite, and E. Severinson (2001)
J. Immunol. 167, 3257-3265
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Regulation of Class Switch Recombination by Switch Region Transcription.

C.-G. Lee, K. Kinoshita, A. Arudchandran, S. M. Cerritelli, R. J. Crouch, and T. Honjo (2001)
J. Exp. Med. 194, 365-374
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Mouse Germline Ig {gamma}1 and {epsilon} Promoters by IL-4 and CD40.

C.-s. Mao and J. Stavnezer (2001)
J. Immunol. 167, 1522-1534
 |  Abstract »  |  Full Text »  |  PDF »

Roles of Ets proteins, NF-{{kappa}}B and nocodazole in regulating induction of transcription of mouse germline Ig {{alpha}} RNA by transforming growth factor-{beta}1.

M.-J. Shi, S.-R. Park, P.-H. Kim, and J. Stavnezer (2001)
Int. Immunol. 13, 733-746
 |  Abstract »  |  Full Text »  |  PDF »

NF-{{kappa}}B p50-Dependent In Vivo Footprints at Ig S{{gamma}}3 DNA Are Correlated with {micro}{->}{{gamma}}3 Switch Recombination.

R. A. Wuerffel, L. Ma, and A. L. Kenter (2001)
J. Immunol. 166, 4552-4559
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Mouse Ig Germline {{epsilon}} Promoter by IL-4 Is Dependent on AP-1 Transcription Factors.

C.-H. Shen and J. Stavnezer (2001)
J. Immunol. 166, 411-423
 |  Abstract »  |  Full Text »  |  PDF »

A DNase I hypersensitive site near the murine {gamma}1 switch region contributes to insertion site independence of transgenes and modulates the amount of transcripts induced by CD40 ligation.

K. Adams, H. Ackerly, K. Cunningham, and W. Dunnick (2000)
Int. Immunol. 12, 1705-1713
 |  Abstract »  |  Full Text »  |  PDF »

One Cytokine, Two Isotypes . A Trojan Horse, Pandora's Box, and an Evolving Paradigm.

D. VERCELLI (2000)
Am. J. Respir. Crit. Care Med. 162, S86-90
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Evidence for Class-specific Factors in Immunoglobulin Isotype Switching.

A. Shanmugam, M.-J. Shi, L. Yauch, J. Stavnezer, and A. L. Kenter (2000)
J. Exp. Med. 191, 1365-1380
 |  Abstract »  |  Full Text »  |  PDF »

Normal Isotype Switching in B Cells Lacking the I{micro} Exon Splice Donor Site: Evidence for Multiple I{micro}-Like Germline Transcripts.

I. I. Kuzin, G. D. Ugine, D. Wu, F. Young, J. Chen, and A. Bottaro (2000)
J. Immunol. 164, 1451-1457
 |  Abstract »  |  Full Text »  |  PDF »

Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage.

G. J. Vanasse, P. Concannon, and D. M. Willerford (1999)
Blood 94, 3997-4010
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DNA from Mycobacterium bovis Bacillus Calmette-Guerin (MY-1) Inhibits Immunoglobulin E Production by Human Lymphocytes.

S. FUJIEDA, S. IHO, Y. KIMURA, H. SUNAGA, H. IGAWA, C. SUGIMOTO, S. YAMAMOTO, and H. SAITO (1999)
Am. J. Respir. Crit. Care Med. 160, 2056-2061
 |  Abstract »  |  Full Text »

Switching to IgG3, IgG2b, and IgA Is Division Linked and Independent, Revealing a Stochastic Framework for Describing Differentiation.

E. K. Deenick, J. Hasbold, and P. D. Hodgkin (1999)
J. Immunol. 163, 4707-4714
 |  Abstract »  |  Full Text »  |  PDF »

The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination.

E. Sakai, A. Bottaro, and F. W. Alt (1999)
Int. Immunol. 11, 1709-1713
 |  Abstract »  |  Full Text »  |  PDF »

Switch Recombination in a Transfected Plasmid Occurs Preferentially in a B Cell Line That Undergoes Switch Recombination of Its Chromosomal Ig Heavy Chain Genes.

J. Stavnezer, S. P. Bradley, N. Rousseau, T. Pearson, A. Shanmugam, D. J. Waite, P. R. Rogers, and A. L. Kenter (1999)
J. Immunol. 163, 2028-2040
 |  Abstract »  |  Full Text »  |  PDF »

An extrachromosomal switch recombination substrate reveals kinetics and substrate requirements of switch recombination in primary murine B cells.

K. Petry, G. Siebenkotten, R. Christine, K. Hein, and A. Radbruch (1999)
Int. Immunol. 11, 753-763
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Induction of the Expression of Multiple IgA Isotype Genes in Rabbit B Cells by TGF-{beta} and IL-2.

H. Spieker-Polet, P.-C. Yam, Z. Arbieva, S.-K. Zhai, and K. L. Knight (1999)
J. Immunol. 162, 5380-5388
 |  Abstract »  |  Full Text »  |  PDF »

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

K. J. Seidl, J. P. Manis, A. Bottaro, J. Zhang, L. Davidson, A. Kisselgof, H. Oettgen, and F. W. Alt (1999)
PNAS 96, 3000-3005
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanism of Immunoglobulin Class Switch Recombination.

K. KINOSHITA, C.-G. LEE, J. TASHIRO, M. MURAMATSU, X.-C. CHEN, K. YOSHIKAWA, and T. HONJO (1999)
Cold Spring Harb Symp Quant Biol 64, 217-226
 |  Abstract »  |  PDF »

I{alpha} exon-replacement mice synthesize a spliced HPRT–C{alpha} transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice.

G. Qiu, G. R. Harriman, and J. Stavnezer (1999)
Int. Immunol. 11, 37-46
 |  Abstract »  |  Full Text »  |  PDF »

Processing of Switch Transcripts Is Required for Targeting of Antibody Class Switch Recombination.

K. Hein, M. G.O. Lorenz, G. Siebenkotten, K. Petry, R. Christine, and A. Radbruch (1998)
J. Exp. Med. 188, 2369-2374
 |  Abstract »  |  Full Text »  |  PDF »

CBF{alpha}3 (AML2) Is Induced by TGF-{beta}1 to Bind and Activate the Mouse Germline Ig {alpha} Promoter.

M.-J. Shi and J. Stavnezer (1998)
J. Immunol. 161, 6751-6760
 |  Abstract »  |  Full Text »  |  PDF »

Class Switching in B Cells Lacking 3' Immunoglobulin Heavy Chain Enhancers.

J. P. Manis, N. van der Stoep, M. Tian, R. Ferrini, L. Davidson, A. Bottaro, and F. W. Alt (1998)
J. Exp. Med. 188, 1421-1431
 |  Abstract »  |  Full Text »  |  PDF »

c-Fos Induces Apoptosis in Germinal Center B Cells.

K. Inada, S. Okada, J. Phuchareon, M. Hatano, T. Sugimoto, H. Moriya, and T. Tokuhisa (1998)
J. Immunol. 161, 3853-3861
 |  Abstract »  |  Full Text »  |  PDF »

Localization of Splenic B Cells Activated for Switch Recombination by In Situ Hybridization with I{gamma}1 Switch Transcript and Rad51 Probes.

M.-C. Peakman and N. Maizels (1998)
J. Immunol. 161, 4008-4015
 |  Abstract »  |  Full Text »  |  PDF »

{gamma}3 Gene-Disrupted Mice Selectively Deficient in the Dominant IgG Subclass Made to Bacterial Polysaccharides Undergo Normal Isotype Switching After Immunization with Polysaccharide-Protein Conjugate Vaccines.

D. A. Shapiro, D. S. Threadgill, M. J. Copfer, D. A. Corey, T. L. McCool, L. L. McCormick, T. R. Magnuson, N. S. Greenspan, and J. R. Schreiber (1998)
J. Immunol. 161, 3393-3399
 |  Abstract »  |  Full Text »  |  PDF »

The Ability of CD40L, but Not Lipopolysaccharide, To Initiate Immunoglobulin Switching to Immunoglobulin G1 Is Explained by Differential Induction of NF-kappa B/Rel Proteins.

S.-C. Lin, H. H. Wortis, and J. Stavnezer (1998)
Mol. Cell. Biol. 18, 5523-5532
 |  Abstract »  |  Full Text »

Efficient Recombination of a Switch Substrate Retrovector in CD40-Activated B Lymphocytes: Implications for the Control of CH Gene Switch Recombination.

J. Ballantyne, D. L. Henry, J. R. Muller, F. Briere, C. M. Snapper, M. Kehry, and K. B. Marcu (1998)
J. Immunol. 161, 1336-1347
 |  Abstract »  |  Full Text »  |  PDF »

STAT6 Is Required for IL-4-Induced Germline Ig Gene Transcription and Switch Recombination.

L. A. Linehan, W. D. Warren, P. A. Thompson, M. J. Grusby, and M. T. Berton (1998)
J. Immunol. 161, 302-310
 |  Abstract »  |  Full Text »  |  PDF »

T Helper 1 (Th1) and Th2 Characteristics Start to Develop During T Cell Priming and Are Associated with an Immediate Ability to Induce Immunoglobulin Class Switching.

K.-M. Toellner, S. A. Luther, D. M.-Y. Sze, R. K.-W. Choy, D. R. Taylor, I. C.M. MacLennan, and H. Acha-Orbea (1998)
J. Exp. Med. 187, 1193-1204
 |  Abstract »  |  Full Text »  |  PDF »

CD40 Ligand Exerts Differential Effects on the Expression of I{gamma} Transcripts in Subclones of an IgM+ Human B Cell Lymphoma Line.

G. S. Ford, C. H. Yin, B. Barnhart, K. Sztam, and L. R. Covey (1998)
J. Immunol. 160, 595-605
 |  Abstract »  |  Full Text »  |  PDF »

alpha 2p controls donor preference during mating type interconversion in yeast by inactivating a recombinational enhancer of chromosome III.

L. Szeto, M. K. Fafalios, H. Zhong, A. K. Vershon, and J. R. Broach (1997)
Genes & Dev. 11, 1899-1911
 |  Abstract »  |  Full Text »  |  PDF »

Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1.

L. A. Hanakahi, L. A. Dempsey, M.-J. Li, and N. Maizels (1997)
PNAS 94, 3605-3610
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 4-inducible Phosphorylation of HMG-I(Y) Is Inhibited by Rapamycin.

D.-Z. Wang, P. Ray, and M. Boothby (1995)
J. Biol. Chem. 270, 22924-22932
 |  Abstract »  |  Full Text »  |  PDF »

Switch transcripts in immunoglobulin class switching.

M Lorenz, S Jung, and A Radbruch (1995)
Science 267, 1825-1828
 |  Abstract »  |  PDF »

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.

S Taki, M Meiering, and K Rajewsky (1993)
Science 262, 1268-1271
 |  Abstract »  |  PDF »

Transcription-induced Cleavage of Immunoglobulin Switch Regions by Nucleotide Excision Repair Nucleases in Vitro.

M. Tian and F. W. Alt (2000)
J. Biol. Chem. 275, 24163-24172
 |  Abstract »  |  Full Text »  |  PDF »

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