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Science 12 February 1993:
Vol. 259. no. 5097, pp. 968 - 971
DOI: 10.1126/science.8438156
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Articles

Science, Vol 259, Issue 5097, 968-971
Copyright © 1993 by American Association for the Advancement of Science

articles

Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia

CL Willman, CE Sever, MG Pallavicini, H Harada, N Tanaka, ML Slovak, H Yamamoto, K Harada, TC Meeker, AF List, and al. et

University of New Mexico School of Medicine, Department of Pathology, Albuquerque 87131.

One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromeric to IL-3 and GM-CSF. Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.


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