Science 5 February 1993: Vol. 259. no. 5096, pp. 822 - 825 DOI: 10.1126/science.8430336

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Articles

CD69 Gene Is Differentially Regulated in T and B Cells by Evolutionarily Conserved Promoter-Distal Elements.

B. N. Vazquez, T. Laguna, J. Carabana, M. S. Krangel, and P. Lauzurica (2009)
J. Immunol. 183, 6513-6521
 |  Abstract »  |  Full Text »  |  PDF »

Flexible Stereospecific Interactions and Composition within Nucleoprotein Complexes Assembled on the TCR{alpha} Gene Enhancer.

B. del Blanco, J. L. Roberts, N. Zamarreno, N. Balmelle-Devaux, and C. Hernandez-Munain (2009)
J. Immunol. 183, 1871-1883
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the Last Cog in a Ligand-Independent Signaling Machine?.

D. L. Wiest (2009)
J. Immunol. 182, 5163-5164
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Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.

C. H. Bassing, S. Ranganath, M. Murphy, V. Savic, M. Gleason, and F. W. Alt (2008)
Blood 111, 2163-2169
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ T Cells Recognizing a Single Self-Peptide Expressed by APCs Induce Spontaneous Autoimmune Arthritis.

A. L. Rankin, A. J. Reed, S. Oh, C. Cozzo Picca, H. M. Guay, J. Larkin III, L. Panarey, M. K. Aitken, B. Koeberlein, P. E. Lipsky, et al. (2008)
J. Immunol. 180, 833-841
 |  Abstract »  |  Full Text »  |  PDF »

Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.

J. G. Bates, D. Cado, H. Nolla, and M. S. Schlissel (2007)
J. Exp. Med. 204, 3247-3256
 |  Abstract »  |  Full Text »  |  PDF »

Expression Profiling of Immature Thymocytes Revealed a Novel Homeobox Gene That Regulates Double-Negative Thymocyte Development.

M. Kawazu, G. Yamamoto, M. Yoshimi, K. Yamamoto, T. Asai, M. Ichikawa, S. Seo, M. Nakagawa, S. Chiba, M. Kurokawa, et al. (2007)
J. Immunol. 179, 5335-5345
 |  Abstract »  |  Full Text »  |  PDF »

Chromosomal reinsertion of broken RSS ends during T cell development.

J. D. Curry, D. Schulz, C. J. Guidos, J. S. Danska, L. Nutter, A. Nussenzweig, and M. S. Schlissel (2007)
J. Exp. Med. 204, 2293-2303
 |  Abstract »  |  Full Text »  |  PDF »

Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia.

N. R. dos Santos, D. S. Rickman, A. de Reynies, F. Cormier, M. Williame, C. Blanchard, M.-H. Stern, and J. Ghysdael (2007)
Blood 109, 3972-3981
 |  Abstract »  |  Full Text »  |  PDF »

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus.

L. Zhao, J. L. Cannons, S. Anderson, M. Kirby, L. Xu, L. H. Castilla, P. L. Schwartzberg, R. Bosselut, and P. P. Liu (2007)
Blood 109, 3432-3440
 |  Abstract »  |  Full Text »  |  PDF »

Role for rearranged variable gene segments in directing secondary T cell receptor {alpha} recombination.

A. Hawwari and M. S. Krangel (2007)
PNAS 104, 903-907
 |  Abstract »  |  Full Text »  |  PDF »

A Natural Structural Variant of the Mouse TCR beta-Chain Displays Intrinsic Receptor Function and Antigen Specificity.

A. Aublin, M. Ciofani, N. Willkomm, A. Hamrouni, A. L. Szymczak-Workman, T. Takahashi, Y. Sandjeu, P. Guillaume, D. A. A. Vignali, O. Michielin, et al. (2006)
J. Immunol. 177, 8587-8594
 |  Abstract »  |  Full Text »  |  PDF »

A Role for MAPK in Feedback Inhibition of Tcrb Recombination..

A. M. Jackson and M. S. Krangel (2006)
J. Immunol. 176, 6824-6830
 |  Abstract »  |  Full Text »  |  PDF »

Expression of TCR{alpha}beta Partly Rescues Developmental Arrest and Apoptosis of {alpha}beta T cells in Bcl11b-/- Mice.

J. Inoue, T. Kanefuji, K. Okazuka, H. Watanabe, Y. Mishima, and R. Kominami (2006)
J. Immunol. 176, 5871-5879
 |  Abstract »  |  Full Text »  |  PDF »

Allele-Specific Regulation of TCR{beta} Variable Gene Segment Chromatin Structure.

A. M. Jackson and M. S. Krangel (2005)
J. Immunol. 175, 5186-5191
 |  Abstract »  |  Full Text »  |  PDF »

The TCR{beta} Enhancer Is Dispensable for the Expression of Rearranged TCR{beta} Genes in Thymic DN2/DN3 Populations but Not at Later Stages.

C. E. Busse, A. Krotkova, and K. Eichmann (2005)
J. Immunol. 175, 3067-3074
 |  Abstract »  |  Full Text »  |  PDF »

Chromosomal excision of TCR{delta} chain genes is dispensable for {alpha}{beta} T cell lineage commitment.

B. Khor, T. D. Wehrly, and B. P. Sleckman (2005)
Int. Immunol. 17, 225-232
 |  Abstract »  |  Full Text »  |  PDF »

Ontogeny and Regulation of IL-7-Expressing Thymic Epithelial Cells.

M. Zamisch, B. Moore-Scott, D.-m. Su, P. J. Lucas, N. Manley, and E. R. Richie (2005)
J. Immunol. 174, 60-67
 |  Abstract »  |  Full Text »  |  PDF »

The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor {beta} locus.

S. Eyquem, K. Chemin, M. Fasseu, and J.-C. Bories (2004)
PNAS 101, 15712-15717
 |  Abstract »  |  Full Text »  |  PDF »

Exclusion and Inclusion of TCR{alpha} Proteins during T Cell Development in TCR-Transgenic and Normal Mice.

H. D. Lacorazza and J. Nikolich-Zugich (2004)
J. Immunol. 173, 5591-5600
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Activation of the TCR {alpha} Enhancer Requires Functional Collaboration among Proteins Bound Inside and Outside the Core Enhancer.

N. Balmelle, N. Zamarreno, M. S. Krangel, and C. Hernandez-Munain (2004)
J. Immunol. 173, 5054-5063
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Thymus Size by Competition for Stromal Niches among Early T Cell Progenitors.

S. E. Prockop and H. T. Petrie (2004)
J. Immunol. 173, 1604-1611
 |  Abstract »  |  Full Text »  |  PDF »

New insights into the proliferation and differentiation of early mouse thymocytes.

J. Laurent, N. Bosco, P. N. Marche, and R. Ceredig (2004)
Int. Immunol. 16, 1069-1080
 |  Abstract »  |  Full Text »  |  PDF »

Obligatory Role for Cooperative Signaling by Pre-TCR and Notch during Thymocyte Differentiation.

M. Ciofani, T. M. Schmitt, A. Ciofani, A. M. Michie, N. Cuburu, A. Aublin, J. L. Maryanski, and J. C. Zuniga-Pflucker (2004)
J. Immunol. 172, 5230-5239
 |  Abstract »  |  Full Text »  |  PDF »

B cell development and immunoglobulin transcription in Oct-1-deficient mice.

V. E. H. Wang, D. Tantin, J. Chen, and P. A. Sharp (2004)
PNAS 101, 2005-2010
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: A Chemical Genetic System for the Analysis of Kinases Regulating T Cell Development.

A. Denzel, K. J. Hare, C. Zhang, K. Shokat, E. J. Jenkinson, G. Anderson, and A. Hayday (2003)
J. Immunol. 171, 519-523
 |  Abstract »  |  Full Text »  |  PDF »

Recognition of a Specific Self-Peptide: Self-MHC Class II Complex Is Critical for Positive Selection of Thymocytes Expressing the D10 TCR.

T. Dao, J. M. Blander, and D. B. Sant'Angelo (2003)
J. Immunol. 170, 48-54
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms of Pre-T Cell Receptor-induced Survival.

C. Murga and D. F. Barber (2002)
J. Biol. Chem. 277, 39156-39162
 |  Abstract »  |  Full Text »  |  PDF »

Editing Autoreactive TCR Enables Efficient Positive Selection.

F. R. Santori, I. Arsov, M. Lili, and S. Vukmanovic (2002)
J. Immunol. 169, 1729-1734
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the TCR C{beta} FG Loop in Thymic Selection and T Cell Function.

T. Sasada, M. Touma, H.-C. Chang, L. K. Clayton, J.-h. Wang, and E. L. Reinherz (2002)
J. Exp. Med. 195, 1419-1431
 |  Abstract »  |  Full Text »  |  PDF »

A Change in the Structure of V{beta} Chromatin Associated with TCR {beta} Allelic Exclusion.

R. Tripathi, A. Jackson, and M. S. Krangel (2002)
J. Immunol. 168, 2316-2324
 |  Abstract »  |  Full Text »  |  PDF »

CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms.

A. Suto, H. Nakajima, K. Ikeda, S. Kubo, T. Nakayama, M. Taniguchi, Y. Saito, and I. Iwamoto (2002)
Blood 99, 555-560
 |  Abstract »  |  Full Text »  |  PDF »

Integrin Functions Play a Key Role in the Differentiation of Thymocytes In Vivo.

P. J. Schmeissner, H. Xie, L. B. Smilenov, F. Shu, and E. E. Marcantonio (2001)
J. Immunol. 167, 3715-3724
 |  Abstract »  |  Full Text »  |  PDF »

MHC Class I Allele Dosage Alters CD8 Expression by Intestinal Intraepithelial Lymphocytes.

B. S. Podd, C. Aberg, K. L. Kudla, L. Keene, E. Tobias, and V. Camerini (2001)
J. Immunol. 167, 2561-2568
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo.

N. Yannoutsos, P. Wilson, W. Yu, H. T. Chen, A. Nussenzweig, H. Petrie, and M. C. Nussenzweig (2001)
J. Exp. Med. 194, 471-480
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD4+ CD25+ Regulatory T Cells in T Helper 2 Cell-mediated Allergic Inflammation in the Airways.

A. SUTO, H. NAKAJIMA, S.-I. KAGAMI, K. SUZUKI, Y. SAITO, and I. IWAMOTO (2001)
Am. J. Respir. Crit. Care Med. 164, 680-687
 |  Abstract »  |  Full Text »  |  PDF »

Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells.

D. Allman, F. G. Karnell, J. A. Punt, S. Bakkour, L. Xu, P. Myung, G. A. Koretzky, J. C. Pui, J. C. Aster, and W. S. Pear (2001)
J. Exp. Med. 194, 99-106
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of IgE Responses in CD23-Transgenic Animals Is Due to Expression of CD23 on Nonlymphoid Cells.

M. Payet-Jamroz, S. L. T. Helm, J. Wu, M. Kilmon, M. Fakher, A. Basalp, J. G. Tew, A. K. Szakal, N. Noben-Trauth, and D. H. Conrad (2001)
J. Immunol. 166, 4863-4869
 |  Abstract »  |  Full Text »  |  PDF »

A Mucosal IgA-Mediated Excretory Immune System In Vivo.

J. K. Robinson, T. G. Blanchard, A. D. Levine, S. N. Emancipator, and M. E. Lamm (2001)
J. Immunol. 166, 3688-3692
 |  Abstract »  |  Full Text »  |  PDF »

Expression of a V Region-Less B Cell Receptor Confers a Tolerance-Like Phenotype on Transgenic B Cells.

D. Corcos, A. Grandien, A. Vazquez, O. Dunda, P. Lores, and D. Bucchini (2001)
J. Immunol. 166, 3083-3089
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a novel pre-TCR isoform in which the accessibility of the TCR{beta} subunit is determined by occupancy of the `missing' V domain of pre-T{alpha}.

M. A. Berger, M. Carleton, M. Rhodes, J. M. Sauder, S. Trop, R. L. Dunbrack, P. Hugo, and D. L. Wiest (2000)
Int. Immunol. 12, 1579-1591
 |  Abstract »  |  Full Text »  |  PDF »

Functions of E2A-HEB Heterodimers in T-Cell Development Revealed by a Dominant Negative Mutation of HEB.

R. J. Barndt, M. Dai, and Y. Zhuang (2000)
Mol. Cell. Biol. 20, 6677-6685
 |  Abstract »  |  Full Text »  |  PDF »

Early Onset of CD8 Transgene Expression Inhibits the Transition from DN3 to DP Thymocytes.

A. Wack, M. Coles, T. Norton, A. Hostert, and D. Kioussis (2000)
J. Immunol. 165, 1236-1242
 |  Abstract »  |  Full Text »  |  PDF »

Functional Analysis of the Murine TCR{beta}-Chain Gene Enhancer.

I. M. Carvajal and R. Sen (2000)
J. Immunol. 164, 6332-6339
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination.

M. T. McMurry and M. S. Krangel (2000)
Science 287, 495-498
 |  Abstract »  |  Full Text »

Rescue of Defective T Cell Development and Function in Atm-/- Mice by a Functional TCR{alpha}{beta} Transgene.

C. Chao, E. M. Yang, and Y. Xu (2000)
J. Immunol. 164, 345-349
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Signal-Regulated Kinase (Erk) Activation by the Pre-T Cell Receptor in Developing Thymocytes in Vivo.

A. M. Michie, S. Trop, D. L. Wiest, and J. C. Zuniga-Pflucker (1999)
J. Exp. Med. 190, 1647-1656
 |  Abstract »  |  Full Text »  |  PDF »

Class II-Independent Generation of CD4 Memory T Cells from Effectors.

S. L. Swain, H. Hu, and G. Huston (1999)
Science 286, 1381-1383
 |  Abstract »  |  Full Text »

Allelic Exclusion of the T Cell Receptor {beta} Locus Requires the Sh2 Domain-Containing Leukocyte Protein (Slp)-76 Adaptor Protein.

I. Aifantis, V. I. Pivniouk, F. Gartner, J. Feinberg, W. Swat, F. W. Alt, H. von Boehmer, and R. S. Geha (1999)
J. Exp. Med. 190, 1093-1102
 |  Abstract »  |  Full Text »  |  PDF »

Failure of Rearranged TCR Transgenes to Prevent Age-Associated Thymic Involution.

H. D. Lacorazza, J. A. Guevara Patino, M. E. Weksler, and D. Radu (1999)
J. Immunol. 163, 4262-4268
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Role for HEB Downstream or Parallel to the Pre-TCR Signaling Pathway During {alpha}{beta} Thymopoiesis.

R. Barndt, M.-F. Dai, and Y. Zhuang (1999)
J. Immunol. 163, 3331-3343
 |  Abstract »  |  Full Text »  |  PDF »

Unique CD4+ T cells in TCR {alpha} chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process.

R. J. Hayashi and O. Kanagawa (1999)
Int. Immunol. 11, 1581-1590
 |  Abstract »  |  Full Text »  |  PDF »

Pro-B-Cell-Specific Transcription and Proapoptotic Function of Protein Kinase Ceta.

T. A. Morrow, S. A. Muljo, J. Zhang, J. M. Hardwick, and M. S. Schlissel (1999)
Mol. Cell. Biol. 19, 5608-5618
 |  Abstract »  |  Full Text »  |  PDF »

A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4–CD8– to CD4+CD8+ thymocytes.

L. B. King, E. Tolosa, J. M. Lenczowski, F. Lu, E. F. Lind, R. Hunziker, H. T. Petrie, and J. D. Ashwell (1999)
Int. Immunol. 11, 1203-1216
 |  Abstract »  |  Full Text »  |  PDF »

Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma.

M.-J. Liao and T. Van Dyke (1999)
Genes & Dev. 13, 1246-1250
 |  Abstract »  |  Full Text »

In Autoimmune Diabetes the Transition from Benign to Pernicious Insulitis Requires an Islet Cell Response to Tumor Necrosis Factor {alpha}.

S. V. Pakala, M. Chivetta, C. B. Kelly, and J. D. Katz (1999)
J. Exp. Med. 189, 1053-1062
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Fetal Thymocyte Development After Efficient Adenovirus-Mediated Inhibition of NF-{kappa}B Activation.

T. R. Bakker, T. Renno, and C. V. Jongeneel (1999)
J. Immunol. 162, 3456-3462
 |  Abstract »  |  Full Text »  |  PDF »

Differential effects of manipulating signaling in early T cell development in intestinal intraepithelial lymphocytes and thymocytes.

S. T. Page, L. Y. Bogatzki, J. A. Hamerman, M. Malissen, R. M. Perlmutter, and A. M. Pullen (1999)
Int. Immunol. 11, 169-177
 |  Abstract »  |  Full Text »  |  PDF »

Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins.

G. Bain, W. J. Romanow, K. Albers, W. L. Havran, and C. Murre (1999)
J. Exp. Med. 189, 289-300
 |  Abstract »  |  Full Text »  |  PDF »

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity.

H. S. Azzam, A. Grinberg, K. Lui, H. Shen, E. W. Shores, and P. E. Love (1998)
J. Exp. Med. 188, 2301-2311
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning of pTAC12 an Alternative Splicing Product of the CD3gamma Chain as a Component of the Pre-T Cell Antigen-Receptor Complex.

K. Takase, Y. Okazaki, K. Wakizaka, A. Shevchenko, M. Mann, and T. Saito (1998)
J. Biol. Chem. 273, 30675-30679
 |  Abstract »  |  Full Text »  |  PDF »

Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.

Y. Ghendler, M.-k. Teng, J.-h. Liu, T. Witte, J. Liu, K. S. Kim, P. Kern, H.-C. Chang, J.-h. Wang, and E. L. Reinherz (1998)
PNAS 95, 10061-10066
 |  Abstract »  |  Full Text »  |  PDF »

TCR Transgenic Mice in Which Usage of Transgenic {alpha}- and {beta}-Chains Is Highly Dependent on the Level of Selecting Ligand.

G. J. Kersh, D. L. Donermeyer, K. E. Frederick, J. M. White, B. L. Hsu, and P. M. Allen (1998)
J. Immunol. 161, 585-593
 |  Abstract »  |  Full Text »  |  PDF »

Role of {micro} Heavy Chain in B Cell Development. I. Blocked B Cell Maturation But Complete Allelic Exclusion in the Absence of Ig{alpha}/{beta}.

F. E. Cronin, M. Jiang, A. K. Abbas, and S. A. Grupp (1998)
J. Immunol. 161, 252-259
 |  Abstract »  |  Full Text »  |  PDF »

Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase.

S. N. Malek, D. I. Dordai, J. Reim, H. Dintzis, and S. Desiderio (1998)
PNAS 95, 7351-7356
 |  Abstract »  |  Full Text »  |  PDF »

The Trophic Action of IL-7 on Pro-T Cells: Inhibition of Apoptosis of Pro-T1, -T2, and -T3 Cells Correlates with Bcl-2 and Bax Levels and Is Independent of Fas and p53 Pathways.

K. Kim, C.-k. Lee, T. J. Sayers, K. Muegge, and S. K. Durum (1998)
J. Immunol. 160, 5735-5741
 |  Abstract »  |  Full Text »  |  PDF »

Thymocyte Development in the Absence of Pre-T Cell Receptor Extracellular Immunoglobulin Domains.

B. A. Irving, F. W. Alt, and N. Killeen (1998)
Science 280, 905-908
 |  Abstract »  |  Full Text »

One of the CD3{varepsilon} Subunits within a T Cell Receptor Complex Lies in Close Proximity to the C{beta} FG Loop.

Y. Ghendler, A. Smolyar, H.-C. Chang, and E. L. Reinherz (1998)
J. Exp. Med. 187, 1529-1536
 |  Abstract »  |  Full Text »  |  PDF »

Natural and Engineered Disorders of Lymphocyte Development.

A. Fischer and B. Malissen (1998)
Science 280, 237-243
 |  Abstract »  |  Full Text »

Biochemical and Functional Analyses of Chromatin Changes at the TCR-{beta} Gene Locus During CD4-CD8- to CD4+CD8+ Thymocyte Differentiation.

S. Chattopadhyay, C. E. Whitehurst, F. Schwenk, and J. Chen (1998)
J. Immunol. 160, 1256-1267
 |  Abstract »  |  Full Text »  |  PDF »

Subunit Composition of Pre-T Cell Receptor Complexes Expressed by Primary Thymocytes: CD3{delta} Is Physically Associated but Not Functionally Required.

M. A. Berger, V. Dave, M. R. Rhodes, G. C. Bosma, M. J. Bosma, D. J. Kappes, and D. L. Wiest (1997)
J. Exp. Med. 186, 1461-1467
 |  Abstract »  |  Full Text »  |  PDF »

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex-Encoded Molecules.

J. Kirberg, A. Berns, and H. v. Boehmer (1997)
J. Exp. Med. 186, 1269-1275
 |  Abstract »  |  Full Text »  |  PDF »

Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes.

H. Nishina, M. Bachmann, A. J. Oliveira-dos-Santos, I. Kozieradzki, K. D. Fischer, B. Odermatt, A. Wakeham, A. Shahinian, H. Takimoto, A. Bernstein, et al. (1997)
J. Exp. Med. 186, 941-953
 |  Abstract »  |  Full Text »  |  PDF »

Allelic Exclusion in pT{alpha}-deficient Mice: No Evidence for Cell Surface Expression of Two T Cell Receptor (TCR)-{beta} Chains, but Less Efficient Inhibition of Endogeneous V{beta}-> (D)J{beta} Rearrangements in the Presence of a Functional TCR-{beta} Transgene.

A. Krotkova, H. v. Boehmer, and H. J. Fehling (1997)
J. Exp. Med. 186, 767-775
 |  Abstract »  |  Full Text »  |  PDF »

Galectin-1, an Endogenous Lectin Produced by Thymic Epithelial Cells, Induces Apoptosis of Human Thymocytes.

N. L. Perillo, C. H. Uittenbogaart, J. T. Nguyen, and L. G. Baum (1997)
J. Exp. Med. 185, 1851-1858
 |  Abstract »  |  Full Text »  |  PDF »

An enhancer-blocking element between alpha  and delta  gene segments within the human T cell receptor alpha /delta  locus.

X.-P. Zhong and M. S. Krangel (1997)
PNAS 94, 5219-5224
 |  Abstract »  |  Full Text »  |  PDF »

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma..

Y Xu, T Ashley, E E Brainerd, R T Bronson, M S Meyn, and D Baltimore (1996)
Genes & Dev. 10, 2411-2422
 |  Abstract »  |  PDF »

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors..

C J Guidos, C J Williams, I Grandal, G Knowles, M T Huang, and J S Danska (1996)
Genes & Dev. 10, 2038-2054
 |  Abstract »  |  PDF »

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo..

E S Hoffman, L Passoni, T Crompton, T M Leu, D G Schatz, A Koff, M J Owen, and A C Hayday (1996)
Genes & Dev. 10, 948-962
 |  Abstract »  |  PDF »

Analysis and expression of a cloned pre-T cell receptor gene.

C Saint-Ruf, K Ungewiss, M Groettrup, L Bruno, H. Fehling, and H von Boehmer (1994)
Science 266, 1208-1212
 |  Abstract »  |  PDF »

Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents.

J. Danska, F Pflumio, C. Williams, O Huner, J. Dick, and C. Guidos (1994)
Science 266, 450-455
 |  Abstract »  |  PDF »

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice..

E Spanopoulou, C A Roman, L M Corcoran, M S Schlissel, D P Silver, D Nemazee, M C Nussenzweig, S A Shinton, R R Hardy, and D Baltimore (1994)
Genes & Dev. 8, 1030-1042
 |  Abstract »  |  PDF »

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation..

F Young, B Ardman, Y Shinkai, R Lansford, T K Blackwell, M Mendelsohn, A Rolink, F Melchers, and F W Alt (1994)
Genes & Dev. 8, 1043-1057
 |  Abstract »  |  PDF »

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.

A. M. Michie, J.-W. Soh, R. G. Hawley, I. B. Weinstein, and J. C. Zuniga-Pflucker (2001)
PNAS 98, 609-614
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WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development.

J. Zhang, F. Shi, K. Badour, Y. Deng, M. K. H. McGavin, and K. A. Siminovitch (2002)
PNAS 99, 2240-2245
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