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Science 5 February 1993:
Vol. 259. no. 5096, pp. 819 - 821
DOI: 10.1126/science.7679223
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Articles

Science, Vol 259, Issue 5096, 819-821
Copyright © 1993 by American Association for the Advancement of Science

articles

Multiple output channels in the basal ganglia

JE Hoover and PL Strick

Research Service, Veterans Administration Medical Center, Syracuse, NY.

The neural circuits that link the basal ganglia with the cerebral cortex are critically involved in the generation and control of voluntary movement. Retrograde transneuronal transport of herpes simplex virus type 1 was used to examine the organization of connections in the cebus monkey between an output nucleus of the basal ganglia, the internal segment of the globus pallidus (GPi), and three cortical areas: the primary motor cortex, the supplementary motor ara, and the ventral premotor area. Spatially separate regions of the GPi were labeled after virus injections into each cortical area. The GPi projects to multiple cortical motor areas, and this pallidal output is organized into discrete channels. This information provides a new anatomical framework for examining the function of the basal ganglia in skeletomotor control.


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