Science 29 January 1993: Vol. 259. no. 5095, pp. 689 - 692 DOI: 10.1126/science.8430320

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Articles

Leukemia Inhibitory Factor Deficiency Modulates the Immune Response and Limits Autoimmune Demyelination: A New Role for Neurotrophic Cytokines in Neuroinflammation.

R. A. Linker, N. Kruse, S. Israel, T. Wei, S. Seubert, A. Hombach, B. Holtmann, F. Luhder, R. M. Ransohoff, M. Sendtner, et al. (2008)
J. Immunol. 180, 2204-2213
 |  Abstract »  |  Full Text »  |  PDF »

Clinical and Immunopathologic Alterations in Rhesus Macaques Affected with Globoid Cell Leukodystrophy.

J. T. Borda, X. Alvarez, M. Mohan, M. S. Ratterree, K. Phillippi-Falkenstein, A. A. Lackner, and B. A. Bunnell (2008)
Am. J. Pathol. 172, 98-111
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Regulation of Rod Phototransduction Machinery by Ciliary Neurotrophic Factor.

R. Wen, Y. Song, S. Kjellstrom, A. Tanikawa, Y. Liu, Y. Li, L. Zhao, R. A. Bush, A. M. Laties, and P. A. Sieving (2006)
J. Neurosci. 26, 13523-13530
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Continued Administration of Ciliary Neurotrophic Factor Protects Mice from Inflammatory Pathology in Experimental Autoimmune Encephalomyelitis.

T. Kuhlmann, L. Remington, I. Cognet, L. Bourbonniere, S. Zehntner, F. Guilhot, A. Herman, A. Guay-Giroux, J. P. Antel, T. Owens, et al. (2006)
Am. J. Pathol. 169, 584-598
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Effects of Circuit Miniaturization in Reducing Inflammatory Response to Infant Cardiopulmonary Bypass by Elimination of Allogeneic Blood Products.

E. Hickey, T. Karamlou, J. You, and R. M. Ungerleider (2006)
Ann. Thorac. Surg. 81, S2367-S2372
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Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures.

R P Lisak, J A Benjamins, B Bealmear, B Yao, S Land, L Nedelkoska, and D Skundric (2006)
Multiple Sclerosis 12, 149-168
 |  Abstract »  |  PDF »

Differential expression of suppressors of cytokine signaling-1 and -3 and related cytokines in central nervous system during remitting versus non-remitting forms of experimental autoimmune encephalomyelitis.

J. L. Stark and A. H. Cross (2006)
Int. Immunol. 18, 347-353
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Parvovirus Nonstructural Proteins Induce an Epigenetic Modification through Histone Acetylation in Host Genes and Revert Tumor Malignancy to Benignancy.

H. Iseki, R. Shimizukawa, F. Sugiyama, S. Kunita, A. Iwama, M. Onodera, H. Nakauchi, and K.-i. Yagami (2005)
J. Virol. 79, 8886-8893
 |  Abstract »  |  Full Text »  |  PDF »

The pathology of primary progressive multiple sclerosis.

C. Lucchinetti and W. Bruck (2004)
Multiple Sclerosis 10, S23-S30
 |  Abstract »  |  PDF »

Oligodendrocytes and Progenitors Become Progressively Depleted within Chronically Demyelinated Lesions.

J. L. Mason, A. Toews, J. D. Hostettler, P. Morell, K. Suzuki, J. E. Goldman, and G. K. Matsushima (2004)
Am. J. Pathol. 164, 1673-1682
 |  Abstract »  |  Full Text »  |  PDF »

The pathology of primary progressive multiple sclerosis.

C. Lucchinetti and W. Bruck (2004)
Multiple Sclerosis 10, S23-S30
 |  Abstract »  |  PDF »

Glial Reactivity in Ciliary Neurotrophic Factor-Deficient Mice after Optic Nerve Lesion.

A. Martin, H.-D. Hofmann, and M. Kirsch (2003)
J. Neurosci. 23, 5416-5424
 |  Abstract »  |  Full Text »  |  PDF »

Cytokines: Powerful Regulators of Glial Cell Activation.

G. R. John, S. C. Lee, and C. F. Brosnan (2003)
Neuroscientist 9, 10-22
 |  Abstract »  |  PDF »

Ciliary Neurotrophic Factor (CNTF) Enhances Myelin Formation: A Novel Role for CNTF and CNTF-Related Molecules.

B. Stankoff, M.-S. Aigrot, F. Noel, A. Wattilliaux, B. Zalc, and C. Lubetzki (2002)
J. Neurosci. 22, 9221-9227
 |  Abstract »  |  Full Text »  |  PDF »

Cytokines in multiple sclerosis: methodological aspects and pathogenic implications.

V Ozenci, M Kouwenhoven, and H Link (2002)
Multiple Sclerosis 8, 396-404
 |  Abstract »  |  PDF »

Cytokine production in T lymphocyte-microglia interaction is attenuated by glatiramer acetate: a mechanism for therapeutic efficacy in multiple sclerosis.

S Chabot, F P Yong, D M Le, L M Metz, T Myles, and V W Yong (2002)
Multiple Sclerosis 8, 299-306
 |  Abstract »  |  PDF »

The pathology of primary progressive multiple sclerosis.

W Bruck, C Lucchinetti, and H Lassmann (2002)
Multiple Sclerosis 8, 93-97
 |  Abstract »  |  PDF »

The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS.

S. Lehnardt, C. Lachance, S. Patrizi, S. Lefebvre, P. L. Follett, F. E. Jensen, P. A. Rosenberg, J. J. Volpe, and T. Vartanian (2002)
J. Neurosci. 22, 2478-2486
 |  Abstract »  |  Full Text »  |  PDF »

Association of a Null Mutation in the CNTF Gene With Early Onset of Multiple Sclerosis.

R. Giess, M. Maurer, R. Linker, R. Gold, M. Warmuth-Metz, K. V. Toyka, M. Sendtner, and P. Rieckmann (2002)
Arch Neurol 59, 407-409
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor Receptor Deletion Reduces Nuclear Factor-{kappa}B Activation, Cellular Inhibitor of Apoptosis Protein 2 Expression, and Functional Recovery after Traumatic Spinal Cord Injury.

G.-M. Kim, J. Xu, J. Xu, S.-K. Song, P. Yan, G. Ku, X. M. Xu, and C. Y. Hsu (2001)
J. Neurosci. 21, 6617-6625
 |  Abstract »  |  Full Text »  |  PDF »

Tumor necrosis factor-{alpha} induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface.

K. Hallermalm, K. Seki, C. Wei, C. Castelli, L. Rivoltini, R. Kiessling, and J. Levitskaya (2001)
Blood 98, 1108-1115
 |  Abstract »  |  Full Text »  |  PDF »

The vulnerable oligodendrocyte: Inflammatory observations on a cause of cerebral palsy.

M. J. Noetzel and J. E. Brunstrom (2001)
Neurology 56, 1254-1255
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Inflammatory cytokines in the pathogenesis of periventricular leukomalacia.

H. Kadhim, B. Tabarki, G. Verellen, C. De Prez, A.-M. Rona, and G. Sebire (2001)
Neurology 56, 1278-1284
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-11 Mediates Oligodendrocyte Cell Death and Pathogenesis of Autoimmune-mediated Demyelination.

S. Hisahara, J. Yuan, T. Momoi, H. Okano, and M. Miura (2001)
J. Exp. Med. 193, 111-122
 |  Abstract »  |  Full Text »  |  PDF »

Akt-Mediated Survival of Oligodendrocytes Induced by Neuregulins.

A. I. Flores, B. S. Mallon, T. Matsui, W. Ogawa, A. Rosenzweig, T. Okamoto, and W. B. Macklin (2000)
J. Neurosci. 20, 7622-7630
 |  Abstract »  |  Full Text »  |  PDF »

Central Nervous System-Initiated Inflammation and Neurotrophism in Trauma: IL-1{beta} Is Required for the Production of Ciliary Neurotrophic Factor.

L. M. Herx, S. Rivest, and V. W. Yong (2000)
J. Immunol. 165, 2232-2239
 |  Abstract »  |  Full Text »  |  PDF »

Neuroprotection by Encephalomyelitis: Rescue of Mechanically Injured Neurons and Neurotrophin Production by CNS-Infiltrating T and Natural Killer Cells.

H. Hammarberg, O. Lidman, C. Lundberg, S. Y. Eltayeb, A. W. Gielen, S. Muhallab, A. Svenningsson, H. Linda, P. H. van der Meide, S. Cullheim, et al. (2000)
J. Neurosci. 20, 5283-5291
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor Requires Concurrent p75LNTR Signaling to Induce Apoptosis of Cultured Sympathetic Neurons.

S. I. Savitz and J. A. Kessler (2000)
J. Neurosci. 20, 4198-4205
 |  Abstract »  |  Full Text »  |  PDF »

AMPA-Kainate Subtypes of Glutamate Receptor in Rat Cerebral Microglia.

M. Noda, H. Nakanishi, J. Nabekura, and N. Akaike (2000)
J. Neurosci. 20, 251-258
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Neurotransplantation of magnetically labeled oligodendrocyte progenitors: Magnetic resonance tracking of cell migration and myelination.

J. W. M. Bulte, S.-C. Zhang, P. van Gelderen, V. Herynek, E. K. Jordan, I. D. Duncan, and J. A. Frank (1999)
PNAS 96, 15256-15261
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Oligodendrocyte Apoptosis by Sublytic C5b-9 Is Associated with Enhanced Synthesis of Bcl-2 and Mediated by Inhibition of Caspase-3 Activation.

L. Soane, H. Rus, F. Niculescu, and M. L. Shin (1999)
J. Immunol. 163, 6132-6138
 |  Abstract »  |  Full Text »  |  PDF »

Activation of NF-{kappa}B and c-jun Transcription Factors in Multiple Sclerosis Lesions : Implications for Oligodendrocyte Pathology.

B. Bonetti, C. Stegagno, B. Cannella, N. Rizzuto, G. Moretto, and C. S. Raine (1999)
Am. J. Pathol. 155, 1433-1438
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Mitogen-Activated Protein Kinases by Sphingolipid Products in Oligodendrocytes.

H. Hida, S. Nagano, M. Takeda, and B. Soliven (1999)
J. Neurosci. 19, 7458-7467
 |  Abstract »  |  Full Text »  |  PDF »

Brain Damage in Preterm Newborns: Might Enhancement of Developmentally Regulated Endogenous Protection Open a Door for Prevention?.

O. Dammann and A. Leviton (1999)
Pediatrics 104, 541-550
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-Like Growth Factor I Protects Oligodendrocytes from Tumor Necrosis Factor-{alpha}-Induced Injury.

P. Ye and A. J. D’Ercole (1999)
Endocrinology 140, 3063-3072
 |  Abstract »  |  Full Text »

Mechanisms of IL-10 Production in Human Microglia-T Cell Interaction.

S. Chabot, G. Williams, M. Hamilton, G. Sutherland, and V. W. Yong (1999)
J. Immunol. 162, 6819-6828
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide Inhibits Inwardly Rectifying K+ Currents via a Ras- and Raf-1-Dependent Pathway in Cultured Oligodendrocytes.

H. Hida, M. Takeda, and B. Soliven (1998)
J. Neurosci. 18, 8712-8719
 |  Abstract »  |  Full Text »  |  PDF »

Late-Onset Chronic Inflammatory Encephalopathy in Immune-Competent and Severe Combined Immune-Deficient (SCID) Mice with Astrocyte-Targeted Expression of Tumor Necrosis Factor.

A. K. Stalder, M. J. Carson, A. Pagenstecher, V. C. Asensio, C. Kincaid, M. Benedict, H. C. Powell, E. Masliah, and I. L. Campbell (1998)
Am. J. Pathol. 153, 767-783
 |  Abstract »  |  Full Text »  |  PDF »

A Bidirectional Regulation between the TR2/TR4 Orphan Receptors (TR2/TR4) and the Ciliary Neurotrophic Factor (CNTF) Signaling Pathway.

W.-J. Young, Y.-F. Lee, S. M. Smith, and C. Chang (1998)
J. Biol. Chem. 273, 20877-20885
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophin-3 and Brain-Derived Neurotrophic Factor Induce Oligodendrocyte Proliferation and Myelination of Regenerating Axons in the Contused Adult Rat Spinal Cord.

D. M. McTigue, P. J. Horner, B. T. Stokes, and F. H. Gage (1998)
J. Neurosci. 18, 5354-5365
 |  Abstract »  |  Full Text »  |  PDF »

Are there indicators of remyelination in blood or CSF of multiple sclerosis patients?.

A R Massaro (1998)
Multiple Sclerosis 4, 228-231
 |  Abstract »  |  PDF »

Cerebrospinal fluid markers in multiple sclerosis: an overview.

A R Massaro and P Tonali (1998)
Multiple Sclerosis 4, 1-4
 |  Abstract »  |  PDF »

Phenotypic Alteration of Astrocytes Induced by Ciliary Neurotrophic Factor in the Intact Adult Brain, As Revealed by Adenovirus-Mediated Gene Transfer.

F. Lisovoski, S. Akli, E. Peltekian, E. Vigne, G. Haase, M. Perricaudet, P. A. Dreyfus, A. Kahn, and M. Peschanski (1997)
J. Neurosci. 17, 7228-7236
 |  Abstract »  |  Full Text »  |  PDF »

Agonistic and Antagonistic Variants of Ciliary Neurotrophic Factor (CNTF) Reveal Functional Differences between Membrane-bound and Soluble CNTF alpha -Receptor.

A. Di Marco, I. Gloaguen, A. Demartis, I. Saggio, R. Graziani, G. Paonessa, and R. Laufer (1997)
J. Biol. Chem. 272, 23069-23075
 |  Abstract »  |  Full Text »  |  PDF »

The In Vivo Time Course for Elimination of Adrenalectomy-Induced Apoptotic Profiles from the Granule Cell Layer of the Rat Hippocampus.

Z. Hu, K. Yuri, H. Ozawa, H. Lu, and M. Kawata (1997)
J. Neurosci. 17, 3981-3989
 |  Abstract »  |  Full Text »  |  PDF »

Astrogliosis in the Neonatal and Adult Murine Brain Post-Trauma: Elevation of Inflammatory Cytokines and the Lack of Requirement for Endogenous Interferon-gamma.

M. Rostworowski, V. Balasingam, S. Chabot, T. Owens, and V. W. Yong (1997)
J. Neurosci. 17, 3664-3674
 |  Abstract »  |  Full Text »  |  PDF »

Axonal Neuregulin Signals Cells of the Oligodendrocyte Lineage through Activation of HER4 and Schwann Cells through HER2 and HER3.

T. Vartanian, A. Goodearl, A. Viehover, and G. Fischbach (1997)
J. Cell Biol. 137, 211-220
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of p75 Tumor Necrosis Factor Receptor by Antisense Oligonucleotides Increases Hypoxic Injury and beta -Amyloid Toxicity in Human Neuronal Cell Line.

Y. Shen, R. Li, and K. Shiosaki (1997)
J. Biol. Chem. 272, 3550-3553
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death.

S. D. D'Souza, B. Bonetti, V. Balasingam, N. R. Cashman, P. A. Barker, A. B. Troutt, C. S. Raine, and J. P. Antel (1996)
J. Exp. Med. 184, 2361-2370
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Cocaine on the JAK-STAT Pathway in the Mesolimbic Dopamine System.

M. T. Berhow, N. Hiroi, L. A. Kobierski, S. E. Hyman, and E. J. Nestler (1996)
J. Neurosci. 16, 8019-8026
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Apoptosis by Pyrrolidinedithiocarbamate and N-Acetylcysteine in Vascular Smooth Muscle Cells.

J.-C. Tsai, M. Jain, C.-M. Hsieh, W.-S. Lee, M. Yoshizumi, C. Patterson, M. A. Perrella, C. Cooke, H. Wang, E. Haber, et al. (1996)
J. Biol. Chem. 271, 3667-3670
 |  Abstract »  |  Full Text »  |  PDF »

Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival.

G. Vemuri and F. McMorris (1996)
Development 122, 2529-2537
 |  Abstract »  |  PDF »

Erythropoietin-dependent Inhibition of Apoptosis Is Supported by Carboxyl-truncated Receptor Forms and Blocked by Dominant-negative Forms of Jak2.

H. Zhuang, Z. Niu, T.-C. He, S. V. Patel, and D. M. Wojchowski (1995)
J. Biol. Chem. 270, 14500-14504
 |  Abstract »  |  Full Text »  |  PDF »

Astroglial control of oligodendrocyte survival mediated by PDGF and leukemia inhibitory factor-like protein.

A. Gard, M. Burrell, S. Pfeiffer, J. Rudge, and W. Williams (1995)
Development 121, 2187-2197
 |  Abstract »  |  PDF »

Binding Characteristics of Ciliary Neurotrophic Factor to Sympathetic Neurons and Neuronal Cell Lines.

V. Wong, D. Pearsall, R. Arriaga, N. Y. Ip, N. Stahl, and R. M. Lindsay (1995)
J. Biol. Chem. 270, 313-318
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis of the midline glia during Drosophila embryogenesis: a correlation with axon contact.

M. Sonnenfeld and J. Jacobs (1995)
Development 121, 569-578
 |  Abstract »  |  PDF »

A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development.

B. Barres, M. Lazar, and M. Raff (1994)
Development 120, 1097-1108
 |  Abstract »  |  PDF »

Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro.

M Mayer, K Bhakoo, and M Noble (1994)
Development 120, 143-153
 |  Abstract »  |  PDF »

Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus.

A Bonni, D. Frank, C Schindler, and M. Greenberg (1993)
Science 262, 1575-1579
 |  Abstract »  |  PDF »

Programmed cell death and the control of cell survival: lessons from the nervous system.

M. Raff, B. Barres, J. Burne, H. Coles, Y Ishizaki, and M. Jacobson (1993)
Science 262, 695-700
 |  Abstract »  |  PDF »

Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.

J. Conover, N. Ip, W. Poueymirou, B Bates, M. Goldfarb, T. DeChiara, and G. Yancopoulos (1993)
Development 119, 559-565
 |  Abstract »  |  PDF »

Nerve Growth Factor Protects Oligodendrocytes from Tumor Necrosis Factor-alpha -induced Injury through Akt-mediated Signaling Mechanisms.

R. Takano, S. Hisahara, K. Namikawa, H. Kiyama, H. Okano, and M. Miura (2000)
J. Biol. Chem. 275, 16360-16365
 |  Abstract »  |  Full Text »  |  PDF »

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