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Science 29 January 1993:
Vol. 259. no. 5095, pp. 633 - 638
DOI: 10.1126/science.8381558
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Articles

Science, Vol 259, Issue 5095, 633-638
Copyright © 1993 by American Association for the Advancement of Science

articles

Hormonal chemoprevention of cancer in women

BE Henderson, RK Ross, and MC Pike

Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033.

The use of oral contraceptives in the United States during the past three decades has led to a dramatic decline in the incidence of cancers of the ovary and endometrium. The magnitude of these declines was predictable both from epidemiologic data and from the biologic effects of oral contraceptives on these tissues. Although the incidence of breast cancer has not been substantially affected by current oral contraceptives, it may be possible to develop alternative forms of contraception that provide protection against all three cancers. The major goal of hormonal chemoprevention of cancer is to reduce cell proliferation in the relevant epithelial tissue. New chemopreventive agents such as tamoxifen exemplify the application of this principle.


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Proceedings of the British Toxicology Society Annual Congress University of Surrey, Guildford 19 - 22 April 1998.
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Human and Experimental Toxicology 17, 469-534
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Bibliography.
(1998)
Current Sociology 46, 128-144
Effect of Dehydroepiandrosterone on Bone Mass, Serum Lipids, and Dimethylbenz(a)anthracene-Induced Mammary Carcinoma in the Rat.
S. Luo, C. Labrie, A. Belanger, and F. Labrie (1997)
Endocrinology 138, 3387-3394
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Negative Interaction between the RelA(p65) Subunit of NF-kappaB and the Progesterone Receptor.
E. Kalkhoven, S. Wissink, P. T. van der Saag, and B. van der Burg (1996)
J. Biol. Chem. 271, 6217-6224
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Organochlorine Residues and Risk of Breast Cancer.
D. L. Houghton and L. Ritter (1995)
International Journal of Toxicology 14, 71-89
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Breast-Feeding and Breast Cancer.
S. J. London, A. B. Mutgi, D. L. Fenster, R. K. Ross, M. C. Yu, P. A. Newcomb, B. E. Storer, and M. P. Longnecker (1994)
N. Engl. J. Med. 330, 1682-1684
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