Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 22 January 1993:
Vol. 259. no. 5094, pp. 531 - 534
DOI: 10.1126/science.8380942
Prev | Table of Contents | Next

Articles

Science, Vol 259, Issue 5094, 531-534
Copyright © 1993 by American Association for the Advancement of Science

articles

GABA-activated chloride channels in secretory nerve endings

SJ Zhang and MB Jackson

Department of Physiology, University of Wisconsin Medical School, Madison 53706.

Neurotransmitters acting on presynaptic terminals regulate synaptic transmission and plasticity. Because of the difficulty of direct electrophysiological recording from small presynaptic terminals, little is known about the ion channels that mediate these actions or about the mechanisms by which transmitter secretion is altered. The patch-clamp technique is used to show that the predominant inhibitory presynaptic neurotransmitter, gamma-aminobutyric acid (GABA), activates a GABAA receptor and gates a chloride channel in the membranes of peptidergic nerve terminals of the posterior pituitary. The opening of a chloride channel by GABA weakly depolarizes the nerve terminal membrane and blocks action potentials. In this way, GABA limits secretion by retarding the spread of excitation into the terminal arborization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
P. Long, A. Mercer, R. Begum, G. J. Stephens, T. S. Sihra, and J. N. Jovanovic (2009)
J. Biol. Chem. 284, 8726-8737
   Abstract »    Full Text »    PDF »
GABAA Receptor {alpha}5 Subunits Contribute to GABAA,slow Synaptic Inhibition in Mouse Hippocampus.
E. D. Zarnowska, R. Keist, U. Rudolph, and R. A. Pearce (2009)
J Neurophysiol 101, 1179-1191
   Abstract »    Full Text »    PDF »
Contributions of Voltage- and Ca2+-Activated Conductances to GABA-Induced Depolarization in Spider Mechanosensory Neurons.
I. Panek, U. Hoger, A. S. French, and P. H. Torkkeli (2008)
J Neurophysiol 99, 1596-1606
   Abstract »    Full Text »    PDF »
Enhancement of GABA Release through Endogenous Activation of Axonal GABAA Receptors in Juvenile Cerebellum.
F. F. Trigo, M. Chat, and A. Marty (2007)
J. Neurosci. 27, 12452-12463
   Abstract »    Full Text »    PDF »
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations.
Y. Ben-Ari, J.-L. Gaiarsa, R. Tyzio, and R. Khazipov (2007)
Physiol Rev 87, 1215-1284
   Abstract »    Full Text »    PDF »
Activation of Presynaptic GABAA Receptors Induces Glutamate Release from Parallel Fiber Synapses.
B. M. Stell, P. Rostaing, A. Triller, and A. Marty (2007)
J. Neurosci. 27, 9022-9031
   Abstract »    Full Text »    PDF »
GABAergic Spill-Over Transmission onto Hippocampal Mossy Fiber Boutons.
H. Alle and J. R. P. Geiger (2007)
J. Neurosci. 27, 942-950
   Abstract »    Full Text »    PDF »
Estimate of the chloride concentration in a central glutamatergic terminal: a gramicidin perforated-patch study on the calyx of held..
G. D. Price and L. O. Trussell (2006)
J. Neurosci. 26, 11432-11436
   Abstract »    Full Text »    PDF »
Cortical Injury Affects Short-Term Plasticity of Evoked Excitatory Synaptic Currents.
H. Li, A. E. Bandrowski, and D. A. Prince (2005)
J Neurophysiol 93, 146-156
   Abstract »    Full Text »    PDF »
Etomidate elevates intracellular calcium levels and promotes catecholamine secretion in bovine chromaffin cells.
Z Xie, K. P. M Currie, and A. P Fox (2004)
J. Physiol. 560, 677-690
   Abstract »    Full Text »    PDF »
Role of Cl- Co-Transporters in the Excitation Produced by GABAA Receptors in Juvenile Bovine Adrenal Chromaffin Cells.
Z. Xie, K.P.M. Currie, A. L. Cahill, and A. P. Fox (2003)
J Neurophysiol 90, 3828-3837
   Abstract »    Full Text »    PDF »
Coexistence of Excitatory and Inhibitory GABA Synapses in the Cerebellar Interneuron Network.
J. Chavas and A. Marty (2003)
J. Neurosci. 23, 2019-2031
   Abstract »    Full Text »    PDF »
Accommodation Enhances Depolarizing Inhibition in Central Neurons.
P. Monsivais and E. W Rubel (2001)
J. Neurosci. 21, 7823-7830
   Abstract »    Full Text »    PDF »
Activation of GABAA Receptors in Subthalamic Neurons In Vitro: Properties of Native Receptors and Inhibition Mechanisms.
J. Baufreton, M. Garret, S. Dovero, B. Dufy, B. Bioulac, and A. Taupignon (2001)
J Neurophysiol 86, 75-85
   Abstract »    Full Text »    PDF »
Neurobiological Mechanisms of the Onset of Puberty in Primates.
E. Terasawa and D. L. Fernandez (2001)
Endocr. Rev. 22, 111-151
   Abstract »    Full Text »
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release.
A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff (1999)
Physiol Rev 79, 1019-1088
   Abstract »    Full Text »    PDF »
Noninvasive Measurements of the Membrane Potential and GABAergic Action in Hippocampal Interneurons.
J. A. H. Verheugen, D. Fricker, and R. Miles (1999)
J. Neurosci. 19, 2546-2555
   Abstract »    Full Text »    PDF »
Somatic Recording of GABAergic Autoreceptor Current in Cerebellar Stellate and Basket Cells.
C. Pouzat and A. Marty (1999)
J. Neurosci. 19, 1675-1690
   Abstract »    Full Text »    PDF »
Differential Blockade of gamma -Aminobutyric Acid Type A Receptors by the Neuroactive Steroid Dehydroepiandrosterone Sulfate in Posterior and Intermediate Pituitary.
S. L. Hansen, B. Fjalland, and M. B. Jackson (1999)
Mol. Pharmacol. 55, 489-496
   Abstract »    Full Text »
A Depolarizing Chloride Current Contributes to Chemoelectrical Transduction in Olfactory Sensory Neurons In Situ.
D. Reuter, K. Zierold, W. H. Schroder, and S. Frings (1998)
J. Neurosci. 18, 6623-6630
   Abstract »    Full Text »    PDF »
Presynaptic Afferent Inhibition of Lobster Olfactory Receptor Cells: Reduced Action-Potential Propagation Into Axon Terminals.
M. Wachowiak and L. B. Cohen (1998)
J Neurophysiol 80, 1011-1015
   Abstract »    Full Text »    PDF »
Expression of functional GABAA receptors in cholecystokinin-secreting gut neuroendocrine murine STC-1 cells.
G Glassmeier, K-H Herzig, M Hopfner, K Lemmer, A Jansen, and H Scherubl (1998)
J. Physiol. 510, 805-814
   Abstract »    Full Text »    PDF »
GABAA Receptor-Mediated Cl- Currents in Rat Thalamic Reticular and Relay Neurons.
S. J. Zhang, J. R. Huguenard, and D. A. Prince (1997)
J Neurophysiol 78, 2280-2286
   Abstract »    Full Text »    PDF »
GABA-Activated Conductance in Cultured Rat Inferior Colliculus Neurons.
H. Hosomi, M. Mori, M. Amatsu, and Y. Okada (1997)
J Neurophysiol 77, 994-1002
   Abstract »    Full Text »    PDF »
Modulation of Conduction Block in Leech Mechanosensory Neurons.
A. Mar and P. Drapeau (1996)
J. Neurosci. 16, 4335-4343
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)