Science 22 January 1993: Vol. 259. no. 5094, pp. 519 - 522 DOI: 10.1126/science.8424175

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Articles

Inhibition of de novo ceramide synthesis upregulates phospholipase D and enhances myogenic differentiation.

S. Mebarek, H. Komati, F. Naro, C. Zeiller, M. Alvisi, M. Lagarde, A.-F. Prigent, and G. Nemoz (2007)
J. Cell Sci. 120, 407-416
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Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent..

V E MacRae, T Burdon, S F Ahmed, and C Farquharson (2006)
J. Endocrinol. 191, 369-377
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CD161 (Human NKR-P1A) Signaling in NK Cells Involves the Activation of Acid Sphingomyelinase.

D. Pozo, M. Vales-Gomez, N. Mavaddat, S. C. Williamson, S. E. Chisholm, and H. Reyburn (2006)
J. Immunol. 176, 2397-2406
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Physiological and pathophysiological aspects of ceramide.

E. Gulbins and P. L. Li (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R11-R26
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The pathophysiology of the growth plate in juvenile idiopathic arthritis.

V. E. MacRae, C. Farquharson, and S. F. Ahmed (2006)
Rheumatology 45, 11-19
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Proinflammatory Cytokine Impairment of Insulin-Like Growth Factor I-Induced Protein Synthesis in Skeletal Muscle Myoblasts Requires Ceramide.

K. Strle, S. R. Broussard, R. H. McCusker, W.-H. Shen, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley (2004)
Endocrinology 145, 4592-4602
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Ceramide Inhibits IL-2 Production by Preventing Protein Kinase C-Dependent NF-{kappa}B Activation: Possible Role in Protein Kinase C{theta} Regulation.

N. Abboushi, A. El-Hed, W. El-Assaad, L. Kozhaya, M. E. El-Sabban, A. Bazarbachi, R. Badreddine, A. Bielawska, J. Usta, and G. S. Dbaibo (2004)
J. Immunol. 173, 3193-3200
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Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl-.

K. S. Lang, S. Myssina, P. A. Lang, V. Tanneur, D. S. Kempe, A. F. Mack, S. M. Huber, T. Wieder, F. Lang, and C. Duranton (2004)
Am J Physiol Renal Physiol 286, F1046-F1053
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Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx.

S. J. Liu and R. H. Kennedy (2003)
Am J Physiol Heart Circ Physiol 285, H735-H744
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Significant Role of Ceramide Pathway in Experimental Gastric Ulcer Formation in Rats.

K. Uehara, S. Miura, T. Takeuchi, T. Taki, M. Nakashita, M. Adachi, T. Inamura, T. Ogawa, Y. Akiba, H. Suzuki, et al. (2003)
J. Pharmacol. Exp. Ther. 305, 232-239
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Role of ceramide in TNF-alpha -induced impairment of endothelium-dependent vasorelaxation in coronary arteries.

D. X. Zhang, F.-X. Yi, A.-P. Zou, and P.-L. Li (2002)
Am J Physiol Heart Circ Physiol 283, H1785-H1794
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Ceramide-induced Inhibition of Akt Is Mediated through Protein Kinase Czeta . IMPLICATIONS FOR GROWTH ARREST.

N. A. Bourbon, L. Sandirasegarane, and M. Kester (2002)
J. Biol. Chem. 277, 3286-3292
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Inhibitory actions of ceramide upon PKC-{epsilon}/ERK interactions.

N. A. Bourbon, J. Yun, D. Berkey, Y. Wang, and M. Kester (2001)
Am J Physiol Cell Physiol 280, C1403-C1411
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Synthetic Phytoceramides Induce Apoptosis with Higher Potency than Ceramides.

O. Hwang, G. Kim, Y. J. Jang, S. W. Kim, G. Choi, H. J. Choi, S. Y. Jeon, D. G. Lee, and J. D. Lee (2001)
Mol. Pharmacol. 59, 1249-1255
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Subtype-Specific Translocation of the {delta} Subtype of Protein Kinase C and Its Activation by Tyrosine Phosphorylation Induced by Ceramide in HeLa Cells.

T. Kajimoto, S. Ohmori, Y. Shirai, N. Sakai, and N. Saito (2001)
Mol. Cell. Biol. 21, 1769-1783
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Raf-induced Transformation Requires an Interleukin 1 Autocrine Loop.

T. Vale, T. T. Ngo, M. A. White, and P. E. Lipsky (2001)
Cancer Res. 61, 602-607
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Ceramide-Induced TCR Up-Regulation.

C. Menne, J. P. H. Lauritsen, J. Dietrich, J. Kastrup, A.-M. K. Wegener, N. Odum, and C. Geisler (2000)
J. Immunol. 165, 3065-3072
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Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor.

W. J. Friedman (2000)
J. Neurosci. 20, 6340-6346
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Proinflammatory Cytokines.

C. A. Dinarello (2000)
Chest 118, 503-508
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Mass Spectrometric Identification of Increased C16 Ceramide Levels During Apoptosis.

R. L. Thomas Jr., C. M. Matsko, M. T. Lotze, and A. A. Amoscato (1999)
J. Biol. Chem. 274, 30580-30588
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Costimulatory action of glycoinositolphospholipids from Trypanosoma cruzi: increased interleukin 2 secretion and induction of nuclear translocation of the nuclear factor of activated T cells 1.

M. BELLIO, A.-C. S. C. O LIVEIRA, C. S. MERMELSTEIN, M. A. M. CAPELLA, J. P. B. VIOLA, J.-P. LEVRAUD, G. A. DOSREIS, J. O. PREVIATO, and L. MENDONÇA-PREVIATO (1999)
FASEB J 13, 1627-1636
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Role of Sphingosine 1-Phosphate in the Mitogenesis Induced by Oxidized Low Density Lipoprotein in Smooth Muscle Cells via Activation of Sphingomyelinase, Ceramidase, and Sphingosine Kinase.

N. Auge, M. Nikolova-Karakashian, S. Carpentier, S. Parthasarathy, A. Negre-Salvayre, R. Salvayre, A. H. Merrill Jr., and T. Levade (1999)
J. Biol. Chem. 274, 21533-21538
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Effect of Ceramide on KCa Channel Activity and Vascular Tone in Coronary Arteries.

P.-L. Li, D. X. Zhang, A.-P. Zou, and W. B. Campbell (1999)
Hypertension 33, 1441-1446
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A Role for Neutral Sphingomyelinase-mediated Ceramide Production in T Cell Receptor-induced Apoptosis and Mitogen-activated Protein Kinase-mediated Signal Transduction.

L. Tonnetti, M.-C. Veri, E. Bonvini, and L. D'Adamio (1999)
J. Exp. Med. 189, 1581-1589
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A Novel Pathway for Tumor Necrosis Factor-alpha and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, p21ras, and Phosphatidylinositol 3-Kinase.

A. N. Hanna, E. Y. W. Chan, J. Xu, J. C. Stone, and D. N. Brindley (1999)
J. Biol. Chem. 274, 12722-12729
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Bradykinin inhibits ceramide production and activates phospholipase D in rabbit cortical collecting duct cells.

G. Liu, L. Kleine, R. Nasrallah, and R. L. Hebert (1999)
Am J Physiol Renal Physiol 276, F589-F598
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Role of Ceramide in Lipopolysaccharide (LPS)-induced Signaling. LPS INCREASES CERAMIDE RATHER THAN ACTING AS A STRUCTURAL HOMOLOG.

M. L. MacKichan and A. L. DeFranco (1999)
J. Biol. Chem. 274, 1767-1775
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Involvement of Sphingomyelin Hydrolysis and the Mitogen-Activated Protein Kinase Cascade in the Delta 9-Tetrahydrocannabinol-Induced Stimulation of Glucose Metabolism in Primary Astrocytes.

C. Sánchez, I. Galve-Roperh, D. Rueda, and M. Guzmán (1998)
Mol. Pharmacol. 54, 834-843
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Proapoptotic Activity of a Trypanosoma cruzi Ceramide-Containing Glycolipid Turned on in Host Macrophages by IFN-{gamma}.

C. G. Freire-de-Lima, M. P. Nunes, S. Corte-Real, M. P. Soares, J. O. Previato, L. Mendonca-Previato, and G. A. DosReis (1998)
J. Immunol. 161, 4909-4916
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TNF-alpha -induced endothelium-independent vasodilation: a role for phospholipase A2-dependent ceramide signaling.

D. G. Johns and R. C. Webb (1998)
Am J Physiol Heart Circ Physiol 275, H1592-H1598
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic GMP and cGMP-binding Phosphodiesterase Are Required for Interleukin-1-induced Nitric Oxide Synthesis in Human Articular Chondrocytes.

Y. Geng, L. Zhou, W. J. Thompson, and M. Lotz (1998)
J. Biol. Chem. 273, 27484-27491
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Cardiac Fibroblasts Arrest at the G1/S Restriction Point in Response to Interleukin (IL)-1beta . EVIDENCE FOR IL-1beta -INDUCED HYPOPHOSPHORYLATION OF THE RETINOBLASTOMA PROTEIN.

F. Koudssi, J. E. Lopez, S. Villegas, and C. S. Long (1998)
J. Biol. Chem. 273, 25796-25803
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Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha , as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells.

N. Mizushima, H. Kohsaka, and N. Miyasaka (1998)
Ann Rheum Dis 57, 495-499
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Increases in Neutral, Mg2+-Dependent and Acidic, Mg2+-Independent Sphingomyelinase Activities Precede Commitment to Apoptosis and Are Not a Consequence of Caspase 3-Like Activity in Molt-4 Cells in Response to Thymidylate Synthase Inhibition by GW1843.

R. M. Laethem, Y. A. Hannun, S. Jayadev, C. J. Sexton, J. C. Strum, R. Sundseth, and G. K. Smith (1998)
Blood 91, 4350-4360
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Sphingomyelinase has an insulin-like effect on glucose transporter translocation in adipocytes.

T. S. David, P. A. Ortiz, T. R. Smith, and J. Turinsky (1998)
Am J Physiol Regulatory Integrative Comp Physiol 274, R1446-R1453
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Activation of p21-CDC42/Rac-Activated Kinases by CD28 Signaling: p21-Activated Kinase (PAK) and MEK Kinase 1 (MEKK1) May Mediate the Interplay Between CD3 and CD28 Signals.

S. Kaga, S. Ragg, K. A. Rogers, and A. Ochi (1998)
J. Immunol. 160, 4182-4189
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Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?.

S. Tomiuk, K. Hofmann, M. Nix, M. Zumbansen, and W. Stoffel (1998)
PNAS 95, 3638-3643
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Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death. INHIBITORY EFFECTS OF Bcl-2 ON CERAMIDE FORMATION AND CASPASE-3 ACTIVATION.

S.-i. Yoshimura, Y. Banno, S. Nakashima, K. Takenaka, H. Sakai, Y. Nishimura, N. Sakai, S. Shimizu, Y. Eguchi, Y. Tsujimoto, et al. (1998)
J. Biol. Chem. 273, 6921-6927
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Tumor Necrosis Factor-alpha Stimulates the Maturation of Sterol Regulatory Element Binding Protein-1 in Human Hepatocytes through the Action of Neutral Sphingomyelinase.

J. F. Lawler Jr., M. Yin, A. M. Diehl, E. Roberts, and S. Chatterjee (1998)
J. Biol. Chem. 273, 5053-5059
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Role of sphingolipid-mediated cell death in neurodegenerative diseases.

T. Ariga, W. D. Jarvis, and R. K. Yu (1998)
J. Lipid Res. 39, 1-16
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Ceramide Stimulates Prostaglandin Production by Human Amnion and Decidual Cells.

S. S. Edwin, M. D. Mitchell, R. M. Silver, D. W. Branch, and D. J. Dudley (1997)
Reproductive Sciences 4, 274-278
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Activation of Acid Sphingomyelinase by Interleukin-1 (IL-1) Requires the IL-1 Receptor Accessory Protein.

R. Hofmeister, K. Wiegmann, C. Korherr, K. Bernardo, M. Kronke, and W. Falk (1997)
J. Biol. Chem. 272, 27730-27736
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Bimodal Regulation of Ceramidase by Interleukin-1beta . IMPLICATIONS FOR THE REGULATION OF CYTOCHROME P450 2C11 (CYP2C11).

M. Nikolova-Karakashian, E. T. Morgan, C. Alexander, D. C. Liotta, and A. H. Merrill Jr. (1997)
J. Biol. Chem. 272, 18718-18724
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Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione.

B. Liu and Y. A. Hannun (1997)
J. Biol. Chem. 272, 16281-16287
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Anti-immunoglobulin-induced Apoptosis in WEHI 231Cells Involves the Slow Formation of Ceramide from Sphingomyelin and Is Blocked by bcl-xL.

D. A. Wiesner, J. P. Kilkus, A. R. Gottschalk, J. Quintans, and G. Dawson (1997)
J. Biol. Chem. 272, 9868-9876
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1alpha ,25-Dihydroxyvitamin D3 Induces Sphingomyelin Hydrolysis in HaCaT Cells via Tumor Necrosis Factor alpha.

C. C. Geilen, M. Bektas, T. Wieder, V. Kodelja, S. Goerdt, and C. E. Orfanos (1997)
J. Biol. Chem. 272, 8997-9001
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TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase.

K. Shirakabe, K. Yamaguchi, H. Shibuya, K. Irie, S. Matsuda, T. Moriguchi, Y. Gotoh, K. Matsumoto, and E. Nishida (1997)
J. Biol. Chem. 272, 8141-8144
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Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins..

R Perona, S Montaner, L Saniger, I Sanchez-Perez, R Bravo, and J C Lacal (1997)
Genes & Dev. 11, 463-475
 |  Abstract »  |  PDF »

Interleukin-1-induced Growth Inhibition of Human Melanoma Cells. INTERLEUKIN-1-INDUCED ANTIZYME EXPRESSION IS RESPONSIBLE FOR ORNITHINE DECARBOXYLASE ACTIVITY DOWN-REGULATION.

D. Yang, H. Hayashi, T. Takii, Y. Mizutani, Y. Inukai, and K. Onozaki (1997)
J. Biol. Chem. 272, 3376-3383
 |  Abstract »  |  Full Text »  |  PDF »

Elevation of Ceramide within Distal Neurites Inhibits Neurite Growth in Cultured Rat Sympathetic Neurons.

E. I.P. de Chaves, M. Bussiere, D. E. Vance, R. B. Campenot, and J. E. Vance (1997)
J. Biol. Chem. 272, 3028-3035
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide-induced Translocation of Protein Kinase C-delta and -epsilon to the Cytosol. IMPLICATIONS IN APOPTOSIS.

H. Sawai, T. Okazaki, Y. Takeda, M. Tashima, H. Sawada, M. Okuma, S. Kishi, H. Umehara, and N. Domae (1997)
J. Biol. Chem. 272, 2452-2458
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Ceramide Inhibits Antigen Uptake and Presentation by Dendritic Cells.

F. Sallusto, C. Nicolo, R. De Maria, S. Corinti, and R. Testi (1996)
J. Exp. Med. 184, 2411-2416
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Nerve Growth Factor mRNA by Interleukin-1 in Rat Hippocampal Astrocytes Is Mediated by NFkappa B.

W. J. Friedman, S. Thakur, L. Seidman, and A. B. Rabson (1996)
J. Biol. Chem. 271, 31115-31120
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide Is Not a Signal for Tumor Necrosis Factor–Induced Gene Expression but Does Cause Programmed Cell Death in Human Vascular Endothelial Cells.

M. R. Slowik, L. G. De Luca, W. Min, and J. S. Pober (1996)
Circ. Res. 79, 736-747
 |  Abstract »  |  Full Text »

The Sphingomyelin-Ceramide Signaling Pathway Is Involved in Oxidized Low Density Lipoprotein-induced Cell Proliferation.

N. Auge, N. Andrieu, A. Negre-Salvayre, J.-C. Thiers, T. Levade, and R. Salvayre (1996)
J. Biol. Chem. 271, 19251-19255
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidate Phosphohydrolase Catalyzes the Hydrolysis of Ceramide 1-Phosphate, Lysophosphatidate, and Sphingosine 1-Phosphate.

D. W. Waggoner, A. Gomez-Munoz, J. Dewald, and D. N. Brindley (1996)
J. Biol. Chem. 271, 16506-16509
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Cytoplasmic Domain of the p55 Tumor Necrosis Factor Receptor Initiates the Neutral Sphingomyelinase Pathway.

D. Adam, K. Wiegmann, S. Adam-Klages, A. Ruff, and M. Kronke (1996)
J. Biol. Chem. 271, 14617-14622
 |  Abstract »  |  Full Text »  |  PDF »

(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase.

A. Bielawska, M. S. Greenberg, D. Perry, S. Jayadev, J. A. Shayman, C. McKay, and Y. A. Hannun (1996)
J. Biol. Chem. 271, 12646-12654
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Regulatory Role of Ceramide in Interleukin (IL)-1beta-induced E-selectin Expression in Human Umbilical Vein Endothelial Cells.

A. Masamune, Y. Igarashi, and S.-i. Hakomori (1996)
J. Biol. Chem. 271, 9368-9375
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-1beta-induced Ceramide and Diacylglycerol Generation May Lead to Activation of the c-Jun NH(2)-terminal Kinase and the Transcription Factor ATF2 in the Insulin-producing Cell Line RINm5F.

N. Welsh and N. Welsh (1996)
J. Biol. Chem. 271, 8307-8312
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Interleukin-1ß Regulation of Nitric Oxide Synthase in Cardiac Myocytes.

M. C. LaPointe and J. R. Sitkins (1996)
Hypertension 27, 709-714
 |  Abstract »  |  Full Text »

A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae..

J T Nickels and J R Broach (1996)
Genes & Dev. 10, 382-394
 |  Abstract »  |  PDF »

Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells.

H. Sawai, T. Okazaki, H. Yamamoto, H. Okano, Y. Takeda, M. Tashima, H. Sawada, M. Okuma, H. Ishikura, H. Umehara, et al. (1995)
J. Biol. Chem. 270, 27326-27331
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Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity.

A. Gómez-Muñoz, D. W. Waggoner, L. O'Brien, and D. N. Brindley (1995)
J. Biol. Chem. 270, 26318-26325
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Cytochrome P450 2C11 (CYP2C11) Gene Expression by Interleukin-1, Sphingomyelin Hydrolysis, and Ceramides in Rat Hepatocytes.

J. Chen, M. Nikolova-Karakashian, A. H. Merrill , Jr., and E. T. Morgan (1995)
J. Biol. Chem. 270, 25233-25238
 |  Abstract »  |  Full Text »  |  PDF »

Low Temperatures and Hypertonicity Do Not Block Cytokine-induced Stimulation of the Sphingomyelin Pathway but Inhibit Nuclear Factor-kappaB Activation.

N. Andrieu, R. Salvayre, J.-P. Jaffrézou, and T. Levade (1995)
J. Biol. Chem. 270, 24518-24524
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines.

E. Coroneos, M. Martinez, S. McKenna, and M. Kester (1995)
J. Biol. Chem. 270, 23305-23309
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophins Induce Sphingomyelin Hydrolysis.

R. T. Dobrowsky, G. M. Jenkins, and Y. A. Hannun (1995)
J. Biol. Chem. 270, 22135-22142
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-1 and Endothelin Stimulate Distinct Species of Diglycerides That Differentially Regulate Protein Kinase C in Mesangial Cells.

A. Musial, A. Mandal, E. Coroneos, and M. Kester (1995)
J. Biol. Chem. 270, 21632-21638
 |  Abstract »  |  Full Text »  |  PDF »

Cross-linking of the p55 Tumor Necrosis Factor Receptor Cytoplasmic Domain by a Dimeric Ligand Induces Nuclear Factor-[IMAGE]B and Mediates Cell Death.

D. Adam, D. Adam, and M. Krönke (1995)
J. Biol. Chem. 270, 17482-17487
 |  Abstract »  |  Full Text »  |  PDF »

Vav Is Necessary for Prolactin-stimulated Proliferation and Is Translocated into the Nucleus of a T-cell Line.

C. V. Clevenger, W. Ngo, D. L. Sokol, S. M. Luger, and , A. M. Gewirtz (1995)
J. Biol. Chem. 270, 13246-13253
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide As a Modulator of Endocytosis.

C.-S. Chen, A. G. Rosenwald, and R. E. Pagano (1995)
J. Biol. Chem. 270, 13291-13297
 |  Abstract »  |  Full Text »  |  PDF »

Role for Ceramide in Cell Cycle Arrest.

S. Jayadev, B. Liu, A. E. Bielawska, J. Y. Lee, F. Nazaire, M. Yu. Pushkareva, L. M. Obeid, and Y. A. Hannun (1995)
J. Biol. Chem. 270, 2047-2052
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor.

R. Dobrowsky, M. Werner, A. Castellino, M. Chao, and Y. Hannun (1994)
Science 265, 1596-1599
 |  Abstract »  |  PDF »

CD95-mediated Apoptosis in Vivo Involves Acid Sphingomyelinase.

S. Kirschnek, F. Paris, M. Weller, H. Grassme, K. Ferlinz, A. Riehle, Z. Fuks, R. Kolesnick, and E. Gulbins (2000)
J. Biol. Chem. 275, 27316-27323
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide Directly Activates Protein Kinase C zeta to Regulate a Stress-activated Protein Kinase Signaling Complex.

N. A. Bourbon, J. Yun, and M. Kester (2000)
J. Biol. Chem. 275, 35617-35623
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide Inhibits Axonal Growth and Nerve Growth Factor Uptake without Compromising the Viability of Sympathetic Neurons.

E. P. de Chaves, M. Bussiere, B. MacInnis, D. E. Vance, R. B. Campenot, and J. E. Vance (2001)
J. Biol. Chem. 276, 36207-36214
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide Reduces Endothelium-Dependent Vasodilation by Increasing Superoxide Production in Small Bovine Coronary Arteries.

D. X. Zhang, A.-P. Zou, and P.-L. Li (2001)
Circ. Res. 88, 824-831
 |  Abstract »  |  Full Text »  |  PDF »

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