Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 January 1993:
Vol. 259. no. 5094, pp. 484 - 489
DOI: 10.1126/science.8424170
Prev | Table of Contents | Next

Articles

Science, Vol 259, Issue 5094, 484-489
Copyright © 1993 by American Association for the Advancement of Science

articles

A wingless-dependent polar coordinate system in Drosophila imaginal discs

JP Couso, M Bate, and A Martinez-Arias

Department of Zoology, University of Cambridge, United Kingdom.

The patterning of the imaginal discs in Drosophila melanogaster is a progressive process that, like the patterning of the larval epidermis during embryogenesis, requires the activity of segment polarity genes. One segment polarity gene, wingless, encodes a homolog of the mouse proto-oncogene Wnt-1 and plays a prominent role in the patterning of the larval epidermis and the imaginal discs. However, whereas the function of wingless in the embryo is initially associated with a pattern of stripes along the anteroposterior axis that are part of a Cartesian coordinate system, it is shown here that during imaginal development wingless is associated with a pattern of sectors that provide references for a polar coordinate system homologous to that postulated in a well-known model for the regeneration of insect and vertebrate limbs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Notch signalling coordinates tissue growth and wing fate specification in Drosophila.
N. Rafel and M. Milan (2008)
Development 135, 3995-4001
   Abstract »    Full Text »    PDF »
Reciprocal roles for bowl and lines in specifying the peripodial epithelium and the disc proper of the Drosophila wing primordium.
D. Nusinow, L. Greenberg, and V. Hatini (2008)
Development 135, 3031-3041
   Abstract »    Full Text »    PDF »
Logic of Wg and Dpp induction of distal and medial fates in the Drosophila leg.
C. Estella and R. S. Mann (2008)
Development 135, 627-636
   Abstract »    Full Text »    PDF »
tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification.
J. de Navascues and J. Modolell (2007)
Development 134, 1779-1788
   Abstract »    Full Text »    PDF »
JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila.
L. A. Ekas, G.-H. Baeg, M. S. Flaherty, A. Ayala-Camargo, and E. A. Bach (2006)
Development 133, 4721-4729
   Abstract »    Full Text »    PDF »
An Unconventional Nuclear Localization Motif Is Crucial for Function of the Drosophila Wnt/Wingless Antagonist Naked Cuticle.
S. Waldrop, C.-C. Chan, T. Cagatay, S. Zhang, R. Rousset, J. Mack, W. Zeng, M. Fish, M. Zhang, M. Amanai, et al. (2006)
Genetics 174, 331-348
   Abstract »    Full Text »    PDF »
Internalization is required for proper Wingless signaling in Drosophila melanogaster..
E. S. Seto and H. J. Bellen (2006)
J. Cell Biol. 173, 95-106
   Abstract »    Full Text »    PDF »
Mutual repression between msh and Iro-C is an essential component of the boundary between body wall and wing in Drosophila.
E. Villa-Cuesta and J. Modolell (2005)
Development 132, 4087-4096
   Abstract »    Full Text »    PDF »
Notch modulates Wnt signalling by associating with Armadillo/{beta}-catenin and regulating its transcriptional activity.
P. Hayward, K. Brennan, P. Sanders, T. Balayo, R. DasGupta, N. Perrimon, and A. M. Arias (2005)
Development 132, 1819-1830
   Abstract »    Full Text »    PDF »
Differing strategies for the establishment and maintenance of teashirt and homothorax repression in the Drosophila wing.
J. D. Zirin and R. S. Mann (2004)
Development 131, 5683-5693
   Abstract »    Full Text »    PDF »
The dachsous gene, a member of the cadherin family, is required for Wg-dependent pattern formation in the Drosophila wing disc.
I. Rodriguez (2004)
Development 131, 3195-3206
   Abstract »    Full Text »    PDF »
Dpp signalling is a key effector of the wing-body wall subdivision of the Drosophila mesothorax.
F. Cavodeassi, I. Rodriguez, and J. Modolell (2003)
Development 129, 3815-3823
   Abstract »    Full Text »    PDF »
Repression of Teashirt marks the initiation of wing development.
J. Wu and S. M. Cohen (2003)
Development 129, 2411-2418
   Abstract »    Full Text »    PDF »
Different mechanisms initiate and maintain wingless expression in the Drosophila wing hinge.
D. d. A. Rodriguez, J. Terriente, M. I. Galindo, J. P. Couso, and F. J. Diaz-Benjumea (2002)
Development 129, 3995-4004
   Abstract »    Full Text »    PDF »
Leg Patterning Driven by Proximal-Distal Interactions and EGFR Signaling.
M. I. Galindo, S. A. Bishop, S. Greig, and J. P. Couso (2002)
Science 297, 256-259
   Abstract »    Full Text »    PDF »
Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development.
S.-H. Wang, A. Simcox, and G. Campbell (2000)
Genes & Dev. 14, 2271-2276
   Abstract »    Full Text »
DER signaling restricts the boundaries of the wing field during Drosophila development.
A. Baonza, F. Roch, and E. Martin-Blanco (2000)
PNAS 97, 7331-7335
   Abstract »    Full Text »    PDF »
A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila.
F Casares and R. Mann (2000)
Development 127, 1499-1508
   Abstract »    PDF »
Leg development in flies versus grasshoppers: differences in dpp expression do not lead to differences in the expression of downstream components of the leg patterning pathway.
E. Jockusch, C Nulsen, S. Newfeld, and L. Nagy (2000)
Development 127, 1617-1626
   Abstract »    PDF »
Cloning and Characterization of a Potassium-Dependent Sodium/Calcium Exchanger in Drosophila.
K. Haug-Collet, B. Pearson, R. Webel, R.T. Szerencsei, R.J. Winkfein, P.P.M. Schnetkamp, and N.J. Colley (1999)
J. Cell Biol. 147, 659-670
   Abstract »    Full Text »    PDF »
Different contributions of pannier and wingless to the patterning of the dorsal mesothorax of Drosophila.
M. Garcia-Garcia, P Ramain, P Simpson, and J Modolell (1999)
Development 126, 3523-3532
   Abstract »    PDF »
Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer.
J Hepker, R. Blackman, and R Holmgren (1999)
Development 126, 3669-3677
   Abstract »    PDF »
Wnt-7a in feather morphogenesis: involvement of anterior-posterior asymmetry and proximal-distal elongation demonstrated with an in vitro reconstitution model.
R. Widelitz, T. Jiang, C. Chen, N. Stott, and C. Chuong (1999)
Development 126, 2577-2587
   Abstract »    PDF »
Hedgehog is required for activation of engrailed during regeneration of fragmented Drosophila imaginal discs.
M. Gibson and G Schubiger (1999)
Development 126, 1591-1599
   Abstract »    PDF »
The developmental basis for allometry in insects.
D. Stern and D. Emlen (1999)
Development 126, 1091-1101
   Abstract »    PDF »
Proximodistal axis formation in the Drosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less.
J Wu and S. Cohen (1999)
Development 126, 109-117
   Abstract »    PDF »
Needs and Targets for the multi sex combs Gene Product in Drosophila melanogaster.
O. Saget, F. Forquignon, P. Santamaria, and N. B. Randsholt (1998)
Genetics 149, 1823-1838
   Abstract »    Full Text »    PDF »
Boundary Formation in Drosophila Wing: Notch Activity Attenuated by the POU Protein Nubbin.
C. J. Neumann and S. M. Cohen (1998)
Science 281, 409-413
   Abstract »    Full Text »
Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development.
T Klein and A. Arias (1998)
Development 125, 2951-2962
   Abstract »    PDF »
Interactions between Wingless and DFz2 during Drosophila wing development.
J Zhang and R. Carthew (1998)
Development 125, 3075-3085
   Abstract »    PDF »
Cell proliferation control by Notch signaling in Drosophila development.
M. Go, D. Eastman, and S Artavanis-Tsakonas (1998)
Development 125, 2031-2040
   Abstract »    PDF »
A molecular basis for transdetermination in Drosophila imaginal discs: interactions between wingless and decapentaplegic signaling.
L Maves and G Schubiger (1998)
Development 125, 115-124
   Abstract »    PDF »
Proximo-distal specification in the wing disc of Drosophila by the nubbin gene.
F. J. Cifuentes and A. Garcia-Bellido (1997)
PNAS 94, 11405-11410
   Abstract »    Full Text »    PDF »
eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins.
J. E. Treisman, A. Luk, G. M. Rubin, and U. Heberlein (1997)
Genes & Dev. 11, 1949-1962
   Abstract »    Full Text »    PDF »
The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate.
C. Micchelli, E. Rulifson, and S. Blair (1997)
Development 124, 1485-1495
   Abstract »    PDF »
Cell Culture and Whole Animal Approaches to Understanding Signaling by Wnt Proteins in Drosophila.
R. Nusse, C. Harryman Samos, M. Brink, K. Willert, K.M. Cadigan, A. Wodarz, M. Fish, and E. Rulifson (1997)
Cold Spring Harb Symp Quant Biol 62, 185-190
   Abstract »    PDF »
Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing.
M. Singer, A Penton, V Twombly, F. Hoffmann, and W. Gelbart (1997)
Development 124, 79-89
   Abstract »    PDF »
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing..
T Kadowaki, E Wilder, J Klingensmith, K Zachary, and N Perrimon (1996)
Genes & Dev. 10, 3116-3128
   Abstract »    PDF »
A procedure for the prediction of temperature-sensitive mutants of a globular protein based solely on the amino acid sequence.
R. Varadarajan, H. A. Nagarajaram, and C. Ramakrishnan (1996)
PNAS 93, 13908-13913
   Abstract »    Full Text »    PDF »
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins..
C Alexandre, A Jacinto, and P W Ingham (1996)
Genes & Dev. 10, 2003-2013
   Abstract »    PDF »
Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation..
D Doherty, G Feger, S Younger-Shepherd, L Y Jan, and Y N Jan (1996)
Genes & Dev. 10, 421-434
   Abstract »    PDF »
Developmental territories created by mutual antagonism between Wingless and Decapentaplegic.
H Theisen, T. Haerry, M. O'Connor, and J. Marsh (1996)
Development 122, 3939-3948
   Abstract »    PDF »
Targeted disruption of the Wnt2 gene results in placentation defects.
S. Monkley, S. Delaney, D. Pennisi, J. Christiansen, and B. Wainwright (1996)
Development 122, 3343-3353
   Abstract »    PDF »
A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing.
C. Neumann and S. Cohen (1996)
Development 122, 3477-3485
   Abstract »    PDF »
Ectopic expression of wingless in imaginal discs interferes with decapentaplegic expression and alters cell determination.
L. Johnston and G Schubiger (1996)
Development 122, 3519-3529
   Abstract »    PDF »
wingless signaling in the Drosophila eye and embryonic epidermis.
K. Cadigan and R Nusse (1996)
Development 122, 2801-2812
   Abstract »    PDF »
hedgehog, wingless and orthodenticle specify adult head development in Drosophila.
J Royet and R Finkelstein (1996)
Development 122, 1849-1858
   Abstract »    PDF »
The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila.
P Bokor and S DiNardo (1996)
Development 122, 1083-1092
   Abstract »    PDF »
Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing.
F. Diaz-Benjumea and S. Cohen (1995)
Development 121, 4215-4225
   Abstract »    PDF »
wingless inhibits morphogenetic furrow movement in the Drosophila eye disc.
J. Treisman and G. Rubin (1995)
Development 121, 3519-3527
   Abstract »    PDF »
four-jointed is required for intermediate growth in the proximal-distal axis in Drosophila.
J. Villano and F. Katz (1995)
Development 121, 2767-2777
   Abstract »    PDF »
Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila.
E. Rulifson and S. Blair (1995)
Development 121, 2813-2824
   Abstract »    PDF »
Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene.
J. Treisman, Z. Lai, and G. Rubin (1995)
Development 121, 2835-2845
   Abstract »    PDF »
Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless.
M Gonzalez-Gaitan and H Jackle (1995)
Development 121, 2313-2325
   Abstract »    PDF »
Wingless induces transdetermination in developing Drosophila imaginal discs.
L Maves and G Schubiger (1995)
Development 121, 1263-1272
   Abstract »    PDF »
Analysis of the genetic hierarchy guiding wing vein development in Drosophila.
M. Sturtevant and E Bier (1995)
Development 121, 785-801
   Abstract »    PDF »
Dual functions of wingless in the Drosophila leg imaginal disc.
E. Wilder and N Perrimon (1995)
Development 121, 477-488
   Abstract »    PDF »
Nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wing.
M Ng, F. Diaz-Benjumea, and S. Cohen (1995)
Development 121, 589-599
   Abstract »    PDF »
DWnt-4, a novel Drosophila Wnt gene acts downstream of homeotic complex genes in the visceral mesoderm.
Y Graba, K Gieseler, D Aragnol, P Laurenti, M. Mariol, H Berenger, T Sagnier, and J Pradel (1995)
Development 121, 209-218
   Abstract »    PDF »
Pattern formation and eyespot determination in butterfly wings.
S. Carroll, J Gates, D. Keys, S. Paddock, G. Panganiban, J. Selegue, and J. Williams (1994)
Science 265, 109-114
   Abstract »    PDF »
Ectopic induction and reorganization of Wnt-1 expression in quail/chick chimeras.
L Bally-Cuif and M Wassef (1994)
Development 120, 3379-3394
   Abstract »    PDF »
Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS.
Y Echelard, G Vassileva, and A. McMahon (1994)
Development 120, 2213-2224
   Abstract »    PDF »
wingless acts through the shaggy/zeste-white 3 kinase to direct dorsal-ventral axis formation in the Drosophila leg.
F. Diaz-Benjumea and S. Cohen (1994)
Development 120, 1661-1670
   Abstract »    PDF »
The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.
S. Speicher, U Thomas, U Hinz, and E Knust (1994)
Development 120, 535-544
   Abstract »    PDF »
The wingless signalling pathway and the patterning of the wing margin in Drosophila.
J. Couso, S. Bishop, and A Martinez Arias (1994)
Development 120, 621-636
   Abstract »    PDF »
dishevelled is required during wingless signaling to establish both cell polarity and cell identity.
H Theisen, J Purcell, M Bennett, D Kansagara, A Syed, and J. Marsh (1994)
Development 120, 347-360
   Abstract »    PDF »
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal..
J Klingensmith, R Nusse, and N Perrimon (1994)
Genes & Dev. 8, 118-130
   Abstract »    PDF »
Pattern formation in the limbs of Drosophila: bric a brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus.
D. Godt, J. L. Couderc, S. E. Cramton, and F. A. Laski (1993)
Development 119, 799-812
   Abstract »    PDF »
The polar coordinate model goes molecular.
P. Bryant (1993)
Science 259, 471-472
   PDF »
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.
B. Parr, M. Shea, G Vassileva, and A. McMahon (1993)
Development 119, 247-261
   Abstract »    PDF »
Expanded: a gene involved in the control of cell proliferation in imaginal discs.
M Boedigheimer and A Laughon (1993)
Development 118, 1291-1301
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)