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Science 22 January 1993:
Vol. 259. no. 5094, pp. 479 - 483
DOI: 10.1126/science.259.5094.479
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Articles

Beyond Nature's Chiral Pool: Enantioselective Catalysis in Industry

William A. Nugent 1, T. V. RajanBabu 1, and Mark J. Burk 1

1 Central Research and Development, Du Pont Company, Post Office Box 80328, Wilmington, DE 19880—0328

Enantioselective catalysts produce organic compounds in enantiomerically enriched form. They are highly efficient tools for the synthesis of biologically active materials, such as pharmaceuticals and crop-protection chemicals, in which enantiomeric purity can be critical. The design of chiral ligands is the key to developing new enantioselective catalysts. Three unusual families of ligands have been used to develop practical technology for enantioselective hydrocyanation of olefins, ring-opening of epoxides, and hydrogenation of various compounds.


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