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Science 15 January 1993:
Vol. 259. no. 5093, pp. 381 - 384
DOI: 10.1126/science.7678352
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Articles

Science, Vol 259, Issue 5093, 381-384
Copyright © 1993 by American Association for the Advancement of Science

articles

Carbon monoxide: a putative neural messenger

A Verma, DJ Hirsch, CE Glatt, GV Ronnett, and SH Snyder

Department of Neurology, Walter Reed Army Medical Center, Washington, DC 20307.

Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of messenger RNA for the constitutive form of heme oxygenase throughout the brain has been demonstrated. This localization is essentially the same as that for soluble guanylyl cyclase messenger RNA. In primary cultures of olfactory neurons, zinc protoporphyrin-9, a potent selective inhibitor of heme oxygenase, depletes endogenous guanosine 3',5'-monophosphate (cGMP). Thus, carbon monoxide, like nitric oxide, may be a physiologic regulator of cGMP. These findings, together with the neuronal localizations of heme oxygenase, suggest that carbon monoxide may function as a neurotransmitter.


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R. Henningsson, P. Alm, and I. Lundquist (2001)
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   Abstract »    Full Text »    PDF »
Gaseous Oxides and Olfactory Computation.
A. Gelperin, J. P. Y. Kao, and I. R. C. Cooke (2001)
Integr. Comp. Biol. 41, 332-345
   Abstract »    Full Text »    PDF »
Heme Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout Mice.
K. Ishikawa, D. Sugawara, X.-p. Wang, K. Suzuki, H. Itabe, Y. Maruyama, and A. J. Lusis (2001)
Circ. Res. 88, 506-512
   Abstract »    Full Text »    PDF »
The Biology of Heme Oxygenase During Development.
P. A. Dennery (2001)
NeoReviews 2, e67-73
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Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase.
H. Moreno, E. V.-S. de Miera, M. S Nadal, Y. Amarillo, and B. Rudy (2001)
J. Physiol. 530, 345-358
   Abstract »    Full Text »    PDF »
Optical recordings of taste responses from fungiform papillae of mouse in situ.
Y. Ohtubo, T. Suemitsu, S. Shiobara, T. Matsumoto, T. Kumazawa, and K. Yoshii (2001)
J. Physiol. 530, 287-293
   Abstract »    Full Text »    PDF »
Real-time measurements of endogenous CO production from vascular cells using an ultrasensitive laser sensor.
Y. Morimoto, W. Durante, D. G. Lancaster, J. Klattenhoff, and F. K. Tittel (2001)
Am J Physiol Heart Circ Physiol 280, H483-H488
   Abstract »    Full Text »    PDF »
Heme oxygenase: colors of defense against cellular stress.
L. E. Otterbein and A. M. K. Choi (2000)
Am J Physiol Lung Cell Mol Physiol 279, L1029-L1037
   Abstract »    Full Text »    PDF »
Role of Carbon Monoxide and Nitric Oxide in Newborn Infants With Postasphyxial Hypoxic-Ischemic Encephalopathy.
Y. Shi, F. Pan, H. Li, J. Pan, S. Qin, and C. Shen (2000)
Pediatrics 106, 1447-1451
   Abstract »    Full Text »
Novel Neurotransmitters and Their Neuropsychiatric Relevance.
S. H. Snyder and C. D. Ferris (2000)
Am J Psychiatry 157, 1738-1751
   Abstract »    Full Text »


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