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Science 8 January 1993:
Vol. 259. no. 5092, pp. 230 - 234
DOI: 10.1126/science.8421783
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Articles

Science, Vol 259, Issue 5092, 230-234
Copyright © 1993 by American Association for the Advancement of Science

articles

Regulation of heat shock factor trimer formation: role of a conserved leucine zipper

SK Rabindran, RI Haroun, J Clos, J Wisniewski, and C Wu

Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

The human and Drosophila heat shock transcription factors (HSFs) are multi-zipper proteins with high-affinity binding to DNA that is regulated by heat shock-induced trimerization. Formation of HSF trimers is dependent on hydrophobic heptad repeats located in the amino-terminal region of the protein. Two subregions at the carboxyl-terminal end of human HSF1 were identified that maintain the monomeric form of the protein under normal conditions. One of these contains a leucine zipper motif that is conserved between vertebrate and insect HSFs. These results suggest that the carboxyl-terminal zipper may suppress formation of trimers by the amino-terminal HSF zipper elements by means of intramolecular coiled-coil interactions that are sensitive to heat shock.


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Heat Shock Factor 1 Represses Transcription of the IL-1beta Gene through Physical Interaction with the Nuclear Factor of Interleukin 6.
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R. I. Morimoto (1998)
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Y. J. Lee and P. M. Corry (1998)
J. Biol. Chem. 273, 29857-29863
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N. Santoro, N. Johansson, and D. J. Thiele (1998)
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Glycogen Synthase Kinase 3beta and Extracellular Signal-Regulated Kinase Inactivate Heat Shock Transcription Factor 1 by Facilitating the Disappearance of Transcriptionally Active Granules after Heat Shock.
B. He, Y.-H. Meng, and N. F. Mivechi (1998)
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HSP90 Interacts with and Regulates the Activity of Heat Shock Factor 1 in Xenopus Oocytes.
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Mol. Cell. Biol. 18, 4949-4960
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Regulation of the Heat-Shock Response.
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Plant Physiology 117, 1135-1141
   Full Text »
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J. Biol. Chem. 273, 18640-18646
   Abstract »    Full Text »    PDF »
Negative regulation of the heat shock transcriptional response by HSBP1.
S. H. Satyal, D. Chen, S. G. Fox, J. M. Kramer, and R. I. Morimoto (1998)
Genes & Dev. 12, 1962-1974
   Abstract »    Full Text »
The Tomato Hsf System: HsfA2 Needs Interaction with HsfA1 for Efficient Nuclear Import and May Be Localized in Cytoplasmic Heat Stress Granules.
K.-D. Scharf, H. Heider, I. Höhfeld, R. Lyck, E. Schmidt, and L. Nover (1998)
Mol. Cell. Biol. 18, 2240-2251
   Abstract »    Full Text »
Molecularchaperones as HSF1-specific transcriptional repressors.
Y. Shi, D. D. Mosser, and R. I. Morimoto (1998)
Genes & Dev. 12, 654-666
   Abstract »    Full Text »
Intramolecular Repression of Mouse Heat Shock Factor 1.
T. Farkas, Y. A. Kutskova, and V. Zimarino (1998)
Mol. Cell. Biol. 18, 906-918
   Abstract »    Full Text »
Conventional and novel PKC isoenzymes modify the heat-induced stress response but are not activated by heat shock.
C. Holmberg, P. Roos, J. Lord, J. Eriksson, and L Sistonen (1998)
J. Cell Sci. 111, 3357-3365
   Abstract »    PDF »
Thioredoxin Is Transcriptionally Induced upon Activation of Heat Shock Factor 2.
S. Leppa, L. Pirkkala, S. C. Chow, J. E. Eriksson, and L. Sistonen (1997)
J. Biol. Chem. 272, 30400-30404
   Abstract »    Full Text »    PDF »
Cloning and Characterization of Murine Glial Cell-Derived Neurotrophic Factor Inducible Transcription Factor (MGIF).
S. Yajima, C.-H. Lammers, S.-H. Lee, Y. Hara, K. Mizuno, and M. M. Mouradian (1997)
J. Neurosci. 17, 8657-8666
   Abstract »    Full Text »    PDF »
Heat Shock Transcription Factor 1 Binds Selectively in Vitro to Ku Protein and the Catalytic Subunit of the DNA-dependent Protein Kinase.
J. Huang, A. Nueda, S. Yoo, and W. S. Dynan (1997)
J. Biol. Chem. 272, 26009-26016
   Abstract »    Full Text »    PDF »
Overexpression of HSF2-beta Inhibits Hemin-induced Heat Shock Gene Expression and Erythroid Differentiation in K562 Cells.
S. Leppa, L. Pirkkala, H. Saarento, K. D. Sarge, and L. Sistonen (1997)
J. Biol. Chem. 272, 15293-15298
   Abstract »    Full Text »    PDF »
Different Thresholds in the Responses of Two Heat Shock Transcription Factors, HSF1 and HSF3.
M. Tanabe, A. Nakai, Y. Kawazoe, and K. Nagata (1997)
J. Biol. Chem. 272, 15389-15395
   Abstract »    Full Text »    PDF »
Nuclear entry, oligomerization, and DNA binding of the Drosophila heat shock transcription factor are regulated by a unique nuclear localization sequence..
E Zandi, T N Tran, W Chamberlain, and C S Parker (1997)
Genes & Dev. 11, 1299-1314
   Abstract »    PDF »
The Phorbol Ester 12-O-Tetradecanoylphorbol 13-Acetate Enhances the Heat-induced Stress Response.
C. I. Holmberg, S. Leppa, J. E. Eriksson, and L. Sistonen (1997)
J. Biol. Chem. 272, 6792-6798
   Abstract »    Full Text »    PDF »
A yeast heat shock transcription factor (Hsf1) mutant is defective in both Hsc82/Hsp82 synthesis and spindle pole body duplication.
P Zarzov, H Boucherie, and C Mann (1997)
J. Cell Sci. 110, 1879-1891
   Abstract »    PDF »
Identification of a novel vertebrate circadian clock-regulated gene encoding the protein nocturnin.
C. B. Green and J. C. Besharse (1996)
PNAS 93, 14884-14888
   Abstract »    Full Text »    PDF »
Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3Represses Transcriptional Activation by Heat Shock Factor-1.
B. Chu, F. Soncin, B. D. Price, M. A. Stevenson, and S. K. Calderwood (1996)
J. Biol. Chem. 271, 30847-30857
   Abstract »    Full Text »    PDF »
Repression of human heat shock factor 1 activity at control temperature by phosphorylation..
U Knauf, E M Newton, J Kyriakis, and R E Kingston (1996)
Genes & Dev. 10, 2782-2793
   Abstract »    PDF »
Evidence That a Rapidly Turning Over Protein, Normally Degraded by Proteasomes, Regulates hsp72 Gene Transcription in HepG2 Cells.
M. Zhou, X. Wu, and H. N. Ginsberg (1996)
J. Biol. Chem. 271, 24769-24775
   Abstract »    Full Text »    PDF »
A Leucine Zipper Stabilizes the Pentameric Membrane Domain of Phospholamban and Forms a Coiled-coil Pore Structure.
H. K. B. Simmerman, Y. M. Kobayashi, J. M. Autry, and L. R. Jones (1996)
J. Biol. Chem. 271, 5941-5946
   Abstract »    Full Text »    PDF »
Activation of Heat Shock Factor 1 DNA Binding Precedes Stress-induced Serine Phosphorylation.
J. J. Cotto, M. Kline, and R. I. Morimoto (1996)
J. Biol. Chem. 271, 3355-3358
   Abstract »    Full Text »    PDF »
Salicylate Triggers Heat Shock Factor Differently than Heat.
D. A. Jurivich, C. Pachetti, L. Qiu, and J. F. Welk (1995)
J. Biol. Chem. 270, 24489-24495
   Abstract »    Full Text »    PDF »
PER protein interactions and temperature compensation of a circadian clock in Drosophila.
Z. Huang, K. Curtin, and M Rosbash (1995)
Science 267, 1169-1172
   Abstract »    PDF »
Heat-inducible DNA Binding of Purified Heat Shock Transcription Factor 1.
M. L. Goodson and K. D. Sarge (1995)
J. Biol. Chem. 270, 2447-2450
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Molecular and genetic characterization of GABP beta..
F C de la Brousse, E H Birkenmeier, D S King, L B Rowe, and S L McKnight (1994)
Genes & Dev. 8, 1853-1865
   Abstract »    PDF »
Regulation of chemical stress-induced hsp70 gene expression in murine L929 cells.
R. Liu, P. Corry, and Y. Lee (1994)
J. Cell Sci. 107, 2209-2214
   Abstract »    PDF »
Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing..
J R Weeks, S E Hardin, J Shen, J M Lee, and A L Greenleaf (1993)
Genes & Dev. 7, 2329-2344
   Abstract »    PDF »
A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants.
P. Harbury, T Zhang, P. Kim, and T Alber (1993)
Science 262, 1401-1407
   Abstract »    PDF »
Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2..
L A Sheldon and R E Kingston (1993)
Genes & Dev. 7, 1549-1558
   Abstract »    PDF »
Cells in stress: transcriptional activation of heat shock genes.
R. Morimoto (1993)
Science 259, 1409-1410
   PDF »
p53 Suppresses the c-Myb-induced Activation of Heat Shock Transcription Factor 3.
J. Tanikawa, E. Ichikawa-Iwata, C. Kanei-Ishii, A. Nakai, S.-i. Matsuzawa, J. C. Reed, and S. Ishii (2000)
J. Biol. Chem. 275, 15578-15585
   Abstract »    Full Text »    PDF »
c-Jun NH2-terminal Kinase Targeting and Phosphorylation of Heat Shock Factor-1 Suppress Its Transcriptional Activity.
R. Dai, W. Frejtag, B. He, Y. Zhang, and N. F. Mivechi (2000)
J. Biol. Chem. 275, 18210-18218
   Abstract »    Full Text »    PDF »
A Nuclear Localization Signal Is Essential for Stress-induced Dimer-to-Trimer Transition of Heat Shock Transcription Factor 3.
A. Nakai and T. Ishikawa (2000)
J. Biol. Chem. 275, 34665-34671
   Abstract »    Full Text »    PDF »
Resolution, Detection, and Characterization of Redox Conformers of Human HSF1.
D. J. Manalo and A. Y.-C. Liu (2001)
J. Biol. Chem. 276, 23554-23561
   Abstract »    Full Text »    PDF »
Differential Induction of Hsp70-encoding Genes in Human Hematopoietic Cells.
S. Leppa, R. Kajanne, L. Arminen, and L. Sistonen (2001)
J. Biol. Chem. 276, 31713-31719
   Abstract »    Full Text »    PDF »
The RheA repressor is the thermosensor of the HSP18 heat shock response in Streptomyces albus.
P. Servant, C. Grandvalet, and P. Mazodier (2000)
PNAS 97, 3538-3543
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)