Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 January 1993:
Vol. 259. no. 5091, pp. 91 - 94
DOI: 10.1126/science.8418501
Prev | Table of Contents | Next

Articles

Science, Vol 259, Issue 5091, 91-94
Copyright © 1993 by American Association for the Advancement of Science

articles

Requirement for CD8+ cells in T cell receptor peptide-induced clonal unresponsiveness

A Gaur, G Ruberti, R Haspel, JP Mayer, and CG Fathman

Department of Medicine, Stanford University School of Medicine, CA 94305.

T cell receptor (TCR) vaccination in rats prevents the development of experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis. The mechanism of this potential immunotherapy was examined by vaccinating mice with an immunogenic peptide fragment of the variable region of the TCR V beta 8.2 gene. Another immunogen that usually induces an immune response mediated by V beta 8.2+ T cells was subsequently inhibited because specific clonal unresponsiveness (anergy) had been induced. Depletion of CD8+ cells before TCR peptide vaccination blocked such inhibition. Thus, the clonal anergy was dependent on CD8+ T cells, and such immunoregulatory T cells may participate in the normal course of EAE.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age.
R. Simone, A. Zicca, and D. Saverino (2008)
J. Leukoc. Biol. 84, 1454-1461
   Abstract »    Full Text »    PDF »
Immunodominance in the TCR Repertoire of {alpha}TCR Peptide-Specific CD4+ Treg Population That Controls Experimental Autoimmune Encephalomyelitis.
L. T. Madakamutil, I. Maricic, E. E. Sercarz, and V. Kumar (2008)
J. Immunol. 180, 4577-4585
   Abstract »    Full Text »    PDF »
Regulation of Immunity by a Novel Population of Qa-1-Restricted CD8{alpha}{alpha}+TCR{alpha}beta+ T Cells.
X. Tang, I. Maricic, N. Purohit, B. Bakamjian, L. M. Reed-Loisel, T. Beeston, P. Jensen, and V. Kumar (2006)
J. Immunol. 177, 7645-7655
   Abstract »    Full Text »    PDF »
Peripheral CD8+CD25+ T Lymphocytes from MHC Class II-Deficient Mice Exhibit Regulatory Activity.
B. Bienvenu, B. Martin, C. Auffray, C. Cordier, C. Becourt, and B. Lucas (2005)
J. Immunol. 175, 246-253
   Abstract »    Full Text »    PDF »
Peptide-Specific CD8 T Regulatory Cells Use IFN-{gamma} to Elaborate TGF-{beta}-Based Suppression.
L. Myers, M. Croft, B. S. Kwon, R. S. Mittler, and A. T. Vella (2005)
J. Immunol. 174, 7625-7632
   Abstract »    Full Text »    PDF »
Self-Reactive T Cell Receptor-Reactive CD8+ T Cells Inhibit T Cell Lymphoma Growth In Vivo.
M. Gonthier, R. Llobera, J. Arnaud, and B. Rubin (2004)
J. Immunol. 173, 7062-7069
   Abstract »    Full Text »    PDF »
Regulatory T Cells Control Autoimmunity In Vivo by Inducing Apoptotic Depletion of Activated Pathogenic Lymphocytes.
L. T. Madakamutil, I. Maricic, E. Sercarz, and V. Kumar (2003)
J. Immunol. 170, 2985-2992
   Abstract »    Full Text »    PDF »
Antigen-bearing immature dendritic cells induce peptide-specific CD8+ regulatory T cells in vivo in humans.
M. V. Dhodapkar and R. M. Steinman (2002)
Blood 100, 174-177
   Abstract »    Full Text »    PDF »
Generation of Human CD8 T Regulatory Cells by CD40 Ligand-activated Plasmacytoid Dendritic Cells.
M. Gilliet and Y.-J. Liu (2002)
J. Exp. Med. 195, 695-704
   Abstract »    Full Text »    PDF »
Induction of TCR V{beta}-Specific CD8+ CTLs by TCR V{beta}-Derived Peptides Bound to HLA-E.
J. Li, I. Goldstein, E. Glickman-Nir, H. Jiang, and L. Chess (2001)
J. Immunol. 167, 3800-3808
   Abstract »    Full Text »    PDF »
Induction of a type 1 regulatory CD4 T cell response following V{beta}8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis.
V. Kumar, J. Maglione, J. Thatte, B. Pederson, E. Sercarz, and E. S. Ward (2001)
Int. Immunol. 13, 835-841
   Abstract »    Full Text »    PDF »
Induction or Protection from Experimental Autoimmune Encephalomyelitis Depends on the Cytokine Secretion Profile of TCR Peptide-Specific Regulatory CD4 T Cells.
V. Kumar and E. Sercarz (1998)
J. Immunol. 161, 6585-6591
   Abstract »    Full Text »    PDF »
T Cell Vaccination in Experimental Autoimmune Encephalomyelitis: A Mathematical Model.
J. A. M. Borghans, R. J. De Boer, E. Sercarz, and V. Kumar (1998)
J. Immunol. 161, 1087-1093
   Abstract »    Full Text »    PDF »
Immunopathology of Herpetic Stromal Keratitis: Discordance in CD4+ T Cell Function Between Euthymic Host and Reconstituted SCID Recipients.
J. Thomas and B. T. Rouse (1998)
J. Immunol. 160, 3965-3970
   Abstract »    Full Text »    PDF »
T cell vaccination induces T cell receptor Vbeta -specific Qa-1-restricted regulatory CD8+ T cells.
H. Jiang, H. Kashleva, L.-X. Xu, J. Forman, L. Flaherty, B. Pernis, N. S. Braunstein, and L. Chess (1998)
PNAS 95, 4533-4537
   Abstract »    Full Text »    PDF »
Identifying strategies for immune intervention.
A Lanzavecchia (1993)
Science 260, 937-944
   Abstract »    PDF »
CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice.
H. Jiang, N. S. Braunstein, B. Yu, R. Winchester, and L. Chess (2001)
PNAS 98, 6301-6306
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)