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Science 18 December 1992:
Vol. 258. no. 5090, pp. 1957 - 1959
DOI: 10.1126/science.1470922

Articles

Science, Vol 258, Issue 5090, 1957-1959
Copyright © 1992 by American Association for the Advancement of Science


articles

Neutrophil recruitment by tumor necrosis factor from mast cells in immune complex peritonitis

Y Zhang, BF Ramos, and BA Jakschik

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110.

During generalized immune complex-induced inflammation of the peritoneal cavity, two peaks of tumor necrosis factor (TNF) were observed in the peritoneal exudate of normal mice. In mast cell-deficient mice, the first peak was undetected, and the second peak of TNF and neutrophil influx were significantly reduced. Antibody to TNF significantly inhibited neutrophil infiltration in normal but not in mast cell-deficient mice. Mast cell repletion of the latter normalized TNF, neutrophil mobilization, and the effect of the antibody to TNF. Thus, in vivo, mast cells produce the TNF that augments neutrophil emigration.


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