Science 18 December 1992: Vol. 258. no. 5090, pp. 1946 - 1949 DOI: 10.1126/science.1470919

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Articles

Monoacylglycerol Lipase Limits the Duration of Endocannabinoid-Mediated Depolarization-Induced Suppression of Excitation in Autaptic Hippocampal Neurons.

A. Straiker, S. S.-J. Hu, J. Z. Long, A. Arnold, J. Wager-Miller, B. F. Cravatt, and K. Mackie (2009)
Mol. Pharmacol. 76, 1220-1227
 |  Abstract »  |  Full Text »  |  PDF »

Immunoneutralization of Agmatine Sensitizes Mice to {micro}-Opioid Receptor Tolerance.

C. L. Wade, L. L. Eskridge, H. O. X. Nguyen, K. F. Kitto, L. S. Stone, G. Wilcox, and C. A. Fairbanks (2009)
J. Pharmacol. Exp. Ther. 331, 539-546
 |  Abstract »  |  Full Text »  |  PDF »

T-Type Calcium Channel Inhibition Underlies the Analgesic Effects of the Endogenous Lipoamino Acids.

G. Barbara, A. Alloui, J. Nargeot, P. Lory, A. Eschalier, E. Bourinet, and J. Chemin (2009)
J. Neurosci. 29, 13106-13114
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoids Suppress Excitatory Synaptic Transmission to Dorsal Raphe Serotonin Neurons through the Activation of Presynaptic CB1 Receptors.

S. Haj-Dahmane and R.-Y. Shen (2009)
J. Pharmacol. Exp. Ther. 331, 186-196
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Anandamide-Stimulated Cannabinoid Receptor Signaling in Human ULTR Myometrial Smooth Muscle Cells.

P. J. Brighton, J. McDonald, A. H. Taylor, R. A. J. Challiss, D. G. Lambert, J. C. Konje, and J. M. Willets (2009)
Mol. Endocrinol. 23, 1415-1427
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain.

S. G. Kinsey, J. Z. Long, S. T. O'Neal, R. A. Abdullah, J. L. Poklis, D. L. Boger, B. F. Cravatt, and A. H. Lichtman (2009)
J. Pharmacol. Exp. Ther. 330, 902-910
 |  Abstract »  |  Full Text »  |  PDF »

TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system.

S. Bittner, S. G. Meuth, K. Gobel, N. Melzer, A. M. Herrmann, O. J. Simon, A. Weishaupt, T. Budde, D. A. Bayliss, M. Bendszus, et al. (2009)
Brain 132, 2501-2516
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacological Characterization of Receptor Redistribution and {beta}-Arrestin Recruitment Assays for the Cannabinoid Receptor 1.

M. M.C. van der Lee, M. Blomenrohr, A. A. van der Doelen, J. W.Y. Wat, N. Smits, B. J. Hanson, C. J. van Koppen, and G. J.R. Zaman (2009)
J Biomol Screen 14, 811-823
 |  Abstract »  |  PDF »

Endocannabinoids May Mediate the Ability of (n-3) Fatty Acids to Reduce Ectopic Fat and Inflammatory Mediators in Obese Zucker Rats.

B. Batetta, M. Griinari, G. Carta, E. Murru, A. Ligresti, L. Cordeddu, E. Giordano, F. Sanna, T. Bisogno, S. Uda, et al. (2009)
J. Nutr. 139, 1495-1501
 |  Abstract »  |  Full Text »  |  PDF »

The Cannabinoid Receptor 2 Is Critical for the Host Response to Sepsis.

J. Tschop, K. R. Kasten, R. Nogueiras, H. S. Goetzman, C. M. Cave, L. G. England, J. Dattilo, A. B. Lentsch, M. H. Tschop, and C. C. Caldwell (2009)
J. Immunol. 183, 499-505
 |  Abstract »  |  Full Text »  |  PDF »

Paracrine Transactivation of the CB1 Cannabinoid Receptor by AT1 Angiotensin and Other Gq/11 Protein-coupled Receptors.

G. Turu, P. Varnai, P. Gyombolai, L. Szidonya, L. Offertaler, G. Bagdy, G. Kunos, and L. Hunyady (2009)
J. Biol. Chem. 284, 16914-16921
 |  Abstract »  |  Full Text »  |  PDF »

The P2Y12 Antagonists, 2-Methylthioadenosine 5'-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a Gi-independent Increase in cAMP Levels.

S. Srinivasan, F. Mir, J.-S. Huang, F. T. Khasawneh, S. C.-T. Lam, and G. C. Le Breton (2009)
J. Biol. Chem. 284, 16108-16117
 |  Abstract »  |  Full Text »  |  PDF »

Electroacupuncture modulates vlPAG release of GABA through presynaptic cannabinoid CB1 receptors.

L.-W. Fu and J. C. Longhurst (2009)
J Appl Physiol 106, 1800-1809
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoids and Their Receptors as Targets for Obesity Therapy.

A. D. de Kloet and S. C. Woods (2009)
Endocrinology 150, 2531-2536
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Functional and Anatomical Architecture of the Endocannabinoid System in the Auditory Brainstem.

Y. Zhao, M. E. Rubio, and T. Tzounopoulos (2009)
J Neurophysiol 101, 2434-2446
 |  Abstract »  |  Full Text »  |  PDF »

Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-{alpha} nuclear receptors.

C. Mazzola, J. Medalie, M. Scherma, L. V. Panlilio, M. Solinas, G. Tanda, F. Drago, J. L. Cadet, S. R. Goldberg, and S. Yasar (2009)
Learn. Mem. 16, 332-337
 |  Abstract »  |  Full Text »  |  PDF »

Identification of intracellular carriers for the endocannabinoid anandamide.

M. Kaczocha, S. T. Glaser, and D. G. Deutsch (2009)
PNAS 106, 6375-6380
 |  Abstract »  |  Full Text »  |  PDF »

Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors.

Y. S. Lin, R.-L. Lin, M.-Y. Bien, C.-Y. Ho, and Y. R. Kou (2009)
J Appl Physiol 106, 1142-1152
 |  Abstract »  |  Full Text »  |  PDF »

A Cytochrome P450-Derived Epoxygenated Metabolite of Anandamide Is a Potent Cannabinoid Receptor 2-Selective Agonist.

N. T. Snider, J. A. Nast, L. A. Tesmer, and P. F. Hollenberg (2009)
Mol. Pharmacol. 75, 965-972
 |  Abstract »  |  Full Text »  |  PDF »

Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages.

L.-s. Jiang, J. Pu, Z.-h. Han, L.-h. Hu, and B. He (2009)
Cardiovasc Res 81, 805-813
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Loss of Faah Compromises Male Fertility in Mice.

X. Sun, H. Wang, M. Okabe, K. Mackie, P. J. Kingsley, L. J. Marnett, B. F. Cravatt, and S. K. Dey (2009)
Biol Reprod 80, 235-242
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function.

E. X. Albuquerque, E. F. R. Pereira, M. Alkondon, and S. W. Rogers (2009)
Physiol Rev 89, 73-120
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Effects of {Delta}9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing.

P. Fusar-Poli, J. A. Crippa, S. Bhattacharyya, S. J. Borgwardt, P. Allen, R. Martin-Santos, M. Seal, S. A. Surguladze, C. O'Carrol, Z. Atakan, et al. (2009)
Arch Gen Psychiatry 66, 95-105
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoid-Mediated Control of Synaptic Transmission.

M. Kano, T. Ohno-Shosaku, Y. Hashimotodani, M. Uchigashima, and M. Watanabe (2009)
Physiol Rev 89, 309-380
 |  Abstract »  |  Full Text »  |  PDF »

Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc42.

A. Shiratsuchi, M. Ichiki, Y. Okamoto, N. Ueda, N. Sugimoto, Y. Takuwa, and Y. Nakanishi (2009)
J. Biochem. 145, 43-50
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase.

M. J. Karbarz, L. Luo, L. Chang, C.-S. Tham, J. A. Palmer, S. J. Wilson, M. L. Wennerholm, S. M. Brown, B. P. Scott, R. L. Apodaca, et al. (2009)
Anesth. Analg. 108, 316-329
 |  Abstract »  |  Full Text »  |  PDF »

The Endocannabinoid 2-Arachidonoylglycerol Is Responsible for the Slow Self-Inhibition in Neocortical Interneurons.

S. Marinelli, S. Pacioni, T. Bisogno, V. Di Marzo, D. A. Prince, J. R. Huguenard, and A. Bacci (2008)
J. Neurosci. 28, 13532-13541
 |  Abstract »  |  Full Text »  |  PDF »

Distribution and function of monoacylglycerol lipase in the gastrointestinal tract.

M. Duncan, A. D. Thomas, N. L. Cluny, A. Patel, K. D. Patel, B. Lutz, D. Piomelli, S. P. H. Alexander, and K. A. Sharkey (2008)
Am J Physiol Gastrointest Liver Physiol 295, G1255-G1265
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoids and the Control of Energy Homeostasis.

G. Kunos, D. Osei-Hyiaman, J. Liu, G. Godlewski, and S. Batkai (2008)
J. Biol. Chem. 283, 33021-33025
 |  Abstract »  |  Full Text »  |  PDF »

N-Arachidonyl Maleimide Potentiates the Pharmacological and Biochemical Effects of the Endocannabinoid 2-Arachidonylglycerol through Inhibition of Monoacylglycerol Lipase.

J. J. Burston, L. J. Sim-Selley, J. P. Harloe, A. Mahadevan, R. K. Razdan, D. E. Selley, and J. L. Wiley (2008)
J. Pharmacol. Exp. Ther. 327, 546-553
 |  Abstract »  |  Full Text »  |  PDF »

Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis.

M Di Filippo, L A Pini, G P Pelliccioli, P Calabresi, and P Sarchielli (2008)
J. Neurol. Neurosurg. Psychiatry 79, 1224-1229
 |  Abstract »  |  Full Text »  |  PDF »

Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors.

N. V. DiPatrizio and K. J. Simansky (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R1409-R1414
 |  Abstract »  |  Full Text »  |  PDF »

N-arachidonylethanolamide-Induced Increase in Aqueous Humor Outflow Facility.

Y. F. Njie, Z. Qiao, Z. Xiao, W. Wang, and Z.-H. Song (2008)
Invest. Ophthalmol. Vis. Sci. 49, 4528-4534
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Type-1 Cannabinoid Receptor During Rat Postnatal Testicular Development: Possible Involvement in Adult Leydig Cell Differentiation.

G. Cacciola, T. Chioccarelli, K. Mackie, R. Meccariello, C. Ledent, S. Fasano, R. Pierantoni, and G. Cobellis (2008)
Biol Reprod 79, 758-765
 |  Abstract »  |  Full Text »  |  PDF »

Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats.

N. V. DiPatrizio and K. J. Simansky (2008)
J. Neurosci. 28, 9702-9709
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Novel Endogenous Cytochrome P450 Arachidonate Metabolites with High Affinity for Cannabinoid Receptors.

J.-K. Chen, J. Chen, J. D. Imig, S. Wei, D. L. Hachey, J. S. Guthi, J. R. Falck, J. H. Capdevila, and R. C. Harris (2008)
J. Biol. Chem. 283, 24514-24524
 |  Abstract »  |  Full Text »  |  PDF »

Structure-guided inhibitor design for human FAAH by interspecies active site conversion.

M. Mileni, D. S. Johnson, Z. Wang, D. S. Everdeen, M. Liimatta, B. Pabst, K. Bhattacharya, R. A. Nugent, S. Kamtekar, B. F. Cravatt, et al. (2008)
PNAS 105, 12820-12824
 |  Abstract »  |  Full Text »  |  PDF »

The Endogenous Cannabinoid System Modulates Nicotine Reward and Dependence.

L. L. Merritt, B. R. Martin, C. Walters, A. H. Lichtman, and M. I. Damaj (2008)
J. Pharmacol. Exp. Ther. 326, 483-492
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Farnesyl Pyrophosphate and N-Arachidonylglycine as Endogenous Ligands for GPR92.

D. Y. Oh, J. M. Yoon, M. J. Moon, J.-I. Hwang, H. Choe, J. Y. Lee, J. I. Kim, S. Kim, H. Rhim, D. K. O'Dell, et al. (2008)
J. Biol. Chem. 283, 21054-21064
 |  Abstract »  |  Full Text »  |  PDF »

Thematic Review Series: Glycerolipids. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids.

J. E. Vance (2008)
J. Lipid Res. 49, 1377-1387
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury.

T. Genovese, E. Esposito, E. Mazzon, R. D. Paola, R. Meli, P. Bramanti, D. Piomelli, A. Calignano, and S. Cuzzocrea (2008)
J. Pharmacol. Exp. Ther. 326, 12-23
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic potential of cannabis in pain medicine.

R. D. Hosking and J. P. Zajicek (2008)
Br. J. Anaesth. 101, 59-68
 |  Abstract »  |  Full Text »  |  PDF »

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells.

V. L. Hegde, S. Hegde, B. F. Cravatt, L. J. Hofseth, M. Nagarkatti, and P. S. Nagarkatti (2008)
Mol. Pharmacol. 74, 20-33
 |  Abstract »  |  Full Text »  |  PDF »

Beta-caryophyllene is a dietary cannabinoid.

J. Gertsch, M. Leonti, S. Raduner, I. Racz, J.-Z. Chen, X.-Q. Xie, K.-H. Altmann, M. Karsak, and A. Zimmer (2008)
PNAS 105, 9099-9104
 |  Abstract »  |  Full Text »  |  PDF »

N-Palmitoyl Glycine, a Novel Endogenous Lipid That Acts As a Modulator of Calcium Influx and Nitric Oxide Production in Sensory Neurons.

N. Rimmerman, H. B. Bradshaw, H. V. Hughes, J. S.-C. Chen, S. S.-J. Hu, D. McHugh, E. Vefring, J. A. Jahnsen, E. L. Thompson, K. Masuda, et al. (2008)
Mol. Pharmacol. 74, 213-224
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoids in endocrine and related tumours.

M. Bifulco, A. M. Malfitano, S. Pisanti, and C. Laezza (2008)
Endocr. Relat. Cancer 15, 391-408
 |  Abstract »  |  Full Text »  |  PDF »

Role in Anxiety Behavior of the Endocannabinoid System in the Prefrontal Cortex.

T. Rubino, N. Realini, C. Castiglioni, C. Guidali, D. Vigano, E. Marras, S. Petrosino, G. Perletti, M. Maccarrone, V. Di Marzo, et al. (2008)
Cereb Cortex 18, 1292-1301
 |  Abstract »  |  Full Text »  |  PDF »

Anandamide Biosynthesis Catalyzed by the Phosphodiesterase GDE1 and Detection of Glycerophospho-N-acyl Ethanolamine Precursors in Mouse Brain.

G. M. Simon and B. F. Cravatt (2008)
J. Biol. Chem. 283, 9341-9349
 |  Abstract »  |  Full Text »  |  PDF »

Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus.

A. Ludanyi, L. Eross, S. Czirjak, J. Vajda, P. Halasz, M. Watanabe, M. Palkovits, Z. Magloczky, T. F. Freund, and I. Katona (2008)
J. Neurosci. 28, 2976-2990
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoid system and its implications for obesity and cardiometabolic risk.

R. W. Nesto and K. Mackie (2008)
Eur. Heart J. Suppl. 10, B34-B41
 |  Abstract »  |  Full Text »  |  PDF »

The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathyic rats: evidence at the cannabinoid CB1 receptor.

M. A. Williams, S. A. Smith, D. E. O'Brien, J. H. Mitchell, and M. G. Garry (2008)
J. Physiol. 586, 835-845
 |  Abstract »  |  Full Text »  |  PDF »

Enzymatic Machinery for Endocannabinoid Biosynthesis Associated with Calcium Stores in Glutamatergic Axon Terminals.

R. Nyilas, B. Dudok, G. M. Urban, K. Mackie, M. Watanabe, B. F. Cravatt, T. F. Freund, and I. Katona (2008)
J. Neurosci. 28, 1058-1063
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of a Novel Type of Prostamide/Prostaglandin F Synthase, Belonging to the Thioredoxin-like Superfamily.

H. Moriuchi, N. Koda, E. Okuda-Ashitaka, H. Daiyasu, K. Ogasawara, H. Toh, S. Ito, D. F. Woodward, and K. Watanabe (2008)
J. Biol. Chem. 283, 792-801
 |  Abstract »  |  Full Text »  |  PDF »

Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain.

G. Astarita, F. Ahmed, and D. Piomelli (2008)
J. Lipid Res. 49, 48-57
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pal Pacher.

H. F. Rosenberg (2007)
J. Leukoc. Biol. 82, 1390-1392
 |  Full Text »  |  PDF »

CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a.

J. L. Niehaus, Y. Liu, K. T. Wallis, M. Egertova, S. G. Bhartur, S. Mukhopadhyay, S. Shi, H. He, D. E. Selley, A. C. Howlett, et al. (2007)
Mol. Pharmacol. 72, 1557-1566
 |  Abstract »  |  Full Text »  |  PDF »

Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury.

R. Durst, H. Danenberg, R. Gallily, R. Mechoulam, K. Meir, E. Grad, R. Beeri, T. Pugatsch, E. Tarsish, and C. Lotan (2007)
Am J Physiol Heart Circ Physiol 293, H3602-H3607
 |  Abstract »  |  Full Text »  |  PDF »

Adaptations of guest and host in expanded self-assembled capsules.

D. Ajami and J. Rebek Jr. (2007)
PNAS 104, 16000-16003
 |  Abstract »  |  Full Text »  |  PDF »

The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy.

A.H. Taylor, C. Ang, S.C. Bell, and J.C. Konje (2007)
Hum. Reprod. Update 13, 501-513
 |  Abstract »  |  Full Text »  |  PDF »

The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species.

S. V. Siegmund, T. Qian, S. de Minicis, J. Harvey-White, G. Kunos, K. Y. Vinod, B. Hungund, and R. F. Schwabe (2007)
FASEB J 21, 2798-2806
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for the Involvement of Cannabinoid CB1 Receptors in the Bimatoprost-Induced Contractions on the Human Isolated Ciliary Muscle.

M. R. Romano and M. D. Lograno (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3677-3682
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats.

T. Fischbach, W. Greffrath, H. Nawrath, and R.-D. Treede (2007)
J Neurophysiol 98, 929-938
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP-activated protein kinase.

Y. Dagon, Y. Avraham, Y. Ilan, R. Mechoulam, and E. M. Berry (2007)
FASEB J 21, 2431-2441
 |  Abstract »  |  Full Text »  |  PDF »

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.

S. Batkai, M. Rajesh, P. Mukhopadhyay, G. Hasko, L. Liaudet, B. F. Cravatt, A. Csiszar, Z. Ungvari, and P. Pacher (2007)
Am J Physiol Heart Circ Physiol 293, H909-H918
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Endocannabinoid System in Retinal Damage after High Intraocular Pressure-Induced Ischemia in Rats.

C. Nucci, V. Gasperi, R. Tartaglione, A. Cerulli, A. Terrinoni, M. Bari, C. De Simone, A. F. Agro, L. A. Morrone, M. T. Corasaniti, et al. (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2997-3004
 |  Abstract »  |  Full Text »  |  PDF »

The Fatty Acid Amide Hydrolase Inhibitor URB597 (Cyclohexylcarbamic Acid 3'-Carbamoylbiphenyl-3-yl Ester) Reduces Neuropathic Pain after Oral Administration in Mice.

R. Russo, J. LoVerme, G. La Rana, T. R. Compton, J. Parrott, A. Duranti, A. Tontini, M. Mor, G. Tarzia, A. Calignano, et al. (2007)
J. Pharmacol. Exp. Ther. 322, 236-242
 |  Abstract »  |  Full Text »  |  PDF »

Anandamide Metabolism by Human Liver and Kidney Microsomal Cytochrome P450 Enzymes to Form Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acid Ethanolamides.

N. T. Snider, A. M. Kornilov, U. M. Kent, and P. F. Hollenberg (2007)
J. Pharmacol. Exp. Ther. 321, 590-597
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoid Regulates Blood Pressure via Activation of the Transient Receptor Potential Vanilloid Type 1 in Wistar Rats Fed a High-Salt Diet.

Y. Wang, N. E. Kaminski, and D. H. Wang (2007)
J. Pharmacol. Exp. Ther. 321, 763-769
 |  Abstract »  |  Full Text »  |  PDF »

Depolarization-induced Rapid Generation of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, in Rat Brain Synaptosomes.

S. Oka, S. Arai, K. Waku, A. Tokumura, and T. Sugiura (2007)
J. Biochem. 141, 687-697
 |  Abstract »  |  Full Text »  |  PDF »

Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth: RECRUITMENT OF Fas AND Fas LIGAND TO LIPID RAFTS.

S. DeMorrow, S. Glaser, H. Francis, J. Venter, B. Vaculin, S. Vaculin, and G. Alpini (2007)
J. Biol. Chem. 282, 13098-13113
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoids and Synaptic Function in the CNS.

Y. Hashimotodani, T. Ohno-Shosaku, and M. Kano (2007)
Neuroscientist 13, 127-137
 |  Abstract »  |  PDF »

The Endocannabinoid System as a Novel Approach for Managing Obesity.

J. L. Lillo (2007)
J Am Osteopath Assoc 107, S12-S20
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Diacylglycerol Lipase in Constitutive and Angiotensin AT1 Receptor-stimulated Cannabinoid CB1 Receptor Activity.

G. Turu, A. Simon, P. Gyombolai, L. Szidonya, G. Bagdy, Z. Lenkei, and L. Hunyady (2007)
J. Biol. Chem. 282, 7753-7757
 |  Abstract »  |  Full Text »  |  PDF »

Discovery and Characterization of a Ca2+-independent Phosphatidylethanolamine N-Acyltransferase Generating the Anandamide Precursor and Its Congeners.

X.-H. Jin, Y. Okamoto, J. Morishita, K. Tsuboi, T. Tonai, and N. Ueda (2007)
J. Biol. Chem. 282, 3614-3623
 |  Abstract »  |  Full Text »  |  PDF »

Oxyhomologation of the Amide Bond Potentiates Neuroprotective Effects of the Endolipid N-Palmitoylethanolamine.

G. Lombardi, G. Miglio, F. Varsaldi, A. Minassi, and G. Appendino (2007)
J. Pharmacol. Exp. Ther. 320, 599-606
 |  Abstract »  |  Full Text »  |  PDF »

Chemical Determinants Involved in Anandamide-induced Inhibition of T-type Calcium Channels.

J. Chemin, J. Nargeot, and P. Lory (2007)
J. Biol. Chem. 282, 2314-2323
 |  Abstract »  |  Full Text »  |  PDF »

Immunocytochemical Distribution of the Cannabinoid CB1 Receptor in the Primate Neocortex: A Regional and Laminar Analysis.

S. M. Eggan and D. A. Lewis (2007)
Cereb Cortex 17, 175-191
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice.

S. Oka, J. Wakui, S. Ikeda, S. Yanagimoto, S. Kishimoto, M. Gokoh, M. Nasui, and T. Sugiura (2006)
J. Immunol. 177, 8796-8805
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Characterization of Cannabinoid Agonists and Apparent pA2 Analysis of Cannabinoid Antagonists in Rhesus Monkeys Discriminating {Delta}9-Tetrahydrocannabinol.

L. R. McMahon (2006)
J. Pharmacol. Exp. Ther. 319, 1211-1218
 |  Abstract »  |  Full Text »  |  PDF »

A Second Fatty Acid Amide Hydrolase with Variable Distribution among Placental Mammals.

B. Q. Wei, T. S. Mikkelsen, M. K. McKinney, E. S. Lander, and B. F. Cravatt (2006)
J. Biol. Chem. 281, 36569-36578
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoid receptors as novel targets for the treatment of melanoma.

C. Blazquez, A. Carracedo, L. Barrado, P. J. Real, J. L. Fernandez-Luna, G. Velasco, M. Malumbres, and M. Guzman (2006)
FASEB J 20, 2633-2635
 |  Abstract »  |  Full Text »  |  PDF »

Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol.

B. Szabo, M. J. Urbanski, T. Bisogno, V. D. Marzo, A. Mendiguren, W. U. Baer, and I. Freiman (2006)
J. Physiol. 577, 263-280
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for Specificity in Lipid-Rhodopsin Interactions.

O. Soubias, W. E. Teague, and K. Gawrisch (2006)
J. Biol. Chem. 281, 33233-33241
 |  Abstract »  |  Full Text »  |  PDF »

Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation.

J. Palazuelos, T. Aguado, A. Egia, R. Mechoulam, M. Guzman, and I. Galve-Roperh (2006)
FASEB J 20, 2405-2407
 |  Abstract »  |  Full Text »  |  PDF »

Lipid Signaling and Synaptic Plasticity.

N. Sang and C. Chen (2006)
Neuroscientist 12, 425-434
 |  Abstract »  |  PDF »

Neuronal control of skin function: the skin as a neuroimmunoendocrine organ..

D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff (2006)
Physiol Rev 86, 1309-1379
 |  Abstract »  |  Full Text »  |  PDF »

Endocannabinoid Biosynthesis Proceeding through Glycerophospho-N-acyl Ethanolamine and a Role for {alpha}/beta-Hydrolase 4 in This Pathway.

G. M. Simon and B. F. Cravatt (2006)
J. Biol. Chem. 281, 26465-26472
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoids Modulate the P-Type High-Voltage-Activated Calcium Currents in Purkinje Neurons.

A. Fisyunov, V. Tsintsadze, R. Min, N. Burnashev, and N. Lozovaya (2006)
J Neurophysiol 96, 1267-1277
 |  Abstract »  |  Full Text »  |  PDF »

The Endocannabinoid System as an Emerging Target of Pharmacotherapy.

P. Pacher, S. Batkai, and G. Kunos (2006)
Pharmacol. Rev. 58, 389-462
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoid-1 Receptor Antagonist, Rimonabant, for Management of Obesity and Related Risks.

K. M. Gadde and D. B. Allison (2006)
Circulation 114, 974-984
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Manipulation of Arabidopsis fatty acid amide hydrolase expression modifies plant growth and sensitivity to N-acylethanolamines.

Y.-S. Wang, R. Shrestha, A. Kilaru, W. Wiant, B. J. Venables, K. D. Chapman, and E. B. Blancaflor (2006)
PNAS 103, 12197-12202
 |  Abstract »  |  Full Text »  |  PDF »

Jekyll and Hyde: Two Faces of Cannabinoid Signaling in Male and Female Fertility.

H. Wang, S. K. Dey, and M. Maccarrone (2006)
Endocr. Rev. 27, 427-448
 |  Abstract »  |  Full Text »  |  PDF »

High-Throughput Screening for the Discovery of Inhibitors of Fatty Acid Amide Hydrolase Using a Microsome-Based Fluorescent Assay.

Y. Wang, F. Ramirez, G. Krishnamurthy, A. Gilbert, N. Kadakia, J. Xu, G. Kalgaonkar, M. K. Ramarao, W. Edris, K. E. Rogers, et al. (2006)
J Biomol Screen 11, 519-527
 |  Abstract »  |  PDF »

Sex and hormonal cycle differences in rat brain levels of pain-related cannabimimetic lipid mediators.

H. B. Bradshaw, N. Rimmerman, J. F. Krey, and J. M. Walker (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R349-R358
 |  Abstract »  |  Full Text »  |  PDF »

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