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Science 18 December 1992: Vol. 258. no. 5090, pp. 1898 - 1902 DOI: 10.1126/science.1281928
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Articles
Science, Vol 258, Issue 5090, 1898-1902
Copyright © 1992 by American Association for the Advancement of Science
Biochemistry of nitric oxide and its redox-activated forms
JS Stamler,
DJ Singel,
and
J Loscalzo
Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.
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- Nonendothelial Source of Nitric Oxide in Arterioles But Not in Venules: Alternative Source Revealed In Vivo by Diaminofluorescein Microfluorography.
- S. Kashiwagi, M. Kajimura, Y. Yoshimura, and M. Suematsu (2002)
Circ. Res.
91
, e55-e64
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- Nitric Oxide Improves Internal Iron Availability in Plants.
- M. Graziano, M. V. Beligni, and L. Lamattina (2002)
Plant Physiology
130, 1852-1859
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- Novel Role for Low Molecular Weight Plasma Thiols in Nitric Oxide-mediated Control of Platelet Function.
- M. S. Crane, R. Ollosson, K. P. Moore, A. G. Rossi, and I. L. Megson (2002)
J. Biol. Chem.
277, 46858-46863
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- Prevention of Experimental Cerebral Vasospasm by Intracranial Delivery of a Nitric Oxide Donor From a Controlled-Release Polymer: Toxicity and Efficacy Studies in Rabbits and Rats.
- P. Gabikian, R. E. Clatterbuck, C. G. Eberhart, B. M. Tyler, T. S. Tierney, and R. J. Tamargo (2002)
Stroke
33, 2681-2686
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- Induction of Heme Oxygenase 1 by Nitrosative Stress. A ROLE FOR NITROXYL ANION.
- P. Naughton, R. Foresti, S. K. Bains, M. Hoque, C. J. Green, and R. Motterlini (2002)
J. Biol. Chem.
277, 40666-40674
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- Tyrosine nitration in prostaglandin H2 synthase.
- R. S. Deeb, M. J. Resnick, D. Mittar, T. McCaffrey, D. P. Hajjar, and R. K. Upmacis (2002)
J. Lipid Res.
43, 1718-1726
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- Nitrogen monoxide-mediated control of ferritin synthesis: Implications for macrophage iron homeostasis.
- S. Kim and P. Ponka (2002)
PNAS
99, 12214-12219
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- Antioxidant responses to oxidant-mediated lung diseases.
- S. A. A. Comhair and S. C. Erzurum (2002)
Am J Physiol Lung Cell Mol Physiol
283, L246-L255
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- Heme Oxygenase-1 . The "Emerging Molecule" Has Arrived.
- D. Morse and A. M. K. Choi (2002)
Am. J. Respir. Cell Mol. Biol.
27, 8-16
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- Nitric Oxide Mediates Apoptosis Through Formation of Peroxynitrite and Fas/Fas-Ligand Interactions in Experimental Autoimmune Uveitis.
- J. Liversidge, A. Dick, and S. Gordon (2002)
Am. J. Pathol.
160, 905-916
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- The relationship between the endothelium and the vessel wall.
- D. Hurlimann, F. Ruschitzka, and T.F. Luscher (2002)
Eur. Heart J. Suppl.
4, A1-A7
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- Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide: An Overview.
- L. J. Ignarro, C. Napoli, and J. Loscalzo (2002)
Circ. Res.
90, 21-28
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- Persistent Ehrlichia chaffeensis Infection Occurs in the Absence of Functional Major Histocompatibility Complex Class II Genes.
- R. R. Ganta, M. J. Wilkerson, C. Cheng, A. M. Rokey, and S. K. Chapes (2002)
Infect. Immun.
70, 380-388
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