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Science 18 December 1992:
Vol. 258. no. 5090, pp. 1898 - 1902
DOI: 10.1126/science.1281928

Articles

Science, Vol 258, Issue 5090, 1898-1902
Copyright © 1992 by American Association for the Advancement of Science


articles

Biochemistry of nitric oxide and its redox-activated forms

JS Stamler, DJ Singel, and J Loscalzo

Department of Medicine, Brigham and Women's Hospital, Boston, MA.

Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.


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Antioxidant responses to oxidant-mediated lung diseases.
S. A. A. Comhair and S. C. Erzurum (2002)
Am J Physiol Lung Cell Mol Physiol 283, L246-L255
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Heme Oxygenase-1 . The "Emerging Molecule" Has Arrived.
D. Morse and A. M. K. Choi (2002)
Am. J. Respir. Cell Mol. Biol. 27, 8-16
   Abstract »    Full Text »    PDF »
Nitric Oxide Mediates Apoptosis Through Formation of Peroxynitrite and Fas/Fas-Ligand Interactions in Experimental Autoimmune Uveitis.
J. Liversidge, A. Dick, and S. Gordon (2002)
Am. J. Pathol. 160, 905-916
   Abstract »    Full Text »    PDF »
The relationship between the endothelium and the vessel wall.
D. Hurlimann, F. Ruschitzka, and T.F. Luscher (2002)
Eur. Heart J. Suppl. 4, A1-A7
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Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide: An Overview.
L. J. Ignarro, C. Napoli, and J. Loscalzo (2002)
Circ. Res. 90, 21-28
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Persistent Ehrlichia chaffeensis Infection Occurs in the Absence of Functional Major Histocompatibility Complex Class II Genes.
R. R. Ganta, M. J. Wilkerson, C. Cheng, A. M. Rokey, and S. K. Chapes (2002)
Infect. Immun. 70, 380-388
   Abstract »    Full Text »    PDF »



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