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Science 27 November 1992:
Vol. 258. no. 5087, pp. 1451 - 1455
DOI: 10.1126/science.258.5087.1451
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Articles

Managing Insect Resistance to Bacillus thuringiensis Toxins

William H. McGaughey 1 and Mark E. Whalon 2

1 U.S. Grain Marketing Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 1515 College Avenue, Manhattan, KS 66502
2 Department of Entomology and Pesticide Research Center, Michigan State University, East Lansing, MI 48824

Bacillus thuringiensis (B.t.) dgr-endotoxins provide an alternative to chemical insecticides for controlling many species of pest insects. Recent biotechnological developments offer the promise of even greater use of B.t. toxins in genetically transformed pest-resistant crops. However, the discovery that insects can adapt to these toxins raises concerns about the long-term usefulness of B.t. toxins. Several methods for managing the development of resistance to B.t. toxins have been suggested, but none of these approaches offer clear advantages in all situations.


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Inheritance of Resistance to Bacillus thuringiensis Toxin (Dipel ES) in the European Corn Borer.
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PNAS 94, 2111-2116
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One gene in diamondback moth confers resistance to four Bacillus thuringiensis toxins.
B. E. Tabashnik, Y.-B. Liu, N. Finson, L. Masson, and D. G. Heckel (1997)
PNAS 94, 1640-1644
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Managing the Evolution of Insect Resistance to Transgenic Plants.
D. N. Alstad and D. A. Andow (1995)
Science 268, 1894-1896
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Kinetics of Bacillus thuringiensis Toxin Binding with Brush Border Membrane Vesicles from Susceptible and Resistant Larvae of Plutella xylostella.
L. Masson, A. Mazza, R. Brousseau, and B. Tabashnik (1995)
J. Biol. Chem. 270, 11887-11896
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