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Science 20 November 1992:
Vol. 258. no. 5086, pp. 1365 - 1369
DOI: 10.1126/science.1360702
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Articles

Science, Vol 258, Issue 5086, 1365-1369
Copyright © 1992 by American Association for the Advancement of Science

articles

Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein

T Lehner, LA Bergmeier, C Panagiotidi, L Tao, R Brookes, LS Klavinskis, P Walker, J Walker, RG Ward, L Hussain, and al. et

Division of Immunology, United Medical School, Guy's Hospital, London, United Kingdom.

Heterosexual transmission through the cervico-vaginal mucosa is the principal route of human immunodeficiency virus (HIV) infection in Africa and is increasing in the United States and Europe. Vaginal immunization with simian immunodeficiency virus (SIV) had not yet been studied in nonhuman primates. Immune responses in macaques were investigated by stimulation of the genital and gut-associated lymphoid tissue with a recombinant, particulate SIV antigen. Vaginal, followed by oral, administration of the vaccine elicited three types of immunity: (i) gag protein p27-specific, secretory immunoglobulin A (IgA) and immunoglobulin G (IgG) in the vaginal fluid, (ii) specific CD4+ T cell proliferation and helper function in B cell p27-specific IgA synthesis in the genital lymph nodes, and (iii) specific serum IgA and IgG, with CD4+ T cell proliferative and helper functions in the circulating blood.


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