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Science 13 November 1992:
Vol. 258. no. 5085, pp. 1156 - 1159
DOI: 10.1126/science.1439825
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Articles

Science, Vol 258, Issue 5085, 1156-1159
Copyright © 1992 by American Association for the Advancement of Science

articles

B cells turn off virgin but not memory T cells

EJ Fuchs and P Matzinger

Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892.

There are three possible outcomes when a T cell recognizes a cell bearing a self or foreign antigen. (i) The T cell is not sufficiently signaled and is unaffected. (ii) The T cell is activated. (iii) The T cell is turned off. The differentiation state of the T cell is critical to the outcome. Although both virgin and memory T cells can be activated by antigens presented by "professional" antigen-presenting cells such as dendritic cells, they differ in their responses to B cells. Experienced T cells respond to antigen presented by B cells, whereas virgin T cells are rendered tolerant. These findings may relate to the phenomena of low- and high-zone tolerance, neonatal tolerance, and the beneficial effect of blood transfusions on allograft survival.


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B. Pulendran, J.L. Smith, M. Jenkins, M. Schoenborn, E. Maraskovsky, and C.R. Maliszewski (1998)
J. Exp. Med. 188, 2075-2082
   Abstract »    Full Text »    PDF »
Efficient Presentation of Multivalent Antigens Targeted to Various Cell Surface Molecules of Dendritic Cells and Surface Ig of Antigen-Specific B Cells.
K. Serre, P. Machy, J.-C. Grivel, G. Jolly, N. Brun, J. Barbet, and L. Leserman (1998)
J. Immunol. 161, 6059-6067
   Abstract »    Full Text »    PDF »
The Role of the CD40 Pathway in Alloantigen-Induced Hyporesponsiveness In Vivo.
M. Niimi, T. C. Pearson, C. P. Larsen, D. Z. Alexander, D. Hollenbaugh, A. Aruffo, P. S. Linsley, E. Thomas, K. Campbell, W. C. Fanslow, et al. (1998)
J. Immunol. 161, 5331-5337
   Abstract »    Full Text »    PDF »
B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice.
D. V. Serreze, S. A. Fleming, H. D. Chapman, S. D. Richard, E. H. Leiter, and R. M. Tisch (1998)
J. Immunol. 161, 3912-3918
   Abstract »    Full Text »    PDF »
B Lymphocytes Are Crucial Antigen-Presenting Cells in the Pathogenic Autoimmune Response to GAD65 Antigen in Nonobese Diabetic Mice.
M. Falcone, J. Lee, G. Patstone, B. Yeung, and N. Sarvetnick (1998)
J. Immunol. 161, 1163-1168
   Abstract »    Full Text »    PDF »
gp100/pmel 17 Is a Murine Tumor Rejection Antigen: Induction of "Self"-reactive, Tumoricidal T Cells Using High-affinity, Altered Peptide Ligand.
W. W. Overwijk, A. Tsung, K. R. Irvine, M. R. Parkhurst, T. J. Goletz, K. Tsung, M. W. Carroll, C. Liu, B. Moss, S. A. Rosenberg, et al. (1998)
J. Exp. Med. 188, 277-286
   Abstract »    Full Text »    PDF »
Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node.
P. Garside, E. Ingulli, R. R. Merica, J. G. Johnson, R. J. Noelle, and M. K. Jenkins (1998)
Science 281, 96-99
   Abstract »    Full Text »
CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow-derived Antigen-presenting Cells.
A. J. Adler, D. W. Marsh, G. S. Yochum, J. L. Guzzo, A. Nigam, W. G. Nelson, and D. M. Pardoll (1998)
J. Exp. Med. 187, 1555-1564
   Abstract »    Full Text »    PDF »
Abortive Proliferation of Rare T Cells Induced by Direct or Indirect Antigen Presentation by Rare B Cells In Vivo.
S. E. Townsend and C. C. Goodnow (1998)
J. Exp. Med. 187, 1611-1621
   Abstract »    Full Text »    PDF »
Cutting Edge: CD40 Ligation Prevents Neonatal Induction of Transplantation Tolerance.
V. Flamand, V. Donckier, F.-X. Demoor, A. Le Moine, P. Matthys, M.-L. Vanderhaeghen, Y.-i. Tagawa, Y. Iwakura, A. Billiau, D. Abramowicz, et al. (1998)
J. Immunol. 160, 4666-4669
   Abstract »    Full Text »    PDF »
Modulation of Naive CD4 T Cell Activation with Altered Peptide Ligands: The Nature of the Peptide and Presentation in the Context of Costimulation Are Critical for a Sustained Response.
P. R. Rogers, H. M. Grey, and M. Croft (1998)
J. Immunol. 160, 3698-3704
   Abstract »    Full Text »    PDF »
A role for B cells in the development of T cell helper function in a malaria infection in mice.
J. Langhorne, C. Cross, E. Seixas, C. Li, and T. von der Weid (1998)
PNAS 95, 1730-1734
   Abstract »    Full Text »    PDF »


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