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Science 6 November 1992:
Vol. 258. no. 5084, pp. 985 - 987
DOI: 10.1126/science.1359642
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Articles

Science, Vol 258, Issue 5084, 985-987
Copyright © 1992 by American Association for the Advancement of Science

articles

Reductase activity encoded by the HM1 disease resistance gene in maize

GS Johal and SP Briggs

Department of Biotechnology Research, Pioneer Hi-Bred International, Inc., Johnston, IA 50131.

The HM1 gene in maize controls both race-specific resistance to the fungus Cochliobolus carbonum race 1 and expression of the NADPH (reduced form of nicotinamide adenine dinucleotide phosphate)-dependent HC toxin reductase (HCTR), which inactivates HC toxin, a cyclic tetrapeptide produced by the fungus to permit infection. Several HM1 alleles were generated and cloned by transposon-induced mutagenesis. The sequence of wild-type HM1 shares homology with dihydroflavonol-4-reductase genes from maize, petunia, and snap-dragon. Sequence homology is greatest in the beta alpha beta-dinucleotide binding fold that is conserved among NADPH- and NADH (reduced form of nicotinamide adenine dinucleotide)-dependent reductases and dehydrogenases. This indicates that HM1 encodes HCTR.


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