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Science 6 November 1992:
Vol. 258. no. 5084, pp. 964 - 969
DOI: 10.1126/science.1439808
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Articles

Science, Vol 258, Issue 5084, 964-969
Copyright © 1992 by American Association for the Advancement of Science

articles

Selectins: interpreters of cell-specific carbohydrate information during inflammation

LA Lasky

Department of Immunology, Genetech, Inc., South San Francisco, CA 94080.

Although a bewildering array of cell surface carbohydrate structures have been described, the physiological relevance of any of these complex molecules has often eluded biologists. A family of cell surface glycoproteins, the "selectins," has a characteristic ability to use some of these carbohydrate structures in adhesive mechanisms that help localize leukocytes to regions of inflammation. This article will review the biology of these carbohydrate-binding adhesive proteins and discuss the potential for developing anti-inflammatory antagonists that could inhibit binding events that are selectin-mediated.


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J. Cell Biol. 137, 743-754
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Prevention of ischemia-reperfusion lung injury by sulfated Lewisa pentasaccharide.
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Sperm from beta 1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly.
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J. Biol. Chem. 271, 7450-7459
   Abstract »    Full Text »    PDF »
A Schiff Base with Mildly Oxidized Carbohydrate Ligands Stabilizes L-selectin and not P-selectin or E-selectin Rolling Adhesions in Shear Flow.
K. D. Puri and T. A. Springer (1996)
J. Biol. Chem. 271, 5404-5413
   Abstract »    Full Text »    PDF »
Gliolectin is a novel carbohydrate-binding protein expressed by a subset of glia in the embryonic Drosophila nervous system.
M Tiemeyer and C. Goodman (1996)
Development 122, 925-936
   Abstract »    PDF »
Oxidized Low-Density Lipoproteins Facilitate Leukocyte Adhesion to Aortic Intima Without Affecting Endothelium-Dependent Relaxation : Role of P-Selectin.
A. Mehta, B. Yang, S. Khan, J. B. Hendricks, C. Stephen, and J. L. Mehta (1995)
Arterioscler Thromb Vasc Biol 15, 2076-2083
   Abstract »    Full Text »
Structural Analysis of the Oligosaccharides Derived from Glycodelin, a Human Glycoprotein with Potent Immunosuppressive and Contraceptive Activities.
A. Dell, H. R. Morris, R. L. Easton, M. Panico, M. Patankar, S. Oehninger, R. Koistinen, H. Koistinen, M. Seppala, and G. F. Clark (1995)
J. Biol. Chem. 270, 24116-24126
   Abstract »    Full Text »    PDF »
Biosynthesis of GlyCAM-1, a Mucin-like Ligand for L-Selectin.
D. Crommie and S. D. Rosen (1995)
J. Biol. Chem. 270, 22614-22624
   Abstract »    Full Text »    PDF »
Peptides Which Bind to E-selectin and Block Neutrophil Adhesion.
C. L. Martens, S. E. Cwirla, R. Y.-W. Lee, E. Whitehorn, E. Y.-F. Chen, A. Bakker, E. L. Martin, C. Wagstrom, P. Gopalan, C. W. Smith, et al. (1995)
J. Biol. Chem. 270, 21129-21136
   Abstract »    Full Text »    PDF »
Expression of Human Chromosome 19p alpha(1,3)-Fucosyltransferase Genes in Normal Tissues.
H. S. Cameron, D. Szczepaniak, and B. W. Weston (1995)
J. Biol. Chem. 270, 20112-20122
   Abstract »    Full Text »    PDF »
Adjunctive Selectin Blockade Successfully Reduces Infarct Size Beyond Thrombolysis in the Electrolytic Canine Coronary Artery Model.
M. J. Silver, J. M. Sutton, S. Hook, P. Lee, J. L. Malycky, M. L. Phillips, S. G. Ellis, E. J. Topol, and F. A. Nicolini (1995)
Circulation 92, 492-499
   Abstract »    Full Text »
Synthesis of Neoglycoconjugates by Transglycosylation with Arthrobacter protophormiae Endo-[IMAGE]-N-acetylglucosaminidase.
J.-Q. Fan, M. S. Quesenberry, K. Takegawa, S. Iwahara, A. Kondo, I. Kato, and Y. C. Lee (1995)
J. Biol. Chem. 270, 17730-17735
   Abstract »    Full Text »    PDF »
Calcium-dependent Conformation of a Mouse Macrophage Calcium-type Lectin.
T. Kimura, Y. Imai, and T. Irimura (1995)
J. Biol. Chem. 270, 16056-16062
   Abstract »    Full Text »    PDF »
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(1995)
J. Biol. Chem. 270, 15211-15221
   Abstract »    Full Text »    PDF »
Signaling Functions of L-selectin.
T. K. Waddell, L. Fialkow, C. K. Chan, T. K. Kishimoto, and G. P. Downey (1995)
J. Biol. Chem. 270, 15403-15411
   Abstract »    Full Text »    PDF »
Endothelial Heparan Sulfate Proteoglycans That Bind to L-Selectin Have Glucosamine Residues with Unsubstituted Amino Groups.
K. Norgard-Sumnicht and A. Varki (1995)
J. Biol. Chem. 270, 12012-12024
   Abstract »    Full Text »    PDF »
Modulation of E-selectin Structure/Function by Metal Ions.
M. Anostario Jr. and K.-S. Huang (1995)
J. Biol. Chem. 270, 8138-8144
   Abstract »    Full Text »    PDF »
CD22-mediated Cell Adhesion to Cytokine-activated Human Endothelial Cells.
K. Hanasaki, A. Varki, and L. D. Powell (1995)
J. Biol. Chem. 270, 7533-7542
   Abstract »    Full Text »    PDF »
Role of Neutrophils in Myocardial Ischemia and Reperfusion.
P. R. Hansen (1995)
Circulation 91, 1872-1885
   Abstract »    Full Text »


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