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Science 6 November 1992:
Vol. 258. no. 5084, pp. 948 - 955
DOI: 10.1126/science.1439806
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Articles
Science, Vol 258, Issue 5084, 948-955
Copyright © 1992 by American Association for the Advancement of Science
Regulation of cell surface polarity from bacteria to mammals
WJ Nelson
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305-5426.
The generation of unique domains on the cell, cell surface polarity, is critical for differentiation into the diversity of cell structures and functions found in a wide variety of organisms and cells, including the bacterium Caulobacter crescentus, the budding yeast Saccharomyces cerevisiae, and mammalian polarized epithelial cells. Comparison of the mechanisms for establishing polarity in these cells indicates that restricted membrane protein distributions are generated by selective protein targeting to, and selective protein retention at, the cell surface. Initiation of these mechanisms involves reorientation of components of the cytoskeleton and protein transport pathways toward restricted sites at the cell surface and formation of a targeting patch at those sites for selective recruitment and retention of proteins.
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