Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 November 1992:
Vol. 258. no. 5084, pp. 948 - 955
DOI: 10.1126/science.1439806
Prev | Table of Contents | Next

Articles

Science, Vol 258, Issue 5084, 948-955
Copyright © 1992 by American Association for the Advancement of Science

articles

Regulation of cell surface polarity from bacteria to mammals

WJ Nelson

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305-5426.

The generation of unique domains on the cell, cell surface polarity, is critical for differentiation into the diversity of cell structures and functions found in a wide variety of organisms and cells, including the bacterium Caulobacter crescentus, the budding yeast Saccharomyces cerevisiae, and mammalian polarized epithelial cells. Comparison of the mechanisms for establishing polarity in these cells indicates that restricted membrane protein distributions are generated by selective protein targeting to, and selective protein retention at, the cell surface. Initiation of these mechanisms involves reorientation of components of the cytoskeleton and protein transport pathways toward restricted sites at the cell surface and formation of a targeting patch at those sites for selective recruitment and retention of proteins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ischaemia/reperfusion in rat renal cortex: vesicle leakiness and Na+, K+-ATPase activity in membrane preparations.
G. Coux, M. M. Elias, and L. Trumper (2009)
Nephrol. Dial. Transplant. 24, 3020-3024
   Abstract »    Full Text »    PDF »
Spontaneous Cell Polarization Through Actomyosin-Based Delivery of the Cdc42 GTPase.
R. Wedlich-Soldner, S. Altschuler, L. Wu, and R. Li (2003)
Science 299, 1231-1235
   Abstract »    Full Text »    PDF »
p34cdc2-mediated Phosphorylation Mobilizes Microtubule-organizing Centers from the Apical Intermediate Filament Scaffold in CACO-2 Epithelial Cells.
Y. Figueroa, F. A. Wald, and P. J. I. Salas (2002)
J. Biol. Chem. 277, 37848-37854
   Abstract »    Full Text »    PDF »
Intestinal Dipeptidyl Peptidase IV Is Efficiently Sorted to the Apical Membrane through the Concerted Action of N- and O-Glycans as Well as Association with Lipid Microdomains.
M. Alfalah, R. Jacob, and H. Y. Naim (2002)
J. Biol. Chem. 277, 10683-10690
   Abstract »    Full Text »    PDF »
P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin.
F. Luciani, A. Molinari, F. Lozupone, A. Calcabrini, L. Lugini, A. Stringaro, P. Puddu, G. Arancia, M. Cianfriglia, and S. Fais (2002)
Blood 99, 641-648
   Abstract »    Full Text »    PDF »
Subunit Heterogeneity of Cytoplasmic Dynein: Differential Expression of 14 kDa Dynein Light Chains in Rat Hippocampus.
J.-Z. Chuang, T. A. Milner, and C.-H. Sung (2001)
J. Neurosci. 21, 5501-5512
   Abstract »    Full Text »    PDF »
Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia.
N. Ameen, Y Figueroa, and P. Salas (2001)
J. Cell Sci. 114, 563-575
   Abstract »    PDF »
Glycoprotein E of Varicella-Zoster Virus Enhances Cell-Cell Contact in Polarized Epithelial Cells.
C. Mo, E. E. Schneeberger, and A. M. Arvin (2000)
J. Virol. 74, 11377-11387
   Abstract »    Full Text »
High Levels of E-/P-Cadherin: Correlation with Decreased Apical Polarity of Na/K ATPase in Bovine RPE Cells In Situ.
J. M. Burke, F. Cao, and P. E. Irving (2000)
Invest. Ophthalmol. Vis. Sci. 41, 1945-1952
   Abstract »    Full Text »
The Human AC133 Hematopoietic Stem Cell Antigen Is also Expressed in Epithelial Cells and Targeted to Plasma Membrane Protrusions.
D. Corbeil, K. Roper, A. Hellwig, M. Tavian, S. Miraglia, S. M. Watt, P. J. Simmons, B. Peault, D. W. Buck, and W. B. Huttner (2000)
J. Biol. Chem. 275, 5512-5520
   Abstract »    Full Text »    PDF »
Expression of E-Cadherin by Human Retinal Pigment Epithelium: Delayed Expression In Vitro.
J. M. Burke, F. Cao, P. E. Irving, and C. M. B. Skumatz (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2963-2970
   Abstract »    Full Text »    PDF »
Cloning and functional expression of the mouse epithelial sodium channel.
Y. J. Ahn, D. R. Brooker, F. Kosari, B. J. Harte, J. Li, S. A. Mackler, and T. R. Kleyman (1999)
Am J Physiol Renal Physiol 277, F121-F129
   Abstract »    Full Text »    PDF »
Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney.
R. B. Thomson and P. S. Aronson (1999)
Am J Physiol Renal Physiol 277, F146-F156
   Abstract »    Full Text »    PDF »
Hierarchy of Sorting Signals in Chimeras of Intestinal Lactase-Phlorizin Hydrolase and the Influenza Virus Hemagglutinin.
R. Jacob, U. Preuss, P. Panzer, M. Alfalah, S. Quack, M. G. Roth, H. Naim, and H. Y. Naim (1999)
J. Biol. Chem. 274, 8061-8067
   Abstract »    Full Text »    PDF »
Coupling Assembly of the E-Cadherin/{beta}-Catenin Complex to Efficient Endoplasmic Reticulum Exit and Basal-lateral Membrane Targeting of E-Cadherin in Polarized MDCK Cells.
Y.-T. Chen, D. B. Stewart, and W. J. Nelson (1999)
J. Cell Biol. 144, 687-699
   Abstract »    Full Text »    PDF »
Insulin stimulation of rat ventricular K+ currents depends on the integrity of the cytoskeleton.
Y Shimoni, H S Ewart, and D Severson (1999)
J. Physiol. 514, 735-745
   Abstract »    Full Text »    PDF »
Interactions of the AP-1 Golgi Adaptor with the Polymeric Immunoglobulin Receptor and Their Possible Role in Mediating Brefeldin A-sensitive Basolateral Targeting from the trans-Golgi Network.
E. Orzech, K. Schlessinger, A. Weiss, C. T. Okamoto, and B. Aroeti (1999)
J. Biol. Chem. 274, 2201-2215
   Abstract »    Full Text »    PDF »
Selective localization of the polytopic membrane protein prominin in microvilli of epithelial cells - a combination of apical sorting and retention in plasma membrane protrusions.
D Corbeil, K Roper, M. Hannah, A Hellwig, and W. Huttner (1999)
J. Cell Sci. 112, 1023-1033
   Abstract »    PDF »
Distribution of Cell Membrane-associated Proteins Along the Human Nephron.
O. Kwon, B. D. Myers, R. Sibley, D. Dafoe, E. Alfrey, and W. J. Nelson (1998)
J. Histochem. Cytochem. 46, 1423-1434
   Abstract »    Full Text »
The Cytoplasmic Domains of a beta 1 Integrin Mediate Polarization in Madin-Darby Canine Kidney Cells by Selective Basolateral Stabilization.
A. Gut, M. S. Balda, and K. Matter (1998)
J. Biol. Chem. 273, 29381-29388
   Abstract »    Full Text »    PDF »
Human calcitonin receptor is directly targeted to and retained in the basolateral surface of MDCK cells.
D. R. Nussenzveig, M. D. F. C. Matos, and C. N. Thaw (1998)
Am J Physiol Cell Physiol 275, C1264-C1276
   Abstract »    Full Text »    PDF »
The Cytoplasmic Tail of Rhodopsin Acts as a Novel Apical Sorting Signal in Polarized MDCK Cells.
J.-Z. Chuang and C.-H. Sung (1998)
J. Cell Biol. 142, 1245-1256
   Abstract »    Full Text »    PDF »
Rab17 Localizes to Recycling Endosomes and Regulates Receptor-mediated Transcytosis in Epithelial Cells.
W. Hunziker and P. J. Peters (1998)
J. Biol. Chem. 273, 15734-15741
   Abstract »    Full Text »    PDF »
Patterns for RANTES Secretion and Intercellular Adhesion Molecule 1 Expression Mediate Transepithelial T Cell Traffic Based on Analyses In Vitro and In Vivo.
M. Taguchi, D. Sampath, T. Koga, M. Castro, D. C. Look, S. Nakajima, and M. J. Holtzman (1998)
J. Exp. Med. 187, 1927-1940
   Abstract »    Full Text »    PDF »
Rab17 Regulates Membrane Trafficking through Apical Recycling Endosomes in Polarized Epithelial Cells.
P. Zacchi, H. Stenmark, R. G. Parton, D. Orioli, F. Lim, A. Giner, I. Mellman, M. Zerial, and C. Murphy (1998)
J. Cell Biol. 140, 1039-1053
   Abstract »    Full Text »    PDF »
Morphogenesis of Escherichia coli.
N. Nanninga (1998)
Microbiol. Mol. Biol. Rev. 62, 110-129
   Abstract »    Full Text »    PDF »
Kanadaptin Is a Protein That Interacts with the Kidney but Not the Erythroid Form of Band 3.
J. Chen, S. Vijayakumar, X. Li, and Q. Al-Awqati (1998)
J. Biol. Chem. 273, 1038-1043
   Abstract »    Full Text »    PDF »
Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye.
G. Thomas, D. Zarnescu, A. Juedes, M. Bales, A Londergan, C. Korte, and D. Kiehart (1998)
Development 125, 2125-2134
   Abstract »    PDF »
Dendroaxonal Transcytosis of Transferrin in Cultured Hippocampal and Sympathetic Neurons.
A. Hemar, J.-C. Olivo, E. Williamson, R. Saffrich, and C. G. Dotti (1997)
J. Neurosci. 17, 9026-9034
   Abstract »    Full Text »    PDF »
Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells.
A. Weigmann, D. Corbeil, A. Hellwig, and W. B. Huttner (1997)
PNAS 94, 12425-12430
   Abstract »    Full Text »    PDF »
Tyrosine-dependent Basolateral Sorting Signals Are Distinct from Tyrosine-dependent Internalization Signals.
S. Lin, H. Y. Naim, and M. G. Roth (1997)
J. Biol. Chem. 272, 26300-26305
   Abstract »    Full Text »    PDF »
Structural Requirements for Basolateral Sorting of the Human Transferrin Receptor in the Biosynthetic and Endocytic Pathways of Madin-Darby Canine Kidney Cells.
G. Odorizzi and I. S. Trowbridge (1997)
J. Cell Biol. 137, 1255-1264
   Abstract »    Full Text »    PDF »
Protein Kinase C Activation Upregulates Intercellular Adhesion of {alpha}-Catenin-negative Human Colon Cancer Cell Variants via Induction of Desmosomes.
J. v. Hengel, L. Gohon, E. Bruyneel, S. Vermeulen, M. Cornelissen, M. Mareel, and F. v. Roy (1997)
J. Cell Biol. 137, 1103-1116
   Abstract »    Full Text »    PDF »
The Apical Submembrane Cytoskeleton Participates in the Organization of the Apical Pole in Epithelial Cells.
P. J.I. Salas, M. L. Rodriguez, A. L. Viciana, D. E. Vega-Salas, and H.-P. Hauri (1997)
J. Cell Biol. 137, 359-375
   Abstract »    Full Text »    PDF »
LI-Cadherin-mediated Cell-Cell Adhesion Does Not Require Cytoplasmic Interactions.
B. Kreft, D. Berndorff, A. Bottinger, S. Finnemann, D. Wedlich, M. Hortsch, R. Tauber, and R. Gessner (1997)
J. Cell Biol. 136, 1109-1121
   Abstract »    Full Text »    PDF »
Occludin dephosphorylation in early development of Xenopus laevis.
M Cordenonsi, E Mazzon, L De Rigo, S Baraldo, F Meggio, and S Citi (1997)
J. Cell Sci. 110, 3131-3139
   Abstract »    PDF »
Mechanisms for de novo biogenesis of an apical membrane compartment in groups of simple epithelial cells surrounded by extracellular matrix.
G. Ojakian, W. Nelson, and K. Beck (1997)
J. Cell Sci. 110, 2781-2794
   Abstract »    PDF »
Changes in the distribution of LFA-1, catenins, and F-actin during transendothelial migration of monocytes in culture.
M Sandig, E Negrou, and K. Rogers (1997)
J. Cell Sci. 110, 2807-2818
   Abstract »    PDF »
Golgi membrane skeleton: identification, localization and oligomerization of a 195 kDa ankyrin isoform associated with the Golgi complex.
K. Beck, J. Buchanan, and W. Nelson (1997)
J. Cell Sci. 110, 1239-1249
   Abstract »    PDF »
alpha-spectrin is required for germline cell division and differentiation in the Drosophila ovary.
M de Cuevas, J. Lee, and A. Spradling (1996)
Development 122, 3959-3968
   Abstract »    PDF »
Occludin is a functional component of the tight junction.
K. McCarthy, I. Skare, M. Stankewich, M Furuse, S Tsukita, R. Rogers, R. Lynch, and E. Schneeberger (1996)
J. Cell Sci. 109, 2287-2298
   Abstract »    PDF »
Non-neural agrin codistributes with acetylcholine receptors during early differentiation of Torpedo electrocytes.
A Cartaud, M. Ludosky, M Haasemann, D Jung, K Campbell, and J Cartaud (1996)
J. Cell Sci. 109, 1837-1846
   Abstract »    PDF »
Establishment of hepatic cell polarity in the rat hepatoma-human fibroblast hybrid WIF-B9. A biphasic phenomenon going from a simple epithelial polarized phenotype to an hepatic polarized one.
C Decaens, P Rodriguez, C Bouchaud, and D Cassio (1996)
J. Cell Sci. 109, 1623-1635
   Abstract »    PDF »
Alternative RNA splicing that determines agrin activity regulates binding to heparin and alpha-dystroglycan.
J. Campanelli, G. Gayer, and R. Scheller (1996)
Development 122, 1663-1672
   Abstract »    PDF »
Association of the {alpha}-Adducin Locus With Essential Hypertension.
G. Casari, C. Barlassina, D. Cusi, L. Zagato, R. Muirhead, M. Righetti, P. Nembri, K. Amar, M. Gatti, F. Macciardi, et al. (1995)
Hypertension 25, 320-326
   Abstract »    Full Text »
Polarized Distribution and Delivery of Plasma Membrane Proteins in Thyroid Follicular Epithelial Cells.
R. Kuliawat, M. P. Lisanti, and P. Arvan (1995)
J. Biol. Chem. 270, 2478-2482
   Abstract »    Full Text »    PDF »
Ankyrin(G).
E. Kordeli, S. Lambert, and V. Bennett (1995)
J. Biol. Chem. 270, 2352-2359
   Abstract »    Full Text »    PDF »
The alpha 2 beta 1 integrin regulates collagen-mediated MDCK epithelial membrane remodeling and tubule formation.
R Schwimmer and G. Ojakian (1995)
J. Cell Sci. 108, 2487-2498
   Abstract »    PDF »
Generation of Epithelial Cell Polarity: Roles for Protein Trafficking, Membrane-Cytoskeleton, and E-Cadherin-mediated Cell Adhesion.
R.W. Mays, W.J. Nelson, and J.A. Marrs (1995)
Cold Spring Harb Symp Quant Biol 60, 763-773
   Abstract »    PDF »
cAMP regulates morphogenesis in the fungal pathogen Ustilago maydis..
S Gold, G Duncan, K Barrett, and J Kronstad (1994)
Genes & Dev. 8, 2805-2816
   Abstract »    PDF »
Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression.
A Lutcke, R. Parton, C Murphy, V. Olkkonen, P Dupree, A Valencia, K Simons, and M Zerial (1994)
J. Cell Sci. 107, 3437-3448
   Abstract »    PDF »
Two proteins associated with secretory granule membranes identified in chicken regulated secretory cells.
J. Thomas, A Stieber, and N Gonatas (1994)
J. Cell Sci. 107, 1297-1308
   Abstract »    PDF »
Regulation of epithelial cell surface polarity reversal by beta 1 integrins.
G. Ojakian and R Schwimmer (1994)
J. Cell Sci. 107, 561-576
   Abstract »    PDF »
Polarized distribution of Listeria monocytogenes surface protein ActA at the site of directional actin assembly.
C Kocks, R Hellio, P Gounon, H Ohayon, and P Cossart (1993)
J. Cell Sci. 105, 699-710
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)