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Science 6 November 1992:
Vol. 258. no. 5084, pp. 917 - 924
DOI: 10.1126/science.1439803

Articles

Science, Vol 258, Issue 5084, 917-924
Copyright © 1992 by American Association for the Advancement of Science


articles

Membrane fusion

JM White

Department of Pharmacology, University of California, San Francisco 94143-0450.

Common themes are emerging from the study of viral, cell-cell, intracellular, and liposome fusion. Viral and cellular membrane fusion events are mediated by fusion proteins or fusion machines. Viral fusion proteins share important characteristics, notably a fusion peptide within a transmembrane-anchored polypeptide chain. At least one protein involved in a cell-cell fusion reaction resembles viral fusion proteins. Components of intracellular fusion machines are utilized in multiple membrane trafficking events and are conserved through evolution. Fusion pores develop during and intracellular fusion events suggesting similar mechanisms for many, if not all, fusion events.


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J. Biol. Chem. 274, 5299-5309
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Cell lysis induces redistribution of the GPI-anchored variant surface glycoprotein on both faces of the plasma membrane of Trypanosoma brucei.
M. Cardoso De Almeida, M Geuskens, and E Pays (1999)
J. Cell Sci. 112, 4461-4473
   Abstract »    PDF »
Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.
J Schlondorff and C. Blobel (1999)
J. Cell Sci. 112, 3603-3617
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Inhibition of Influenza A Virus Replication by Compounds Interfering with the Fusogenic Function of the Viral Hemagglutinin.
S. J. Plotch, B. O'Hara, J. Morin, O. Palant, J. LaRocque, J. D. Bloom, S. A. Lang Jr., M. J. DiGrandi, M. Bradley, R. Nilakantan, et al. (1999)
J. Virol. 73, 140-151
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Novel Entry Pathway of Bovine Herpesvirus 1 and 5.
P. Wild, E. M. Schraner, J. Peter, E. Loepfe, and M. Engels (1998)
J. Virol. 72, 9561-9566
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A Proline-Rich Motif Downstream of the Receptor Binding Domain Modulates Conformation and Fusogenicity of Murine Retroviral Envelopes.
D. Lavillette, M. Maurice, C. Roche, S. J. Russell, M. Sitbon, and F.-L. Cosset (1998)
J. Virol. 72, 9955-9965
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Virus Maturation by Budding.
H. Garoff, R. Hewson, and D.-J. E. Opstelten (1998)
Microbiol. Mol. Biol. Rev. 62, 1171-1190
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Effects of Mutations in the Rubella Virus E1 Glycoprotein on E1-E2 Interaction and Membrane Fusion Activity.
D. Yang, D. Hwang, Z. Qiu, and S. Gillam (1998)
J. Virol. 72, 8747-8755
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Mitochondrial Fusion in Yeast Requires the Transmembrane GTPase Fzo1p.
G. J. Hermann, J. W. Thatcher, J. P. Mills, K. G. Hales, M. T. Fuller, J. Nunnari, and J. M. Shaw (1998)
J. Cell Biol. 143, 359-373
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A Role for a Protease in Morphogenic Responses during Yeast Cell Fusion.
L. Elia and L. Marsh (1998)
J. Cell Biol. 142, 1473-1485
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Secretory and viral fusion may share mechanistic events with fusion between curved lipid bilayers.
J. Lee and B. R. Lentz (1998)
PNAS 95, 9274-9279
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The Cytomegalovirus-Encoded Chemokine Receptor US28 Can Enhance Cell-Cell Fusion Mediated by Different Viral Proteins.
O. Pleskoff, C. Treboute, and M. Alizon (1998)
J. Virol. 72, 6389-6397
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Characterization of the Proline-Rich Region of Murine Leukemia Virus Envelope Protein.
B. Weimin Wu, P. M. Cannon, E. M. Gordon, F. L. Hall, and W. F. Anderson (1998)
J. Virol. 72, 5383-5391
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Functional Domains in the Retroviral Transmembrane Protein.
Y. Zhao, L. Zhu, C. A. Benedict, D. Chen, W. F. Anderson, and P. M. Cannon (1998)
J. Virol. 72, 5392-5398
   Abstract »    Full Text »    PDF »
A synthetic all D-amino acid peptide corresponding to the N-terminal sequence of HIV-1 gp41 recognizes the wild-type fusion peptide in the membrane and inhibits HIV-1 envelope glycoprotein-mediated cell fusion.
M. Pritsker, P. Jones, R. Blumenthal, and Y. Shai (1998)
PNAS 95, 7287-7292
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Incorporation of Fowl Plague Virus Hemagglutinin into Murine Leukemia Virus Particles and Analysis of the Infectivity of the Pseudotyped Retroviruses.
T. Hatziioannou, S. Valsesia-Wittmann, S. J. Russell, and F.-L. Cosset (1998)
J. Virol. 72, 5313-5317
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Effect of Cleavage Mutants on Syncytium Formation Directed by the Wild-Type Fusion Protein of Newcastle Disease Virus.
Z. Li, T. Sergel, E. Razvi, and T. Morrison (1998)
J. Virol. 72, 3789-3795
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In Vivo Evolution of a Novel, Syncytium-Inducing and Cytopathic Feline Leukemia Virus Variant.
J. L. Rohn, M. S. Moser, S. R. Gwynn, D. N. Baldwin, and J. Overbaugh (1998)
J. Virol. 72, 2686-2696
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Mutational Analysis of the Candidate Internal Fusion Peptide of the Avian Leukosis and Sarcoma Virus Subgroup A Envelope Glycoprotein.
L. D. Hernandez and J. M. White (1998)
J. Virol. 72, 3259-3267
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Intracellular Complexes of Viral Spike and Cellular Receptor Accumulate during Cytopathic Murine Coronavirus Infections.
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R. L. Damico, J. Crane, and P. Bates (1998)
PNAS 95, 2580-2585
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Phosphatidylinositol-Dependent Membrane Fusion Induced by a Putative Fusogenic Sequence of Ebola Virus.
M. B. Ruiz-Arguello, F. M. Goni, F. B. Pereira, and J. L. Nieva (1998)
J. Virol. 72, 1775-1781
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Mutational Analysis of the Fusion Peptide of Moloney Murine Leukemia Virus Transmembrane Protein p15E.
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Dilation of the Human Immunodeficiency Virus-1 Envelope Glycoprotein Fusion Pore Revealed by the Inhibitory Action of a Synthetic Peptide from gp41.
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Structural Features of Membrane Fusion between Influenza Virus and Liposome as Revealed by Quick-Freezing Electron Microscopy.
T. Kanaseki, K. Kawasaki, M. Murata, Y. Ikeuchi, and S.-i. Ohnishi (1997)
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Fusion Peptides Derived from the HIV Type 1 Glycoprotein 41 Associate within Phospholipid Membranes and Inhibit Cell-Cell Fusion. STRUCTURE-FUNCTION STUDY.
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Inner but Not Outer Membrane Leaflets Control the Transition from Glycosylphosphatidylinositol-anchored Influenza Hemagglutinin-induced Hemifusion to Full Fusion.
G. B. Melikyan, S. A. Brener, D. C. Ok, and F. S. Cohen (1997)
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Evidence That Cholesteryl Ester Transfer Protein-mediated Reductions in Reconstituted High Density Lipoprotein Size Involve Particle Fusion.
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Photolabeling Identifies a Putative Fusion Domain in the Envelope Glycoprotein of Rabies and Vesicular Stomatitis Viruses.
P. Durrer, Y. Gaudin, R. W. H. Ruigrok, R. Graf, and J. Brunner (1995)
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Monoclonal antibodies which recognize equatorial segment epitopes presented de novo following the A23187-induced acrosome reaction of guinea pig sperm.
C. Allen and D. Green (1995)
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Membrane Fusion: The Influenza Paradigm.
J.M. White (1995)
Cold Spring Harb Symp Quant Biol 60, 581-588
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Flu virus invasion: halfway there.
C. Carr and P. Kim (1994)
Science 266, 234-236
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Insertion of a coiled-coil peptide from influenza virus hemagglutinin into membranes.
Y. Yu, D. King, and Y. Shin (1994)
Science 266, 274-276
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S Chiruvolu, S Walker, J Israelachvili, F. Schmitt, D Leckband, and J. Zasadzinski (1994)
Science 264, 1753-1756
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Characterization of a homolog of human bone morphogenetic protein 1 in the embryo of the sea urchin, Strongylocentrotus purpuratus.
S. Hwang, J. Partin, and W. Lennarz (1994)
Development 120, 559-568
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The Transmembrane Domains of Hepatitis C Virus Envelope Glycoproteins E1 and E2 Play a Major Role in Heterodimerization.
A. Op De Beeck, R. Montserret, S. Duvet, L. Cocquerel, R. Cacan, B. Barberot, M. Le Maire, F. Penin, and J. Dubuisson (2000)
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Mode of Action of an Antiviral Peptide from HIV-1. INHIBITION AT A POST-LIPID MIXING STAGE.
Y. Kliger, S. A. Gallo, S. G. Peisajovich, I. Munoz-Barroso, S. Avkin, R. Blumenthal, and Y. Shai (2001)
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The Amino-terminal Region of the Fusion Peptide of Influenza Virus Hemagglutinin HA2 Inserts into Sodium Dodecyl Sulfate Micelle with Residues 16-18 at the Aqueous Boundary at Acidic pH. OLIGOMERIZATION AND THE CONFORMATIONAL FLEXIBILITY.
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J. Biol. Chem. 275, 19150-19158
   Abstract »    Full Text »    PDF »
Calcium triggers an intramolecular association of the C2 domains in synaptotagmin.
R. A. Garcia, C. E. Forde, and H. A. Godwin (2000)
PNAS 97, 5883-5888
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Science. ISSN 0036-8075 (print), 1095-9203 (online)