Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 30 October 1992:
Vol. 258. no. 5083, pp. 815 - 818
DOI: 10.1126/science.1439792
Prev | Table of Contents | Next

Articles

Science, Vol 258, Issue 5083, 815-818
Copyright © 1992 by American Association for the Advancement of Science

articles

Selecting T cell receptors with high affinity for self-MHC by decreasing the contribution of CD8

LA Sherman, SV Hesse, MJ Irwin, D La Face, and P Peterson

Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.

Selective events during T cell repertoire development in the thymus include both the positive selection of cells whose receptors recognize self-major histocompatibility complex (MHC) molecules and negative selection (tolerance) of cells whose interaction with self-MHC is of high affinity. The affinity of T cell interactions with class I MHC molecules includes contributions by both the T cell receptor and the CD8 coreceptor. Therefore, by decreasing the affinity of the interaction with CD8, T cells whose receptors have relatively high affinities for self-MHC may survive negative selection. Such T cells were generated and those T cells reactive with self-MHC plus antigen also displayed low affinity for self.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain.
J. Kuball, B. Hauptrock, V. Malina, E. Antunes, R.-H. Voss, M. Wolfl, R. Strong, M. Theobald, and P. D. Greenberg (2009)
J. Exp. Med. 206, 463-475
   Abstract »    Full Text »    PDF »
A T cell receptor associated with naturally occurring human tumor immunity.
B. D. Santomasso, W. K. Roberts, A. Thomas, T. Williams, N. E. Blachere, M. E. Dudley, A. N. Houghton, J. B. Posner, and R. B. Darnell (2007)
PNAS 104, 19073-19078
   Abstract »    Full Text »    PDF »
Facilitating matched pairing and expression of TCR chains introduced into human T cells.
J. Kuball, M. L. Dossett, M. Wolfl, W. Y. Ho, R.-H. Voss, C. Fowler, and P. D. Greenberg (2007)
Blood 109, 2331-2338
   Abstract »    Full Text »    PDF »
Enhanced Antitumor Activity of Murine-Human Hybrid T-Cell Receptor (TCR) in Human Lymphocytes Is Associated with Improved Pairing and TCR/CD3 Stability..
C. J. Cohen, Y. Zhao, Z. Zheng, S. A. Rosenberg, and R. A. Morgan (2006)
Cancer Res. 66, 8878-8886
   Abstract »    Full Text »    PDF »
Recognition of Fresh Human Tumor by Human Peripheral Blood Lymphocytes Transduced with a Bicistronic Retroviral Vector Encoding a Murine Anti-p53 TCR.
C. J. Cohen, Z. Zheng, R. Bray, Y. Zhao, L. A. Sherman, S. A. Rosenberg, and R. A. Morgan (2005)
J. Immunol. 175, 5799-5808
   Abstract »    Full Text »    PDF »
Targeting Positive Regulatory Domain I-Binding Factor 1 and X Box-Binding Protein 1 Transcription Factors by Multiple Myeloma-Reactive CTL.
C. Lotz, S. A. Mutallib, N. Oehlrich, U. Liewer, E. A. Ferreira, M. Moos, M. Hundemer, S. Schneider, S. Strand, C. Huber, et al. (2005)
J. Immunol. 175, 1301-1309
   Abstract »    Full Text »    PDF »
Human CTLs to Wild-Type and Enhanced Epitopes of a Novel Prostate and Breast Tumor-Associated Protein, TARP, Lyse Human Breast Cancer Cells.
S. Oh, M. Terabe, C. D. Pendleton, A. Bhattacharyya, T. K. Bera, M. Epel, Y. Reiter, J. Phillips, W. M. Linehan, C. Kasten-Sportes, et al. (2004)
Cancer Res. 64, 2610-2618
   Abstract »    Full Text »    PDF »
Genetically Modified HLA Class I Molecules Able to Inhibit Human NK Cells Without Provoking Alloreactive CD8+ CTLs.
A. Sharland, A. Patel, J. H. Lee, A. E. Cestra, S. Saidman, and G. L. Waneck (2002)
J. Immunol. 168, 3266-3274
   Abstract »    Full Text »    PDF »
Identification and Characterization of a Human Agonist Cytotoxic T-Lymphocyte Epitope of Human Prostate-specific Antigen.
H. Terasawa, K.-Y. Tsang, J. Gulley, P. Arlen, and J. Schlom (2002)
Clin. Cancer Res. 8, 41-53
   Abstract »    Full Text »    PDF »
{alpha}-Fetoprotein-specific Tumor Immunity Induced by Plasmid Prime-Adenovirus Boost Genetic Vaccination.
W. S. Meng, L. H. Butterfield, A. Ribas, V. B. Dissette, J. B. Heller, G. A. Miranda, J. A. Glaspy, W. H. McBride, and J. S. Economou (2001)
Cancer Res. 61, 8782-8786
   Abstract »    Full Text »    PDF »
CTLA-4 Blockade Enhances the CTL Responses to the p53 Self-Tumor Antigen.
J. Hernandez, A. Ko, and L. A. Sherman (2001)
J. Immunol. 166, 3908-3914
   Abstract »    Full Text »    PDF »
Adoptive T Cell Immunotherapy of Human Uveal Melanoma Targeting gp100.
R. P. M. Sutmuller, L. R. H. M. Schurmans, L. M. van Duivenvoorde, J. A. Tine, E. I. H. van der Voort, R. E. M. Toes, C. J. M. Melief, M. J. Jager, and R. Offringa (2000)
J. Immunol. 165, 7308-7315
   Abstract »    Full Text »    PDF »
The Quantity of TCR Signal Determines Positive Selection and Lineage Commitment of T Cells.
N. Watanabe, H. Arase, M. Onodera, P. S. Ohashi, and T. Saito (2000)
J. Immunol. 165, 6252-6261
   Abstract »    Full Text »    PDF »
CD8+ T Cells Are Necessary for Recognition of Allelic, But Not Locus-Mismatched or Xeno-, HLA Class I Transplantation Antigens.
S. H. Borenstein, J. Graham, X.-L. Zhang, and J. W. Chamberlain (2000)
J. Immunol. 165, 2341-2353
   Abstract »    Full Text »    PDF »
Status of Activation of Circulating Vaccine-Elicited CD8+ T Cells.
M.-B. Nielsen, V. Monsurro, S. A. Migueles, E. Wang, A. Perez-Diez, K.-H. Lee, U. Kammula, S. A. Rosenberg, and F. M. Marincola (2000)
J. Immunol. 165, 2287-2296
   Abstract »    Full Text »    PDF »
Dense Bodies of Human Cytomegalovirus Induce both Humoral and Cellular Immune Responses in the Absence of Viral Gene Expression.
S. Pepperl, J. Münster, M. Mach, J. R. Harris, and B. Plachter (2000)
J. Virol. 74, 6132-6146
   Abstract »    Full Text »
Glucocorticoids Regulate TCR-Induced Elevation of CD4: Functional Implications.
G. J. Wiegers, I. E. M. Stec, W. E. F. Klinkert, and J. M. H. M. Reul (2000)
J. Immunol. 164, 6213-6220
   Abstract »    Full Text »    PDF »
The Use of HLA A2.1/p53 Peptide Tetramers to Visualize the Impact of Self Tolerance on the TCR Repertoire.
J. Hernandez, P. P. Lee, M. M. Davis, and L. A. Sherman (2000)
J. Immunol. 164, 596-602
   Abstract »    Full Text »    PDF »
Modified Vaccinia Virus Ankara for Delivery of Human Tyrosinase as Melanoma-associated Antigen: Induction of Tyrosinase- and Melanoma-specific Human Leukocyte Antigen A*0201-restricted Cytotoxic T Cells in Vitro and in Vivo.
I. Drexler, E. Antunes, M. Schmitz, T. Wolfel, C. Huber, V. Erfle, P. Rieber, M. Theobald, and G. Sutter (1999)
Cancer Res. 59, 4955-4963
   Abstract »    Full Text »    PDF »
Involvement of the SHP-1 Tyrosine Phosphatase in Regulation of T Cell Selection.
J. Zhang, A.-K. Somani, D. Yuen, Y. Yang, P. E. Love, and K. A. Siminovitch (1999)
J. Immunol. 163, 3012-3021
   Abstract »    Full Text »    PDF »
Coreceptor-Independent T Cell Activation in Mice Expressing MHC Class II Molecules Mutated in the CD4 Binding Domain.
E. A. Mostaghel, J. M. Riberdy, D. A. Steeber, and C. Doyle (1998)
J. Immunol. 161, 6559-6566
   Abstract »    Full Text »    PDF »
Generation of Human Cytolytic T Lymphocyte Lines Directed Against Prostate-Specific Antigen (PSA) Employing a PSA Oligoepitope Peptide.
P. Correale, K. Walmsley, S. Zaremba, M. Zhu, J. Schlom, and K. Y. Tsang (1998)
J. Immunol. 161, 3186-3194
   Abstract »    Full Text »    PDF »
An Opposite Pattern of Selection of a Single T Cell Antigen Receptor in the Thymus and among Intraepithelial Lymphocytes.
D. Cruz, B. C. Sydora, K. Hetzel, G. Yakoub, M. Kronenberg, and H. Cheroutre (1998)
J. Exp. Med. 188, 255-265
   Abstract »    Full Text »    PDF »
Alloreactive T Cells That Do Not Require TCR and CD8 Coengagement Are Present in Naive Mice and Contribute to Graft Rejection.
P. A. Smith and T. A. Potter (1998)
J. Immunol. 160, 5382-5389
   Abstract »    Full Text »    PDF »
Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4+ T cells in vivo.
J. M. Riberdy, E. Mostaghel, and C. Doyle (1998)
PNAS 95, 4493-4498
   Abstract »    Full Text »    PDF »
alpha beta T cell receptor interactions with syngeneic and allogeneic ligands: Affinity measurements and crystallization.
K. C. Garcia, M. D. Tallquist, L. R. Pease, A. Brunmark, C. A. Scott, M. Degano, E. A. Stura, P. A. Peterson, I. A. Wilson, and L. Teyton (1997)
PNAS 94, 13838-13843
   Abstract »    Full Text »    PDF »
Tolerance to p53 by A2.1-restricted Cytotoxic T Lymphocytes.
M. Theobald, J. Biggs, J. Hernandez, J. Lustgarten, C. Labadie, and L. A. Sherman (1997)
J. Exp. Med. 185, 833-842
   Abstract »    Full Text »    PDF »
Positive and negative thymocyte selection induced by different concentrations of a single peptide.
E Sebzda, V. Wallace, J Mayer, R. Yeung, T. Mak, and P. Ohashi (1994)
Science 263, 1615-1618
   Abstract »    PDF »
Requirement for CD8 beta chain in positive selection of CD8-lineage T cells.
K Nakayama, K Nakayama, I Negishi, K Kuida, M. Louie, O Kanagawa, H Nakauchi, and D. Loh (1994)
Science 263, 1131-1133
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)