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Science 30 October 1992:
Vol. 258. no. 5083, pp. 806 - 808
DOI: 10.1126/science.1439789
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Articles

Science, Vol 258, Issue 5083, 806-808
Copyright © 1992 by American Association for the Advancement of Science

articles

Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism

LG Goldfarb, RB Petersen, M Tabaton, P Brown, AC LeBlanc, P Montagna, P Cortelli, J Julien, C Vital, WW Pendelbury, and al. et

Laboratory of Central Nervous System Studies, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892.

Fatal familial insomnia (FFI) and a subtype of familial Creutzfeldt-Jakob disease (CJD), two clinically and pathologically distinct diseases, are linked to the same mutation at codon 178 (Asn178) of the prion protein gene. The possibility that a second genetic component modified the phenotypic expression of the Asn178 mutation was investigated. FFI and the familial CJD subtype segregated with different genotypes determined by the Asn178 mutation and the methionine-valine polymorphism at codon 129. The Met129, Asn178 allele segregated with FFI in all 15 affected members of five kindreds whereas the Val129, Asn178 allele segregated with the familial CJD subtype in all 15 affected members of six kindreds. Thus, two distinct disease phenotypes linked to a single pathogenic mutation can be determined by a common polymorphism.


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BMJ 311, 1420-1421
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Structural clues to prion replication.
F. Cohen, K. Pan, Z Huang, M Baldwin, R. Fletterick, and S. Prusiner (1994)
Science 264, 530-531
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Genetic and Infectious Prion Diseases.
S. B. Prusiner (1993)
Arch Neurol 50, 1129-1153
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Molecular genetics of neurological diseases.
J. Martin (1993)
Science 262, 674-676
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