Science 30 October 1992: Vol. 258. no. 5083, pp. 766 - 770 DOI: 10.1126/science.1439783

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Articles

Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism.

Y. Shi and D. Cheng (2009)
Am J Physiol Endocrinol Metab 297, E10-E18
 |  Abstract »  |  Full Text »  |  PDF »

Diabetes Mellitus: Considerations for Dentistry.

S. Kidambi and S. B. Patel (2008)
J Am Dent Assoc 139, 8S-18S
 |  Abstract »  |  Full Text »  |  PDF »

Berberine Acutely Inhibits Insulin Secretion from {beta}-Cells through 3',5'-Cyclic Adenosine 5'-Monophosphate Signaling Pathway.

L. Zhou, X. Wang, L. Shao, Y. Yang, W. Shang, G. Yuan, B. Jiang, F. Li, J. Tang, H. Jing, et al. (2008)
Endocrinology 149, 4510-4518
 |  Abstract »  |  Full Text »  |  PDF »

Pyruvate Dehydrogenase Kinase 4: Regulation by Thiazolidinediones and Implication in Glyceroneogenesis in Adipose Tissue.

T. Cadoudal, E. Distel, S. Durant, F. Fouque, J.-M. Blouin, M. Collinet, S. Bortoli, C. Forest, and C. Benelli (2008)
Diabetes 57, 2272-2279
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Reinventing Type 2 Diabetes: Pathogenesis, Treatment, and Prevention.

R. H. Unger (2008)
JAMA 299, 1185-1187
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Minireview: Mitochondrial Energetics and Insulin Resistance.

A. E. Civitarese and E. Ravussin (2008)
Endocrinology 149, 950-954
 |  Abstract »  |  Full Text »  |  PDF »

Targets for Intervention in Dyslipidemia in Diabetes.

G. H. Tomkin (2008)
Diabetes Care 31, S241-S248
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The effect of insulin on net lipid oxidation predicts worsening of insulin resistance and development of type 2 diabetes mellitus.

J. Koska, E. Ortega, C. Bogardus, J. Krakoff, and J. C. Bunt (2007)
Am J Physiol Endocrinol Metab 293, E264-E269
 |  Abstract »  |  Full Text »  |  PDF »

Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes.

Y.-R. Cho, H.-J. Kim, S.-Y. Park, H. J. Ko, E.-G. Hong, T. Higashimori, Z. Zhang, D. Y. Jung, M. S. Ola, K. F. LaNoue, et al. (2007)
Am J Physiol Endocrinol Metab 293, E327-E336
 |  Abstract »  |  Full Text »  |  PDF »

Palmitate Induced Mitochondrial Deoxyribonucleic Acid Damage and Apoptosis in L6 Rat Skeletal Muscle Cells.

L. I. Rachek, S. I. Musiyenko, S. P. LeDoux, and G. L. Wilson (2007)
Endocrinology 148, 293-299
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Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men.

K. F. Petersen, S. Dufour, J. Feng, D. Befroy, J. Dziura, C. D. Man, C. Cobelli, and G. I. Shulman (2006)
PNAS 103, 18273-18277
 |  Abstract »  |  Full Text »  |  PDF »

The Endocannabinoid System as an Emerging Target of Pharmacotherapy.

P. Pacher, S. Batkai, and G. Kunos (2006)
Pharmacol. Rev. 58, 389-462
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Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.

S.-Y. Park, Y.-R. Cho, H.-J. Kim, E.-G. Hong, T. Higashimori, S. J. Lee, I. J. Goldberg, G. I. Shulman, S. M. Najjar, and J. K. Kim (2006)
Am J Physiol Endocrinol Metab 291, E517-E524
 |  Abstract »  |  Full Text »  |  PDF »

Free Fatty acids and atherosclerosis--guilty or innocent?.

S. R. Smith and P. W. F. Wilson (2006)
J. Clin. Endocrinol. Metab. 91, 2506-2508
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Protection of INS-1 Cells From Free Fatty Acid-Induced Apoptosis by Targeting hOGG1 to Mitochondria..

L. I. Rachek, N. P. Thornley, V. I. Grishko, S. P. LeDoux, and G. L. Wilson (2006)
Diabetes 55, 1022-1028
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of glycogen synthesis by increased lipid availability is associated with subcellular redistribution of glycogen synthase.

A J Taylor, J-M Ye, and C Schmitz-Peiffer (2006)
J. Endocrinol. 188, 11-23
 |  Abstract »  |  Full Text »  |  PDF »

The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus.

W. L. Isley, J. M. Miles, B. W. Patterson, and W. S. Harris (2006)
J. Lipid Res. 47, 193-200
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Diet-induced obesity and acute hyperlipidemia reduce I{kappa}B{alpha} levels in rat skeletal muscle in a fiber-type dependent manner.

B. A. Bhatt, J. J. Dube, N. Dedousis, J. A. Reider, and R. M. O'Doherty (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R233-R240
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Unraveling the Temporal Pattern of Diet-Induced Insulin Resistance in Individual Organs and Cardiac Dysfunction in C57BL/6 Mice.

S.-Y. Park, Y.-R. Cho, H.-J. Kim, T. Higashimori, C. Danton, M.-K. Lee, A. Dey, B. Rothermel, Y.-B. Kim, A. Kalinowski, et al. (2005)
Diabetes 54, 3530-3540
 |  Abstract »  |  Full Text »  |  PDF »

Activation of PPAR{gamma} enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats.

L. S. Golfman, C. R. Wilson, S. Sharma, M. Burgmaier, M. E. Young, P. H. Guthrie, M. Van Arsdall, J. V. Adrogue, K. K. Brown, and H. Taegtmeyer (2005)
Am J Physiol Endocrinol Metab 289, E328-E336
 |  Abstract »  |  Full Text »  |  PDF »

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.

S.-Y. Park, H.-J. Kim, S. Wang, T. Higashimori, J. Dong, Y.-J. Kim, G. Cline, H. Li, M. Prentki, G. I. Shulman, et al. (2005)
Am J Physiol Endocrinol Metab 289, E30-E39
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Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance.

J. K. Kim, H.-J. Kim, S.-Y. Park, A. Cederberg, R. Westergren, D. Nilsson, T. Higashimori, Y.-R. Cho, Z.-X. Liu, J. Dong, et al. (2005)
Diabetes 54, 1657-1663
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Diet and Genetic Background on Sterol Regulatory Element-Binding Protein-1c, Stearoyl-CoA Desaturase 1, and the Development of the Metabolic Syndrome.

S. B. Biddinger, K. Almind, M. Miyazaki, E. Kokkotou, J. M. Ntambi, and C. R. Kahn (2005)
Diabetes 54, 1314-1323
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Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic {beta}-Cells.

A. Takahashi, K. Motomura, T. Kato, T. Yoshikawa, Y. Nakagawa, N. Yahagi, H. Sone, H. Suzuki, H. Toyoshima, N. Yamada, et al. (2005)
Diabetes 54, 492-499
 |  Abstract »  |  Full Text »  |  PDF »

Peroxisomal Proliferator-activated Receptor-{gamma} Coactivator-1{alpha} (PGC-1{alpha}) Enhances the Thyroid Hormone Induction of Carnitine Palmitoyltransferase I (CPT-I{alpha}).

Y. Zhang, K. Ma, S. Song, Marshall. B. Elam, G. A. Cook, and E. A. Park (2004)
J. Biol. Chem. 279, 53963-53971
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Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II.

L. W. Castellani, P. Gargalovic, M. Febbraio, S. Charugundla, M.-L. Jien, and A. J. Lusis (2004)
J. Lipid Res. 45, 2377-2387
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Modulation of Adipoinsular Axis in Prediabetic Zucker Diabetic Fatty Rats by Diazoxide.

R. Alemzadeh and K. M. Tushaus (2004)
Endocrinology 145, 5476-5484
 |  Abstract »  |  Full Text »  |  PDF »

The Hypoglycemic Effects of Hesperidin and Naringin Are Partly Mediated by Hepatic Glucose-Regulating Enzymes in C57BL/KsJ-db/db Mice.

U. J. Jung, M.-K. Lee, K.-S. Jeong, and M.-S. Choi (2004)
J. Nutr. 134, 2499-2503
 |  Abstract »  |  Full Text »  |  PDF »

Lipids and Glucose in Type 2 Diabetes: What is the cause and effect?.

G. Boden and M. Laakso (2004)
Diabetes Care 27, 2253-2259
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Leptin and the Control of Metabolism: Role for Stearoyl-CoA Desaturase-1 (SCD-1).

P. Cohen and J. M. Friedman (2004)
J. Nutr. 134, 2455S-2463S
 |  Abstract »  |  Full Text »  |  PDF »

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

G. Chen, G. Liang, J. Ou, J. L. Goldstein, and M. S. Brown (2004)
PNAS 101, 11245-11250
 |  Abstract »  |  Full Text »  |  PDF »

Metabolic syndrome without obesity: Hepatic overexpression of 11{beta}-hydroxysteroid dehydrogenase type 1 in transgenic mice.

J. M. Paterson, N. M. Morton, C. Fievet, C. J. Kenyon, M. C. Holmes, B. Staels, J. R. Seckl, and J. J. Mullins (2004)
PNAS 101, 7088-7093
 |  Abstract »  |  Full Text »  |  PDF »

Dissociation between Fat-Induced in Vivo Insulin Resistance and Proximal Insulin Signaling in Skeletal Muscle in Men at Risk for Type 2 Diabetes.

H. Storgaard, C. B. Jensen, M. Bjornholm, X. M. Song, S. Madsbad, J. R. Zierath, and A. A. Vaag (2004)
J. Clin. Endocrinol. Metab. 89, 1301-1311
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Heart disease in diabetes--resist the beginnings.

H. Taegtmeyer and P. Razeghi (2004)
J. Am. Coll. Cardiol. 43, 315
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Gene and Protein Kinase Expression Profiling of Reactive Oxygen Species-Associated Lipotoxicity in the Pancreatic {beta}-Cell Line MIN6.

X. Wang, H. Li, D. De Leo, W. Guo, V. Koshkin, I. G. Fantus, A. Giacca, C. B. Chan, S. Der, and M. B. Wheeler (2004)
Diabetes 53, 129-140
 |  Abstract »  |  Full Text »  |  PDF »

Insulin resistance, intramyocellular lipid content, and plasma adiponectin in patients with type 1 diabetes.

G. Perseghin, G. Lattuada, M. Danna, L. P. Sereni, P. Maffi, F. De Cobelli, A. Battezzati, A. Secchi, A. Del Maschio, and L. Luzi (2003)
Am J Physiol Endocrinol Metab 285, E1174-E1181
 |  Abstract »  |  Full Text »  |  PDF »

Dyslipidemia, but Not Hyperglycemia, Induces Inflammatory Adhesion Molecules in Human Retinal Vascular Endothelial Cells.

W. Chen, D. B. Jump, M. B. Grant, W. J. Esselman, and J. V. Busik (2003)
Invest. Ophthalmol. Vis. Sci. 44, 5016-5022
 |  Abstract »  |  Full Text »  |  PDF »

Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals.

H. J. Harwood Jr., S. F. Petras, L. D. Shelly, L. M. Zaccaro, D. A. Perry, M. R. Makowski, D. M. Hargrove, K. A. Martin, W. R. Tracey, J. G. Chapman, et al. (2003)
J. Biol. Chem. 278, 37099-37111
 |  Abstract »  |  Full Text »  |  PDF »

Thiazolidinediones Block Fatty Acid Release by Inducing Glyceroneogenesis in Fat Cells.

J. Tordjman, G. Chauvet, J. Quette, E. G. Beale, C. Forest, and B. Antoine (2003)
J. Biol. Chem. 278, 18785-18790
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-secreting beta -Cell Dysfunction Induced by Human Lipoproteins.

M.-E. Roehrich, V. Mooser, V. Lenain, J. Herz, J. Nimpf, S. Azhar, M. Bideau, A. Capponi, P. Nicod, J.-A. Haefliger, et al. (2003)
J. Biol. Chem. 278, 18368-18375
 |  Abstract »  |  Full Text »  |  PDF »

Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets.

J.-M. Schwarz, P. Linfoot, D. Dare, and K. Aghajanian (2003)
Am. J. Clinical Nutrition 77, 43-50
 |  Abstract »  |  Full Text »  |  PDF »

Genetics of Obesity and Type 2 Diabetes: Tracking Pathogenic Traits During the Predisease Period.

P. Bougneres (2002)
Diabetes 51, S295-303
 |  Abstract »  |  Full Text »  |  PDF »

Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity: Role in {beta}-Cell Adaptation and Failure in the Etiology of Diabetes.

M. Prentki, E. Joly, W. El-Assaad, and R. Roduit (2002)
Diabetes 51, S405-413
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes.

J. L. Evans, I. D. Goldfine, B. A. Maddux, and G. M. Grodsky (2002)
Endocr. Rev. 23, 599-622
 |  Abstract »  |  Full Text »  |  PDF »

Low Density Lipoprotein Can Cause Death of Islet {beta}-Cells by Its Cellular Uptake and Oxidative Modification.

M. Cnop, J. C. Hannaert, A. Y. Grupping, and D. G. Pipeleers (2002)
Endocrinology 143, 3449-3453
 |  Abstract »  |  Full Text »  |  PDF »

Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation.

G. Perseghin, P. Scifo, M. Danna, A. Battezzati, S. Benedini, E. Meneghini, A. Del Maschio, and L. Luzi (2002)
Am J Physiol Endocrinol Metab 283, E556-E564
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of cardiac protein kinase B is regulated by palmitate.

C.-L. M. Soltys, L. Buchholz, M. Gandhi, A. S. Clanachan, K. Walsh, and J. R. B. Dyck (2002)
Am J Physiol Heart Circ Physiol 283, H1056-H1064
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Benfluorex on Fatty Acid and Glucose Metabolism in Isolated Rat Hepatocytes: From Metabolic Fluxes to Gene Expression.

C. Kohl, D. Ravel, J. Girard, and J.-P. Pegorier (2002)
Diabetes 51, 2363-2368
 |  Abstract »  |  Full Text »  |  PDF »

Estrogen Can Prevent or Reverse Obesity and Diabetes in Mice Expressing Human Islet Amyloid Polypeptide.

J. G. Geisler, W. Zawalich, K. Zawalich, J. R.T. Lakey, H. Stukenbrok, A. J. Milici, and W. C. Soeller (2002)
Diabetes 51, 2158-2169
 |  Abstract »  |  Full Text »  |  PDF »

Increased Efficiency of Fatty Acid Uptake Contributes to Lipid Accumulation in Skeletal Muscle of High Fat-Fed Insulin-Resistant Rats.

B. D. Hegarty, G. J. Cooney, E. W. Kraegen, and S. M. Furler (2002)
Diabetes 51, 1477-1484
 |  Abstract »  |  Full Text »  |  PDF »

John Denis McGarry, PhD.

D. W. Foster (2002)
Diabetes 51, 1651
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Adaptation and Maladaptation of the Heart in Diabetes: Part II: Potential Mechanisms.

M. E. Young, P. McNulty, and H. Taegtmeyer (2002)
Circulation 105, 1861-1870
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Adaptation and Maladaptation of the Heart in Diabetes: Part I: General Concepts.

H. Taegtmeyer, P. McNulty, and M. E. Young (2002)
Circulation 105, 1727-1733
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Increased Reactive Oxygen Species Production Down-regulates Peroxisome Proliferator-activated alpha Pathway in C2C12 Skeletal Muscle Cells.

A. Cabrero, M. Alegret, R. M. Sanchez, T. Adzet, J. C. Laguna, and M. V. Carrera (2002)
J. Biol. Chem. 277, 10100-10107
 |  Abstract »  |  Full Text »  |  PDF »

Fatty Acid-Induced Insulin Resistance: Decreased Muscle PI3K Activation But Unchanged Akt Phosphorylation.

Y. T. Kruszynska, D. S. Worrall, J. Ofrecio, J. P. Frias, G. Macaraeg, and J. M. Olefsky (2002)
J. Clin. Endocrinol. Metab. 87, 226-234
 |  Abstract »  |  Full Text »  |  PDF »

Banting Lecture 2001: Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes.

J. D. McGarry (2002)
Diabetes 51, 7-18
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Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR:LA-cp rat.

M. B. Elam, H. G. Wilcox, L. M. Cagen, X. Deng, R. Raghow, P. Kumar, M. Heimberg, and J. C. Russell (2001)
J. Lipid Res. 42, 2039-2048
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Protein Phosphatase 2A-Like Activity, but Not Atypical Protein Kinase C{zeta}, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate.

R. Cazzolli, L. Carpenter, T. J. Biden, and C. Schmitz-Peiffer (2001)
Diabetes 50, 2210-2218
 |  Abstract »  |  Full Text »

Dehydroepiandrosterone Alters Zucker Rat Soleus and Cardiac Muscle Lipid Profiles.

J. M. Abadie, G. T. Malcom, J. R. Porter, and F. Svec (2001)
Experimental Biology and Medicine 226, 782-789
 |  Abstract »  |  Full Text »  |  PDF »

Gender Factors Affect Fatty Acids-Induced Insulin Resistance in Nonobese Humans: Effects of Oral Steroidal Contraception.

G. Perseghin, P. Scifo, E. Pagliato, A. Battezzati, S. Benedini, L. Soldini, G. Testolin, A. Del Maschio, and L. Luzi (2001)
J. Clin. Endocrinol. Metab. 86, 3188-3196
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Inhibits Peroxisomal Fatty Acid Oxidation in Isolated Rat Hepatocytes.

F. G. Hamel, R. G. Bennett, J. L. Upward, and W. C. Duckworth (2001)
Endocrinology 142, 2702-2706
 |  Abstract »  |  Full Text »  |  PDF »

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.

P. A. Kern, S. Ranganathan, C. Li, L. Wood, and G. Ranganathan (2001)
Am J Physiol Endocrinol Metab 280, E745-E751
 |  Abstract »  |  Full Text »  |  PDF »

Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?.

N. Lameloise, P. Muzzin, M. Prentki, and F. Assimacopoulos-Jeannet (2001)
Diabetes 50, 803-809
 |  Abstract »  |  Full Text »

Studies With Apolipoprotein A-II Transgenic Mice Indicate a Role for HDLs in Adiposity and Insulin Resistance.

L. W. Castellani, A. M. Goto, and A. J. Lusis (2001)
Diabetes 50, 643-651
 |  Abstract »  |  Full Text »

Diseases of liporegulation: new perspective on obesity and related disorders.

R. H. UNGER and L. ORCI (2001)
FASEB J 15, 312-321
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of 1-Acyl-Glycerol-3-Phosphate Acyltransferase-{alpha} Enhances Lipid Storage in Cellular Models of Adipose Tissue and Skeletal Muscle.

H. Ruan and H. J. Pownall (2001)
Diabetes 50, 233-240
 |  Abstract »  |  Full Text »

The role of leptin resistance in the lipid abnormalities of aging.

Z.-W. WANG, W.-T. PAN, Y. LEE, T. KAKUMA, Y.-T. ZHOU, and R. H. UNGER (2001)
FASEB J 15, 108-114
 |  Abstract »  |  Full Text »  |  PDF »

Prolonged Inhibition of Muscle Carnitine Palmitoyltransferase-1 Promotes Intramyocellular Lipid Accumulation and Insulin Resistance in Rats.

R. L. Dobbins, L. S. Szczepaniak, B. Bentley, V. Esser, J. Myhill, and J. D. McGarry (2001)
Diabetes 50, 123-130
 |  Abstract »  |  Full Text »

Transgenic studies of fatty acid oxidation gene expression in nonobese diabetic mice.

D. M. Kurtz, L. Tian, B. A. Gower, T. R. Nagy, C. A. Pinkert, and P. A. Wood (2000)
J. Lipid Res. 41, 2063-2070
 |  Abstract »  |  Full Text »

Glucagon-like Peptide-1 in Fishes: The Liver and Beyond.

T. P. Mommsen (2000)
Integr. Comp. Biol. 40, 259-268
 |  Abstract »  |  Full Text »  |  PDF »

Acute Stimulation with Long Chain Acyl-CoA Enhances Exocytosis in Insulin-secreting Cells (HIT T-15 and NMRI beta -Cells).

J. T. Deeney, J. Gromada, M. Hoy, H. L. Olsen, C. J. Rhodes, M. Prentki, P.-O. Berggren, and B. E. Corkey (2000)
J. Biol. Chem. 275, 9363-9368
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice.

J. K. Kim, O. Gavrilova, Y. Chen, M. L. Reitman, and G. I. Shulman (2000)
J. Biol. Chem. 275, 8456-8460
 |  Abstract »  |  Full Text »  |  PDF »

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss.

D. E. Kelley, B. Goodpaster, R. R. Wing, and J.-A. Simoneau (1999)
Am J Physiol Endocrinol Metab 277, E1130-E1141
 |  Abstract »  |  Full Text »  |  PDF »

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes.

I. Shimomura, Y. Bashmakov, S. Ikemoto, J. D. Horton, M. S. Brown, and J. L. Goldstein (1999)
PNAS 96, 13656-13661
 |  Abstract »  |  Full Text »  |  PDF »

Glucokinase Overexpression Restores Glucose Utilization and Storage in Cultured Hepatocytes from Male Zucker Diabetic Fatty Rats.

J. Seoane, A. Barbera, S. Telemaque-Potts, C. B. Newgard, and J. J. Guinovart (1999)
J. Biol. Chem. 274, 31833-31838
 |  Abstract »  |  Full Text »  |  PDF »

Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells.

L. Segall, N. Lameloise, F. Assimacopoulos-Jeannet, E. Roche, P. Corkey, S. Thumelin, B. E. Corkey, and M. Prentki (1999)
Am J Physiol Endocrinol Metab 277, E521-E528
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate.

C. Schmitz-Peiffer, D. L. Craig, and T. J. Biden (1999)
J. Biol. Chem. 274, 24202-24210
 |  Abstract »  |  Full Text »  |  PDF »

L-Carnitine Improves Glucose Disposal in Type 2 Diabetic Patients.

G. Mingrone, A. V. Greco, E. Capristo, G. Benedetti, A. Giancaterini, A. D. Gaetano, and G. Gasbarrini (1999)
J. Am. Coll. Nutr. 18, 77-82
 |  Abstract »  |  Full Text »  |  PDF »

Life without white fat: a transgenic mouse.

J. Moitra, M. M. Mason, M. Olive, D. Krylov, O. Gavrilova, B. Marcus-Samuels, L. Feigenbaum, E. Lee, T. Aoyama, M. Eckhaus, et al. (1998)
Genes & Dev. 12, 3168-3181
 |  Abstract »  |  Full Text »

Control of Human Muscle-type Carnitine Palmitoyltransferase I Gene Transcription by Peroxisome Proliferator-activated Receptor.

C. Mascaro, E. Acosta, J. A. Ortiz, P. F. Marrero, F. G. Hegardt, and D. Haro (1998)
J. Biol. Chem. 273, 8560-8563
 |  Abstract »  |  Full Text »  |  PDF »

A Sequence Element in the GLUT4 Gene That Mediates Repression by Insulin.

D. W. Cooke and M. D. Lane (1998)
J. Biol. Chem. 273, 6210-6217
 |  Abstract »  |  Full Text »  |  PDF »

Fatty Acids Decrease IDX-1 Expression in Rat Pancreatic Islets and Reduce GLUT2, Glucokinase, Insulin, and Somatostatin Levels.

S. Gremlich, C. Bonny, G. Waeber, and B. Thorens (1997)
J. Biol. Chem. 272, 30261-30269
 |  Abstract »  |  Full Text »  |  PDF »

Rat amylin-(8---37) enhances insulin action and alters lipid metabolism in normal and insulin-resistant rats.

M. Hettiarachchi, S. Chalkley, S. M. Furler, Y.-S. Choong, M. Heller, G. J. S. Cooper, and E. W. Kraegen (1997)
Am J Physiol Endocrinol Metab 273, E859-E867
 |  Abstract »  |  Full Text »  |  PDF »

Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.

C. Schmitz-Peiffer, N. D. Oakes, C. L. Browne, E. W. Kraegen, and T. J. Biden (1997)
Am J Physiol Endocrinol Metab 273, E915-E921
 |  Abstract »  |  Full Text »  |  PDF »

Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity.

K. Koyama, G. Chen, Y. Lee, and R. H. Unger (1997)
Am J Physiol Endocrinol Metab 273, E708-E713
 |  Abstract »  |  Full Text »  |  PDF »

Uptake of Long Chain Free Fatty Acids Is Selectively Up-regulated in Adipocytes of Zucker Rats with Genetic Obesity and Non-insulin-dependent Diabetes Mellitus.

P. D. Berk, S.-L. Zhou, C.-L. Kiang, D. Stump, M. Bradbury, and L. M. Isola (1997)
J. Biol. Chem. 272, 8830-8835
 |  Abstract »  |  Full Text »  |  PDF »

Dexamethasone Induces Posttranslational Degradation of GLUT2 and Inhibition of Insulin Secretion in Isolated Pancreatic beta Cells. COMPARISON WITH THE EFFECTS OF FATTY ACIDS.

S. Gremlich, R. Roduit, and B. Thorens (1997)
J. Biol. Chem. 272, 3216-3222
 |  Abstract »  |  Full Text »  |  PDF »

Fatty Acids Rapidly Induce the Carnitine Palmitoyltransferase I Gene in the Pancreatic beta -Cell Line INS-1.

F. Assimacopoulos-Jeannet, S. Thumelin, E. Roche, V. Esser, J. D. McGarry, and M. Prentki (1997)
J. Biol. Chem. 272, 1659-1664
 |  Abstract »  |  Full Text »  |  PDF »

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy.

G. Chen, K. Koyama, X. Yuan, Y. Lee, Y.-T. Zhou, R. O'Doherty, C. B. Newgard, and R. H. Unger (1996)
PNAS 93, 14795-14799
 |  Abstract »  |  Full Text »  |  PDF »

Defective Fatty Acid-mediated beta-Cell Compensation in Zucker Diabetic Fatty Rats.

H. Hirose, Y. H. Lee, L. R. Inman, Y. Nagasawa, J. H. Johnson, and R. H. Unger (1996)
J. Biol. Chem. 271, 5633-5637
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial Carnitine Palmitoyltransferase I Isoform Switching in the Developing Rat Heart.

N. F. Brown, B. C. Weis, J. E. Husti, D. W. Foster, and J. D. McGarry (1995)
J. Biol. Chem. 270, 8952-8957
 |  Abstract »  |  Full Text »  |  PDF »

Pancreatic beta-Cells in Obesity.

J. L. Milburn Jr., H. Hirose, Y. H. Lee, Y. Nagasawa, A. Ogawa, M. Ohneda, H. BeltrandelRio, C. B. Newgard, J. H. Johnson, and R. H. Unger (1995)
J. Biol. Chem. 270, 1295-1299
 |  Abstract »  |  Full Text »  |  PDF »

Thyroid Hormone Regulates Carnitine Palmitoyltransferase Ialpha Gene Expression through Elements in the Promoter and First Intron.

M. S. Jansen, G. A. Cook, S. Song, and E. A. Park (2000)
J. Biol. Chem. 275, 34989-34997
 |  Abstract »  |  Full Text »  |  PDF »

Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-alpha Gene in the Pancreatic beta -Cell.

R. Roduit, J. Morin, F. Masse, L. Segall, E. Roche, C. B. Newgard, F. Assimacopoulos-Jeannet, and M. Prentki (2000)
J. Biol. Chem. 275, 35799-35806
 |  Abstract »  |  Full Text »  |  PDF »

Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo.

S. F. Previs, D. J. Withers, J.-M. Ren, M. F. White, and G. I. Shulman (2000)
J. Biol. Chem. 275, 38990-38994
 |  Abstract »  |  Full Text »  |  PDF »

Liporegulation in Diet-induced Obesity. THE ANTISTEATOTIC ROLE OF HYPERLEPTINEMIA.

Y. Lee, M.-Y. Wang, T. Kakuma, Z.-W. Wang, E. Babcock, K. McCorkle, M. Higa, Y.-T. Zhou, and R. H. Unger (2001)
J. Biol. Chem. 276, 5629-5635
 |  Abstract »  |  Full Text »  |  PDF »

Arachidonic Acid Stimulates Glucose Uptake in 3T3-L1 Adipocytes by Increasing GLUT1 and GLUT4 Levels at the Plasma Membrane. EVIDENCE FOR INVOLVEMENT OF LIPOXYGENASE METABOLITES AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR gamma.

C. Nugent, J. B. Prins, J. P. Whitehead, J. M. Wentworth, V. K. K. Chatterjee, and S. O'Rahilly (2001)
J. Biol. Chem. 276, 9149-9157
 |  Abstract »  |  Full Text »  |  PDF »

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance.

J. K. Kim, J. J. Fillmore, Y. Chen, C. Yu, I. K. Moore, M. Pypaert, E. P. Lutz, Y. Kako, W. Velez-Carrasco, I. J. Goldberg, et al. (2001)
PNAS 98, 7522-7527
 |  Abstract »  |  Full Text »  |  PDF »

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