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Science 23 October 1992:
Vol. 258. no. 5082, pp. 668 - 671
DOI: 10.1126/science.1411576
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Articles

Science, Vol 258, Issue 5082, 668-671
Copyright © 1992 by American Association for the Advancement of Science

articles

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

GD Schellenberg, TD Bird, EM Wijsman, HT Orr, L Anderson, E Nemens, JA White, L Bonnycastle, JL Weber, ME Alonso, and al. et

Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Zmax of 9.15 (theta = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (theta = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Zmax = 5.94, theta = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.


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