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Science 23 October 1992:
Vol. 258. no. 5082, pp. 651 - 653
DOI: 10.1126/science.1411574
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Articles

Science, Vol 258, Issue 5082, 651-653
Copyright © 1992 by American Association for the Advancement of Science

articles

Hemoglobin-AGE: a circulating marker of advanced glycosylation

Z Makita, H Vlassara, E Rayfield, K Cartwright, E Friedman, R Rodby, A Cerami, and R Bucala

Picower Institute for Medical Research, Manhasset, NY 11030.

Advanced glycosylation end products (AGEs) form spontaneously from glucose-derived Amadori products and accumulate on long-lived tissue proteins. AGEs have been implicated in the pathogenesis of several of the complications of aging and diabetes, including atherosclerosis and renal disease. With the use of recently developed AGE-specific antibodies, an AGE-modified form of human hemoglobin has been identified. Termed hemoglobin-AGE (Hb-AGE), this modified species accounts for 0.42 percent of circulating hemoglobin in normal individuals but increases to 0.75 percent in patients with diabetes-induced hyperglycemia. In a group of diabetic patients treated with the advanced glycosylation inhibitor aminoguanidine, Hb-AGE levels decreased significantly over a 1-month period. Hemoglobin-AGE measurements may provide an index of long-term tissue modification by AGEs and prove useful in assessing the contribution of advanced glycosylation to a variety of diabetic and age-related complications.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)