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Science 23 October 1992:
Vol. 258. no. 5082, pp. 593 - 597
DOI: 10.1126/science.1411569

Articles

Science, Vol 258, Issue 5082, 593-597
Copyright © 1992 by American Association for the Advancement of Science


articles

Interleukin-6 and its receptor: a paradigm for cytokines

T Kishimoto, S Akira, and T Taga

Department of Internal Medicine III, Osaka University Medical School, Japan.

Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune responses, and inflammation have been identified and characterized at the molecular level. Several characteristic features of cytokines, such as pleiotropy and redundancy, are now more clearly understood on the basis of their molecular structures. Accumulating evidence has demonstrated an intimate link between cytokines and various diseases such as allergy, autoimmune diseases, and cancer. The pathogenesis of these diseases and therapies to treat them will be discussed based on insights derived from cytokine research.


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Development 122, 1235-1242
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Development 122, 419-428
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Interaction between the Components of the Interferon [IMAGE] Receptor Complex.
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J. Biol. Chem. 270, 10915-10922
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Combining Two Mutations of Human Interleukin-6 That Affect gp130 Activation Results in a Potent Interleukin-6 Receptor Antagonist on Human Myeloma Cells.
M. Ehlers, F. D. de Hon, H. K. Bos, U. Horsten, Gün. Kurapkat, H. S. van De Leur, J. Grötzinger, A. Wollmer, J. P. J. Brakenhoff, and S. Rose-John (1995)
J. Biol. Chem. 270, 8158-8163
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Detection of a Novel Transcription Factor for the Aalpha Fibrinogen Gene in Response to Interleukin-6.
Z. Liu and Z. Liu (1995)
J. Biol. Chem. 270, 7580-7586
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Separation of Transactivation and AP1 Antagonism Functions of Retinoic Acid Receptor alpha.
S. Nagpal, J. Athanikar, and R. A. S. Chandraratna (1995)
J. Biol. Chem. 270, 923-927
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Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus.
A Bonni, D. Frank, C Schindler, and M. Greenberg (1993)
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LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.
S Davis, T. Aldrich, N Stahl, L Pan, T Taga, T Kishimoto, N. Ip, and G. Yancopoulos (1993)
Science 260, 1805-1808
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IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase.
M Murakami, M Hibi, N Nakagawa, T Nakagawa, K Yasukawa, K Yamanishi, T Taga, and T Kishimoto (1993)
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Influence of Dietary Fatty Acids on Cytokine Production and Its Clinical Implications.
S. N. Meydani and C. A. Dinarello (1993)
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