Science 16 October 1992: Vol. 258. no. 5081, pp. 478 - 480 DOI: 10.1126/science.1411546

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Articles

A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.

M. Yamamoto, D. M. Standley, S. Takashima, H. Saiga, M. Okuyama, H. Kayama, E. Kubo, H. Ito, M. Takaura, T. Matsuda, et al. (2009)
J. Exp. Med. 206, 2747-2760
 |  Abstract »  |  Full Text »  |  PDF »

A critical role of TAK1 in B-cell receptor-mediated nuclear factor {kappa}B activation.

J. Schuman, Y. Chen, A. Podd, M. Yu, H.-H. Liu, R. Wen, Z. J. Chen, and D. Wang (2009)
Blood 113, 4566-4574
 |  Abstract »  |  Full Text »  |  PDF »

Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation.

V. Nadeau, S. Guillemette, L.-F. Belanger, O. Jacob, S. Roy, and J. Charron (2009)
Development 136, 1363-1374
 |  Abstract »  |  Full Text »  |  PDF »

Heparin Binding Epidermal Growth Factor-Like Growth Factor and PD169316 Prevent Apoptosis in Mouse Embryonic Stem Cells.

M. Krishnamoorthy, J. Heimburg-Molinaro, A. M. Bargo, R. J. Nash, and R. J. Nash (2009)
J. Biochem. 145, 177-184
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C{gamma}2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis.

Y. Chen, X. Wang, L. Di, G. Fu, Y. Chen, L. Bai, J. Liu, X. Feng, J. M. McDonald, S. Michalek, et al. (2008)
J. Biol. Chem. 283, 29593-29601
 |  Abstract »  |  Full Text »  |  PDF »

Novel MEK1 Mutation Identified by Mutational Analysis of Epidermal Growth Factor Receptor Signaling Pathway Genes in Lung Adenocarcinoma.

J. L. Marks, Y. Gong, D. Chitale, B. Golas, M. D. McLellan, Y. Kasai, L. Ding, E. R. Mardis, R. K. Wilson, D. Solit, et al. (2008)
Cancer Res. 68, 5524-5528
 |  Abstract »  |  Full Text »  |  PDF »

Phase I Targeted Combination Trial of Sorafenib and Erlotinib in Patients with Advanced Solid Tumors.

I. Duran, S. J. Hotte, H. Hirte, E. X. Chen, M. MacLean, S. Turner, L. Duan, G. R. Pond, C. Lathia, S. Walsh, et al. (2007)
Clin. Cancer Res. 13, 4849-4857
 |  Abstract »  |  Full Text »  |  PDF »

Lipid Rafts and Nonrafts Mediate Tumor Necrosis Factor Related Apoptosis-Inducing Ligand Induced Apoptotic and Nonapoptotic Signals in Non Small Cell Lung Carcinoma Cells.

J. H. Song, M. C.L. Tse, A. Bellail, S. Phuphanich, F. Khuri, N. M. Kneteman, and C. Hao (2007)
Cancer Res. 67, 6946-6955
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Receptor Cross-Talk: Exposure to Lipopolysaccharide Induces an Alternate Pathway for B Cell Receptor-Induced ERK Phosphorylation and NF-{kappa}B Activation.

J. R. Dye, A. Palvanov, B. Guo, and T. L. Rothstein (2007)
J. Immunol. 179, 229-235
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Monocyte Chemoattractant Protein-1 Expression by Angiotensin II in the Pancreatic Islets and {beta}-Cells.

G. Chipitsyna, Q. Gong, C. F. Gray, Y. Haroon, E. Kamer, and H. A. Arafat (2007)
Endocrinology 148, 2198-2208
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Replicative Senescence of Diploid Human Cells by Nuclear ERK Signaling.

M. Tresini, A. Lorenzini, C. Torres, and V. J. Cristofalo (2007)
J. Biol. Chem. 282, 4136-4151
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Lymphoma 10 Is Essential for Fc{epsilon}R-Mediated Degranulation and IL-6 Production in Mast Cells.

Y. Chen, B. P. Pappu, H. Zeng, L. Xue, S. W. Morris, X. Lin, R. Wen, and D. Wang (2007)
J. Immunol. 178, 49-57
 |  Abstract »  |  Full Text »  |  PDF »

Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway.

S. Zhang, Z. Li, X. Wu, Q. Huang, H.-M. Shen, and C.-N. Ong (2006)
Mol. Cancer Ther. 5, 3285-3293
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis.

V. Bissonauth, S. Roy, M. Gravel, S. Guillemette, and J. Charron (2006)
Development 133, 3429-3440
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Serine 526 Is Required for MEKK3 Activity, and Association with 14-3-3 Blocks Dephosphorylation.

A. Fritz, K. J. Brayer, N. McCormick, D. G. Adams, B. E. Wadzinski, and R. R. Vaillancourt (2006)
J. Biol. Chem. 281, 6236-6245
 |  Abstract »  |  Full Text »  |  PDF »

Raf: A Strategic Target for Therapeutic Development Against Cancer.

M. Beeram, A. Patnaik, and E. K. Rowinsky (2005)
J. Clin. Oncol. 23, 6771-6790
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Receptor (BCR) Cross-Talk: IL-4 Creates an Alternate Pathway for BCR-Induced ERK Activation That Is Phosphatidylinositol 3-Kinase Independent.

B. Guo and T. L. Rothstein (2005)
J. Immunol. 174, 5375-5381
 |  Abstract »  |  Full Text »  |  PDF »

Interferon {gamma} Induces Neurite Outgrowth by Up-regulation of p35 Neuron-specific Cyclin-dependent Kinase 5 Activator via Activation of ERK1/2 Pathway.

J. H. Song, C. X. Wang, D. K. Song, P. Wang, A. Shuaib, and C. Hao (2005)
J. Biol. Chem. 280, 12896-12901
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Receptor (BCR) Cross-Talk: CD40 Engagement Enhances BCR-Induced ERK Activation.

T. Mizuno and T. L. Rothstein (2005)
J. Immunol. 174, 3369-3376
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor Inhibition by Tyrphostin 51 Induces Apoptosis in Luteinized Granulosa Cells.

S. M. Khan, R. H. Oliver, and J. Yeh (2005)
J. Clin. Endocrinol. Metab. 90, 469-473
 |  Abstract »  |  Full Text »  |  PDF »

Alterations in Receptor Expression or Agonist Concentration Change the Pathways Gastrin-Releasing Peptide Receptor Uses to Regulate Extracellular Signal-Regulated Kinase.

P.-W. Chen and G. S. Kroog (2004)
Mol. Pharmacol. 66, 1625-1634
 |  Abstract »  |  Full Text »  |  PDF »

Reverse Signaling through Membrane-bound Interleukin-15.

V. Budagian, E. Bulanova, Z. Orinska, T. Pohl, E. C. Borden, R. Silverman, and S. Bulfone-Paus (2004)
J. Biol. Chem. 279, 42192-42201
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of Epidermal Growth Factor (EGF) Receptor Downstream Signaling Pathways by Betacellulin and EGF.

T. Saito, S. Okada, K. Ohshima, E. Yamada, M. Sato, Y. Uehara, H. Shimizu, J. E. Pessin, and M. Mori (2004)
Endocrinology 145, 4232-4243
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of 3-Phosphoinositide-dependent Protein Kinase-1 in the MEK/MAPK Signal Transduction Pathway.

S. Sato, N. Fujita, and T. Tsuruo (2004)
J. Biol. Chem. 279, 33759-33767
 |  Abstract »  |  Full Text »  |  PDF »

Cation Diffusion Facilitator Proteins Modulate Raf-1 Activity.

T. Jirakulaporn and A. J. Muslin (2004)
J. Biol. Chem. 279, 27807-27815
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for epidermal growth factor receptor as negative-feedback control in aldosterone-induced Na+ reabsorption.

C. Grossmann, R. Freudinger, S. Mildenberger, A. W. Krug, and M. Gekle (2004)
Am J Physiol Renal Physiol 286, F1226-F1231
 |  Abstract »  |  Full Text »  |  PDF »

Jak2 Tyrosine Kinase Mediates Angiotensin II-dependent Inactivation of ERK2 via Induction of Mitogen-activated Protein Kinase Phosphatase 1.

E. M. Sandberg, X. Ma, D. VonDerLinden, M. D. Godeny, and P. P. Sayeski (2004)
J. Biol. Chem. 279, 1956-1967
 |  Abstract »  |  Full Text »  |  PDF »

The Cyclin-dependent Kinase Inhibitor CYC202 (R-Roscovitine) Inhibits Retinoblastoma Protein Phosphorylation, Causes Loss of Cyclin D1, and Activates the Mitogen-activated Protein Kinase Pathway.

S. R. Whittaker, M. I. Walton, M. D. Garrett, and P. Workman (2004)
Cancer Res. 64, 262-272
 |  Abstract »  |  Full Text »  |  PDF »

Specific activation of ERK pathways by chitin oligosaccharides in embryonic zebrafish cell lines.

B. E. Snaar-Jagalska, S. F. G. Krens, I. Robina, L.-X. Wang, and H. P. Spaink (2003)
Glycobiology 13, 725-732
 |  Abstract »  |  Full Text »  |  PDF »

Migration Inhibitory Factor Mediates Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol Kinase.

M. A. Amin, O. V. Volpert, J. M. Woods, P. Kumar, L. A. Harlow, and A. E. Koch (2003)
Circ. Res. 93, 321-329
 |  Abstract »  |  Full Text »  |  PDF »

Mek2 Is Dispensable for Mouse Growth and Development.

L.-F. Belanger, S. Roy, M. Tremblay, B. Brott, A.-M. Steff, W. Mourad, P. Hugo, R. Erikson, and J. Charron (2003)
Mol. Cell. Biol. 23, 4778-4787
 |  Abstract »  |  Full Text »  |  PDF »

The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells.

S. M. L. Tamma, V. S. Kalyanaraman, S. Pahwa, P. Dominguez, and R. R. Modesto (2003)
J. Leukoc. Biol. 73, 682-688
 |  Abstract »  |  Full Text »  |  PDF »

Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs.

B. J. Tunquist and J. L. Maller (2003)
Genes & Dev. 17, 683-710
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TrkA as a Life and Death Receptor: Receptor Dose as a Mediator of Function.

C. Yan, Y. Liang, K. D. Nylander, and N. F. Schor (2002)
Cancer Res. 62, 4867-4875
 |  Abstract »  |  Full Text »  |  PDF »

MEK1 Signaling Mediates Transformation and Metastasis of EpH4 Mammary Epithelial Cells Independent of an Epithelial to Mesenchymal Transition.

J. Pinkas and P. Leder (2002)
Cancer Res. 62, 4781-4790
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Human Monoamine Oxidase B Gene Expression by a Protein Kinase C MAPK Signal Transduction Pathway Involves c-Jun and Egr-1.

W. K. Wong, X.-M. Ou, K. Chen, and J. C. Shih (2002)
J. Biol. Chem. 277, 22222-22230
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1.

F. L. Robinson, A. W. Whitehurst, M. Raman, and M. H. Cobb (2002)
J. Biol. Chem. 277, 14844-14852
 |  Abstract »  |  Full Text »  |  PDF »

Inhibitory Effect With Antisense Mitogen-Activated Protein Kinase Oligodeoxynucleotide Against Cerebral Vasospasm in Rats.

M. Satoh, A. D. Parent, and J. H. Zhang (2002)
Stroke 33, 775-781
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.

C. Berry, R. Touyz, A. F. Dominiczak, R. C. Webb, and D. G. Johns (2001)
Am J Physiol Heart Circ Physiol 281, H2337-H2365
 |  Abstract »  |  Full Text »  |  PDF »

Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos.

M. Shinya, S. Koshida, A. Sawada, A. Kuroiwa, and H. Takeda (2001)
Development 128, 4153-4164
 |  Abstract »  |  Full Text »  |  PDF »

Glial Cell-Derived Neurotrophic Factor (GDNF)-Induced Migration and Signal Transduction in Corneal Epithelial Cells.

L. You, S. Ebner, and F. E. Kruse (2001)
Invest. Ophthalmol. Vis. Sci. 42, 2496-2504
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions.

G. Pearson, F. Robinson, T. Beers Gibson, B.-e Xu, M. Karandikar, K. Berman, and M. H. Cobb (2001)
Endocr. Rev. 22, 153-183
 |  Abstract »  |  Full Text »

Analysis of the Role of the Mitogen-Activated Protein Kinase in Mediating Cyclic-Adenosine 3',5'-Monophosphate Effects on Prolactin Promoter Activity.

P. Kievit, J. D. Lauten, and R. A. Maurer (2001)
Mol. Endocrinol. 15, 614-624
 |  Abstract »  |  Full Text »

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38{gamma}) MAP kinase pathway.

M. J. Marinissen, M. Chiariello, and J. S. Gutkind (2001)
Genes & Dev. 15, 535-553
 |  Abstract »  |  Full Text »

Molecular mechanisms of ATP and insulin synergistic stimulation of coronary artery smooth muscle growth.

Y. M. Agazie, J. C. Bagot, E. Trickey, S. P. Halenda, and P. A. Wilden (2001)
Am J Physiol Heart Circ Physiol 280, H795-H801
 |  Abstract »  |  Full Text »  |  PDF »

Heritable effects of paternal irradiation in mice on signaling protein kinase activities in F3 offspring.

J. E. Baulch, O. G. Raabe, and L. M. Wiley (2001)
Mutagenesis 16, 17-23
 |  Abstract »  |  Full Text »  |  PDF »

Small GTP-Binding Proteins.

Y. Takai, T. Sasaki, and T. Matozaki (2001)
Physiol Rev 81, 153-208
 |  Abstract »  |  Full Text »  |  PDF »

Vitamin E inhibits cell proliferation and the activation of extracellular signal-regulated kinase during the promotion phase of lung tumorigenesis irrespective of antioxidative effect.

T. Yano, S. Yajima, K. Hagiwara, I. Kumadaki, Y. Yano, S. Otani, M. Uchida, and T. Ichikawa (2000)
Carcinogenesis 21, 2129-2133
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?.

C. W. M. Reuter, M. A. Morgan, and L. Bergmann (2000)
Blood 96, 1655-1669
 |  Abstract »  |  Full Text »  |  PDF »

A MAP Kinase-Signaling Pathway Mediates Neurite Outgrowth on L1 and Requires Src-Dependent Endocytosis.

R.-S. Schmid, W. M. Pruitt, and P. F. Maness (2000)
J. Neurosci. 20, 4177-4188
 |  Abstract »  |  Full Text »  |  PDF »

A Phase I Trial of c-Raf Kinase Antisense Oligonucleotide ISIS 5132 Administered as a Continuous Intravenous Infusion in Patients with Advanced Cancer.

C. C. Cunningham, J. T. Holmlund, J. H. Schiller, R. S. Geary, T. J. Kwoh, A. Dorr, and J. Nemunaitis (2000)
Clin. Cancer Res. 6, 1626-1631
 |  Abstract »  |  Full Text »  |  PDF »

A Specific Activation of the Mitogen-Activated Protein Kinase Kinase 1 (Mek1) Is Required for Golgi Fragmentation during Mitosis.

A. Colanzi, T. J. Deerinck, M. H. Ellisman, and V. Malhotra (2000)
J. Cell Biol. 149, 331-340
 |  Abstract »  |  Full Text »  |  PDF »

Granulocyte-macrophage colony-stimulating factor stimulation results in phosphorylation of cAMP response element-binding protein through activation of pp90RSK.

E. M. Kwon, M. A. Raines, J. Blenis, and K. M. Sakamoto (2000)
Blood 95, 2552-2558
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of Mitogen-Activated Protein Kinases in Smooth Muscle Cells by Angiotensin II : Involvement of p22phox and Reactive Oxygen Species.

C. Viedt, U. Soto, H. I. Krieger-Brauer, J. Fei, C. Elsing, W. Kubler, and J. Kreuzer (2000)
Arterioscler Thromb Vasc Biol 20, 940-948
 |  Abstract »  |  Full Text »  |  PDF »

The Differential Time-course of Extracellular-regulated Kinase Activity Correlates with the Macrophage Response toward Proliferation or Activation.

A. F. Valledor, M. Comalada, J. Xaus, and A. Celada (2000)
J. Biol. Chem. 275, 7403-7409
 |  Abstract »  |  Full Text »  |  PDF »

Neural Cell Adhesion Molecule-Stimulated Neurite Outgrowth Depends on Activation of Protein Kinase C and the Ras-Mitogen-Activated Protein Kinase Pathway.

K. Kolkova, V. Novitskaya, N. Pedersen, V. Berezin, and E. Bock (2000)
J. Neurosci. 20, 2238-2246
 |  Abstract »  |  Full Text »  |  PDF »

Selective induction of p38 mitogen-activated protein kinase activity following A6H co-stimulation in primary human CD4+ T cells.

T. Labuda, A. Sundstedt, and M. Dohlsten (2000)
Int. Immunol. 12, 253-261
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation and Function of Fas Expression on Glial Cells.

S. J. Lee, T. Zhou, C. Choi, Z. Wang, and E. N. Benveniste (2000)
J. Immunol. 164, 1277-1285
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical characterization and localization of the dual specificity kinase CLK1.

H. Menegay, M. Myers, F. Moeslein, and G. Landreth (2000)
J. Cell Sci. 113, 3241-3253
 |  Abstract »  |  PDF »

Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44MAPK-Dependent Phosphorylation.

J. Brondello, J. Pouysségur, and F. R. McKenzie (1999)
Science 286, 2514-2517
 |  Abstract »  |  Full Text »

Transcriptional Regulation of Fas Gene Expression by GA-binding Protein and AP-1 in T Cell Antigen Receptor{middle dot}CD3 Complex-stimulated T Cells.

X. R. Li, A. S.-F. Chong, J. Wu, K. A. Roebuck, A. Kumar, J. E. Parrillo, U. R. Rapp, R. P. Kimberly, J. W. Williams, and X. Xu (1999)
J. Biol. Chem. 274, 35203-35210
 |  Abstract »  |  Full Text »  |  PDF »

Novel Membrane-Targeted ERK1 and ERK2 Chimeras Which Act as Dominant Negative, Isotype-Specific Mitogen-Activated Protein Kinase Inhibitors of Ras-Raf-Mediated Transcriptional Activation of c-fos in NIH 3T3 Cells.

F. Hochholdinger, G. Baier, A. Nogalo, B. Bauer, H. H. Grunicke, and F. Uberall (1999)
Mol. Cell. Biol. 19, 8052-8065
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of c-Jun-NH2 Terminal Kinase and Extracellular-Signal Regulated Kinase in Human Platelets.

F. Bugaud, F. Nadal-Wollbold, S. Levy-Toledano, J.-P. Rosa, and M. Bryckaert (1999)
Blood 94, 3800-3805
 |  Abstract »  |  Full Text »  |  PDF »

The Interferon-induced Double-stranded RNA-activated Protein Kinase PKR Will Phosphorylate Serine, Threonine, or Tyrosine at Residue 51 in Eukaryotic Initiation Factor 2alpha.

J. Lu, E. B. O'Hara, B. A. Trieselmann, P. R. Romano, and T. E. Dever (1999)
J. Biol. Chem. 274, 32198-32203
 |  Abstract »  |  Full Text »  |  PDF »

Distinct, Constitutively Active MAPK Phosphatases Function in Xenopus Oocytes: Implications for p42 MAPK Regulation In Vivo.

M. L. Sohaskey and J. E. Ferrell Jr. (1999)
Mol. Biol. Cell 10, 3729-3743
 |  Abstract »  |  Full Text »

JNK Activation Is Required for JB6 Cell Transformation Induced by Tumor Necrosis Factor-alpha but Not by 12-O-Tetradecanoylphorbol-13-Acetate.

C. Huang, J. Li, W.-Y. Ma, and Z. Dong (1999)
J. Biol. Chem. 274, 29672-29676
 |  Abstract »  |  Full Text »  |  PDF »

Activation of cJUN N-Terminal Kinase by Herpes Simplex Virus Type 1 Enhances Viral Replication.

T. I. McLean and S. L. Bachenheimer (1999)
J. Virol. 73, 8415-8426
 |  Abstract »  |  Full Text »  |  PDF »

Macrophage Colony-Stimulating Factor Induces the Expression of Mitogen-Activated Protein Kinase Phosphatase-1 Through a Protein Kinase C-Dependent Pathway.

A. F. Valledor, J. Xaus, L. Marques, and A. Celada (1999)
J. Immunol. 163, 2452-2462
 |  Abstract »  |  Full Text »  |  PDF »

Neurite Extension Occurs in the Absence of Regulated Exocytosis in PC12 Subclones.

C. Leoni, A. Menegon, F. Benfenati, D. Toniolo, M. Pennuto, and F. Valtorta (1999)
Mol. Biol. Cell 10, 2919-2931
 |  Abstract »  |  Full Text »

A Role for the Mitogen-Activated Protein Kinase in Mediating the Ability of Thyrotropin-Releasing Hormone to Stimulate the Prolactin Promoter.

Y.-H. Wang and R. A. Maurer (1999)
Mol. Endocrinol. 13, 1094-1104
 |  Abstract »  |  Full Text »

Constitutive Activation of Extracellular Signal-Regulated Kinase in Human Acute Leukemias: Combined Role of Activation of MEK, Hyperexpression of Extracellular Signal-Regulated Kinase, and Downregulation of a Phosphatase, PAC1.

S.-C. Kim, J.-S. Hahn, Y.-H. Min, N.-C. Yoo, Y.-W. Ko, and W.-J. Lee (1999)
Blood 93, 3893-3899
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor-stimulated B-Raf Catalytic Activity Is Refractory to Inhibition by cAMP-dependent Protein Kinase.

M. C. MacNicol and A. M. MacNicol (1999)
J. Biol. Chem. 274, 13193-13197
 |  Abstract »  |  Full Text »  |  PDF »

Phorbol Ester-induced Mononuclear Cell Differentiation Is Blocked by the Mitogen-activated Protein Kinase Kinase (MEK) Inhibitor PD98059.

H. He, X. Wang, M. Gorospe, N. J. Holbrook, and M. A. Trush (1999)
Cell Growth Differ. 10, 307-315
 |  Abstract »  |  Full Text »

Activated Ki-Ras Suppresses 12-O-Tetradecanoylphorbol-13-acetate-induced Activation of the c-Jun NH2-Terminal Kinase Pathway in Human Colon Cancer Cells.

K. Okumura, S. Shirasawa, M. Nishioka, and T. Sasazuki (1999)
Cancer Res. 59, 2445-2450
 |  Abstract »  |  Full Text »  |  PDF »

IL-3 and IL-4 Activate Cyclic Nucleotide Phosphodiesterases 3 (PDE3) and 4 (PDE4) by Different Mechanisms in FDCP2 Myeloid Cells.

F. Ahmad, G. Gao, L. M. Wang, T. R. Landstrom, E. Degerman, J. H. Pierce, and V. C. Manganiello (1999)
J. Immunol. 162, 4864-4875
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Signal-Regulated Kinases Regulate Leukotriene C4 Generation, But Not Histamine Release or IL-4 Production from Human Basophils.

K. Miura, J. T. Schroeder, W. C. Hubbard, and D. W. MacGlashan Jr. (1999)
J. Immunol. 162, 4198-4206
 |  Abstract »  |  Full Text »  |  PDF »

Murine p38-delta Mitogen-activated Protein Kinase, a Developmentally Regulated Protein Kinase That Is Activated by Stress and Proinflammatory Cytokines.

M. C.-T. Hu, Y.-p. Wang, A. Mikhail, W. R. Qiu, and T.-H. Tan (1999)
J. Biol. Chem. 274, 7095-7102
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth.

M. K. Abe, W.-L. Kuo, M. B. Hershenson, and M. R. Rosner (1999)
Mol. Cell. Biol. 19, 1301-1312
 |  Abstract »  |  Full Text »  |  PDF »

Galectin-1 Specifically Modulates TCR Signals to Enhance TCR Apoptosis but Inhibit IL-2 Production and Proliferation.

G. N. R. Vespa, L. A. Lewis, K. R. Kozak, M. Moran, J. T. Nguyen, L. G. Baum, and M. C. Miceli (1999)
J. Immunol. 162, 799-806
 |  Abstract »  |  Full Text »  |  PDF »

The Repertoire of Fos and Jun Proteins Expressed during the G1 Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation.

S. J. Cook, N. Aziz, and M. McMahon (1999)
Mol. Cell. Biol. 19, 330-341
 |  Abstract »  |  Full Text »  |  PDF »

Endothelin-Stimulated ERK Activation in Airway Smooth-Muscle Cells Requires Calcium Influx and Raf Activation.

P. Vichi, A. Whelchel, H. Knot, M. Nelson, W. Kolch, and J. Posada (1999)
Am. J. Respir. Cell Mol. Biol. 20, 99-105
 |  Abstract »  |  Full Text »

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human.

C. WIDMANN, S. GIBSON, M. B. JARPE, and G. L. JOHNSON (1999)
Physiol Rev 79, 143-180
 |  Abstract »  |  Full Text »  |  PDF »

Ectopic Expression of Hepatitis C Virus Core Protein Differentially Regulates Nuclear Transcription Factors.

A. Shrivastava, S. K. Manna, R. Ray, and B. B. Aggarwal (1998)
J. Virol. 72, 9722-9728
 |  Abstract »  |  Full Text »  |  PDF »

Convergence of CD19 and B Cell Antigen Receptor Signals at MEK1 in the ERK2 Activation Cascade.

X. Li and R. H. Carter (1998)
J. Immunol. 161, 5901-5908
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Anergized CD4+ T Cells Have Defective Expression and Function of the Activating Protein-1 Transcription Factor.

A. Sundstedt and M. Dohlsten (1998)
J. Immunol. 161, 5930-5936
 |  Abstract »  |  Full Text »  |  PDF »

The Amiloride-sensitive Epithelial Sodium Channel alpha -Subunit Is Transcriptionally Down-regulated in Rat Parotid Cells by the Extracellular Signal-regulated Protein Kinase Pathway.

M. D. Zentner, H. H. Lin, X. Wen, K. J. Kim, and D. K. Ann (1998)
J. Biol. Chem. 273, 30770-30776
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin II Induces Monocyte Chemoattractant Protein-1 Gene Expression in Rat Vascular Smooth Muscle Cells.

X.-L. Chen, P. E. Tummala, M. T. Olbrych, R. W. Alexander, and R. M. Medford (1998)
Circ. Res. 83, 952-959
 |  Abstract »  |  Full Text »  |  PDF »

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.

Y. Xia, Z. Wu, B. Su, B. Murray, and M. Karin (1998)
Genes & Dev. 12, 3369-3381
 |  Abstract »  |  Full Text »

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E.

M. Zecevic, A. D. Catling, S. T. Eblen, L. Renzi, J. C. Hittle, T. J. Yen, G. J. Gorbsky, and M. J. Weber (1998)
J. Cell Biol. 142, 1547-1558
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Human Involucrin Promoter Activity by a Protein Kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 Signal Transduction Pathway.

T. Efimova, P. LaCelle, J. F. Welter, and R. L. Eckert (1998)
J. Biol. Chem. 273, 24387-24395
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Kinase Activity and Oncogenic Properties by Alternative Splicing Reveals a Novel Regulatory Mechanism for B-Raf.

C. Papin, A. Denouel-Galy, D. Laugier, G. Calothy, and A. Eychene (1998)
J. Biol. Chem. 273, 24939-24947
 |  Abstract »  |  Full Text »  |  PDF »

Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.

S. Sif, P. T. Stukenberg, M. W. Kirschner, and R. E. Kingston (1998)
Genes & Dev. 12, 2842-2851
 |  Abstract »  |  Full Text »

Genetic Analysis of the Caenorhabditis elegans MAP Kinase Gene mpk-1.

M. R. Lackner and S. K. Kim (1998)
Genetics 150, 103-117
 |  Abstract »  |  Full Text »

Calmodulin Inhibitor W13 Induces Sustained Activation of ERK2 and Expression of p21cip1.

M. Bosch, J. Gil, O. Bachs, and N. Agell (1998)
J. Biol. Chem. 273, 22145-22150
 |  Abstract »  |  Full Text »  |  PDF »

Growth Factor-induced p42/p44 MAPK Nuclear Translocation and Retention Requires Both MAPK Activation and Neosynthesis of Nuclear Anchoring Proteins.

P. Lenormand, J.-M. Brondello, A. Brunet, and J. Pouyssegur (1998)
J. Cell Biol. 142, 625-633
 |  Abstract »  |  Full Text »  |  PDF »

Nitroxides Tempol and Tempo Induce Divergent Signal Transduction Pathways in MDA-MB 231 Breast Cancer Cells.

S. Suy, J. B. Mitchell, D. Ehleiter, A. Haimovitz-Friedman, and U. Kasid (1998)
J. Biol. Chem. 273, 17871-17878
 |  Abstract »  |  Full Text »  |  PDF »

Applied Pressure Enhances Cell Proliferation through Mitogen-activated Protein Kinase Activation in Mesangial Cells.

Y. Kawata, Y. Mizukami, Z. Fujii, T. Sakumura, K.-i. Yoshida, and M. Matsuzaki (1998)
J. Biol. Chem. 273, 16905-16912
 |  Abstract »  |  Full Text »  |  PDF »

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