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Science 9 October 1992:
Vol. 258. no. 5080, pp. 302 - 304
DOI: 10.1126/science.1411528

Articles

Science, Vol 258, Issue 5080, 302-304
Copyright © 1992 by American Association for the Advancement of Science


articles

Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

I Garcia, I Martinou, Y Tsujimoto, and JC Martinou

Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland.

Approximately half of the neurons produced during embryogenesis normally die before adulthood. Although target-derived neurotrophic factors are known to be major determinants of programmed cell death--apoptosis--the molecular mechanisms by which trophic factors interfere with cell death regulation are largely unknown. Overexpression of the bcl-2 proto-oncogene in cultured sympathetic neurons has now been shown to prevent apoptosis normally induced by deprivation of nerve growth factor. This finding, together with the previous demonstration of bcl-2 expression in the nervous system, suggests that the Bcl-2 protein may be a major mediator of the effects of neurotrophic factors on neuronal survival.


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