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Science 9 October 1992:
Vol. 258. no. 5080, pp. 299 - 302
DOI: 10.1126/science.1411527
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Articles

Science, Vol 258, Issue 5080, 299-302
Copyright © 1992 by American Association for the Advancement of Science

articles

Diverse migratory pathways in the developing cerebral cortex

NA O'Rourke, ME Dailey, SJ Smith, and SK McConnell

Department of Biological Sciences, Stanford University, CA 94305.

During early development of the mammalian cerebral cortex, young neurons migrate outward from the site of their final mitosis in the ventricular zone into the cortical plate, where they form the adult cortex. Time-lapse confocal microscopy was used to observe directly the dynamic behaviors of migrating cells in living slices of developing cortex. The majority of cells migrated along a radial pathway, consistent with the view that cortical neurons migrate along radial glial fibers. A fraction of cells, however, turned within the intermediate zone and migrated orthogonal to the radial fibers. This orthogonal migration may contribute to the tangential dispersion of clonally related cortical neurons.


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   Abstract »    PDF »
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   Abstract »    PDF »
Network of tangential pathways for neuronal migration in adult mammalian brain.
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Interkinetic and Migratory Behavior of a Cohort of Neocortical Neurons Arising in the Early Embryonic Murine Cerebral Wall.
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   Abstract »    Full Text »    PDF »
Nonradial migration of interneurons can be experimentally altered in spinal cord slice cultures.
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   Abstract »    PDF »
The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration.
B Wightman, S. Clark, A. Taskar, W. Forrester, A. Maricq, C. Bargmann, and G Garriga (1996)
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   Abstract »    PDF »
Tangential migration of neurons in the developing cerebral cortex.
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   Abstract »    PDF »
Cell dispersion patterns in different cortical regions studied with an X-inactivated transgenic marker.
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   Abstract »    PDF »
Regulation of regional differences in the differentiation of cerebral cortical neurons by EGF family-matrix interactions.
R. Ferri and P Levitt (1995)
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   Abstract »    PDF »
Striatal precursors adopt cortical identities in response to local cues.
G Fishell (1995)
Development 121, 803-812
   Abstract »    PDF »
Long-distance neuronal migration in the adult mammalian brain.
C Lois and A Alvarez-Buylla (1994)
Science 264, 1145-1148
   Abstract »    PDF »
The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated.
S. W. Levison, C. Chuang, B. J. Abramson, and J. E. Goldman (1993)
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   Abstract »    PDF »
Multiple restricted lineages in the embryonic rat cerebral cortex.
E. Grove, B. Williams, D. Li, M Hajihosseini, A Friedrich, and J Price (1993)
Development 117, 553-561
   Abstract »    PDF »
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