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Science 9 October 1992:
Vol. 258. no. 5080, pp. 299 - 302
DOI: 10.1126/science.1411527
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Articles

Science, Vol 258, Issue 5080, 299-302
Copyright © 1992 by American Association for the Advancement of Science

articles

Diverse migratory pathways in the developing cerebral cortex

NA O'Rourke, ME Dailey, SJ Smith, and SK McConnell

Department of Biological Sciences, Stanford University, CA 94305.

During early development of the mammalian cerebral cortex, young neurons migrate outward from the site of their final mitosis in the ventricular zone into the cortical plate, where they form the adult cortex. Time-lapse confocal microscopy was used to observe directly the dynamic behaviors of migrating cells in living slices of developing cortex. The majority of cells migrated along a radial pathway, consistent with the view that cortical neurons migrate along radial glial fibers. A fraction of cells, however, turned within the intermediate zone and migrated orthogonal to the radial fibers. This orthogonal migration may contribute to the tangential dispersion of clonally related cortical neurons.


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Regulation of regional differences in the differentiation of cerebral cortical neurons by EGF family-matrix interactions.
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Science 264, 1145-1148
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The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated.
S. Levison, C Chuang, B. Abramson, and J. Goldman (1993)
Development 119, 611-622
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Development 117, 553-561
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Dividing up the neocortex.
C. Shatz (1992)
Science 258, 237-238
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