Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 October 1992:
Vol. 258. no. 5079, pp. 67 - 86
DOI: 10.1126/science.1439770
Prev | Table of Contents | Next

Articles

Science, Vol 258, Issue 5079, 67-86
Copyright © 1992 by American Association for the Advancement of Science

articles

A comprehensive genetic linkage map of the human genome. NIH/CEPH Collaborative Mapping Group

A genetic linkage map of the human genome was constructed that consists of 1416 loci, including 279 genes and expressed sequences. The loci are represented by 1676 polymorphic systems genotyped with the CEPH reference pedigree resource. A total of 339 microsatellite repeat markers assayed by PCR are contained within the map, and of the 351 markers with heterozygosities of at least 70%, 205 are microsatellites. Seven telomere loci define physical and genetic endpoints for 2q, 4p, 7q, 8p, 14q, 16p, and 16q, and in other cases distal markers on the maps have been localized to terminal cytogenetic bands. Therefore, at least 92% of the autosomal length of the genome and 95% of the X chromosome is estimated to be spanned by the map. Since the maps have relatively high marker density and numerous highly informative loci, they can be used to map disease phenotypes, even for those with limited pedigree resources. The baseline map provides a foundation for achieving continuity of clone-based physical maps and for the development of a truly integrated physical, genetic, and cytogenetic map of the human.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The human Major Histocompatibility Complex as a paradigm in genomics research.
C. Vandiedonck and J. C. Knight (2009)
Brief Funct Genomic Proteomic 8, 379-394
   Abstract »    Full Text »    PDF »
Multiple Repeats of a Promoter Segment Causes Transcription Factor Autoregulation in Red Apples.
R. V. Espley, C. Brendolise, D. Chagne, S. Kutty-Amma, S. Green, R. Volz, J. Putterill, H. J. Schouten, S. E. Gardiner, R. P. Hellens, et al. (2009)
PLANT CELL 21, 168-183
   Abstract »    Full Text »    PDF »
Natural Variation in a Subtelomeric Region of Arabidopsis: Implications for the Genomic Dynamics of a Chromosome End.
H.-F. Kuo, K. M. Olsen, and E. J. Richards (2006)
Genetics 173, 401-417
   Abstract »    Full Text »    PDF »
MAP-O-MAT: internet-based linkage mapping.
X. Kong and T. C. Matise (2005)
Bioinformatics 21, 557-559
   Abstract »    Full Text »    PDF »
Predicting Human Minisatellite Polymorphism.
F. Denoeud, G. Vergnaud, and G. Benson (2003)
Genome Res. 13, 856-867
   Abstract »    Full Text »    PDF »
Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide.
U.-k. Kim, E. Jorgenson, H. Coon, M. Leppert, N. Risch, and D. Drayna (2003)
Science 299, 1221-1225
   Abstract »    Full Text »    PDF »
A Model System for Identifying Genes Underlying Complex Traits.
D. DRAYNA, U.-K. KIM, H. COON, E. JORGENSON, N. RISCH, and M. LEPPERT (2003)
Cold Spring Harb Symp Quant Biol 68, 365-372
   Abstract »    PDF »
Quantitative Trait Linkage Analysis of Lipid-Related Traits in Familial Type 2 Diabetes: Evidence for Linkage of Triglyceride Levels to Chromosome 19q.
S.C. Elbein and S.J. Hasstedt (2002)
Diabetes 51, 528-535
   Abstract »    Full Text »    PDF »
Interchromosomal repeat array interactions between chromosomes 4 and 10: a model for subtelomeric plasticity.
P. G.M. v. Overveld, R. J.F.L. Lemmers, G. Deidda, L. Sandkuijl, G. W. Padberg, R. R. Frants, and S. M. van der Maarel (2000)
Hum. Mol. Genet. 9, 2879-2884
   Abstract »    Full Text »    PDF »
Patterns of Meiotic Recombination on the Long Arm of Human Chromosome 21.
A. Lynn, C. Kashuk, M. B. Petersen, J. A. Bailey, D. R. Cox, S. E. Antonarakis, and A. Chakravarti (2000)
Genome Res. 10, 1319-1332
   Abstract »    Full Text »
Minisatellites: Mutability and Genome Architecture.
G. Vergnaud and F. Denoeud (2000)
Genome Res. 10, 899-907
   Abstract »    Full Text »
Finding New Human Minisatellite Sequences in the Vicinity of Long CA-Rich Sequences.
F. Giraudeau, E. Petit, H. Avet-Loiseau, Y. Hauck, G. Vergnaud, and V. Amarger (1999)
Genome Res. 9, 647-653
   Abstract »    Full Text »
Identification of a Genetic Locus for Familial Atrial Fibrillation.
R. Brugada, T. Tapscott, G. Z. Czernuszewicz, A.J. Marian, A. Iglesias, L. Mont, J. Brugada, J. Girona, A. Domingo, L. L. Bachinski, et al. (1997)
N. Engl. J. Med. 336, 905-911
   Abstract »    Full Text »    PDF »
A De Novo Mutation in {alpha}-Tropomyosin That Causes Hypertrophic Cardiomyopathy.
H. Watkins, R. Anan, D. A. Coviello, P. Spirito, J.G. Seidman, and C. E. Seidman (1995)
Circulation 91, 2302-2305
   Abstract »    Full Text »
A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC).
J. Murray, K. Buetow, J. Weber, S Ludwigsen, T Scherpbier-Heddema, F Manion, J Quillen, V. Sheffield, S Sunden, G. Duyk, et al. (1994)
Science 265, 2049-2054
   Abstract »    PDF »
Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer.
J. Jen, H. Kim, S. Piantadosi, Z.-F. Liu, R. C. Levitt, P. Sistonen, K. W. Kinzler, B. Vogelstein, and S. R. Hamilton (1994)
N. Engl. J. Med. 331, 213-221
   Abstract »    Full Text »
A Dominant Stargardt's Macular Dystrophy Locus Maps to Chromosome 13q34.
K. Zhang, P. P. Bither, R. Park, L. A. Donoso, J. G. Seidman, and C. E. Seidman (1994)
Arch Ophthalmol 112, 759-764
   Abstract »    PDF »
Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations.
D. Marsh, J. Neely, D. Breazeale, B Ghosh, L. Freidhoff, E Ehrlich-Kautzky, C Schou, G Krishnaswamy, and T. Beaty (1994)
Science 264, 1152-1156
   Abstract »    PDF »
The Clinical and Genetic Spectrum of the Holt-Oram Syndrome (Heart-Hand Syndrome).
C. T. Basson, G. S. Cowley, S. D. Solomon, B. Weissman, A. K. Poznanski, T. A. Traill, J.G. Seidman, and C. E. Seidman (1994)
N. Engl. J. Med. 330, 885-891
   Abstract »    Full Text »
Analysis of DNA sequences.
B. Weir (1993)
Statistical Methods in Medical Research 2, 225-239
   Abstract »    PDF »
The Human Genome Project and the Future of Medicine.
M. S. Guyer and F. S. Collins (1993)
Arch Pediatr Adolesc Med 147, 1145-1152
   Abstract »    PDF »
A method for accurate amplification of polymorphic CA-repeat sequences..
S J Odelberg and R White (1993)
Genome Res. 3, 7-12
   Abstract »    PDF »
Pediatrics.
V. A. Fulginiti and J. E. Lewy (1993)
JAMA 270, 246-248
   Abstract »    PDF »
Criterion for the Completeness of Large-scale Physical Maps of DNA.
M.V. Olson and P. Green (1993)
Cold Spring Harb Symp Quant Biol 58, 349-355
   Abstract »    PDF »
Identification of a second pseudoautosomal region near the Xq and Yq telomeres.
D Freije, C Helms, M. Watson, and H Donis-Keller (1992)
Science 258, 1784-1787
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)