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Science 2 October 1992:
Vol. 258. no. 5079, pp. 135 - 140
DOI: 10.1126/science.1279801
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Articles

Science, Vol 258, Issue 5079, 135-140
Copyright © 1992 by American Association for the Advancement of Science

articles

Lack of protective immunity against reinfection with hepatitis C virus

P Farci, HJ Alter, S Govindarajan, DC Wong, R Engle, RR Lesniewski, IK Mushahwar, SM Desai, RH Miller, N Ogata, and al. et

Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Some individuals infected with hepatitis C virus (HCV) experience multiple episodes of acute hepatitis. It is unclear whether these episodes are due to reinfection with HCV or to reactivation of the original virus infection. Markers of viral replication and host immunity were studied in five chimpanzees sequentially inoculated over a period of 3 years with different HCV strains of proven infectivity. Each rechallenge of a convalescent chimpanzee with the same or a different HCV strain resulted in the reappearance of viremia, which was due to infection with the subsequent challenge virus. The evidence indicates that HCV infection does not elicit protective immunity against reinfection with homologous or heterologous strains, which raises concerns for the development of effective vaccines against HCV.


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Hepatitis C virus (HCV) specific immune responses in anti-HCV positive patients without hepatitis C viraemia.
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Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli.
E. Ferrari, J. Wright-Minogue, J. W. S. Fang, B. M. Baroudy, J. Y. N. Lau, and Z. Hong (1999)
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J. Virol. 73, 11-18
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IV. Pathogenetic mechanisms involved in hepatitis C virus-induced liver diseases.
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Am J Physiol Gastrointest Liver Physiol 275, G1217-G1220
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J. Virol. 72, 8430-8436
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Analysis of Hepatitis C Virus-Inoculated Chimpanzees Reveals Unexpected Clinical Profiles.
S. E. Bassett, K. M. Brasky, and R. E. Lanford (1998)
J. Virol. 72, 2589-2599
   Abstract »    Full Text »    PDF »
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J. Virol. 72, 1725-1730
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Hepatitis C Virus Infection.
Committee on Infectious Diseases (1998)
Pediatrics 101, 481-485
   Abstract »    Full Text »    PDF »
Sexual Transmission of the Hepatitis C Virus and Efficacy of Prophylaxis With Intramuscular Immune Serum Globulin: A Randomized Controlled Trial.
M. Piazza, L. Sagliocca, G. Tosone, V. Guadagnino, M. A. Stazi, R. Orlando, G. Borgia, D. Rosa, S. Abrignani, F. Palumbo, et al. (1997)
Arch Intern Med 157, 1537-1544
   Abstract »    PDF »
Vaccines to Prevent Viral Hepatitis.
S. M. Lemon and D. L. Thomas (1997)
N. Engl. J. Med. 336, 196-204
   Full Text »    PDF »
Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein.
P. Farci, A. Shimoda, D. Wong, T. Cabezon, D. De Gioannis, A. Strazzera, Y. Shimizu, M. Shapiro, H. J. Alter, and R. H. Purcell (1996)
PNAS 93, 15394-15399
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Hepatitis C Virus-Associated Fulminant Hepatic Failure.
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N. Engl. J. Med. 335, 631-634
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Prevention, Diagnosis, and Management of Viral Hepatitis: A Guide for Primary Care Physicians.
G. A. Noskin (1995)
Arch Fam Med 4, 923-934
   Abstract »    PDF »
Management of Occupational Exposures to Blood-Borne Viruses.
J. L. Gerberding (1995)
N. Engl. J. Med. 332, 444-451
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Renal Transplantation.
P. D. King, C. Lidor, T. P. Vail, M. Suthanthiran, and T. B. Strom (1994)
N. Engl. J. Med. 331, 1719-1720
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Transmission of Hepatitis C Virus -- Route, Dose, and Titer.
M. J. Alter (1994)
N. Engl. J. Med. 330, 784-786
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Hepatitis C Virus and Organ Transplantation.
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N. Engl. J. Med. 328, 511-513
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Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system.
R. T. Chung, W. He, A. Saquib, A. M. Contreras, R. J. Xavier, A. Chawla, T. C. Wang, and E. V. Schmidt (2001)
PNAS 98, 9847-9852
   Abstract »    Full Text »    PDF »


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