Science 2 October 1992: Vol. 258. no. 5079, pp. 126 - 129 DOI: 10.1126/science.1439760

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Articles

Inhibition of {gamma}-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes.

R. A. Sharples, L. J. Vella, R. M. Nisbet, R. Naylor, K. Perez, K. J. Barnham, C. L. Masters, and A. F. Hill (2008)
FASEB J 22, 1469-1478
 |  Abstract »  |  Full Text »  |  PDF »

Independent Inhibition of Alzheimer Disease {beta}- and {gamma}-Secretase Cleavage by Lowered Cholesterol Levels.

M. O. W. Grimm, H. S. Grimm, I. Tomic, K. Beyreuther, T. Hartmann, and C. Bergmann (2008)
J. Biol. Chem. 283, 11302-11311
 |  Abstract »  |  Full Text »  |  PDF »

Immunoreactivity of Phage Library-derived Human Single-Chain Antibodies to Amyloid Beta Conformers In Vitro.

T. Yoshihara, S. Takiguchi, A. Kyuno, K. Tanaka, S. Kuba, S. Hashiguchi, Y. Ito, T. Hashimoto, T. Iwatsubo, S. Tsuyama, et al. (2008)
J. Biochem. 143, 475-486
 |  Abstract »  |  Full Text »  |  PDF »

Amyloidogenic Processing but Not Amyloid Precursor Protein (APP) Intracellular C-terminal Domain Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs.

P. Kienlen-Campard, B. Tasiaux, J. Van Hees, M. Li, S. Huysseune, T. Sato, J. Z. Fei, S. Aimoto, P. J. Courtoy, S. O. Smith, et al. (2008)
J. Biol. Chem. 283, 7733-7744
 |  Abstract »  |  Full Text »  |  PDF »

The Cell-Selective Neurotoxicity of the Alzheimer's A Peptide Is Determined by Surface Phosphatidylserine and Cytosolic ATP Levels. Membrane Binding Is Required for A Toxicity.

O. Simakova and N. J. Arispe (2007)
J. Neurosci. 27, 13719-13729
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated A{beta} Deposition in APPswe/PS1{Delta}E9 Mice with Hemizygous Deletions of TTR (Transthyretin).

S. H. Choi, S. N. Leight, V. M.-Y. Lee, T. Li, P. C. Wong, J. A. Johnson, M. J. Saraiva, and S. S. Sisodia (2007)
J. Neurosci. 27, 7006-7010
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A Century of Alzheimer's Disease.

M. Goedert and M. G. Spillantini (2006)
Science 314, 777-781
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the A{beta} amyloid pathway.

C. L. Masters and K. Beyreuther (2006)
Brain 129, 2823-2839
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic approaches to Alzheimer's disease.

H.-W. Klafki, M. Staufenbiel, J. Kornhuber, and J. Wiltfang (2006)
Brain 129, 2840-2855
 |  Abstract »  |  Full Text »  |  PDF »

Synapse formation and function is modulated by the amyloid precursor protein..

C. Priller, T. Bauer, G. Mitteregger, B. Krebs, H. A. Kretzschmar, and J. Herms (2006)
J. Neurosci. 26, 7212-7221
 |  Abstract »  |  Full Text »  |  PDF »

An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures.

N. N. Dewji, D. Mukhopadhyay, and S. J. Singer (2006)
PNAS 103, 1540-1545
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Glucose-Induced Secretion of Pancreatic-Derived Factor (PANDER or FAM3B) in Pancreatic {beta}-Cells.

J. Yang, C. E. Robert, B. R. Burkhardt, R. A. Young, J. Wu, Z. Gao, and B. A. Wolf (2005)
Diabetes 54, 3217-3228
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Scavenger Receptors in Glial Cells: COMPARING THE ADHESION OF ASTROCYTES AND MICROGLIA FROM NEONATAL RATS TO SURFACE-BOUND {beta}-AMYLOID.

R. Alarcon, C. Fuenzalida, M. Santibanez, and R. von Bernhardi (2005)
J. Biol. Chem. 280, 30406-30415
 |  Abstract »  |  Full Text »  |  PDF »

On the nucleation of amyloid {beta}-protein monomer folding.

N. D. Lazo, M. A. Grant, M. C. Condron, A. C. Rigby, and D. B. Teplow (2005)
Protein Sci. 14, 1581-1596
 |  Abstract »  |  Full Text »  |  PDF »

Autoantibodies to Redox-modified Oligomeric A{beta} Are Attenuated in the Plasma of Alzheimer's Disease Patients.

R. D. Moir, K. A. Tseitlin, S. Soscia, B. T. Hyman, M. C. Irizarry, and R. E Tanzi (2005)
J. Biol. Chem. 280, 17458-17463
 |  Abstract »  |  Full Text »  |  PDF »

Metal Ion-dependent Effects of Clioquinol on the Fibril Growth of an Amyloid {beta} Peptide.

B. Raman, T. Ban, K.-i. Yamaguchi, M. Sakai, T. Kawai, H. Naiki, and Y. Goto (2005)
J. Biol. Chem. 280, 16157-16162
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w.

M. Yao, T.-V. V. Nguyen, and C. J. Pike (2005)
J. Neurosci. 25, 1149-1158
 |  Abstract »  |  Full Text »  |  PDF »

Systemic Catabolism of Alzheimer's A{beta}40 and A{beta}42.

J. Ghiso, M. Shayo, M. Calero, D. Ng, Y. Tomidokoro, S. Gandy, A. Rostagno, and B. Frangione (2004)
J. Biol. Chem. 279, 45897-45908
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the neurotoxic species in Alzheimer's disease: inhibitors of A{beta} oligomerization.

F. G. DE FELICE, M. N. N. VIEIRA, L. M. SARAIVA, J. D. FIGUEROA-VILLAR, J. GARCIA-ABREU, R. LIU, L. CHANG, W. L. KLEIN, and S. T. FERREIRA (2004)
FASEB J 18, 1366-1372
 |  Abstract »  |  Full Text »  |  PDF »

Luteinizing Hormone, a Reproductive Regulator That Modulates the Processing of Amyloid-{beta} Precursor Protein and Amyloid-{beta} Deposition.

R. L. Bowen, G. Verdile, T. Liu, A. F. Parlow, G. Perry, M. A. Smith, R. N. Martins, and C. S. Atwood (2004)
J. Biol. Chem. 279, 20539-20545
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies.

D. J. Selkoe (2004)
Ann Intern Med 140, 627-638
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Styrylbenzoxazole Derivatives for In Vivo Imaging of Amyloid Plaques in the Brain.

N. Okamura, T. Suemoto, H. Shimadzu, M. Suzuki, T. Shiomitsu, H. Akatsu, T. Yamamoto, M. Staufenbiel, K. Yanai, H. Arai, et al. (2004)
J. Neurosci. 24, 2535-2541
 |  Abstract »  |  Full Text »  |  PDF »

Mutant presenilins specifically elevate the levels of the 42 residue {beta}-amyloid peptide in vivo: evidence for augmentation of a 42-specific {gamma} secretase.

J. L. Jankowsky, D. J. Fadale, J. Anderson, G. M. Xu, V. Gonzales, N. A. Jenkins, N. G. Copeland, M. K. Lee, L. H. Younkin, S. L. Wagner, et al. (2004)
Hum. Mol. Genet. 13, 159-170
 |  Abstract »  |  Full Text »  |  PDF »

Fine mapping of the {alpha}-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.

N. Ertekin-Taner, J. Ronald, H. Asahara, L. Younkin, M. Hella, S. Jain, E. Gnida, S. Younkin, D. Fadale, Y. Ohyagi, et al. (2003)
Hum. Mol. Genet. 12, 3133-3143
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer {beta}-Amyloid Homodimers Facilitate A{beta} Fibrillization and the Generation of Conformational Antibodies.

A. Schmechel, H. Zentgraf, S. Scheuermann, G. Fritz, R. Pipkorn, J. Reed, K. Beyreuther, T. A. Bayer, and G. Multhaup (2003)
J. Biol. Chem. 278, 35317-35324
 |  Abstract »  |  Full Text »  |  PDF »

Spherical aggregates of {beta}-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3{beta}.

M. Hoshi, M. Sato, S. Matsumoto, A. Noguchi, K. Yasutake, N. Yoshida, and K. Sato (2003)
PNAS 100, 6370-6375
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Peptide-Induced Cytokine and Chemokine Expression in THP-1 Monocytes Is Blocked by Small Inhibitory RNA Duplexes for Early Growth Response-1 Messenger RNA.

R. K. Giri, S. K. Selvaraj, and V. K. Kalra (2003)
J. Immunol. 170, 5281-5294
 |  Abstract »  |  Full Text »  |  PDF »

gamma -Secretase Cleavage Site Specificity Differs for Intracellular and Secretory Amyloid beta.

H. S. Grimm, D. Beher, S. F. Lichtenthaler, M. S. Shearman, K. Beyreuther, and T. Hartmann (2003)
J. Biol. Chem. 278, 13077-13085
 |  Abstract »  |  Full Text »  |  PDF »

The Transmembrane Domain of the Amyloid Precursor Protein in Microsomal Membranes Is on Both Sides Shorter than Predicted.

B. Grziwa, M. O. W. Grimm, C. L. Masters, K. Beyreuther, T. Hartmann, and S. F. Lichtenthaler (2003)
J. Biol. Chem. 278, 6803-6808
 |  Abstract »  |  Full Text »  |  PDF »

The Class A Scavenger Receptor Binds to Proteoglycans and Mediates Adhesion of Macrophages to the Extracellular Matrix.

J. Santiago-Garcia, T. Kodama, and R. E. Pitas (2003)
J. Biol. Chem. 278, 6942-6946
 |  Abstract »  |  Full Text »  |  PDF »

Secretion and Intracellular Generation of Truncated Abeta in beta -Site Amyloid-beta Precursor Protein-cleaving Enzyme Expressing Human Neurons.

E. B. Lee, D. M. Skovronsky, F. Abtahian, R. W. Doms, and V. M.-Y. Lee (2003)
J. Biol. Chem. 278, 4458-4466
 |  Abstract »  |  Full Text »  |  PDF »

Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-{epsilon}4 Allele.

D. G. Cook, J. B. Leverenz, P. J. McMillan, J. J. Kulstad, S. Ericksen, R. A. Roth, G. D. Schellenberg, L.-W. Jin, K. S. Kovacina, and S. Craft (2003)
Am. J. Pathol. 162, 313-319
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein, Presenilins, and alpha -Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer's Disease.

Y.-H. Suh and F. Checler (2002)
Pharmacol. Rev. 54, 469-525
 |  Abstract »  |  Full Text »  |  PDF »

Effect of endothelial cell polarity on beta -amyloid-induced migration of monocytes across normal and AD endothelium.

R. Giri, S. Selvaraj, C. A. Miller, F. Hofman, S. D. Yan, D. Stern, B. V. Zlokovic, and V. K. Kalra (2002)
Am J Physiol Cell Physiol 283, C895-C904
 |  Abstract »  |  Full Text »  |  PDF »

beta -Secretase Processing in the Trans-Golgi Network Preferentially Generates Truncated Amyloid Species That Accumulate in Alzheimer's Disease Brain.

J. T. Huse, K. Liu, D. S. Pijak, D. Carlin, V. M.-Y. Lee, and R. W. Doms (2002)
J. Biol. Chem. 277, 16278-16284
 |  Abstract »  |  Full Text »  |  PDF »

Accumulation of the Amyloid-{beta} Precursor Protein in Multivesicular Body-like Organelles.

M. M. Verbeek, I. Otte-Holler, J. A.M. Fransen, and R. M.W. de Waal (2002)
J. Histochem. Cytochem. 50, 681-690
 |  Abstract »  |  Full Text »  |  PDF »

Cholesterol Is an Important Factor Affecting the Membrane Insertion of beta -Amyloid Peptide (Abeta 1-40), Which May Potentially Inhibit the Fibril Formation.

S.-R. Ji, Y. Wu, and S.-f. Sui (2002)
J. Biol. Chem. 277, 6273-6279
 |  Abstract »  |  Full Text »  |  PDF »

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.

C. Lesuisse, G. Xu, J. Anderson, M. Wong, J. Jankowsky, G. Holtz, V. Gonzalez, P. C. Y. Wong, D. L. Price, F. Tang, et al. (2001)
Hum. Mol. Genet. 10, 2525-2537
 |  Abstract »  |  Full Text »  |  PDF »

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.

D. J. Selkoe (2001)
PNAS 98, 11039-11041
 |  Abstract »  |  Full Text »  |  PDF »

Reduced levels of amyloid {beta}-peptide antibody in Alzheimer disease.

Y. Du, R. Dodel, H. Hampel, K. Buerger, S. Lin, B. Eastwood, K. Bales, F. Gao, H.-J. Moeller, W. Oertel, et al. (2001)
Neurology 57, 801-805
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Mechanisms for Amyloid {beta}-Protein Activation of Rat Cholinergic Basal Forebrain Neurons.

J. H. Jhamandas, C. Cho, B. Jassar, K. Harris, D. MacTavish, and J. Easaw (2001)
J Neurophysiol 86, 1312-1320
 |  Abstract »  |  Full Text »  |  PDF »

A Portrait of Alzheimer Secretases--New Features and Familiar Faces.

W. P. Esler and M. S. Wolfe (2001)
Science 293, 1449-1454
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease: Genes, Proteins, and Therapy.

D. J. Selkoe (2001)
Physiol Rev 81, 741-766
 |  Abstract »  |  Full Text »  |  PDF »

Regional Distribution of Amyloid-Bri Deposition and Its Association with Neurofibrillary Degeneration in Familial British Dementia.

J. L. Holton, J. Ghiso, T. Lashley, A. Rostagno, C. J. Guerin, G. Gibb, H. Houlden, H. Ayling, L. Martinian, B. H. Anderton, et al. (2001)
Am. J. Pathol. 158, 515-526
 |  Abstract »  |  Full Text »  |  PDF »

In search of gamma -secretase: Presenilin at the cutting edge.

D. J. Selkoe and M. S. Wolfe (2000)
PNAS 97, 5690-5692
 |  Full Text »  |  PDF »

Alzheimer's Disease, {beta}-Amyloid Protein and Zinc.

X. Huang, M. P. Cuajungco, C. S. Atwood, R. D. Moir, R. E. Tanzi, and A. I. Bush (2000)
J. Nutr. 130, 1488S-1492
 |  Abstract »  |  Full Text »

The Origins of Alzheimer Disease: A Is for Amyloid.

D. J. Selkoe (2000)
JAMA 283, 1615-1617
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Decreased {beta}-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.

M. Otto, H. Esselmann, W. Schulz-Schaeffer, M. Neumann, A. Schroter, P. Ratzka, L. Cepek, I. Zerr, P. Steinacker, O. Windl, et al. (2000)
Neurology 54, 1099-1102
 |  Abstract »  |  Full Text »  |  PDF »

Expression of beta -Amyloid Precursor Protein-CD3gamma Chimeras to Demonstrate the Selective Generation of Amyloid beta 1-40 and Amyloid beta 1-42 Peptides within Secretory and Endocytic Compartments.

S. Soriano, A. S. C. Chyung, X. Chen, G. B. Stokin, V. M.-Y. Lee, and E. H. Koo (1999)
J. Biol. Chem. 274, 32295-32300
 |  Abstract »  |  Full Text »  |  PDF »

Uptake, Degradation, and Release of Fibrillar and Soluble Forms of Alzheimer's Amyloid beta -Peptide by Microglial Cells.

H. Chung, M. I. Brazil, T. T. Soe, and F. R. Maxfield (1999)
J. Biol. Chem. 274, 32301-32308
 |  Abstract »  |  Full Text »  |  PDF »

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation.

L. Lin, B. Georgievska, A. Mattsson, and O. Isacson (1999)
PNAS 96, 12108-12113
 |  Abstract »  |  Full Text »  |  PDF »

Mutagenesis Identifies New Signals for beta -Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Abeta 42.

R. G. Perez, S. Soriano, J. D. Hayes, B. Ostaszewski, W. Xia, D. J. Selkoe, X. Chen, G. B. Stokin, and E. H. Koo (1999)
J. Biol. Chem. 274, 18851-18856
 |  Abstract »  |  Full Text »  |  PDF »

Cerebrospinal Fluid {beta}-Amyloid(1-42) in Alzheimer Disease: Differences Between Early- and Late-Onset Alzheimer Disease and Stability During the Course of Disease.

N. Andreasen, C. Hesse, P. Davidsson, L. Minthon, A. Wallin, B. Winblad, H. Vanderstichele, E. Vanmechelen, and K. Blennow (1999)
Arch Neurol 56, 673-680
 |  Abstract »  |  Full Text »  |  PDF »

{gamma}-Secretase, Evidence for Multiple Proteolytic Activities and Influence of Membrane Positioning of Substrate on Generation of Amyloid {beta} Peptides of Varying Length.

M. P. Murphy, L. J. Hickman, C. B. Eckman, S. N. Uljon, R. Wang, and T. E. Golde (1999)
J. Biol. Chem. 274, 11914-11923
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of the cleavage specificity of Alzheimer's disease gamma -secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.

S. F. Lichtenthaler, R. Wang, H. Grimm, S. N. Uljon, C. L. Masters, and K. Beyreuther (1999)
PNAS 96, 3053-3058
 |  Abstract »  |  Full Text »  |  PDF »

Competition of Aß amyloid peptide and apolipoprotein E for receptor-mediated endocytosis.

K. Winkler, H. Scharnagl, U. Tisljar, H. Hoschützky, I. Friedrich, M. M. Hoffmann, M. Hüttinger, H. Wieland, and W. März (1999)
J. Lipid Res. 40, 447-455
 |  Abstract »  |  Full Text »

Role of ERAB/L-3-Hydroxyacyl-coenzyme A Dehydrogenase Type II Activity in Abeta -induced Cytotoxicity.

S. Du Yan, Y. Shi, A. Zhu, J. Fu, H. Zhu, Y. Zhu, L. Gibson, E. Stern, K. Collison, F. Al-Mohanna, et al. (1999)
J. Biol. Chem. 274, 2145-2156
 |  Abstract »  |  Full Text »  |  PDF »

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.

J Schlondorff and C. Blobel (1999)
J. Cell Sci. 112, 3603-3617
 |  Abstract »  |  PDF »

Protease Inhibitor Coinfusion with Amyloid beta -Protein Results in Enhanced Deposition and Toxicity in Rat Brain.

S. A. Frautschy, D. L. Horn, J. J. Sigel, M. E. Harris-White, J. J. Mendoza, F. Yang, T. C. Saido, and G. M. Cole (1998)
J. Neurosci. 18, 8311-8321
 |  Abstract »  |  Full Text »  |  PDF »

Products of the Alzheimer's disease amyloid precursor protein generated by,{beta}-secretase are present in human platelets, and secreted upon degranulation.

Q.-X. Li, R. Cappai, G. Evin, J. E. Tanner, C. W. Gray, K. Beyreuther, and C. L. Masters (1998)
American Journal of Alzheimer's Disease and Other Dementias 13, 236-244
 |  Abstract »  |  PDF »

Alzheimer's amyloid beta and lipid metabolism: a missing link?.

A. R. Koudinov, T. T. Berezov, and N. V. Koudinova (1998)
FASEB J 12, 1097-1099
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X11 Interaction with beta -Amyloid Precursor Protein Modulates Its Cellular Stabilization and Reduces Amyloid beta -Protein Secretion.

M. Sastre, R. S. Turner, and E. Levy (1998)
J. Biol. Chem. 273, 22351-22357
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic imbalance in Alzheimer fibroblasts as potential pathological trait of disease.

F. Paoletti and D. Tombaccini (1998)
FASEB J 12, 925-927
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Increased Production of Amyloid Precursor Protein Provides a Substrate for Caspase-3 in Dying Motoneurons.

N. Y. Barnes, L. Li, K. Yoshikawa, L. M. Schwartz, R. W. Oppenheim, and C. E. Milligan (1998)
J. Neurosci. 18, 5869-5880
 |  Abstract »  |  Full Text »  |  PDF »

Thyroid Hormones Regulate {beta}-Amyloid Gene Splicing and Protein Secretion in Neuroblastoma Cells.

M. J. Latasa, B. Belandia, and A. Pascual (1998)
Endocrinology 139, 2692-2698
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta  Protein-(1-42) Forms Calcium-permeable, Zn2+-sensitive Channel.

S. K. Rhee, A. P. Quist, and R. Lal (1998)
J. Biol. Chem. 273, 13379-13382
 |  Abstract »  |  Full Text »  |  PDF »

Dramatic Aggregation of Alzheimer Abeta by Cu(II) Is Induced by Conditions Representing Physiological Acidosis.

C. S. Atwood, R. D. Moir, X. Huang, R. C. Scarpa, N. M. E. Bacarra, D. M. Romano, M. A. Hartshorn, R. E. Tanzi, and A. I. Bush (1998)
J. Biol. Chem. 273, 12817-12826
 |  Abstract »  |  Full Text »  |  PDF »

Detection of a Novel Intraneuronal Pool of Insoluble Amyloid beta  Protein that Accumulates with Time in Culture.

D. M. Skovronsky, R. W. Doms, and V. M.-Y. Lee (1998)
J. Cell Biol. 141, 1031-1039
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's-specific effects of soluble beta -amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts.

A. Favit, M. Grimaldi, T. J. Nelson, and D. L. Alkon (1998)
PNAS 95, 5562-5567
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Abeta Production in Human Primary Neuron Cultures..

A. C. LeBlanc, M. Koutroumanis, and C. G. Goodyer (1998)
J. Neurosci. 18, 2907-2913
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Alzheimer beta -Fibrillogenesis by Melatonin.

M. Pappolla, P. Bozner, C. Soto, H. Shao, N. K. Robakis, M. Zagorski, B. Frangione, and J. Ghiso (1998)
J. Biol. Chem. 273, 7185-7188
 |  Abstract »  |  Full Text »  |  PDF »

alpha 2-macroglobulin associates with beta -amyloid peptide and prevents fibril formation.

S. R. Hughes, O. Khorkova, S. Goyal, J. Knaeblein, J. Heroux, N. G. Riedel, and S. Sahasrabudhe (1998)
PNAS 95, 3275-3280
 |  Abstract »  |  Full Text »  |  PDF »

Fibrillar beta -Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS In Vivo.

D. T. Weldon, S. D. Rogers, J. R. Ghilardi, M. P. Finke, J. P. Cleary, E. O'Hare, W. P. Esler, J. E. Maggio, and P. W. Mantyh (1998)
J. Neurosci. 18, 2161-2173
 |  Abstract »  |  Full Text »  |  PDF »

Cleavage of Alzheimer's Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway. IDENTIFICATION OF INTRACELLULAR COMPARTMENTS IN WHICH APP CLEAVAGE OCCURS WITHOUT USING TOXIC AGENTS THAT INTERFERE WITH PROTEIN METABOLISM.

S. Tomita, Y. Kirino, and T. Suzuki (1998)
J. Biol. Chem. 273, 6277-6284
 |  Abstract »  |  Full Text »  |  PDF »

Turnover of Amyloid beta -Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester.

M. J. Savage, S. P. Trusko, D. S. Howland, L. R. Pinsker, S. Mistretta, A. G. Reaume, B. D. Greenberg, R. Siman, and R. W. Scott (1998)
J. Neurosci. 18, 1743-1752
 |  Abstract »  |  Full Text »  |  PDF »

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease.

L. Gasparini, M. Racchi, G. Binetti, M. Trabucchi, S. B. Solerte, D. Alkon, R. Etcheberrigaray, G. Gibson, J. Blass, R. Paoletti, et al. (1998)
FASEB J 12, 17-34
 |  Abstract »  |  Full Text »

The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of Drosophila Enabled.

K. S. Ermekova, N. Zambrano, H. Linn, G. Minopoli, F. Gertler, T. Russo, and M. Sudol (1997)
J. Biol. Chem. 272, 32869-32877
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Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction Pathway.

J. Mills, D. Laurent Charest, F. Lam, K. Beyreuther, N. Ida, S. L. Pelech, and P. B. Reiner (1997)
J. Neurosci. 17, 9415-9422
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Amyloid beta -Protein (Abeta ) 1-40 But Not Abeta 1-42 Contributes to the Experimental Formation of Alzheimer Disease Amyloid Fibrils in Rat Brain.

R.-W. Shin, K. Ogino, A. Kondo, T. C. Saido, J. Q. Trojanowski, T. Kitamoto, and J. Tateishi (1997)
J. Neurosci. 17, 8187-8193
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Zinc-induced Alzheimer's Abeta 1-40 Aggregation Is Mediated by Conformational Factors.

X. Huang, C. S. Atwood, R. D. Moir, M. A. Hartshorn, J.-P. Vonsattel, R. E. Tanzi, and A. I. Bush (1997)
J. Biol. Chem. 272, 26464-26470
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Late Compartments of Amyloid Precursor Protein Transport in SY5Y Cells Are Involved in beta -Amyloid Secretion.

G. C. Peraus, C. L. Masters, and K. Beyreuther (1997)
J. Neurosci. 17, 7714-7724
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Novel beta -Secretase Cleavage of beta -Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells.

A. S.C. Chyung, B. D. Greenberg, D. G. Cook, R. W. Doms, and V. M.-Y. Lee (1997)
J. Cell Biol. 138, 671-680
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Aggregation and disaggregation of senile plaques in Alzheimer disease.

L. Cruz, B. Urbanc, S. V. Buldyrev, R. Christie, T. Gomez-Isla, S. Havlin, M. McNamara, H. E. Stanley, and B. T. Hyman (1997)
PNAS 94, 7612-7616
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Generation of Alzheimer beta -amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation.

H. Xu, D. Sweeney, R. Wang, G. Thinakaran, A. C. Y. Lo, S. S. Sisodia, P. Greengard, and S. Gandy (1997)
PNAS 94, 3748-3752
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Disaggregation of Alzheimer beta -amyloid by site-directed mAb.

B. Solomon, R. Koppel, D. Frankel, and E. Hanan-Aharon (1997)
PNAS 94, 4109-4112
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