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Science 2 October 1992:
Vol. 258. no. 5079, pp. 103 - 109
DOI: 10.1126/science.1439756
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Articles

Science, Vol 258, Issue 5079, 103-109
Copyright © 1992 by American Association for the Advancement of Science

articles

Genome analysis and the human X chromosome

JL Mandel, AP Monaco, DL Nelson, D Schlessinger, and H Willard

Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, INSERM, Strasbourg, France.

A unified genetic, physical, and functional map of the human X chromosome is being built through a concerted, international effort. About 40 percent of the 160 million base pairs of the X chromosome DNA have been cloned in overlapping, ordered contigs derived from yeast artificial chromosomes. This rapid progress toward a physical map is accelerating the identification of inherited disease genes, 26 of which are already cloned and more than 50 others regionally localized by linkage analysis. This article summarizes the mapping strategies now used and the impact of genome research on the understanding of X chromosome inactivation and X-linked diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
4.5-Mb YAC STS contig at 50-kb resolution, spanning Xq25 deletions in two patients with lymphoproliferative syndrome..
G Porta, S MacMillan, R Nagaraja, S Mumm, I Zucchi, G Pilia, S Maio, T Featherstone, and D Schlessinger (1997)
Genome Res. 7, 27-36
   Abstract »    PDF »
Epigenetic and Chromosomal Control of Gene Expression: Molecular and Genetic Analysis of X Chromosome Inactivation.
H.F. Willard, C.J. Brown, L. Carrel, B. Hendrich, and A.P. Miller (1993)
Cold Spring Harb Symp Quant Biol 58, 315-322
   Abstract »    PDF »


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