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Science 4 September 1992:
Vol. 257. no. 5075, pp. 1412 - 1415
DOI: 10.1126/science.1529342
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Articles

Science, Vol 257, Issue 5075, 1412-1415
Copyright © 1992 by American Association for the Advancement of Science

articles

Dependence of cortical plasticity on correlated activity of single neurons and on behavioral context

E Ahissar, E Vaadia, M Ahissar, H Bergman, A Arieli, and M Abeles

Department of Physiology, Hebrew University, Hadassah Medical School, Jerusalem, Israel.

It has not been possible to analyze the cellular mechanisms underlying learning in behaving mammals because of the difficulties in recording intracellularly from awake animals. Therefore, in the present study of neuronal plasticity in behaving monkeys, the net effect of a single neuron on another neuron (the "functional connection") was evaluated by cross-correlating the times of firing of the two neurons. When two neurons were induced to fire together within a short time window, the functional connection between them was potentiated, and when simultaneous firing was prevented, the connection was depressed. These modifications were strongly dependent on the behavioral context of the stimuli that induced them. The results indicate that changes in the temporal contingency between neurons are often necessary, but not sufficient, for cortical plasticity in the adult monkey: behavioral relevance is required.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)