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Science 4 September 1992:
Vol. 257. no. 5075, pp. 1407 - 1409
DOI: 10.1126/science.1529341
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Articles

Science, Vol 257, Issue 5075, 1407-1409
Copyright © 1992 by American Association for the Advancement of Science

articles

A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans

M Salmi and S Jalkanen

National Public Health Institute, Turku University, Finland.

Interactions between leukocyte surface receptors and their ligands on vascular endothelial cells control lymphocyte traffic between the blood and various lymphoid organs, as well as extravasation of leukocytes into sites of inflammation. A heretofore undescribed 90-kilodalton human endothelial cell adhesion molecule (VAP-1) defined by a monoclonal antibody 1B2 is described. The expression pattern, molecular mass, functional properties, and an amino-terminal amino acid sequence define VAP-1 as an endothelial ligand for lymphocytes. VAP-1 helps to elucidate the complex heterotypic cell interactions that direct tissue-selective lymphocyte migration in man.


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Isolation, Structural Characterization, and Chromosomal Mapping of the Mouse Vascular Adhesion Protein-1 Gene and Promoter.
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Circulating Form of Human Vascular Adhesion Protein-1 (VAP-1): Increased Serum Levels in Inflammatory Liver Diseases.
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J. Immunol. 161, 1549-1557
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Cloning of  Vascular Adhesion Protein 1 Reveals a Novel Multifunctional Adhesion Molecule.
D. J. Smith, M. Salmi, P. Bono, J. Hellman, T. Leu, and S. Jalkanen (1998)
J. Exp. Med. 188, 17-27
   Abstract »    Full Text »    PDF »
Cloning and Characterization of Mouse Vascular Adhesion Protein-1 Reveals a Novel Molecule with Enzymatic Activity.
P. Bono, M. Salmi, D. J. Smith, and S. Jalkanen (1998)
J. Immunol. 160, 5563-5571
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The Role of Two Distinct Endothelial Molecules, Vascular Adhesion Protein-1 and Peripheral Lymph Node Addressin, in the Binding of Lymphocyte Subsets to Human Lymph Nodes.
M. Salmi, J. Hellman, and S. Jalkanen (1998)
J. Immunol. 160, 5629-5636
   Abstract »    Full Text »    PDF »
Vascular Adhesion Protein-1 and ICAM-1 Support the Adhesion of Tumor-Infiltrating Lymphocytes to Tumor Endothelium in Human Hepatocellular Carcinoma.
K. F. Yoong, G. McNab, S. G. Hubscher, and D. H. Adams (1998)
J. Immunol. 160, 3978-3988
   Abstract »    Full Text »    PDF »
Vascular Adhesion Protein 1 (VAP-1) Mediates Lymphocyte Subtype-specific, Selectin-independent Recognition of Vascular Endothelium in Human Lymph Nodes.
M. Salmi, S. Tohka, E. L. Berg, E. C. Butcher, and S. Jalkanen (1997)
J. Exp. Med. 186, 589-600
   Abstract »    Full Text »    PDF »
Heterogeneity of Endothelial Cells : Specific Markers.
C. Garlanda and E. Dejana (1997)
Arterioscler. Thromb. Vasc. Biol. 17, 1193-1202
   Abstract »    Full Text »


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